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Cancer Science, ISSN 1347-9032, 03/2017, Volume 108, Issue 3, pp. 419 - 426
Vasohibin‐2 ( VASH 2) is a homolog of VASH 1, an endothelium‐derived angiogenesis inhibitor. Vasohibin‐2 is mainly expressed in cancer cells, and has been... 
ALK | TGF | vasohibin‐2 | ovarian cancer | EMT | TGF-β | ALK5 | vasohibin-2 | PROTEIN | REPRESSES E-CADHERIN | TUMOR ANGIOGENESIS | R-I | FAMILY | TGF-beta | ONCOLOGY | ENDOTHELIUM | ROLES | INHIBITOR | BINDING | Angiogenic Proteins - genetics | RNA, Small Interfering - genetics | Fibronectins - biosynthesis | Humans | Ovarian Neoplasms - pathology | Smad3 Protein - metabolism | Snail Family Transcription Factors - biosynthesis | Epithelial-Mesenchymal Transition - genetics | Zinc Finger E-box Binding Homeobox 2 | Cadherins - biosynthesis | Ovarian Neoplasms - genetics | Phosphorylation - genetics | RNA Interference | Female | Matrix Metalloproteinase 2 - biosynthesis | Cell Proliferation - genetics | Homeodomain Proteins - biosynthesis | Smad2 Protein - metabolism | Signal Transduction - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Plasminogen Activator Inhibitor 1 - biosynthesis | Receptors, Transforming Growth Factor beta - biosynthesis | Repressor Proteins - biosynthesis | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Transforming Growth Factor beta - metabolism | Phosphorylation | Mesenchyme | Laboratories | Genes | Cytology | Smad3 protein | Kinases | Fibronectin | Ovarian cancer | Proteins | Liver cancer | Angiogenesis | Smad2 protein | Growth factors | Immunoglobulins | Cytokines | Endothelium | Gelatinase A | MicroRNAs | Adenoviruses | Morphology | Plasminogen activator inhibitors | Angiogenesis inhibitors | Activin | Cell migration | TGF‐β | Original
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2017, Volume 23, Issue 3, pp. 804 - 813
Purpose: Immunotherapy of high-risk neuroblastoma using the anti-GD2 antibody dinutuximab induces antibody-dependent cell-mediated cytotoxicity (ADCC).... 
BREAST-CANCER | RECEPTOR KINASE INHIBITOR | TGF-BETA | GAMMA PRODUCTION | METASTASIS | ONCOLOGY | GROWTH | TUMOR-TISSUE | ANTITUMOR-ACTIVITY | EX-VIVO | CYTOTOXICITY | Receptor, Transforming Growth Factor-beta Type I | Receptors, Transforming Growth Factor beta - genetics | Humans | Neoplasm Proteins - physiology | Male | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Transforming Growth Factor beta - physiology | Smad2 Protein - antagonists & inhibitors | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Phosphorylation - drug effects | Neuroblastoma - pathology | Transforming Growth Factor beta1 - biosynthesis | Pyrazoles - pharmacology | Killer Cells, Natural - transplantation | Specific Pathogen-Free Organisms | Immunotherapy, Adoptive | Protein-Serine-Threonine Kinases - physiology | Antibodies, Monoclonal - pharmacology | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Transforming Growth Factor beta1 - genetics | Transforming Growth Factor beta1 - physiology | Antineoplastic Agents, Immunological - pharmacology | Drug Synergism | Protein-Serine-Threonine Kinases - biosynthesis | Xenograft Model Antitumor Assays | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | RNA, Neoplasm - biosynthesis | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice, Inbred NOD | Mice | Neuroblastoma - metabolism | Cytotoxicity, Immunologic | Phosphorylation | Smad protein | Severe combined immunodeficiency | Toxicity | Cytotoxicity | Activation | Neuroblastoma | Blood | Neuroblastoma cells | NKG2 antigen | Receptors | Smad2 protein | Immunotherapy | Xenografts | Bone marrow | Plasmas | CD226 antigen | Natural killer cells | Perforin | Antibody-dependent cell-mediated cytotoxicity | Cell survival | Transforming growth factor-b1 | Risk groups | Gene expression | Experimental design | Cell lines | TRAIL protein | Bone | Tumors | Cancer | Index Medicus | TGFβR1 inhibitor | dinutuximab | adoptive cell therapy | galunisertib | immunotherapy
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2001, Volume 194, Issue 5, pp. 629 - 644
Journal Article
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8844 - 8852
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells.... 
