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1. Full Text Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
by Yang, Dahai and He, Yuan and Muñoz-Planillo, Raul and Liu, Qin and Núñez, Gabriel
Immunity, ISSN 1074-7613, 11/2015, Volume 43, Issue 5, pp. 923 - 932
The noncanonical inflammasome induced by intracellular lipopolysaccharide (LPS) leads to caspase-11-dependent pyroptosis, which is critical for induction of... 
APOPTOSIS | RECEPTOR P2X | RECOGNITION | NLRP3 INFLAMMASOME ACTIVATION | CYTOPLASMIC LPS | ATP RELEASE | INTRACELLULAR LPS | IMMUNOLOGY | TUMORIGENESIS | EXPRESSION | CUTTING EDGE | Pyroptosis - physiology | Cell Line | Inflammasomes - metabolism | Pyroptosis - drug effects | Humans | Mice, Inbred C57BL | Toll-Like Receptor 3 - metabolism | Shock, Septic - metabolism | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Animals | Caspases - metabolism | Inflammasomes - drug effects | Signal Transduction - drug effects | Adenosine Triphosphate - metabolism | HEK293 Cells | Lipopolysaccharides - pharmacology | Receptors, Purinergic P2X7 - metabolism | Signal Transduction - physiology | Mice | Septic shock | Mortality | Cytotoxicity | Tumor necrosis factor-TNF | Statistical analysis | E coli | Apoptosis | Index Medicus
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2. Full Text Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
by Gulbransen, Brian D and Bashashati, Mohammad and Hirota, Simon A and Gui, Xianyong and Roberts, Jane A and MacDonald, Justin A and Muruve, Daniel A and McKay, Derek M and Beck, Paul L and Mawe, Gary M and Thompson, Roger J and Sharkey, Keith A
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 600 - 604
Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions associated with long-term gut dysfunction resulting from alterations to the... 
MEDICINE, RESEARCH & EXPERIMENTAL | STIMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNERVATION | RELEASE | CELL BIOLOGY | RECOVERY | INHIBITION | P2X RECEPTORS | MYENTERIC NEURONS | GLIA | ATP | MOTILITY | Myenteric Plexus - pathology | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Gastrointestinal Motility - drug effects | Colitis - pathology | Male | Glial Fibrillary Acidic Protein - metabolism | Cytoskeletal Proteins - deficiency | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Caspases - metabolism | Time Factors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Cytoskeletal Proteins - metabolism | Neurons - metabolism | Cell Death - drug effects | Dinitrofluorobenzene - analogs & derivatives | Neurons - drug effects | Disease Models, Animal | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Gastrointestinal Motility - genetics | Phosphodiesterase Inhibitors - pharmacology | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Connexins - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Dinitrofluorobenzene - pharmacology | Analysis of Variance | Cell Death - physiology | Signal Transduction - drug effects | CARD Signaling Adaptor Proteins | Nitric Oxide Synthase Type I - metabolism | Receptors, Purinergic P2X7 - metabolism | Mice | Neural receptors | Neurons | Physiological aspects | Development and progression | Genetic aspects | Research | Colitis | Inflammatory bowel disease | Nervous system | Gene expression | Apoptosis | Index Medicus
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3. Full Text Expression of P2X7 receptor increases in vivo tumor growth
by Adinolfi, Elena and Raffaghello, Lizzia and Giuliani, Anna Lisa and Cavazzini, Luigi and Capece, Marina and Chiozzi, Paola and Bianchi, Giovanna and Kroemer, Guido and Pistoia, Vito and Di Virgilio, Francesco
Cancer Research, ISSN 0008-5472, 06/2012, Volume 72, Issue 12, pp. 2957 - 2969
The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, recent evidence suggests a role for P2X7 in cell proliferation. Here,... 
