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International Journal of Cancer, ISSN 0020-7136, 03/2019, Volume 144, Issue 5, pp. 1104 - 1114
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0118588 - e0118588
Purpose The aim of this study was to define somatostatin (SST) and somatostatin receptor type 1 (SSTR1) methylation profiles for head and neck squamous cell... 
PATHOGENESIS | POTENTIAL BIOMARKER | HYPERMETHYLATION | PROMOTER METHYLATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GALANIN | TUMOR-SUPPRESSOR ACTIVITY | TACHYKININ-1 | EXPRESSION | ASSOCIATION | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Oropharyngeal Neoplasms - mortality | Male | Oropharyngeal Neoplasms - pathology | Galanin - metabolism | Carcinoma, Squamous Cell - diagnosis | Receptors, Somatostatin - genetics | DNA Methylation | Mouth Neoplasms - diagnosis | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Tachykinins - genetics | Aged, 80 and over | Biomarkers, Tumor - metabolism | Receptor, Galanin, Type 2 - genetics | Adult | Female | Transcription, Genetic | Receptors, Somatostatin - metabolism | Retrospective Studies | Odds Ratio | Mouth Neoplasms - genetics | Somatostatin - metabolism | Oropharyngeal Neoplasms - diagnosis | Promoter Regions, Genetic | Oropharyngeal Neoplasms - genetics | Somatostatin - genetics | Tachykinins - metabolism | Risk Factors | Mouth Neoplasms - mortality | Head and Neck Neoplasms - pathology | Survival Analysis | CpG Islands | Mouth Neoplasms - pathology | Head and Neck Neoplasms - diagnosis | Head and Neck Neoplasms - genetics | Receptor, Galanin, Type 2 - metabolism | Aged | Biomarkers, Tumor - genetics | Head and Neck Neoplasms - mortality | Galanin - genetics | Neoplasm Staging | Neuropeptides | Squamous cell carcinoma | Methylation | Analysis | Tachykinin receptors | Correlation | Galanin | Mucosa | Otolaryngology | Inactivation | Tissues | Epidermal growth factor | DNA methylation | Measurement methods | Tumorigenesis | Bioindicators | Neck | Somatostatin | CpG islands | Head | Deactivation | Oropharynx | Regression analysis | Gene expression | Survival | Promoters | Polymerase chain reaction | Oral cavity | Epigenetics | Biomarkers | Head and neck cancer | Aberration | Tachykinin | Tumors | Cancer | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1012 - 1021
BackgroundGastric carcinoids are slow growing neuroendocrine tumours arising from enterochromaffin-like (ECL) cells in the corpus of stomach. Although most of... 
ACID SECRETION | GASTRIN | CANCER GENETICS | GASTRIN RECEPTORS | ENDOCRINE TUMOURS | MASTOMYS-NATALENSIS | INHIBITOR P27(KIP1) | AFRICAN RODENT | CANCER CELLS | RAT STOMACH | GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS | ENDOCRINE TUMORS | ENTEROCHROMAFFIN-LIKE CELLS | ZOLLINGER-ELLISON-SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | TRANSGENIC MICE | Proton Pump Inhibitors - pharmacology | Humans | Receptor, Cholecystokinin B - metabolism | Stomach Neoplasms - metabolism | Male | RNA, Messenger - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Adenocarcinoma - metabolism | Gene Deletion | Adult | Female | Omeprazole - pharmacology | Gastrins - genetics | Phosphorylation - drug effects | Gastrins - pharmacology | Gastrins - blood | Stomach Neoplasms - genetics | Hormones - pharmacology | Somatostatin - genetics | Benzodiazepines - pharmacology | Signal Transduction | Carcinogenesis - genetics | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Gastrins - metabolism | Receptor, Cholecystokinin B - genetics | Hormone Antagonists - pharmacology | Carcinogenesis - drug effects | Animals | Carcinoid Tumor - genetics | Cell Line, Tumor | Mice | Causes of | Genetic aspects | Carcinoid | Somatostatin | Research | Stomach diseases | Index Medicus | Abridged Index Medicus | gastrin receptor | cancer genetics | endocrine tumors | Acid secretion | gastrin
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3909 - 3923
In the stomach, somatostatin (SST) acts as a general paracrine negative regulator of exocrine secretion of gastric acid and pepsinogen and endocrine secretion... 
PERFUSED RAT STOMACH | CALCIUM-SENSING RECEPTOR | GLUCAGON-LIKE PEPTIDE-1 | GROWTH-HORMONE | GHRELIN SECRETION | ENTEROENDOCRINE CELLS | ACID-SECRETION | ENDOCRINOLOGY & METABOLISM | ISLET AMYLOID POLYPEPTIDE | RELEASE-INHIBITING HORMONE | ENDOCRINE-CELLS | Peptide YY - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Transcriptome | Male | Receptors, Muscarinic - metabolism | Receptors, Neuropeptide - metabolism | Islet Amyloid Polypeptide - genetics | Stomach - metabolism | Gastric Mucosa - metabolism | Receptors, Somatostatin - genetics | Glucagon-Like Peptide-1 Receptor - genetics | Glucagon-Like Peptide-1 Receptor - metabolism | In Situ Hybridization | Receptors, Adrenergic - genetics | Receptors, Somatostatin - metabolism | Peptide YY - genetics | Somatostatin - metabolism | Receptors, Muscarinic - genetics | Somatostatin - secretion | Somatostatin - genetics | Receptors, Adrenergic - metabolism | Cells, Cultured | Islet Amyloid Polypeptide - metabolism | Receptors, Neuropeptide - genetics | Mice, Transgenic | Gastric Mucosa - cytology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Microscopy, Confocal | Animals | Stomach - cytology | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Somatostatin-Secreting Cells - metabolism | Luminescent Proteins - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2017, Volume 140, Issue 8, pp. 1870 - 1880
The role of progenitor/stem cells in pituitary tumorigenesis, resistance to pharmacological treatments and tumor recurrence is still unclear. This study... 
