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1. Full Text Glutaminolysis and Transferrin Regulate Ferroptosis
by Gao, Minghui and Monian, Prashant and Quadri, Nosirudeen and Ramasamy, Ravichandran and Jiang, Xuejun
Molecular Cell, ISSN 1097-2765, 07/2015, Volume 59, Issue 2, pp. 298 - 308
Ferroptosis has emerged as a new form of regulated necrosis that is implicated in various human diseases. However, the mechanisms of ferroptosis are not well... 
HEMOLYTIC-ANEMIA | SYNTHETASE DEFICIENCY | GLUTAMINASE ACTIVITY | NECROSIS | PROTEIN | GLUTATHIONE | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR SWITCH | RIP3 | CELL-DEATH | CELL BIOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oxidation-Reduction | Glutathione - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | Glutamine - metabolism | Male | Necrosis - metabolism | Iron - metabolism | Receptors, Transferrin - metabolism | Myocardial Reperfusion Injury - metabolism | Animals | Cell Death - physiology | Metabolic Networks and Pathways | Culture Media | Cystine - metabolism | Mice | Apoptosis - physiology | Transferrin - metabolism | Myocardial Reperfusion Injury - prevention & control | Transferrin | Cell death | Cells | Glutamine
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2. Full Text Transferrin-conjugated nanoparticles of Poly(lactide)- d -α-Tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood–brain barrier
by Gan, Chee Wee and Feng, Si-Shen
Biomaterials, ISSN 0142-9612, 2010, Volume 31, Issue 30, pp. 7748 - 7757
Abstract We developed in this research a nanoparticle system for targeted drug delivery across the blood–brain barrier (BBB), which consists of the transferrin... 
Advanced Basic Science | Dentistry | Surface modification | Cancer nanotechnology | Drug targeting | Nanomedicine | Biodegradable polymers | Docetaxel | VITRO | MATERIALS SCIENCE, BIOMATERIALS | PROTEIN | ENGINEERING, BIOMEDICAL | RECEPTOR-MEDIATED TRANSCYTOSIS | ENDOCYTOSIS | CANCER | TUMORS | CHEMOTHERAPY | TRANSPORT | IN-VIVO EVALUATION | PLGA NANOPARTICLES | Biocompatible Materials - metabolism | Coumarins - metabolism | Succinates - chemistry | Thiazoles - metabolism | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Coumarins - chemistry | Male | Polyethylene Glycols - chemistry | Taxoids - metabolism | Drug Carriers - chemistry | Antineoplastic Agents - metabolism | Brain - metabolism | Tissue Distribution | Succinates - metabolism | Polyethylene Glycols - metabolism | Taxoids - chemistry | Brain - cytology | Drug Carriers - metabolism | Rats | Materials Testing | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Animals | Transferrin - chemistry | Thiazoles - chemistry | Transferrin - metabolism | Drug Delivery Systems - methods
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3. Full Text Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression
by Gao, Junwei and Chen, Juxing and Kramer, Maxwell and Tsukamoto, Hidekazu and Zhang, An-Sheng and Enns, Caroline A
Cell Metabolism, ISSN 1550-4131, 2009, Volume 9, Issue 3, pp. 217 - 227
The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most common form of hereditary... 
HUMDISEASE | ANTIMICROBIAL PEPTIDE HEPCIDIN | MUTANT MICE | WIF-B CELLS | JUVENILE HEMOCHROMATOSIS | CRYSTAL-STRUCTURE | MOUSE MODEL | LIVER | MUTATION | ENDOCRINOLOGY & METABOLISM | IRON OVERLOAD | GENE-PRODUCT | CELL BIOLOGY | RNA, Small Interfering - genetics | Hemochromatosis Protein | Humans | Homeostasis | Hepatocytes - metabolism | Antimicrobial Cationic Peptides - metabolism | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Transferrin - genetics | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | Hepatocytes - cytology | Hepcidins | Membrane Proteins - metabolism | Receptors, Transferrin - genetics | Antimicrobial Cationic Peptides - genetics | Promoter Regions, Genetic | Membrane Proteins - genetics | Liver - metabolism | Cells, Cultured | Histocompatibility Antigens Class I - genetics | Iron - metabolism | Receptors, Transferrin - metabolism | Mice, Knockout | Animals | Recombinant Fusion Proteins - genetics | Liver - cytology | Mice | Transferrin - metabolism | RNA, Small Interfering - metabolism | Transferrin | Hemochromatosis | Chorionic gonadotropin | Cholecystokinin | Peptide hormones | Developmental biology | hepcidin | TfR2 | HFE | TfR1 | hereditary hemochromatosis
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4. Full Text Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
by Devin T. Wiley and Paul Webster and Aaron Gale and Mark E. Davis
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8662 - 8667
Receptor-mediated transcytosis across the blood-brain barrier (BBB) may be a useful way to transport therapeutics into the brain. Here we report that... 