EXTRACELLULAR ATP | ACTIVATION | P2X ATP RECEPTOR | DENDRITIC CELLS | ONCOLOGY | DISEASE | PROLIFERATION | PURINERGIC RECEPTOR | RELEASE | CANCER | HUMAN NEUROBLASTOMA | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Biomarkers, Tumor | Bevacizumab | Adenosine Triphosphate - pharmacology | Neoplasms, Experimental - pathology | Antibodies, Monoclonal, Humanized - pharmacology | HEK293 Cells | Female | Mice, Inbred C57BL | Adenosine Triphosphate - analogs & derivatives | Animals | Cell Transformation, Neoplastic | Mice, Nude | NFATC Transcription Factors - biosynthesis | Cell Line, Tumor | Receptors, Purinergic P2X7 - metabolism | Receptors, Purinergic P2X7 - biosynthesis | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Apoptosis | Neoplasms, Experimental - blood supply | Index Medicus
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4. Full Text P2X7 receptor channels allow direct permeation of nanometer-sized dyes
by Browne, Liam E and Compan, Vincent and Bragg, Laricia and North, R. Alan
Journal of Neuroscience, ISSN 0270-6474, 02/2013, Volume 33, Issue 8, pp. 3557 - 3566
P2X receptors are widely distributed in the nervous system, and P2X7 receptors have roles in neuropathic pain and in the release of cytokines from microglia.... 
EXTRACELLULAR ATP | P-2X RECEPTOR | DOMAIN | P2X RECEPTOR | GATED ION CHANNELS | RAT MAST-CELLS | PORE FORMATION | RELEASE | SELECTIVITY | NEUROSCIENCES | UNITARY CONDUCTANCE | Nanoparticles | Particle Size | Animals | Cell Membrane Permeability - physiology | Humans | HEK293 Cells | Fluorescent Dyes - metabolism | Rats | Receptors, Purinergic P2X7 - metabolism | Receptors, Purinergic P2X7 - biosynthesis | Cell Membrane Permeability - genetics | Receptors, Purinergic P2X7 - genetics | Index Medicus
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5. Full Text Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A‐438079
by Jimenez‐Pacheco, Alba and Mesuret, Guillaume and Sanz‐Rodriguez, Amaya and Tanaka, Katsuhiro and Mooney, Claire and Conroy, Ronan and Miras‐Portugal, Maria Teresa and Diaz‐Hernandez, Miguel and Henshall, David C and Engel, Tobias
Epilepsia, ISSN 0013-9580, 09/2013, Volume 54, Issue 9, pp. 1551 - 1561
Purpose: ATP is an essential transmitter/cotransmitter in neuron function and pathophysiology and has recently emerged as a potential contributor to prolonged... 
2X7 receptor | Neuroprotection | ATP | Status epilepticus | Cortex | P2X7 receptor | MICROGLIAL ACTIVATION | TEMPORAL-LOBE EPILEPSY | TERMINALS | KAINIC ACID | EPILEPTOGENESIS | DAMAGE | CLINICAL NEUROLOGY | PATHOPHYSIOLOGY | P2X RECEPTORS | NEURONAL DEATH | Tetrazoles - pharmacology | Seizures - drug therapy | Status Epilepticus - chemically induced | Status Epilepticus - pathology | Mice, Transgenic | Hippocampus - drug effects | Hippocampus - cytology | Anticonvulsants - pharmacology | Seizures - chemically induced | Up-Regulation - drug effects | Neocortex - drug effects | Animals | Neuroprotective Agents - pharmacology | Cell Death - physiology | Receptors, Purinergic P2X7 - metabolism | Mice | Pyridines - pharmacology | Status Epilepticus - metabolism | Brain | Anticonvulsants | Epilepsy | Index Medicus
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6. Full Text The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein
by Franceschini, Alessia and Capece, Marina and Chiozzi, Paola and Falzoni, Simonetta and Sanz, Juana Maria and Sarti, Alba Clara and Bonora, Massimo and Pinton, Paolo and Di Virgilio, Francesco
FASEB Journal, ISSN 0892-6638, 06/2015, Volume 29, Issue 6, pp. 2450 - 2461
The P2X7 receptor (P2X7R) is a known and powerful activator of the NOD-like receptor (NLR) P3 inflammasome; however, the underlying pathways are poorly... 
