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1. Full Text The 5-HT3 receptor – the relationship between structure and function
by Barnes, Nicholas M and Hales, Tim G and Lummis, Sarah C.R and Peters, John A
Neuropharmacology, ISSN 0028-3908, 01/2009, Volume 56, Issue 1, pp. 273 - 284
The 5-hydroxytryptamine type-3 (5-HT ) receptor is a cation-selective ion channel of the Cys-loop superfamily. 5-HT receptor activation in the central and... 
5-Hydroxytryptamine type-3 (5-HT3) receptor | Ligand binding domain | HTR3A and HTR3B polymorphisms | Single channel conductance | 5-HT3 subunit distribution | Ion selectivity | subunit distribution | receptor | 5-Hydroxytryptamine type-3 (5-HT | 5-HT | GATED ION-CHANNEL | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | NUCLEUS-TRACTUS-SOLITARIUS | CELL-SURFACE EXPRESSION | DIFFERENTIAL SUBCELLULAR-LOCALIZATION | SUPERIOR CERVICAL-GANGLION | DORSAL-ROOT GANGLION | NEUROSCIENCES | NICOTINIC ACETYLCHOLINE-RECEPTOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | LIGAND-BINDING DOMAIN | Protein Structure, Tertiary | Receptors, Serotonin, 5-HT3 - chemistry | Animals | Receptors, Serotonin, 5-HT3 - genetics | Humans | Models, Molecular | Receptors, Serotonin, 5-HT3 - physiology | Protein Subunits - chemistry | Protein Subunits - physiology | Protein Subunits - genetics | Index Medicus
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2. Full Text Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence
by Enoch, M.-A and Gorodetsky, E and Hodgkinson, C and Roy, A and Goldman, D
Molecular Psychiatry, ISSN 1359-4184, 11/2011, Volume 16, Issue 11, pp. 1139 - 1146
The 5-HT3 receptor is rapidly potentiated by ethanol and mediates fast excitatory serotonin (5-HT) transmission that modulates dopamine release in the reward... 
rs1176744 | heroin | HTR3B | 5-HTTLPR | alcoholism | cocaine | HEROIN DEPENDENCE | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | ONDANSETRON | MAJOR DEPRESSION | POLYMORPHISM | NEUROSCIENCES | HIPPOCAMPUS | N-ALCOHOLS | ASSOCIATION | SUBUNIT | Serotonin - physiology | Genetic Predisposition to Disease | Heroin Dependence - ethnology | Receptors, Serotonin, 5-HT3 - genetics | Comorbidity | Humans | Middle Aged | African Americans - genetics | Genotype | Male | Alcoholism - ethnology | Cocaine-Related Disorders - genetics | Cocaine-Related Disorders - ethnology | Haplotypes - genetics | Serotonin Plasma Membrane Transport Proteins - genetics | Dopamine - physiology | Alleles | Adult | Alcoholism - genetics | Polymorphism, Single Nucleotide | Reward | Heroin Dependence - genetics | Drug abuse | Serotonin | Alcoholism | Physiological aspects | Diagnosis | Research | Single nucleotide polymorphisms
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3. Full Text Discriminating between 5‐HT3A and 5‐HT3AB receptors
by Thompson, AJ and Lummis, SCR
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 736 - 747
The 5‐HT3B subunit was first cloned in 1999, and co‐expression with the 5‐HT3A subunit results in heteromeric 5‐HT3AB receptors that are functionally distinct... 