drug resistance | dopamine | tumor stem cells | pituitary adenomas | somatostatin | NEUROENDOCRINE TUMORS | ANALOG | BROMOCRIPTINE | SCINTIGRAPHY | IN-VITRO | THERAPY | ONCOLOGY | CABERGOLINE | STEM-CELL | EXPRESSION | ADENOMAS | Neoplastic Stem Cells - drug effects | Humans | Middle Aged | Spheroids, Cellular - pathology | Neoplasm Recurrence, Local - drug therapy | Male | Neoplasm Recurrence, Local - pathology | Receptors, Somatostatin - genetics | Receptors, Somatostatin - agonists | Adult | DAX-1 Orphan Nuclear Receptor - biosynthesis | Female | Dopamine Agents - administration & dosage | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Gonadotropins - biosynthesis | Pituitary Neoplasms - genetics | Receptors, Dopamine D2 - agonists | Carcinogenesis - genetics | Pituitary Neoplasms - pathology | ERG1 Potassium Channel - biosynthesis | Receptors, Dopamine D2 - genetics | Carcinogenesis - drug effects | Drug Resistance, Neoplasm - genetics | Pituitary Neoplasms - drug therapy | Cyclin D3 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p27 - biosynthesis | RNA Splicing Factors - biosynthesis | Neoplasm Recurrence, Local - genetics | Cell Proliferation - drug effects | Dopamine | Pituitary gland tumors | Analysis | Stem cells | Phenols | Gonadotropin | Drug resistance | Dopamine receptors | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2013, Volume 98, Issue 12, pp. E1880 - E1890
Context: Corticotroph pituitary adenomas often highly express the dopamine 2 receptor (D2R) and somatostatin receptor subtype 5 (sst5). The sst2 expression is... 
POTENT INHIBITOR | OCTREOTIDE | ACTH-SECRETION | INTERNALIZATION | GLUCOCORTICOIDS | CORTICOTROPH ADENOMAS | ENDOCRINOLOGY & METABOLISM | ADRENOCORTICOTROPIN SECRETION | NELSONS SYNDROME | TUMOR-CELLS | PITUITARY-ADENOMAS | ACTH-Secreting Pituitary Adenoma - drug therapy | Pituitary Gland - metabolism | Humans | Middle Aged | Hydrocortisone - secretion | Hydrocortisone - urine | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Receptors, Dopamine D2 - metabolism | ACTH-Secreting Pituitary Adenoma - physiopathology | Somatostatin - pharmacology | Receptors, Somatostatin - genetics | Young Adult | Receptors, Somatostatin - agonists | Protein Isoforms - metabolism | Adult | Female | Receptors, Somatostatin - antagonists & inhibitors | Adrenal Glands - secretion | Antineoplastic Agents - pharmacology | Receptors, Somatostatin - metabolism | Tumor Cells, Cultured | Adrenal Glands - drug effects | Neoplasm Proteins - genetics | Pituitary ACTH Hypersecretion - prevention & control | Dopamine Agonists - pharmacology | Somatostatin - analogs & derivatives | Pituitary ACTH Hypersecretion - etiology | ACTH-Secreting Pituitary Adenoma - metabolism | Pituitary Gland - pathology | Receptors, Dopamine D2 - genetics | Gene Expression Regulation - drug effects | Neoplasm Proteins - agonists | Adolescent | Aged | Dopamine D2 Receptor Antagonists | ACTH-Secreting Pituitary Adenoma - pathology | Pituitary Gland - drug effects | Protein Isoforms - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 46, pp. 19003 - 19008
Both ghrelin and somatostatin (SST) inhibit glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells, but how these independent actions are... 
Receptors | HEK293 cells | Secretion | Agonists | Growth hormones | Islets of Langerhans | Physiological regulation | Insulin | Somatostatin receptors | Insulin secretion | Glucose homeostasis | GPCR oligomers | ALPHA-CELLS | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | IDENTIFICATION | HETERODIMERS | PEPTIDE | GLUCAGON-SECRETION | ACYLTRANSFERASE | glucose homeostasis | GROWTH-HORMONE | MICE | HORMONE SECRETAGOGUE RECEPTOR | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Humans | Receptors, Ghrelin - genetics | Receptors, Somatostatin - genetics | Insulin-Secreting Cells - metabolism | Protein Multimerization - physiology | HEK293 Cells | Receptors, Ghrelin - metabolism | Insulin-Secreting Cells - cytology | Receptors, Somatostatin - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Insulin - genetics | Insulin Secretion | Somatostatin - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Somatostatin - genetics | Ghrelin - genetics | Rats | Ghrelin - metabolism | Insulin - metabolism | Animals | Cell Line, Tumor | Signal Transduction - physiology | Mice | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Physiological aspects | Pancreatic beta cells | Somatostatin | Ghrelin | Health aspects | Proteins | Signal transduction | Biochemistry | Bioenergetics | Statins | Index Medicus | Biological Sciences
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3924 - 3936
Journal Article
Journal Article