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Current Opinion in Pharmacology, ISSN 1471-4892, 08/2019, Volume 47, pp. 97 - 101
Osteoclasts are cells of the hematopoietic lineage that are responsible for bone resorption. Their activity is crucial in the initiation of bone remodeling and... 
ACTIVATION | BONE LOSS | NUCLEOTIDE RECEPTORS | PAIN | ANTAGONIST | RESORPTION | GENE | FUNCTIONAL POLYMORPHISMS | A-317491 | PHARMACOLOGY & PHARMACY | ATP | Physiological aspects | Medicine, Experimental | Osteoporosis | Medical research | Development and progression | Estrogen
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 561 - 580
The purinergic P2X receptors are ligand-gated cation channels activated by the endogenous ligand ATP. They assemble as homo- or heterotrimers from seven cloned... 
Molecular modelling | Nucleotides | Purinergic receptors | P2X receptor antagonists | P2X receptor agonists | P2X receptors | POTENT ANTAGONIST | SURAMIN ANALOG NF279 | CHEMISTRY, MEDICINAL | PHARMACOLOGICAL CHARACTERIZATION | AGONIST BINDING | ATP-BINDING | EXTRACELLULAR LOOP | NEUROPATHIC PAIN | CONFORMATIONAL ENERGIES | MOLECULAR-FORCE FIELD | IN-VITRO ACTIVITY | Anthraquinones - metabolism | Receptors, Purinergic P2X - chemistry | Humans | Molecular Conformation | Azoles - metabolism | Guanidines - pharmacology | Purinergic P2X Receptor Agonists - metabolism | Purinergic P2X Receptor Antagonists - pharmacology | Structure-Activity Relationship | Adenosine Triphosphate - metabolism | Purinergic P2X Receptor Agonists - chemistry | Receptors, Purinergic P2X - metabolism | Binding Sites | Guanidines - metabolism | Polycyclic Compounds - metabolism | Phenols - pharmacology | Polycyclic Compounds - chemistry | Models, Molecular | Rats | Zebrafish | Phenols - metabolism | Azoles - pharmacology | Purinergic P2X Receptor Agonists - pharmacology | Azoles - chemistry | Guanidines - chemistry | Polycyclic Compounds - pharmacology | Animals | Purinergic P2X Receptor Antagonists - chemistry | Purinergic P2X Receptor Antagonists - metabolism | Ligands | Phenols - chemistry | Anthraquinones - pharmacology | Anthraquinones - chemistry | Structure | Analysis | Crystals | Membrane proteins | Index Medicus
Journal Article
CANCER LETTERS, ISSN 0304-3835, 08/2017, Volume 402, pp. 93 - 99
This review considers evidence suggesting that activation of the ionotropic purinergic receptor P2X(7) (P2X(7)R) is a contributing factor in the growth of... 
EXTRACELLULAR ATP | lonotropic purinergic receptor P2X | ALZHEIMERS-DISEASE | MACROPHAGES | NECROSIS-FACTOR-ALPHA | RELEASE | Microglia | Brain tumor | P2X7 RECEPTOR | INHIBITION | Elevated extracellular ATP | ONCOLOGY | Glioma cells | IN-VIVO | EXPRESSION | P2XR antagonist | ENDOTHELIAL GROWTH-FACTOR
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 03/2016, Volume 27, Issue 3, pp. 848 - 862
Podocytes are specialized, highly differentiated epithelial cells in the kidney glomerulus that are exposed to glomerular capillary pressure and possible... 
GLOMERULOSCLEROSIS | ACTIVATION | TRPC6 | PROTEIN | SLIT DIAPHRAGM | UROLOGY & NEPHROLOGY | FAWN-HOODED RAT | ANGIOTENSIN-II | ACTIN CYTOSKELETON | TYPE-1 RECEPTOR | HYPERTENSION
Journal Article
NEUROREPORT, ISSN 0959-4965, 11/2008, Volume 19, Issue 17, pp. 1715 - 1719
Pharmacological antagonism of the ionotropic purinergic P2X(7)R has been studied for effects on inflammatory reactivity and neuronal viability in... 
