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Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 4094 - 4104
TNF, an inflammatory cytokine that is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. We... 
MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | INHIBITION | INFLAMMATION | MACROPHAGES | DEATH | EXPRESSION | CANCER | ANTITUMOR | T-CELLS | FACTOR-ALPHA | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Neoplasm Transplantation | Tumor Escape | Receptors, Tumor Necrosis Factor, Type I - immunology | Tumor Necrosis Factor-alpha - genetics | Caspase 8 - metabolism | Graft Rejection - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Receptors, Tumor Necrosis Factor, Type II - immunology | Caspase 8 - genetics | Signal Transduction - immunology | Neoplasms - genetics | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Receptors, Tumor Necrosis Factor, Type II - metabolism | Tumor Necrosis Factor-alpha - immunology | T-Lymphocytes - pathology | Graft Rejection - pathology | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Signal Transduction - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | CASP8 and FADD-Like Apoptosis Regulating Protein - biosynthesis | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Caspase 8 - immunology | Animals | Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | CASP8 and FADD-Like Apoptosis Regulating Protein - immunology | Graft Rejection - immunology | Myeloid Cells - pathology | Graft Rejection - genetics | Neoplasms - pathology | Tumor necrosis factor | Genetic aspects | Cellular signal transduction | Research | Properties | Gene expression | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7412, pp. 508 - 511
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2009, Volume 284, Issue 52, pp. 36213 - 36222
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6028, pp. 478 - 484
The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain... 
Cartilage | Immunization | Antiinflammatories | Medical treatment | REPORTS | Collagens | Antibodies | Bones | Arthritis | Mice | Inflammation | TUMOR-NECROSIS-FACTOR | GENE | MULTIDISCIPLINARY SCIENCES | HOST-DEFENSE | DEGRADATION | OLIGOMERIC MATRIX PROTEIN | GRANULIN-EPITHELIN PRECURSOR | ADAMTS-7 | MUTATIONS | TRANSCRIPTION FACTOR | PSEUDOACHONDROPLASIA | Recombinant Proteins - therapeutic use | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Recombinant Fusion Proteins - pharmacology | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Intercellular Signaling Peptides and Proteins - chemistry | Male | Receptors, Tumor Necrosis Factor, Type I - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | T-Lymphocytes, Regulatory - immunology | Arthritis, Experimental - pathology | Young Adult | Intercellular Signaling Peptides and Proteins - metabolism | Cartilage, Articular - metabolism | Receptors, Tumor Necrosis Factor, Type II - metabolism | Adult | Female | Protein Interaction Domains and Motifs | Anti-Inflammatory Agents, Non-Steroidal - metabolism | T-Lymphocytes, Regulatory - physiology | Arthritis, Experimental - physiopathology | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Arthritis, Experimental - immunology | Mice, Inbred Strains | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Cartilage, Articular - pathology | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Ligands | Aged | Intercellular Signaling Peptides and Proteins - therapeutic use | Care and treatment | Genetic aspects | Properties | Tumor necrosis factor | Growth factors | Index Medicus | Binding | Pathology | Receptors | Pathogenesis
Journal Article
Journal Article
Journal Article
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2009, Volume 84, Issue 2, pp. 201 - 208
Aims Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion... 
