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1. Full Text The 5-HT3 receptor – the relationship between structure and function
by Barnes, Nicholas M and Hales, Tim G and Lummis, Sarah C.R and Peters, John A
Neuropharmacology, ISSN 0028-3908, 01/2009, Volume 56, Issue 1, pp. 273 - 284
5-Hydroxytryptamine type-3 (5-HT3) receptor | Ligand binding domain | HTR3A and HTR3B polymorphisms | Single channel conductance | 5-HT3 subunit distribution | Ion selectivity | subunit distribution | receptor | 5-Hydroxytryptamine type-3 (5-HT | 5-HT | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Protein Structure, Tertiary | Receptors, Serotonin, 5-HT3 - chemistry | Animals | Receptors, Serotonin, 5-HT3 - genetics | Humans | Models, Molecular | Receptors, Serotonin, 5-HT3 - physiology | Protein Subunits - chemistry | Protein Subunits - physiology | Protein Subunits - genetics | Index Medicus
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2. Full Text Discriminating between 5‐HT3A and 5‐HT3AB receptors
by Thompson, AJ and Lummis, SCR
British journal of pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 736 - 747
5‐HT3A | 5‐HT3B | allosteric | 5‐HT3 | 5‐HT3AB | ion channel | Cys‐loop | ligand gated | antagonist | ligand | 5-HT3AB | 5-HT | 5-HT3A | Cys-loop | 5-HT3B | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptors, Serotonin, 5-HT3 - chemistry | Humans | Molecular Conformation | Protein Multimerization | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - metabolism | Serotonin 5-HT3 Receptor Agonists - metabolism | Protein Subunits - metabolism | Antiemetics - therapeutic use | Antiemetics - chemistry | Serotonin 5-HT3 Receptor Antagonists - chemistry | Binding Sites - drug effects | Protein Subunits - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Drug Partial Agonism | Receptors, Serotonin, 5-HT3 - genetics | Models, Molecular | Recombinant Proteins - chemistry | Binding, Competitive - drug effects | Serotonin 5-HT3 Receptor Antagonists - therapeutic use | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Ligands | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Serotonin 5-HT3 Receptor Antagonists - pharmacology | Serotonin 5-HT3 Receptor Agonists - therapeutic use | Antiemetics - pharmacology | Competition | Index Medicus | Reviews | 5-HT3
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3. Full Text 5‐Chloroindole: a potent allosteric modulator of the 5‐HT3 receptor
by Newman, Amy S and Batis, Nikolaos and Grafton, Gillian and Caputo, Francesca and Brady, Catherine A and Lambert, Jeremy J and Peters, John A and Gordon, John and Brain, Keith L and Powell, Andrew D and Barnes, Nicholas M
British journal of pharmacology, ISSN 0007-1188, 07/2013, Volume 169, Issue 6, pp. 1228 - 1238
ligand‐gated ion channel | 5‐HT3 receptor | allosteric modulation | receptor | 5-HT | ligand-gated ion channel | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptors, Serotonin, 5-HT3 - chemistry | Allosteric Regulation | Humans | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - metabolism | Male | Receptors, Serotonin - genetics | Serotonin 5-HT3 Receptor Agonists - metabolism | Protein Subunits - metabolism | Indoles - metabolism | HEK293 Cells | Indoles - pharmacology | Serotonin 5-HT3 Receptor Antagonists - chemistry | Protein Subunits - genetics | Recombinant Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Drug Partial Agonism | Receptors, Serotonin, 5-HT3 - genetics | Nerve Tissue Proteins - agonists | Protein Subunits - agonists | Recombinant Proteins - chemistry | Receptors, Serotonin - chemistry | Nerve Tissue Proteins - genetics | Receptors, Serotonin - metabolism | Evoked Potentials - drug effects | Nerve Tissue Proteins - metabolism | Animals | Calcium Signaling - drug effects | Muscle Contraction - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | Urinary Bladder - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Analysis | Colchicine | Index Medicus | Research Papers | 5-HT3 receptor
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4. Full Text Discovery of a novel allosteric modulator of 5-HT3 receptors: Inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site
by Trattnig, Sarah M and Harpsøe, Kasper and Thygesen, Sarah B and Rahr, Louise M and Ahring, Philip K and Balle, Thomas and Jensen, Anders A
The Journal of biological chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 30, pp. 25241 - 25254
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Allosteric Regulation - drug effects | Allosteric Regulation - genetics | Receptors, Serotonin, 5-HT3 - genetics | Protein Structure, Secondary | Humans | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Signal Transduction - genetics | Mutation, Missense | Mutagenesis | Peptide Mapping | Signal Transduction - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | HEK293 Cells | Serotonin 5-HT3 Receptor Antagonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - chemistry | Binding Sites | Amino Acid Substitution | Index Medicus | Site-directed Mutagenesis | Cys-loop Receptors | PU02 | Signal Transduction | Ion Channels | Serotonin | 5-HT3 Receptors | Allosteric Modulation | Negative Allosteric Modulator | Homology Modeling