Purinergic receptors | Inflammation | Extracellular ATP | purinergic receptors | IMMUNITY | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXINS | MECHANISMS | RELEASE | PLASMA-MEMBRANE | BETA | CELL BIOLOGY | inflammation | P2X RECEPTOR | BIOLOGY | extracellular ATP | Microglia - metabolism | Inflammasomes - metabolism | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Cytoplasm - metabolism | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | HEK293 Cells | Microglia - cytology | Cell Line | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Adenosine Triphosphate - analogs & derivatives | Blotting, Western | Mice, Knockout | Up-Regulation - drug effects | Carrier Proteins - genetics | Microscopy, Confocal | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Protein Binding | Receptors, Purinergic P2X7 - metabolism | Macrophages - drug effects | Cytoplasm - drug effects | Index Medicus
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7. Full Text Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice
by Engel, Tobias and Gomez-Villafuertes, Rosa and Tanaka, Katsuhiro and Mesuret, Guillaume and Sanz-Rodriguez, Amaya and Garcia-Huerta, Paula and Miras-Portugal, M. Teresa and Henshall, David C and Diaz-Hernandez, Miguel
FASEB Journal, ISSN 0892-6638, 04/2012, Volume 26, Issue 4, pp. 1616 - 1628
Prolonged seizures [status epilepticus (SE)] constitute a neurological emergency that can permanently damage the brain. SE results from a failure of the normal... 
Pharmacoresistance | Temporal lobe epilepsy | Anticonvulsant | ATP | EXTRACELLULAR ATP | temporal lobe epilepsy | MICROGLIAL ACTIVATION | TEMPORAL-LOBE EPILEPSY | GLUTAMATE RELEASE | anticonvulsant | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFICIENT MICE | CELL BIOLOGY | pharmacoresistance | P2X RECEPTOR | BIOLOGY | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | SYNAPTIC TERMINALS | C-FOS EXPRESSION | Lorazepam - pharmacology | Neuroprotective Agents - therapeutic use | Microglia - metabolism | Seizures - prevention & control | Seizures - drug therapy | Status Epilepticus - chemically induced | Status Epilepticus - drug therapy | Male | Neurons - cytology | Purinergic P2X Receptor Antagonists - pharmacology | Anticonvulsants - pharmacology | Receptors, Purinergic P2X7 - genetics | Seizures - chemically induced | Lorazepam - therapeutic use | Seizures - physiopathology | Neuroprotective Agents - pharmacology | Seizures - pathology | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Neurons - metabolism | Neurons - drug effects | Microglia - cytology | Glutamic Acid - pharmacology | Kainic Acid - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Status Epilepticus - pathology | Anticonvulsants - therapeutic use | Excitatory Amino Acid Agonists - pharmacology | Hippocampus - pathology | Hippocampus - cytology | Purinergic P2X Receptor Agonists - pharmacology | Mice, Knockout | Animals | Receptors, Purinergic P2X7 - metabolism | Status Epilepticus - physiopathology | Mice | Index Medicus
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8. Full Text Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567
by Bhattacharya, Anindya and Wang, Qi and Ao, Hong and Shoblock, James R and Lord, Brian and Aluisio, Leah and Fraser, Ian and Nepomuceno, Diane and Neff, Robert A and Welty, Natalie and Lovenberg, Timothy W and Bonaventure, Pascal and Wickenden, Alan D and Letavic, Michael A
British Journal of Pharmacology, ISSN 0007-1188, 10/2013, Volume 170, Issue 3, pp. 624 - 640
Background and PurposeAn increasing body of evidence suggests that the purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7) in the CNS may play a key... 
interleukin 1β | 1β | neuropathic pain | purinergic | P2X7 | autoradiography | microdialysis | depression | mania | interleukin 1β (IL-1β) | NERVOUS-SYSTEM | interleukin 1 (IL-1) | BIPOLAR DISORDER | KNOCKOUT MICE | ARRIVE GUIDELINES | P2RX7 GENE | P2X RECEPTOR | ANIMAL-MODELS | ION-CHANNEL | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | Niacinamide - analogs & derivatives | Analgesics - pharmacology | Bipolar Disorder - metabolism | Capillary Permeability | Receptors, Purinergic P2X7 - drug effects | Humans | Neuralgia - metabolism | Analgesics - metabolism | Male | Piperazines - metabolism | Purinergic P2X Receptor Antagonists - pharmacology | Adenosine Triphosphate - pharmacology | Brain - metabolism | Dose-Response Relationship, Drug | Depression - metabolism | Transfection | Neuralgia - prevention & control | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Behavior, Animal - drug effects | Neuralgia - psychology | Antidepressive Agents - pharmacology | Macaca | Disease Models, Animal | Binding, Competitive | Cell Line | Antimanic Agents - pharmacology | Niacinamide - metabolism | Mice, Inbred C57BL | Rats | Piperazines - pharmacology | Rats, Sprague-Dawley | Adenosine Triphosphate - analogs & derivatives | Bipolar Disorder - psychology | Blood-Brain Barrier - metabolism | Brain - drug effects | Animals | Depression - prevention & control | Calcium Signaling - drug effects | Dogs | Depression - psychology | Protein Binding | Purinergic P2X Receptor Antagonists - metabolism | Receptors, Purinergic P2X7 - metabolism | Mice | Niacinamide - pharmacology | Bipolar Disorder - prevention & control | Chemical properties | Depression, Mental | Analysis | Chronic pain | Index Medicus | Research Papers
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9. Full Text P2X7 receptor antagonism: Implications in diabetic retinopathy
by Platania, Chiara Bianca Maria and Giurdanella, Giovanni and Di Paola, Luisa and Leggio, Gian Marco and Drago, Filippo and Salomone, Salvatore and Bucolo, Claudio
Biochemical Pharmacology, ISSN 0006-2952, 08/2017, Volume 138, pp. 130 - 139
Diabetic retinopathy (DR) is the most frequent complication of diabetes and one of leading causes of blindness worldwide. Early phases of DR are characterized... 