5‐HT3A | 5‐HT3B | allosteric | 5‐HT3 | 5‐HT3AB | ion channel | Cys‐loop | ligand gated | antagonist | ligand | 5-HT3AB | 5-HT | 5-HT3A | Cys-loop | 5-HT3B | GATED ION-CHANNEL | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | SEROTONIN 5-HT3 | CYS-LOOP RECEPTORS | MOLECULAR DETERMINANTS | NEUROBLASTOMA-CELLS | STRUCTURAL DETERMINANTS | 5-HT3 | 5-HTAB RECEPTORS | GABA(A) RECEPTOR | PHARMACOLOGY & PHARMACY | LIGAND-BINDING SITE | Receptors, Serotonin, 5-HT3 - chemistry | Humans | Molecular Conformation | Protein Multimerization | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - metabolism | Serotonin 5-HT3 Receptor Agonists - metabolism | Protein Subunits - metabolism | Antiemetics - therapeutic use | Antiemetics - chemistry | Serotonin 5-HT3 Receptor Antagonists - chemistry | Binding Sites - drug effects | Protein Subunits - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Drug Partial Agonism | Receptors, Serotonin, 5-HT3 - genetics | Models, Molecular | Recombinant Proteins - chemistry | Binding, Competitive - drug effects | Serotonin 5-HT3 Receptor Antagonists - therapeutic use | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Ligands | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Serotonin 5-HT3 Receptor Antagonists - pharmacology | Serotonin 5-HT3 Receptor Agonists - therapeutic use | Antiemetics - pharmacology | Competition | Reviews
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4. Full Text The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
by Lee, SooHyun and Hjerling-Leffler, Jens and Zagha, Edward and Fishell, Gord and Rudy, Bernardo
Journal of Neuroscience, ISSN 0270-6474, 12/2010, Volume 30, Issue 50, pp. 16796 - 16808
A highly diverse population of neocortical GABAergic inhibitory interneurons has been implicated in multiple functions in information processing within... 
GREEN FLUORESCENT PROTEIN | RAT FRONTAL-CORTEX | CORTICAL GABA INTERNEURONS | CENTRAL-NERVOUS-SYSTEM | BASAL FOREBRAIN | CAUDAL GANGLIONIC EMINENCE | SOMATOSENSORY BARREL CORTEX | FATE MAPPING REVEALS | FEEDFORWARD INHIBITION | NEUROSCIENCES | CEREBRAL-CORTEX | Interneurons - physiology | Receptors, Serotonin, 5-HT3 - genetics | Synaptic Transmission - physiology | Acetylcholine - pharmacology | gamma-Aminobutyric Acid - metabolism | Male | Mice, Transgenic | Patch-Clamp Techniques - methods | Somatosensory Cortex - physiology | Cell Differentiation - genetics | Animals | Interneurons - metabolism | Receptors, Nicotinic - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Chromosomes, Artificial, Bacterial | Somatosensory Cortex - embryology | Receptors, Serotonin, 5-HT3 - physiology | Female | Interneurons - cytology | Mice | Somatosensory Cortex - metabolism
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5. Full Text The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects
by Kondo, M and Nakamura, Y and Ishida, Y and Shimada, S
Molecular Psychiatry, ISSN 1359-4184, 11/2015, Volume 20, Issue 11, pp. 1428 - 1437
Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown... 
SEROTONIN RECEPTOR | ADULT-RAT HIPPOCAMPUS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | VOLUNTARY EXERCISE | ENVIRONMENTAL ENRICHMENT | VENTRAL HIPPOCAMPUS | PHYSICAL-EXERCISE | SYNAPTIC PLASTICITY | NEUROSCIENCES | LONG-TERM POTENTIATION | DENTATE GYRUS | PARKINSONS-DISEASE | Microtubule-Associated Proteins - metabolism | Fear - drug effects | Phosphopyruvate Hydratase - metabolism | Hippocampus - drug effects | Piperidines - pharmacology | Swimming - psychology | Exploratory Behavior - drug effects | Fear - psychology | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Mice, Inbred C57BL | Cell Proliferation - physiology | Mice, Transgenic | Neuropeptides - metabolism | Hindlimb Suspension | Hippocampus - cytology | Physical Conditioning, Animal - physiology | Animals | Serotonin Agents - pharmacology | Neurogenesis - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Cell Proliferation - drug effects | Mice
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6. Menthol inhibits 5-HT3 receptor-mediated currents
by Ashoor, Abrar and Nordman, Jacob C and Veltri, Daniel and Yang, Keun-Hang Susan and Shuba, Yaroslav and Al Kury, Lina and Sadek, Bassem and Howarth, Frank C and Shehu, Amarda and Kabbani, Nadine and Oz, Murat
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2013, Volume 347, Issue 2, pp. 398 - 409
The effects of alcohol monoterpene menthol, a major active ingredient of the peppermint plant, were tested on the function of human 5-hydroxytryptamine type 3... 
