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Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2012, Volume 26, Issue 7, pp. 2951 - 2962
Prostaglandins (PGs) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well-established endogenous... 
Inflammation | Purinergic receptors | Macrophages | Pyrogen | In vivo bioluminescence | EXTRACELLULAR ATP | purinergic receptors | ACTIVATED PROTEIN-KINASE | CYCLOOXYGENASE-2 | pyrogen | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | macrophages | MESSENGER-RNA | inflammation | in vivo bioluminescence | P2X RECEPTOR | MOUSE MODEL | BIOLOGY | ANTIINFLAMMATORY DRUGS | PROSTAGLANDIN E-2 | Adenosine Triphosphate - administration & dosage | Dinoprostone - physiology | Humans | Lipopolysaccharides - administration & dosage | Purinergic P2X Receptor Antagonists - pharmacology | Leukotriene B4 - biosynthesis | Fever - physiopathology | Receptors, Purinergic P2X7 - genetics | MAP Kinase Signaling System | Adenosine Triphosphate - metabolism | Inflammation Mediators - physiology | Calcium Signaling | Macrophages - physiology | Interleukin-1beta - physiology | Mice, Inbred C57BL | Injections, Intraperitoneal | Receptors, Purinergic P2X4 - physiology | Thromboxane B2 - biosynthesis | Purinergic P2X Receptor Agonists - pharmacology | Receptors, Purinergic P2X7 - physiology | Recombinant Proteins - administration & dosage | Mice, Knockout | Receptors, Purinergic P2X7 - deficiency | Animals | Interleukin-1beta - administration & dosage | Cyclooxygenase 2 - metabolism | Fever - etiology | Macrophages - drug effects | Mice | In Vitro Techniques
Journal Article
Glia, ISSN 0894-1491, 04/2014, Volume 62, Issue 4, pp. 592 - 607
ATP is an important regulator of microglia and its effects on microglial cytokine release are currently discussed as important contributors in a variety of... 
antagonists | purine receptors | neuroinflammation | neuroprotection | Neuroprotection | Neuroinflammation | Antagonists | Purine receptors | EXTRACELLULAR ATP | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | FOCAL CEREBRAL-ISCHEMIA | NEUROSCIENCES | P2X7 RECEPTOR | TUMOR-NECROSIS-FACTOR | P2X RECEPTOR | PURINERGIC RECEPTORS | INTERLEUKIN-1-BETA RELEASE | ACTIVATED MICROGLIA | CYTOKINE RELEASE | Tumor Necrosis Factor-alpha - metabolism | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Receptors, Purinergic P2X4 - deficiency | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Microglia - physiology | Chemokine CCL2 - metabolism | Cell Differentiation - physiology | Interleukin-6 - metabolism | Animals, Newborn | Brain - cytology | Interleukin-6 - genetics | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Connexins - genetics | Chemokine CCL2 - genetics | Nerve Tissue Proteins - genetics | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 - physiology | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Purinergic P2X7 - deficiency | Animals | Cell Differentiation - drug effects | Mice
Journal Article
Journal Article
Pain, ISSN 0304-3959, 08/2011, Volume 152, Issue 8, pp. 1766 - 1776
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2012, Volume 695, Issue 1-3, pp. 20 - 26
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 34, pp. 11559 - 11573
Microglia are known to invade the mammalian spinal cord (SC) at an early embryonic stage. While the mechanisms underlying this early colonization of the... 
EXTRACELLULAR ATP | IN-VITRO | ACTIVATION | RAT P2X RECEPTORS | MOUSE | PORE | INTERLEUKIN-1-BETA RELEASE | CHANNELS | ATP RELEASE | NEUROSCIENCES | CELL-DEATH | Membrane Potentials - genetics | Electric Stimulation | Embryo, Mammalian | Spinal Cord - growth & development | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Gene Expression Regulation, Developmental - genetics | Ki-67 Antigen - metabolism | Purinergic P2X Receptor Antagonists - pharmacology | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Receptors, Purinergic P2X7 - genetics | Rosaniline Dyes | Antigens, CD - metabolism | Adenosine Triphosphate - pharmacology | Cell Differentiation - genetics | Microglia - physiology | Spinal Cord - cytology | Receptors, Chemokine - genetics | Cell Differentiation - physiology | Membrane Potentials - drug effects | Connexins - deficiency | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Biophysics | Cell Adhesion Molecules - metabolism | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | GPI-Linked Proteins - metabolism | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Purinergic P2X7 - deficiency | Patch-Clamp Techniques | Animals | Cell Differentiation - drug effects | Receptors, Purinergic P2X7 - metabolism | Mice | CX3C Chemokine Receptor 1 | Life Sciences | Neurons and Cognition
Journal Article
Immunity, ISSN 1074-7613, 07/2018, Volume 49, Issue 1, pp. 56 - 65.e4
Potassium (K ) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the... 
KCNK6 | potassium channel | NLRP3 inflammasome | TWIK2 | inflammation | P2X7 receptor | P-2X RECEPTOR | ASC | MECHANISM | CLONING | P2X | K+ EFFLUX | IMMUNOLOGY | HYPERTENSION | CASPASE-1 ACTIVATION | Macrophages - transplantation | Inflammasomes - metabolism | Caspase 1 - metabolism | Adenosine Triphosphate - pharmacology | Potassium Channels - metabolism | Inflammasomes - drug effects | Interleukin-1beta - metabolism | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Lung Injury - metabolism | Quinine - pharmacology | Potassium Channels, Tandem Pore Domain - metabolism | Cell Line | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Potassium Channels, Tandem Pore Domain - deficiency | Potassium Channels - drug effects | Sepsis - physiopathology | Mice, Knockout | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Receptors, Purinergic P2X7 - deficiency | Lung Injury - physiopathology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Caspase 1 - deficiency | Lipopolysaccharides - pharmacology | Potassium Channels, Tandem Pore Domain - antagonists & inhibitors | Receptors, Purinergic P2X7 - metabolism | Inflammation - physiopathology | Prevention | Medical colleges | Inflammation | Potassium channels | Macrophages | Efflux | Cytokines | Pathogenesis | Activation | Adoptive transfer | Proteins | Cell activation | Injury prevention | Clonal deletion | Lungs | Rodents | Bone marrow | Deletion | Sepsis | Potassium
Journal Article