SURVIVAL | THERAPY | BECLIN-1 | ONCOLOGY | INDUCED APOPTOSIS | MESANGIAL CELLS | PAI-1 GENE-EXPRESSION | INDUCTION | TUMORIGENESIS | CANCER | LC3 | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Cell Growth Processes - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Autophagy - physiology | Proto-Oncogene Proteins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Breast Neoplasms - metabolism | Transfection | Bcl-2-Like Protein 11 | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Membrane Proteins - genetics | Transforming Growth Factor beta - physiology | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - biosynthesis | Autophagy-Related Protein 7 | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Smad Proteins - metabolism | Carcinoma, Hepatocellular - metabolism
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7482, pp. 212 - 217
Non-small-cell lung cancer (NSCLC) is the most prevalent histological cancer subtype worldwide(1). As the majority of patients present with invasive,... 
TRANSFORMATION | MESSENGER-RNAS | OVEREXPRESSION | TGF-BETA | GENE | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | LET-7 | INHIBITOR | BINDING | EXPRESSION DATA | Receptors, Transforming Growth Factor beta - genetics | Cell Proliferation | Humans | Lung Neoplasms - pathology | MicroRNAs - metabolism | Proteoglycans - deficiency | RNA Isoforms - metabolism | HMGA2 Protein - genetics | Gene Expression Regulation, Neoplastic - genetics | Disease Models, Animal | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Argonaute Proteins - metabolism | RNA Isoforms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Proteoglycans - biosynthesis | Disease Progression | Neoplasm Metastasis - genetics | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | Cell Line, Tumor | Binding, Competitive - genetics | Mice | MicroRNAs - genetics | Transcription, Genetic - genetics | Neoplasm Invasiveness - genetics | Transforming Growth Factor beta - metabolism | Proteoglycans - genetics | Receptors, Transforming Growth Factor beta - deficiency | RNA sequencing | Gene targeting | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Identification and classification | Methods | Proteins | Hypothesis testing | Survival analysis | Hypotheses | Transplants & implants | Lung cancer | Genomes | Tumorigenesis | Mutation | Gene expression | Tumors | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2013, Volume 288, Issue 52, pp. 37319 - 37331
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2014, Volume 134, Issue 8, pp. 1785 - 1795
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 01/2004, Volume 172, Issue 2, pp. 834 - 842
In previous studies, we have shown that murine CD4(+)CD25(+) regulatory T cells produce high levels of TGF-beta1 in a cell surface and/or secreted form, and... 
ANTIGEN 4 | GROWTH-FACTOR-BETA | IN-VITRO | ACTIVATION | TGF-BETA | IMMUNOSUPPRESSION | LATENCY-ASSOCIATED PEPTIDE | IMMUNOLOGICAL SELF-TOLERANCE | IMMUNOLOGY | AUTOIMMUNE-DISEASE | EXPRESSION | T-Lymphocyte Subsets - immunology | Colitis - genetics | Humans | Peptide Fragments - pharmacology | Adoptive Transfer | Receptors, Transforming Growth Factor beta - physiology | Transforming Growth Factor beta - deficiency | Transforming Growth Factor beta - biosynthesis | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Signal Transduction - immunology | Intestinal Mucosa - immunology | Inflammation Mediators - metabolism | Female | Cell Membrane - metabolism | Colitis - immunology | Inflammation Mediators - physiology | Transforming Growth Factor beta1 | Receptors, Interleukin-2 - biosynthesis | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Transforming Growth Factor beta - physiology | Recombinant Proteins - pharmacology | Mice, SCID | Protein Binding - immunology | T-Lymphocyte Subsets - transplantation | Peptide Fragments - biosynthesis | Mice, Knockout | Protein Precursors - pharmacology | Animals | Transforming Growth Factor beta - genetics | CD4-Positive T-Lymphocytes - transplantation | Down-Regulation - immunology | Protein Precursors - biosynthesis | T-Lymphocyte Subsets - metabolism | Mice | Mice, Inbred BALB C | Intestinal Mucosa - pathology
Journal Article