ACETYLCHOLINE-RECEPTORS | GABA(A) RECEPTOR | 5-HYDROXYTRYPTAMINE RECEPTOR | XENOPUS-LAEVIS OOCYTES | PROTEIN-STRUCTURE | PHARMACOLOGY & PHARMACY | TRPM8 ION-CHANNEL | PEPPERMINT OIL | NONCOMPETITIVE INHIBITION | SENSORY NEURONS | I-TASSER | Binding, Competitive | Membrane Potentials - drug effects | Receptors, Serotonin, 5-HT3 - genetics | Oocytes - metabolism | Humans | Xenopus laevis | Rats | Imidazoles - pharmacology | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Animals | Menthol - pharmacology | Transfection | Receptors, Serotonin, 5-HT3 - metabolism | Protein Binding | Female | Indoles - pharmacology | Molecular Docking Simulation | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - pharmacology
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7. Full Text Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy
by Mica Ohara-Imaizumi and Hail Kim and Masashi Yoshida and Tomonori Fujiwara and Kyota Aoyagi and Yukiko Toyofuku and Yoko Nakamichi and Chiyono Nishiwaki and Tadashi Okamura and Toyoyoshi Uchida and Yoshio Fujitani and Kimio Akagawa and Masafumi Kakei and Hirotaka Watada and Michael S. German and Shinya Nagamatsu
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 48, pp. 19420 - 19425
In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin... 
Pregnancy | Beta cells | Receptors | Serotonin receptors | Islet cells | Cell membranes | Islets of Langerhans | Gestational diabetes | Insulin | Insulin secretion | 5-HT3 RECEPTORS | IN-VITRO | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | MASS | GESTATIONAL DIABETES-MELLITUS | PLACENTAL-LACTOGEN | RAT ISLETS | PROLIFERATION | PROLACTIN | LANGERHANS | Immunohistochemistry | Receptors, Serotonin, 5-HT3 - genetics | Mice, Inbred C57BL | Immunoblotting | Serotonin - pharmacology | Mice, Knockout | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | Glucose - metabolism | Female | Signal Transduction - physiology | Mice | Insulin Secretion | Microscopy, Fluorescence | Biological Sciences
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8. Full Text The role of 5-HT3 receptors in signaling from taste buds to nerves
by Larson, Eric D and Vandenbeuch, Aurelie and Voigt, Anja and Meyerhof, Wolfgang and Kinnamon, Sue C and Finger, Thomas E
Journal of Neuroscience, ISSN 0270-6474, 12/2015, Volume 35, Issue 48, pp. 15984 - 15995
Activation of taste buds triggers the release of several neurotransmitters, including ATP and serotonin (5-hydroxytryptamine; 5-HT). Type III taste cells... 
Geniculate ganglion | 5ht3 | Calcium | Serotonin | Taste signaling | Barbiturate | OUTSIDE-OUT PATCHES | calcium | taste signaling | ENTERIC NERVOUS-SYSTEM | SYNAPTIC-TRANSMISSION | BASIC PROPERTIES | barbiturate | NEUROSCIENCES | N1E-115 NEUROBLASTOMA-CELLS | ACID TASTE | serotonin | NEURAL RESPONSES | 3 DIFFERENT STRAINS | geniculate ganglion | III CELLS | ATP RELEASE | Taste Buds - physiology | Adjuvants, Anesthesia - pharmacology | Pentobarbital - pharmacology | Male | Green Fluorescent Proteins - genetics | Serotonin - pharmacology | Adenosine Triphosphate - pharmacology | Sensory Receptor Cells - physiology | Female | Transducin - metabolism | Taste - genetics | Action Potentials - drug effects | Taste Buds - drug effects | Green Fluorescent Proteins - metabolism | Stilbamidines - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Mice, Transgenic | Taste - physiology | Action Potentials - physiology | Animals | Sensory Receptor Cells - drug effects | Signal Transduction - drug effects | Receptors, Purinergic P2X3 - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Signal Transduction - physiology | Mice | Geniculate Ganglion - metabolism
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9. Full Text Characterizing new fluorescent tools for studying 5-HT3 receptor pharmacology
by Jack, Thomas and Simonin, Jonathan and Ruepp, Marc-David and Thompson, Andrew J and Gertsch, Jürg and Lochner, Martin
Neuropharmacology, ISSN 0028-3908, 03/2015, Volume 90, pp. 63 - 73
The pharmacological characterization of ligands depends upon the ability to accurately measure their binding properties. Fluorescence provides an alternative... 