blood-brain barrier | EXTRACELLULAR ATP | HUMAN MICROGLIA | MACROPHAGES | amyloid-beta-peptide | Alzheimer's disease animal model | INJECTED RAT HIPPOCAMPUS | NEUROSCIENCES | P2X receptor antagonist brilliant blue G | purinergic P2X receptor | INHIBITION | neuroprotection | LIPOPOLYSACCHARIDE | FUNCTIONAL-RESPONSES | inflammatory reactivity | microglia | EXPRESSION | BRAIN | Immunohistochemistry | Adenosine Triphosphate - administration & dosage | Neurons - pathology | Peptide Fragments - toxicity | Neuroprotective Agents - antagonists & inhibitors | Male | Hippocampus - drug effects | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Adenosine Triphosphate - pharmacology | Gliosis - pathology | Platelet Aggregation Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - pharmacology | Neurons - metabolism | Amyloid beta-Peptides - administration & dosage | Alzheimer Disease - chemically induced | Neurons - drug effects | Disease Models, Animal | Amyloid beta-Peptides - toxicity | Gliosis - metabolism | Peptide Fragments - administration & dosage | Purinergic P2 Receptor Antagonists | Rats | Hippocampus - pathology | Purinergic P2 Receptor Agonists | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Adenosine Triphosphate - analogs & derivatives | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Hippocampus - metabolism | Animals | Receptors, Purinergic P2 - metabolism | Alzheimer Disease - metabolism | Neuroprotective Agents - agonists | Index Medicus
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 08/2009, Volume 52, Issue 8, pp. 1579 - 1588
In obesity, beta cells activate compensatory mechanisms to adapt to the higher insulin demand. Interleukin-1 receptor antagonist (IL-1Ra) prevents... 
Obesity | APOPTOSIS | HUMAN PANCREATIC-ISLETS | Interleukin-1 receptor antagonist | URINE INHIBITOR | RELEASE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | HIGH GLUCOSE | Islets | MICE | IL-1-BETA | Diabetes | Purinergic receptor P2X | TYPE-2 DIABETES-MELLITUS | EXPRESSION
Journal Article
Current Topics in Membranes, ISSN 1063-5823, 2017, Volume 80, pp. 211 - 232
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 05/2007, Volume 27, Issue 18, pp. 4957 - 4968
We investigated the involvement and roles of the ionotropic purinergic receptor P2X(7)R in microglia in mediating lipopolysaccharide (LPS)-induced inflammatory... 
oxidized ATP | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | NUCLEOTIDE RECEPTOR | P2X receptor | SUBSTANTIA-NIGRA | NEUROSCIENCES | CELL-DEATH | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | IN-VITRO | PROGRESSIVE NEURODEGENERATION | inflammation | cytokines | lipopolysaccharide | microglia | EXPRESSION
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 02/2010, Volume 24, Issue 2, pp. 337 - 345
Purine nucleotides are well established as extracellular signaling molecules. P2X receptors are ATP-gated cation channels that mediate fast excitatory... 
EXTRACELLULAR ATP | chronic pain | BIOCHEMISTRY & MOLECULAR BIOLOGY | neurodegeneration | MAJOR-DEPRESSIVE-DISORDER | NECROSIS-FACTOR-ALPHA | PORE FORMATION | MICROGLIAL CELLS | P2X7 NUCLEOTIDE RECEPTOR | CELL BIOLOGY | CYTOKINE PRODUCTION | inflammation | BIOLOGY | cytokines | SPINAL-CORD-INJURY | INTERLEUKIN-1-BETA RELEASE | depression | ATP | microglia | NF-KAPPA-B
Journal Article
Neuropharmacology, ISSN 0028-3908, 05/2016, Volume 104, pp. 31 - 49
Pharmacological tool compounds are now available to define action at the adenosine (ARs), P2Y and P2X receptors. We present a selection of the most commonly... 
Nucleosides | GPCR | Agonists | Antagonists | Nucleotides | Ion channel | ATP | PROTEIN-COUPLED RECEPTORS | ALLOSTERIC MODULATION | NEUROSCIENCES | NEUROPATHIC PAIN | NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE | IN-VIVO | ION-CHANNEL | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | PURINERGIC RECEPTOR | P2Y RECEPTOR | STRUCTURE-BASED DESIGN | Purinergic P1 Receptor Agonists - chemistry | Receptors, Purinergic P2Y - chemistry | Receptors, Purinergic P2X - chemistry | Humans | Purinergic P1 Receptor Agonists - pharmacology | Receptors, Purinergic P2Y - metabolism | Purinergic P1 Receptor Antagonists - therapeutic use | Purinergic P2Y Receptor Agonists - chemistry | Purinergic P2Y Receptor Agonists - therapeutic use | Structure-Activity Relationship | Purinergic P1 Receptor Agonists - therapeutic use | Chemistry, Pharmaceutical | Purinergic P1 Receptor Antagonists - pharmacology | Purinergic P2Y Receptor Agonists - pharmacology | Receptors, Purinergic P1 - chemistry | Animals | Purinergic Agents - chemistry | Purinergic Agents - therapeutic use | Receptors, Purinergic P2X - metabolism | Receptors, Purinergic P1 - metabolism | Purinergic Agents - pharmacology | Purinergic P1 Receptor Antagonists - chemistry | Prevention | Brain | Purines | Enzymes | Injuries | Chronic pain | Cancer | antagonists | nucleosides | agonists | ion channel | nucleotides
Journal Article