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5. Full Text Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence
by Enoch, M.-A and Gorodetsky, E and Hodgkinson, C and Roy, A and Goldman, D
Molecular psychiatry, ISSN 1359-4184, 11/2011, Volume 16, Issue 11, pp. 1139 - 1146
rs1176744 | heroin | HTR3B | 5-HTTLPR | alcoholism | cocaine | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Drug addiction | Toxicology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Alcoholism | Psychopathology. Psychiatry | Addictive behaviors | Biological and medical sciences | Medical sciences | Alcoholism and acute alcohol poisoning | Serotonin - physiology | Genetic Predisposition to Disease | Heroin Dependence - ethnology | Receptors, Serotonin, 5-HT3 - genetics | Comorbidity | Humans | Middle Aged | African Americans - genetics | Genotype | Male | Alcoholism - ethnology | Cocaine-Related Disorders - genetics | Cocaine-Related Disorders - ethnology | Haplotypes - genetics | Serotonin Plasma Membrane Transport Proteins - genetics | Dopamine - physiology | Alleles | Adult | Alcoholism - genetics | Polymorphism, Single Nucleotide | Reward | Heroin Dependence - genetics | Drug abuse | Serotonin | Physiological aspects | Diagnosis | Research | Single nucleotide polymorphisms | Index Medicus
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6. Full Text The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects
by Kondo, M and Nakamura, Y and Ishida, Y and Shimada, S
Molecular psychiatry, ISSN 1359-4184, 11/2015, Volume 20, Issue 11, pp. 1428 - 1437
Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Microtubule-Associated Proteins - metabolism | Fear - drug effects | Phosphopyruvate Hydratase - metabolism | Hippocampus - drug effects | Piperidines - pharmacology | Swimming - psychology | Exploratory Behavior - drug effects | Fear - psychology | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Mice, Inbred C57BL | Cell Proliferation - physiology | Mice, Transgenic | Neuropeptides - metabolism | Hindlimb Suspension | Hippocampus - cytology | Physical Conditioning, Animal - physiology | Animals | Serotonin Agents - pharmacology | Neurogenesis - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Cell Proliferation - drug effects | Mice | Learning | Brain | Functional anatomy | Mood | Serotonin S3 receptors | Serotonin | Antidepressants | Psychological effects | Neurogenesis | Learning behavior | Hippocampus | Structure-function relationships | Index Medicus
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7. Menthol inhibits 5-HT3 receptor-mediated currents
by Ashoor, Abrar and Nordman, Jacob C and Veltri, Daniel and Yang, Keun-Hang Susan and Shuba, Yaroslav and Al Kury, Lina and Sadek, Bassem and Howarth, Frank C and Shehu, Amarda and Kabbani, Nadine and Oz, Murat
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 11/2013, Volume 347, Issue 2, pp. 398 - 409
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Binding, Competitive | Membrane Potentials - drug effects | Receptors, Serotonin, 5-HT3 - genetics | Oocytes - metabolism | Humans | Xenopus laevis | Rats | Imidazoles - pharmacology | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Animals | Menthol - pharmacology | Transfection | Receptors, Serotonin, 5-HT3 - metabolism | Protein Binding | Female | Indoles - pharmacology | Molecular Docking Simulation | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - pharmacology
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8. Full Text The role of 5-HT3 receptors in signaling from taste buds to nerves
by Larson, Eric D and Vandenbeuch, Aurelie and Voigt, Anja and Meyerhof, Wolfgang and Kinnamon, Sue C and Finger, Thomas E
The Journal of neuroscience, ISSN 0270-6474, 12/2015, Volume 35, Issue 48, pp. 15984 - 15995
Geniculate ganglion | 5ht3 | Calcium | Serotonin | Taste signaling | Barbiturate | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Taste Buds - physiology | Adjuvants, Anesthesia - pharmacology | Pentobarbital - pharmacology | Male | Green Fluorescent Proteins - genetics | Serotonin - pharmacology | Adenosine Triphosphate - pharmacology | Sensory Receptor Cells - physiology | Female | Transducin - metabolism | Taste - genetics | Action Potentials - drug effects | Taste Buds - drug effects | Green Fluorescent Proteins - metabolism | Stilbamidines - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Mice, Transgenic | Taste - physiology | Action Potentials - physiology