Fluorescence | Ligand binding | Flow cytometry | Fluorescence polarization | Cys-loop | 5-HT3 receptor | receptor | 5-HT | SEROTONIN RECEPTOR | LIGAND-BINDING | SUPERRESOLUTION MICROSCOPY | MEMBRANE | 5-HTAB RECEPTOR | MOUSE | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | ION CHANNELS | ANTAGONISTS | EXPRESSION | LIVING CELLS | Fluorescent Dyes - chemistry | Fluorescent Dyes - pharmacokinetics | Receptors, Serotonin, 5-HT3 - genetics | Humans | Mice, Inbred C57BL | Male | Intestines - metabolism | Blotting, Western | Animals | Flow Cytometry | Serotonin Agents - chemistry | Serotonin Agents - pharmacology | Receptors, Serotonin, 5-HT3 - metabolism | HEK293 Cells | Fluorescent Dyes - pharmacology | Cysteine - metabolism | Molecular Structure | Serotonin Agents - pharmacokinetics | Mutation | Radioligand Assay | Fluorescence Polarization | Salivary Glands - metabolism
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10. Full Text Discovery of a novel allosteric modulator of 5-HT3 receptors: Inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site
by Trattnig, Sarah M and Harpsøe, Kasper and Thygesen, Sarah B and Rahr, Louise M and Ahring, Philip K and Balle, Thomas and Jensen, Anders A
Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 30, pp. 25241 - 25254
The ligand-gated ion channels in the Cys-loop receptor superfamily mediate the effects of neurotransmitters acetylcholine, serotonin, GABA, and glycine.... 
ACTIVATION | LIGAND-BINDING | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | IVERMECTIN | GLYCINE RECEPTOR | GENERAL-ANESTHETICS | FUNCTIONAL-CHARACTERIZATION | GABA(A) RECEPTORS | NICOTINIC ACETYLCHOLINE-RECEPTORS | Allosteric Regulation - drug effects | Allosteric Regulation - genetics | Receptors, Serotonin, 5-HT3 - genetics | Protein Structure, Secondary | Humans | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Signal Transduction - genetics | Mutation, Missense | Mutagenesis | Peptide Mapping | Signal Transduction - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | HEK293 Cells | Serotonin 5-HT3 Receptor Antagonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - chemistry | Binding Sites | Amino Acid Substitution | Site-directed Mutagenesis | Cys-loop Receptors | PU02 | Signal Transduction | Ion Channels | Serotonin | 5-HT3 Receptors | Allosteric Modulation | Negative Allosteric Modulator | Homology Modeling
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11. Full Text The auspicious role of the 5-HT3 receptor in depression: A probable neuronal target?
by Rajkumar, Ramamoorthy and Mahesh, Radhakrishnan
Journal of Psychopharmacology, ISSN 0269-8811, 04/2010, Volume 24, Issue 4, pp. 455 - 469
The serotonergic mechanisms have been successfully utilized by the majority of antidepressant drug discovery programmes, while the search for newer targets... 