Nanoparticles | Silver | Receptors | Medical treatment | Imaging | Parenchyma | Antibodies | Transcytosis | Blood brain barrier | Endothelial cells | DESIGN | MULTIDISCIPLINARY SCIENCES | SIZE | HUMANS | BARRIERS | SIRNA | DELIVERY | Gold - chemistry | Endothelial Cells - metabolism | Humans | Gold - pharmacology | Receptors, Transferrin - metabolism | Blood-Brain Barrier - ultrastructure | Blood-Brain Barrier - metabolism | Endothelial Cells - ultrastructure | Animals | Transferrin - chemistry | Female | Mice | Mice, Inbred BALB C | Transcytosis - drug effects | Transferrin - metabolism | Metal Nanoparticles | Transferrin - pharmacology | Physiological aspects | Brain | Transferrin | Blood-brain barrier | Properties | Agriculture | Livestock | Wildlife | Epidemiology | Risk assessment | Biological Sciences
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5. Full Text Altered iron metabolism, transferrin receptor 1 and ferritin in patients with colon cancer
by Prutki, Maja and Poljak-Blazi, Marija and Jakopovic, Marko and Tomas, Davor and Stipancic, Igor and Zarkovic, Neven
Cancer Letters, ISSN 0304-3835, 2006, Volume 238, Issue 2, pp. 188 - 196
In this study, the level and distribution of transferrin receptor 1 (TfR1) and ferritin in colorectal carcinoma and in normal colon epithelium has been... 
Iron metabolism | Metastasis | Colon carcinoma | Transferrin receptor 1 | Ferritin | ferritin | RECEPTOR EXPRESSION | PHENOTYPE | NEUTROPHIL ELASTASE | CELL-GROWTH | BREAST | iron metabolism | PATHOGENESIS | colon carcinoma | ONCOLOGY | metastasis | transferrin receptor 1 | ANEMIA | CARCINOMA | PROGRESSION | SATURATION | Immunohistochemistry | Humans | Middle Aged | Colon - chemistry | Ferritins - analysis | Male | Iron - metabolism | Antigens, CD - analysis | Receptors, Transferrin - analysis | Adult | Female | Aged | Colorectal Neoplasms - metabolism | Medical colleges | Infiltration (Military science) | Care and treatment | Transferrin | Cancer patients | Colon cancer | Analysis | Physiological aspects | Free radicals | Histopathology | Anemia | Mortality | Colorectal cancer | Homeostasis | Iron | Colon | Metabolism | Tumors
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6. Full Text Structural basis for iron piracy by pathogenic Neisseria
by Noinaj, Nicholas and Easley, Nicole C and Oke, Muse and Mizuno, Naoko and Gumbart, James and Boura, Evzen and Steere, Ashley N and Zak, Olga and Aisen, Philip and Tajkhorshid, Emad and Evans, Robert W and Gorringe, Andrew R and Mason, Anne B and Steven, Alasdair C and Buchanan, Susan K
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7387, pp. 53 - 61
Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it... 