Ischaemia | Infarction | Reperfusion | Postconditioning | Preconditioning | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | NECROSIS-FACTOR-ALPHA | CARDIAC MYOCYTE | MURINE MODEL | ISOLATED MOUSE HEARTS | INDUCED CARDIOPROTECTION | ACUTE MYOCARDIAL-INFARCTION | TNF-ALPHA | PROSURVIVAL KINASES | SIGNAL TRANSDUCER | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Tumor Necrosis Factor-alpha - genetics | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Tumor Necrosis Factor-alpha - deficiency | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Receptors, Tumor Necrosis Factor, Type II - metabolism | Myocardial Infarction - pathology | Myocardium - metabolism | STAT3 Transcription Factor - deficiency | Flavonoids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Myocardium - pathology | Tyrphostins - pharmacology | Myocardial Infarction - metabolism | Glycogen Synthase Kinase 3 - metabolism | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Receptors, Tumor Necrosis Factor, Type II - deficiency | Myocardial Reperfusion Injury - metabolism | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Mice | Myocardial Infarction - prevention & control | Protein Kinase Inhibitors - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Myocardial Reperfusion Injury - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 08/2016, Volume 68, Issue 8, pp. 2044 - 2049
To investigate the molecular cause of persistent fevers in a patient returning from working overseas, in whom investigations for tropical diseases yielded... 
Sequence Deletion | Humans | Fever - genetics | Adult | Male | Mosaicism | Receptors, Tumor Necrosis Factor, Type I - genetics | Hereditary Autoinflammatory Diseases - genetics | Gangrene | Tumor necrosis factor-TNF | Sperm | Rodents | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2009, Volume 16, Issue 4, pp. 295 - 308
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines... 
CELLCYCLE | LYMPHOID-TISSUES | ONCOLOGY | SIGNAL PATHWAY | CHRONIC HEPATITIS-C | LIVER | VIRUS CORE PROTEIN | OVAL CELLS | CELL-LINES | NF-KAPPA-B | EXPRESSION | BETA-RECEPTOR | Liver - virology | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Hepatitis B, Chronic - immunology | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Male | Lymphotoxin-alpha - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Lymphotoxin beta Receptor - metabolism | Lymphotoxin-alpha - genetics | Liver - immunology | Lymphocytes - immunology | I-kappa B Kinase - metabolism | Lymphocytes - virology | Receptors, Tumor Necrosis Factor, Type II - metabolism | Carcinoma, Hepatocellular - genetics | Biomarkers, Tumor - metabolism | Carcinoma, Hepatocellular - immunology | Liver Neoplasms - virology | Recombinant Proteins - metabolism | Liver Neoplasms - genetics | Signal Transduction | Lymphotoxin-beta - genetics | Mice, Inbred C57BL | Liver Neoplasms - immunology | Mice, Transgenic | Carcinoma, Hepatocellular - virology | I-kappa B Kinase - genetics | Hepatocytes - immunology | Receptors, Tumor Necrosis Factor, Type I - genetics | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | Receptors, Tumor Necrosis Factor, Type II - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Lymphotoxin-beta - metabolism | Animals | Lymphotoxin beta Receptor - genetics | Chromosome Aberrations | Hepatitis C, Chronic - immunology | Hepatocytes - virology | Ligands | Chemokines - metabolism | Mice | Cell Transformation, Viral | Medical colleges | Liver cancer | Hepatoma | Hepatitis C | Lymphocytes | Health aspects | Index Medicus
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 01/2018, Volume 20, Issue 1, pp. 58 - 58
Ubiquitylation of the TNFR1 signalling complex (TNF-RSC) controls the activation of RIPK1, a kinase critically involved in mediating multiple TNF... 
CHRONIC INTESTINAL INFLAMMATION | NECROPTOSIS | INDUCED APOPTOSIS | LINEAR UBIQUITIN | PROGRAMMED NECROSIS | KINASE RIP | NF-KAPPA-B | CELL-DEATH | SIGNALING COMPLEX | A20 | CELL BIOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Phosphoproteins - metabolism | Genes, Lethal | Ubiquitination | HEK293 Cells | Fibroblasts - metabolism | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Phosphoproteins - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Fibroblasts - cytology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Cell Line, Transformed | Cellular signal transduction | Research | Gene expression | Tumor necrosis factor | Protein kinases | Tumor necrosis factor receptors | Ubiquitin | Signaling | Licenses | Activation | Lethality | Tumor necrosis factor-α | Kinases | Embryos | Apoptosis | Recruitment | Index Medicus
Journal Article