Pericytes | Diabetic retinopathy | Inflammation | IL-1β | P2X7 receptor | Molecular modeling | MOLECULAR-DYNAMICS | ACTIVATION | MECHANISM | IL-1 beta | RELEASE | ASTROCYTES | ATP-BINDING | NETWORK ANALYSIS | IN-VITRO | PHARMACOLOGY & PHARMACY | BINDING-SITES | P2X-INDUCED PORE FORMATION | Niacinamide - analogs & derivatives | Diabetic Retinopathy - drug therapy | Pericytes - drug effects | Purinergic P2X Receptor Antagonists - pharmacokinetics | Apoptosis - drug effects | Expert Systems | Humans | Molecular Conformation | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Piperazines - metabolism | Purinergic P2X Receptor Antagonists - pharmacology | Piperazines - chemistry | Diabetic Retinopathy - pathology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Niacinamide - chemistry | Pericytes - pathology | Databases, Protein | Niacinamide - pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Piperazines - pharmacokinetics | Biomarkers - metabolism | Diabetic Retinopathy - immunology | Niacinamide - metabolism | Allosteric Site - drug effects | Pericytes - metabolism | Cells, Cultured | Computational Biology | Models, Molecular | Piperazines - pharmacology | Diabetic Retinopathy - metabolism | Pericytes - immunology | Animals | Databases, Chemical | Purinergic P2X Receptor Antagonists - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Purinergic P2X Receptor Antagonists - metabolism | Receptors, Purinergic P2X7 - metabolism | Ligands | ROC Curve | Molecular Docking Simulation | Structural Homology, Protein | Niacinamide - pharmacology | Receptors, Purinergic P2X7 - chemistry | Medical colleges | Analysis | Blindness | Physiological aspects | Glucose | Dextrose | Index Medicus
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10. Full Text The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice
by Kim, Ji-Eun and Kang, Tae-Cheon
Journal of Clinical Investigation, ISSN 0021-9738, 05/2011, Volume 121, Issue 5, pp. 2037 - 2047
Pannexin-1 (Panx1) plays a role in the release of ATP and glutamate in neurons and astrocytes. Panx1 can be opened at the resting membrane potential by... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | IN-VITRO | P2X RECEPTOR | CALCIUM | GAP-JUNCTION HEMICHANNELS | STATUS EPILEPTICUS | INTERLEUKIN-1-BETA RELEASE | CELL-CELL COMMUNICATION | PANNEXIN-1 HEMICHANNELS | ATP RELEASE | Genetic Predisposition to Disease | Mice, Inbred C57BL | Gene Expression Regulation | Gene Silencing | Electrophysiology | Male | Mice, Transgenic | Receptors, Muscarinic - metabolism | Seizures - metabolism | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Animals | Models, Biological | Receptors, Purinergic P2X7 - metabolism | Mice | Neurons - metabolism | Receptors | Physiological aspects | Acetylcholine | Disease susceptibility | Research | Seizures (Medicine) | Risk factors | Membrane proteins | Index Medicus | Abridged Index Medicus
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11. Full Text The purinergic receptor P2x7 triggers α-secretase-dependent processing of the amyloid precursor protein
by Delarasse, Cécile and Auger, Rodolphe and Gonnord, Pauline and Fontaine, Bertrand and Kanellopoulos, Jean M
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 4, pp. 2596 - 2606
The amyloid precursor protein (APP) is cleaved by beta- and gamma-secretases to generate the beta-amyloid (A beta) peptides, which are present in large amounts... 