ANTIBODIES | MOLECULAR-DYNAMICS | C-LOBE | MULTIDISCIPLINARY SCIENCES | BINDING PROTEIN-B | X-RAY | RECEPTOR | MENINGITIDIS | IDENTIFICATION | SCATTERING | HUMAN SERUM TRANSFERRIN | Apoproteins - chemistry | Transferrin-Binding Protein A - ultrastructure | Transferrin-Binding Protein B - metabolism | Species Specificity | Humans | Transferrin-Binding Protein A - metabolism | Bacterial Proteins - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Transferrin-Binding Protein B - ultrastructure | Biological Transport | Cattle | X-Ray Diffraction | Binding Sites | Apoproteins - metabolism | Models, Molecular | Scattering, Small Angle | Iron - metabolism | Molecular Dynamics Simulation | Animals | Neisseria - metabolism | Transferrin - ultrastructure | Neisseria - pathogenicity | Transferrin - chemistry | Transferrin-Binding Protein A - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Bacterial Proteins - ultrastructure | Mice | Transferrin - metabolism | Transferrin-Binding Protein B - chemistry | Proteins | Transferrin | Neisseriaceae | Iron in the body | Research | Binding proteins | Properties | Structure | Health aspects | Bacteria | Vaccines | Mortality
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7. Full Text Renal iron metabolism: Transferrin iron delivery and the role of iron regulatory proteins
by Zhang, Deliang and Meyron-Holtz, Esther and Rouault, Tracey A
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2007, Volume 18, Issue 2, pp. 401 - 406
CELLS | HOMEOSTASIS | TRANSPORTER | MESSENGER-RNA | RAT-KIDNEY | IN-VIVO | UROLOGY & NEPHROLOGY | RECEPTOR | MICE | TARGETED DELETION | EXPRESSION | Iron Regulatory Protein 2 - physiology | Kidney - physiology | Iron Regulatory Protein 1 - physiology | Humans | Iron-Regulatory Proteins - metabolism | Iron - metabolism | Animals | Kidney Neoplasms - physiopathology | Ferritins - genetics | Models, Animal | Mice | Receptors, Transferrin - genetics | Transferrin - metabolism | Kidney Tubules, Proximal - physiology
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8. Full Text Escape from bacterial iron piracy through rapid evolution of transferrin
by Barber, Matthew F and Elde, Nels C
Science, ISSN 0036-8075, 12/2014, Volume 346, Issue 6215, pp. 1362 - 1366
Can a single conversation change minds on divisive social issues, such as same-sex marriage? A randomized placebo-controlled trial assessed whether gay (n =... 
NUTRITIONAL IMMUNITY | PROTEIN | STRUCTURAL BASIS | LACTOFERRIN | MULTIDISCIPLINARY SCIENCES | NEISSERIA-MENINGITIDIS | DISEASE | INFECTION | RECEPTORS | BINDING | ASSOCIATION | Neisseria meningitidis - metabolism | Humans | Transferrin-Binding Protein A - metabolism | Molecular Sequence Data | Phylogeny | Transferrin - genetics | Haplorhini - immunology | Amino Acid Sequence | Haemophilus influenzae - metabolism | Selection, Genetic | Models, Molecular | Haplorhini - metabolism | Immunity, Innate | Polymorphism, Genetic | Transferrin-Binding Protein A - genetics | Animals | Neisseria - metabolism | Transferrin - chemistry | Protein Binding | Transferrin-Binding Protein A - chemistry | Neisseria gonorrhoeae - metabolism | Transferrin - metabolism | Haplorhini - genetics | Amino Acid Substitution | Evolution, Molecular | Host-bacteria relationships | Protein research | Transferrin | Immune response | Iron in the body | Research | Health aspects | Immunological research | Iron | Bacterial infections | Immune system | Binding | Pathogens | Evolutionary | Bacteria | Evolution | Piracy
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9. Full Text The intracellular trafficking pathway of transferrin
by Mayle, Kristine M and Le, Alexander M and Kamei, Daniel T
BBA - General Subjects, ISSN 0304-4165, 03/2012, Volume 1820, Issue 3, pp. 264 - 281
Transferrin (Tf) is an iron-binding protein that facilitates iron-uptake in cells. Iron-loaded Tf first binds to the Tf receptor (TfR) and enters the cell... 
Transferrin | Microscopy | SPR | Modeling | Trafficking | Radioactivity | IRON UPTAKE | HEPATOMA-CELL LINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMOCHROMATOSIS PROTEIN HFE | CLATHRIN-COATED PITS | ISOLATED RAT HEPATOCYTES | RECEPTOR-MEDIATED ENDOCYTOSIS | BIOPHYSICS | EPIDERMAL-GROWTH-FACTOR | EARLY ENDOSOMES | SURFACE-PLASMON RESONANCE | RECYCLING COMPARTMENT | Endocytosis | Humans | Ion Transport | Transferrin - metabolism | Iron - metabolism | Receptors, Transferrin - metabolism | Endosomes - metabolism | Receptors, Transferrin - chemistry | Binding proteins
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10. Full Text The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression
by Schmidt, Paul J and Toran, Paul T and Giannetti, Anthony M and Bjorkman, Pamela J and Andrews, Nancy C
Cell Metabolism, ISSN 1550-4131, 2008, Volume 7, Issue 3, pp. 205 - 214
Hemochromatosis is caused by mutations in HFE, a protein that competes with transferrin (TF) for binding to transferrin receptor 1 (TFR1). We developed mutant... 
