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Journal Article
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2014, Volume 171, Issue 23, pp. 5330 - 5344
Background and PurposeIsotretinoin (13-cis-retinoic acid; 13-cRA) is a differentiation inducer used to treat minimal residual disease after myeloablative... 
CELL LUNG-CANCER | RECEPTOR-ALPHA EXPRESSION | RETINOIC ACID | HUMAN NEURO-BLASTOMA | 2ND PRIMARY TUMORS | BONE-MARROW-TRANSPLANTATION | PHARMACOLOGY & PHARMACY | HIGH-RISK NEUROBLASTOMA | CANCER-STUDY-GROUP | MYELOABLATIVE THERAPY | CHILDRENS ONCOLOGY GROUP | Central Nervous System Neoplasms - blood | Microsomes - metabolism | Oncogene Proteins - genetics | Humans | Neuroblastoma - blood | Chromatography, High Pressure Liquid | RNA, Messenger - metabolism | Receptors, Retinoic Acid - genetics | Microsomes - drug effects | Tandem Mass Spectrometry | Tretinoin - analogs & derivatives | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | N-Myc Proto-Oncogene Protein | Isotretinoin - pharmacokinetics | Nuclear Proteins - genetics | Neurites - drug effects | Tretinoin - blood | Tretinoin - pharmacology | Central Nervous System Neoplasms - metabolism | Isotretinoin - pharmacology | Isotretinoin - blood | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Receptors, Retinoic Acid - metabolism | Animals | Cytochrome P-450 CYP3A - metabolism | Neuroblastoma - drug therapy | Antineoplastic Agents - blood | Cell Line, Tumor | Cell Proliferation - drug effects | Mice, Inbred BALB C | Neuroblastoma - metabolism | Central Nervous System Neoplasms - drug therapy | Antiacne agents | Metabolites | RNA | Liver | Cytochrome P-450 | Development and progression | Isotretinoin | Neuroblastoma | Tumors | Vitamin A | Acids | Metabolism | Index Medicus | Research Papers
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 50, pp. 42195 - 42205
Retinoic acid (RA) regulates gene transcription by activating the nuclear receptors retinoic acid receptor (RAR) and peroxisome proliferator-activated receptor... 
LIM PROTEIN | STEM-CELLS | EMBRYONAL CARCINOMA-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | F9 TERATOCARCINOMA CELLS | REV-ERB-ALPHA | NEURONAL DIFFERENTIATION | KERATINOCYTES | EXPRESSION | BINDING PROTEIN-II | Sirtuin 1 - metabolism | Neurons - cytology | Fatty Acid-Binding Proteins - metabolism | LIM Domain Proteins - metabolism | Neoplasm Proteins - metabolism | Neural Stem Cells - cytology | Sirtuin 1 - genetics | Receptors, Retinoic Acid - genetics | Mice, Mutant Strains | Antineoplastic Agents - pharmacology | Neurogenesis - drug effects | Neurons - metabolism | Neoplasm Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tretinoin - pharmacology | Cell Line | PPAR-beta - metabolism | Protein-Serine-Threonine Kinases - genetics | Receptors, Retinoic Acid - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Hippocampus - cytology | PPAR-beta - genetics | Fatty Acid-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Animals | Signal Transduction - drug effects | Neurogenesis - physiology | LIM Domain Proteins - genetics | Signal Transduction - physiology | Mice | Neural Stem Cells - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Transcription Regulation | Retinoid-binding Protein | Neurodifferentiation | Nuclear Receptors | Retinoid | Cell Biology
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 129, Issue 4, pp. 723 - 733
Transcriptional activation of the nuclear receptor RAR by retinoic acid (RA) often leads to inhibition of cell growth. However, in some tissues, RA promotes... 
ACUTE-PROMYELOCYTIC-LEUKEMIA | PPAR-BETA | BREAST-CANCER CELLS | TERATOCARCINOMA STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMARY-CARCINOMA | SYMPATHETIC NEURONS | E-FABP | FATTY-ACIDS | TARGET GENE | BINDING PROTEIN-II | CELL BIOLOGY | Active Transport, Cell Nucleus - physiology | Apoptosis - drug effects | Humans | Transcriptional Activation - drug effects | Cell Survival - genetics | Apoptosis - genetics | Mammary Neoplasms, Experimental - physiopathology | Fatty Acid-Binding Proteins - metabolism | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Receptors, Retinoic Acid - genetics | Cell Nucleus - metabolism | Mammary Neoplasms, Animal - physiopathology | Female | Gene Expression Regulation, Neoplastic - physiology | Mammary Neoplasms, Animal - genetics | Tretinoin - pharmacology | Receptors, Retinoic Acid - drug effects | Cell Survival - drug effects | PPAR-beta - metabolism | Keratinocytes | Receptors, Retinoic Acid - metabolism | Cell Transformation, Neoplastic - metabolism | Fatty Acid-Binding Proteins - genetics | Animals | PPAR-beta - drug effects | Active Transport, Cell Nucleus - drug effects | Mammary Neoplasms, Animal - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transcriptional Activation - physiology | Cell Transformation, Neoplastic - drug effects | Cell Nucleus - drug effects | Growth | Tretinoin | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 60, Issue 2, pp. 308 - 320
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16582 - 16587
Direct evidence for a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differentiation and meiotic entry of... 
Germ cells | Spermatocytes | Spermatogenesis | Spermatogonia | Stem cells | Meiosis | Testes | Seminiferous tubules | Cellular differentiation | Sertoli cells | Mouse | Mutagenesis | RAR/RXR heterodimer | Retinoid antagonist | MOUSE TESTIS | SPERMATOGENESIS | retinoid antagonist | UNDIFFERENTIATED SPERMATOGONIA | MULTIDISCIPLINARY SCIENCES | mutagenesis | VITAMIN-A | mouse | GENE | GERM-CELLS | SEX DETERMINATION | EXPRESSION PATTERN | TRANSGENIC MICE | KIT EXPRESSION | Immunohistochemistry | Spermatocytes - metabolism | Gene Expression - drug effects | Retinal Dehydrogenase - metabolism | Male | Mice, 129 Strain | Receptors, Retinoic Acid - genetics | Sertoli Cells - drug effects | Spermatogonia - metabolism | Cell Differentiation - genetics | Meiosis - drug effects | In Situ Hybridization | Spermatocytes - drug effects | Tretinoin - metabolism | Female | Spermatogonia - cytology | Aldehyde Dehydrogenase - metabolism | Tretinoin - pharmacology | Sertoli Cells - metabolism | Spermatogonia - drug effects | Mice, Inbred C57BL | Paracrine Communication - genetics | Aldehyde Dehydrogenase - genetics | Mice, Transgenic | Receptors, Retinoic Acid - metabolism | Retinal Dehydrogenase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Meiosis - genetics | Animals | Cell Differentiation - drug effects | Paracrine Communication - drug effects | Mice | Physiological aspects | Research | Cell differentiation | Health aspects | Tretinoin | Cell division | Enzymes | Biosynthesis | Metabolites | Insects | Gene expression | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Biological Sciences | RAR | RXR heterodimer
Journal Article