Postsynaptic | Serotonin type-3 receptor | Depression | Antagonist | Behaviour | PSYCHIATRY | postsynaptic | FORCED SWIMMING TEST | antagonist | NEUROSCIENCES | CLINICAL NEUROLOGY | RAT NUCLEUS-ACCUMBENS | BIOLOGICALLY PREDISPOSED ALCOHOLICS | FUNCTIONAL EXPRESSION | IN-VIVO | serotonin type-3 receptor | MEDIAL PREFRONTAL CORTEX | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | behaviour | CENTRAL-NERVOUS-SYSTEM | OPEN-LABEL TRIAL | depression | VIVO DOPAMINE OUTFLOW | Receptors, Serotonin, 5-HT3 - genetics | Humans | Serotonin Antagonists - therapeutic use | Serotonin 5-HT3 Receptor Antagonists | Treatment Outcome | Clinical Trials as Topic | Depression - genetics | Evidence-Based Medicine | Polymorphism, Genetic | Antidepressive Agents - therapeutic use | Depression - drug therapy | Depression - metabolism | Animals | Receptors, Serotonin, 5-HT3 - metabolism | Depression - psychology | Models, Animal | Neurons - metabolism | Drug Evaluation, Preclinical | Neurons - drug effects | Molecular neurobiology | Usage | Serotonin agents | Depression, Mental | Research | Drug therapy | Health aspects
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12. Full Text Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel
by Lummis, Sarah C. R and Beene, Darren L and Lee, Lori W and Lester, Henry A and Broadhurst, R. William and Dougherty, Dennis A
Nature, ISSN 0028-0836, 11/2005, Volume 438, Issue 7065, pp. 248 - 252
5-Hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily(1). Neurotransmitter binding in these proteins triggers the... 
GABA(A) RECEPTOR | 5-HT3 RECEPTOR | GATING MECHANISM | MULTIDISCIPLINARY SCIENCES | ACCESSIBILITY | NICOTINIC RECEPTOR | CONFORMATION | RECEPTOR M2-M3 LOOP | AGONIST-BINDING | RESIDUES | ACETYLCHOLINE-RECEPTOR | Receptors, Serotonin, 5-HT3 - chemistry | Receptors, Serotonin, 5-HT3 - genetics | Magnetic Resonance Spectroscopy | Oocytes - metabolism | Mutagenesis - genetics | Neurotransmitter Agents - metabolism | Electrophysiology | Ion Channels - genetics | Models, Molecular | Neuroblastoma | Isomerism | Proline - chemistry | Proline - genetics | Proline - physiology | Animals | Ion Channels - metabolism | Models, Biological | Neurotransmitter Agents - pharmacology | Protein Structure, Secondary - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | Cell Line, Tumor | Mice | Ion Channels - chemistry | Ion Channel Gating - drug effects | Proteins | Ions | Amino acids | Neurotransmitters | Molecular biology | Binding sites
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13. Full Text Regulation of systemic energy homeostasis by serotonin in adipose tissues
by Oh, Chang-Myung and Namkung, Jun and Go, Younghoon and Shong, Ko Eun and Kim, Kyuho and Kim, Hyeongseok and Park, Bo-Yoon and Lee, Ho Won and Jeon, Yong Hyun and Song, Junghan and Shong, Minho and Yadav, Vijay K and Karsenty, Gerard and Kajimura, Shingo and Lee, In-Kyu and Park, Sangkyu and Kim, Hail
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6794
Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy... 
OBESITY | TRANSPORTER | ADIPOCYTES | HYPERPHAGIA | METABOLISM | MULTIDISCIPLINARY SCIENCES | PROOPIOMELANOCORTIN NEURONS | MOUSE | RECEPTOR | ASSOCIATION | EXPRESSION | Epididymis - metabolism | Thermogenesis - genetics | Receptor, Serotonin, 5-HT2A - genetics | Adipocytes, Brown - metabolism | Adipose Tissue, White - metabolism | Male | Tryptophan Hydroxylase - deficiency | Diet, High-Fat | Obesity - etiology | Energy Metabolism - genetics | Adipogenesis - genetics | Adipocytes, Brown - pathology | Adipose Tissue, White - pathology | Gene Expression | Receptors, Serotonin, 5-HT3 - genetics | 3T3-L1 Cells | Receptors, Serotonin, 5-HT3 - deficiency | Adipose Tissue, Brown - pathology | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Tryptophan Hydroxylase - genetics | Epididymis - pathology | Adipocytes, White - pathology | Animals | Serotonin - metabolism | Adipose Tissue, Brown - metabolism | Mice | Receptor, Serotonin, 5-HT2A - metabolism | Adipocytes, White - metabolism | Homeostasis - genetics | Brain | Phenotypes | Adipose tissue | Serotonin | Homeostasis | Energy expenditure | Lipids | Pharmacology | Adipocytes | Accumulation | High fat diet | Energy balance | Browning | Synthesis | Thermogenesis | Weight reduction | Inhibition | Lipogenesis | Adipose tissue (brown)
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