HUMDISEASE | OVERLOAD | HEREDITARY HEMOCHROMATOSIS PROTEIN | IRON-METABOLISM | CRYSTAL-STRUCTURE | LIVER | ENDOCRINOLOGY & METABOLISM | HEPATIC IRON | ABSORPTION | ANEMIA | BINDING | TRANSGENIC MICE | CELL BIOLOGY | Erythropoiesis | Hemochromatosis Protein | Homeostasis | Mutation, Missense | Antimicrobial Cationic Peptides - metabolism | RNA, Messenger - metabolism | Iron Overload - physiopathology | Histocompatibility Antigens Class I - metabolism | Iron Overload - metabolism | Hepcidins | Iron - deficiency | Membrane Proteins - metabolism | Receptors, Transferrin - genetics | Antimicrobial Cationic Peptides - genetics | Binding Sites | Iron Overload - genetics | Membrane Proteins - genetics | Liver - metabolism | Gene Expression Regulation | Genotype | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Signal Transduction - genetics | Iron - metabolism | Receptors, Transferrin - metabolism | Mice, Knockout | Phenotype | Animals | Protein Binding | Mice | Transferrin - metabolism | Transferrin | Analysis
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11. Full Text Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
by Bien-Ly, Nga and Yu, Y. Joy and Bumbaca, Daniela and Elstrott, Justin and Boswell, C. Andrew and Zhang, Yin and Luk, Wilman and Lu, Yanmei and Dennis, Mark S and Weimer, Robby M and Chung, Inhee and Watts, Ryan J
Journal of Experimental Medicine, ISSN 0022-1007, 02/2014, Volume 211, Issue 2, pp. 233 - 244
Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and... 
THERAPEUTICS | MEDICINE, RESEARCH & EXPERIMENTAL | TRANSPORT | IMMUNOLOGY | TRANSCYTOSIS | BARRIER | Amyloid Precursor Protein Secretases - immunology | Blood-Brain Barrier - immunology | Transcytosis - physiology | Mice, Inbred C57BL | Antibody Affinity | Transcytosis - immunology | Receptors, Transferrin - metabolism | Blood-Brain Barrier - metabolism | Protein Transport | Brain - metabolism | Animals | Antibodies, Bispecific - metabolism | Lysosomes - metabolism | Receptors, Transferrin - immunology | Female | Mice | Aspartic Acid Endopeptidases - immunology | Brain - immunology | Lysosomes - immunology
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12. Full Text Binding and Uptake of H-Ferritin Are Mediated by Human Transferrin Receptor-1
by Li Li and Celia J. Fang and James C. Ryan and Eréne C. Niemi and José A. Lebrón and Pamela J. Björkman and Hisashi Arase and Frank M. Torti and Suzy V. Torti and Mary C. Nakamura and William E. Seaman
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 8, pp. 3505 - 3510
Ferritin is a spherical molecule composed of 24 subunits of two types, ferritin H chain (FHC) and ferritin L chain (FLC). Ferritin stores iron within cells,... 
T lymphocytes | Receptors | K562 cells | B lymphocytes | Epithelial cells | Cell lines | Lysosomes | Ferritins | Blood | Endosomes | Endocytosis | Iron | HFE | Ferritin | STORAGE | CELLS | ferritin | IRON UPTAKE | PROTEIN | FERRIREDUCTASE | receptors | EXTRACELLULAR FERRITIN | MULTIDISCIPLINARY SCIENCES | HUMAN ERYTHROID PRECURSORS | HEAVY-CHAIN | iron | endocytosis | EXPRESSION | HUMAN-LIVER | Cell Line | Humans | Antigens, CD - genetics | Receptors, Transferrin - metabolism | Apoferritins - metabolism | Endosomes - metabolism | Antigens, CD - metabolism | Lysosomes - metabolism | T-Lymphocytes - metabolism | Cloning, Molecular | Protein Binding | Receptors, Transferrin - genetics | Transferrin - metabolism | B-Lymphocytes - metabolism | Transferrin | Research | Chemical properties | Protein binding | Proteins | Molecules | Cloning | T cell receptors | Gene expression | Cells | Binding sites | Biological Sciences
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