EXTRACELLULAR ATP | ALZHEIMER-DISEASE | TUMOR-NECROSIS-FACTOR | L-SELECTIN | P2X RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID RAFTS | MOUSE MODEL | RELEASE | MICE LACKING | CELL-DEATH | Amyloid Precursor Protein Secretases - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Stem Cells - metabolism | Receptors, Purinergic P2X7 - genetics | Gene Knockdown Techniques | Protease Inhibitors - pharmacology | MAP Kinase Kinase 4 - metabolism | Mice, Mutant Strains | Amyloid beta-Protein Precursor - metabolism | MAP Kinase Kinase 4 - antagonists & inhibitors | Neurons - metabolism | Hydroxamic Acids - pharmacology | Protein Structure, Tertiary | ADAM Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Dipeptides - pharmacology | Alzheimer Disease - drug therapy | Hippocampus - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Alzheimer Disease - metabolism | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Receptors, Purinergic P2X7 - metabolism | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Alzheimer Disease - genetics | Astrocytes - metabolism | Index Medicus | MAP Kinases (MAPKs) | Purinergic Receptor | Secretases | Alzheimer Disease | ATP | Cell Biology
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12. Full Text P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice
by Furlan-Freguia, Christian and Marchese, Patrizia and Gruber, András and Ruggeri, Zaverio M and Ruf, Wolfram
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2932 - 2944
Thrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the vessel wall, on myeloid cells, and on microparticles (MPs) with... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-DISULFIDE-ISOMERASE | FORMATION IN-VIVO | P2X RECEPTOR | ENDOTHELIAL-CELLS | FACTOR ACTIVATION | SMOOTH-MUSCLE-CELLS | INTERLEUKIN-1-BETA RELEASE | PORE FORMATION | FIBRIN GENERATION | PROCOAGULANT ACTIVITY | Myeloid Cells - cytology | Thrombosis - physiopathology | Enzyme Inhibitors - metabolism | Protein Disulfide-Isomerases - metabolism | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | NADPH Oxidases - metabolism | Macrophages - cytology | Receptors, Purinergic P2X7 - genetics | Mice, Knockout | Inflammation - metabolism | Macrophages - metabolism | Protein Disulfide-Isomerases - genetics | Animals | Adenosine Triphosphate - metabolism | Bone Marrow Transplantation | Myeloid Cells - metabolism | Receptors, Purinergic P2X7 - metabolism | Signal Transduction - physiology | Cell-Derived Microparticles - metabolism | Mice | Thromboplastin - metabolism | Cell receptors | Physiological aspects | Cellular signal transduction | Research | Thrombosis | Blood clot | Risk factors | Index Medicus | Abridged Index Medicus
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13. Full Text Structural basis for subtype-specific inhibition of the P2X7 receptor
by Karasawa, Akira and Kawate, Toshimitsu and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
eLife, ISSN 2050-084X, 12/2016, Volume 5, Issue 2016
The P2X7 receptor is a non-selective cation channel activated by extracellular adenosine triphosphate (ATP). Chronic activation of P2X7 underlies many health... 
RHEUMATOID-ARTHRITIS | NEUROPATHIC PAIN | ACTIVATION | ANTAGONIST | MANAGEMENT | P2X RECEPTOR | BIOLOGY | ION-CHANNEL | METHOTREXATE | PURINOCEPTOR | DISCOVERY | Animals | Purinergic P2X Receptor Antagonists - chemistry | Humans | Models, Molecular | Protein Binding | Purinergic P2X Receptor Antagonists - metabolism | Receptors, Purinergic P2X7 - metabolism | Crystallography, X-Ray | Protein Conformation | Receptors, Purinergic P2X7 - chemistry | Channel opening | Allosteric properties | Pain | Antagonists | Hydrophobicity | Drug development | ATP | Experiments | Crystallography | Drug dosages | Binding sites | Index Medicus | BASIC BIOLOGICAL SCIENCES
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