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Cephalalgia, ISSN 0333-1024, 1/2011, Volume 31, Issue 2, pp. 181 - 189
Objective: We pharmacologically characterized pituitary adenylate cyclase–activating polypeptides (PACAPs), vasoactive intestinal peptide (VIP) and the VPAC1,... 
PAC1 | PACAP38 | VPAC1 | VIP | VPAC2 | CYCLASE-ACTIVATING POLYPEPTIDE | RAT | IMMUNOHISTOCHEMICAL LOCALIZATION | MIGRAINE | NEUROSCIENCES | PEPTIDE | CLINICAL NEUROLOGY | PAC | VPAC | MESSENGER-RNA | HEADACHE | CEREBRAL-ARTERIES | HEALTHY-VOLUNTEERS | EXPRESSION | Pituitary Adenylate Cyclase-Activating Polypeptide - antagonists & inhibitors | Receptors, Vasoactive Intestinal Polypeptide, Type I - antagonists & inhibitors | Gene Expression - drug effects | Receptors, Vasoactive Intestinal Peptide, Type II - agonists | Humans | Middle Aged | Male | Peptide Fragments - pharmacology | Receptors, Vasoactive Intestinal Peptide - genetics | RNA, Messenger - metabolism | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Meningeal Arteries - physiology | Vasoactive Intestinal Peptide - pharmacology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Gene Expression - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Migraine Disorders - physiopathology | Adult | Female | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Vasodilation - physiology | Coronary Vessels - drug effects | Receptors, Vasoactive Intestinal Peptide, Type II - antagonists & inhibitors | Vasodilator Agents - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Coronary Vessels - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - adverse effects | Meningeal Arteries - drug effects | Migraine Disorders - drug therapy | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Aged | Receptors, Vasoactive Intestinal Peptide - antagonists & inhibitors | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Vasodilation - drug effects | Receptors, Vasoactive Intestinal Peptide - agonists | Vasoactive Intestinal Peptide - analogs & derivatives | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9865 - 9881
The glucagon receptor (GCGR) belongs to the secretin-like (class B) family of G protein-coupled receptors (GPCRs) and is activated by the peptide hormone... 
BETA ADRENERGIC-RECEPTOR | LIGAND-BINDING | GLUCAGON RECEPTOR | IONIC LOCK | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING STRATEGY | METAPHYSEAL CHONDRODYSPLASIA | BETA-ADRENERGIC RECEPTOR | PEPTIDE | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptors, Corticotropin-Releasing Hormone - metabolism | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Receptors, Corticotropin-Releasing Hormone - agonists | Receptors, Corticotropin-Releasing Hormone - genetics | Receptor, Parathyroid Hormone, Type 1 - agonists | Recombinant Fusion Proteins - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - chemistry | Conserved Sequence | Protein Interaction Domains and Motifs | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Protein Stability | Binding Sites | Peptide Fragments - genetics | Second Messenger Systems | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Receptors, Vasoactive Intestinal Polypeptide, Type I - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Models, Molecular | Receptors, Glucagon - metabolism | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Peptide Fragments - chemistry | Peptide Fragments - agonists | Receptors, Glucagon - chemistry | Hydrophobic and Hydrophilic Interactions | Receptor, Parathyroid Hormone, Type 1 - genetics | Ligands | Protein Conformation | Structural Homology, Protein | Mutation | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Receptors, Corticotropin-Releasing Hormone - chemistry | Amino Acid Substitution | Index Medicus | Editors' Picks | 7-helix receptor | G protein-coupled receptor (GPCR) | parathyroid hormone | glucagon | arrestin
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2014, Volume 85, pp. 538 - 547
We have earlier shown that PACAP-38 decreases neurogenic inflammation. However, there were no data on its receptorial mechanism and the involvement of its PAC1... 
Plasma leakage | Neurogenic inflammation | PACAP | Maxadilan | VIP | Vasodilation | SENSORY NERVE-TERMINALS | CYCLASE-ACTIVATING POLYPEPTIDE | VASOACTIVE-INTESTINAL-PEPTIDE | LUTZOMYIA-LONGIPALPIS | INDUCED PLASMA EXTRAVASATION | INFLAMMATORY DISEASE | NEUROSCIENCES | TRPA1 RECEPTORS | COVALENT MODIFICATION | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | SUBSTANCE-P | Mustard Plant | Capillary Permeability - physiology | Skin Physiological Phenomena - drug effects | Receptors, Vasoactive Intestinal Peptide, Type II - agonists | Capillary Permeability - drug effects | Male | Microcirculation - drug effects | Microcirculation - physiology | Vasoactive Intestinal Peptide - pharmacology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Female | Plant Oils | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Vasodilation - physiology | Disease Models, Animal | Ear - physiopathology | Vasoconstrictor Agents - pharmacology | Edema | Insect Proteins - pharmacology | Receptors, Vasoactive Intestinal Peptide, Type II - metabolism | Animals | Substance P - metabolism | Ear - pathology | Mice | Vasodilation - drug effects | Peroxidase - metabolism | Dropsy | Dilatation | Measuring instruments | Blood vessels | Fluorescence | Skin | Permeability | Index Medicus
Journal Article
Journal of Vascular Research, ISSN 1018-1172, 05/2017, Volume 54, Issue 3, pp. 180 - 192
Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide in the VIP/secretin/glucagon peptide superfamily. Two... 
Pituitary adenylate cyclase-activating polypeptide | PACAP-KO mice | Femoral arteries | VPAC1/VPAC2 receptors | Vasoactive intestinal peptide | Carotid arteries | PAC1 receptor | Vasomotor responses | SYSTEM | CELLS | PHYSIOLOGY | VASOACTIVE-INTESTINAL-PEPTIDE | RAT | VASCULAR-RESPONSES | PHARMACOLOGICAL CHARACTERIZATION | PERIPHERAL VASCULAR DISEASE | CEREBRAL-ARTERIES | VIP | EXPRESSION | RECEPTOR-BINDING | Vasodilator Agents - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Genotype | Male | Peptide Fragments - pharmacology | Femoral Artery - drug effects | Mice, Knockout | Dose-Response Relationship, Drug | Femoral Artery - enzymology | Phenotype | Animals | Signal Transduction - drug effects | Vasoactive Intestinal Peptide - pharmacology | Carotid Artery, Common - enzymology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Carotid Artery, Common - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Vasodilation - drug effects | In Vitro Techniques | Pituitary Adenylate Cyclase-Activating Polypeptide - deficiency | Index Medicus
Journal Article
Brain Research, ISSN 0006-8993, 2008, Volume 1241, pp. 29 - 35
Abstract Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are structurally endogenous peptides showing rich... 
Neurology | Schwannoma cells | PACAP | VIP | Apoptosis | SURVIVAL | CYCLASE-ACTIVATING POLYPEPTIDE | HUMAN BRAIN-TUMORS | VASOACTIVE-INTESTINAL-PEPTIDE | HUMAN PITUITARY-ADENOMAS | SPINAL-CORD | NEUROSCIENCES | MESSENGER-RNA | RAT-BRAIN | RECEPTORS | EXPRESSION | Vasoactive Intestinal Peptide - metabolism | Apoptosis - drug effects | Nerve Growth Factors - metabolism | RNA, Messenger - metabolism | Schwann Cells - cytology | Dose-Response Relationship, Drug | Nerve Growth Factors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Vasoactive Intestinal Peptide - pharmacology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Cell Survival - physiology | bcl-2-Associated X Protein - genetics | RNA, Messenger - drug effects | Schwann Cells - drug effects | Cell Survival - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | bcl-2-Associated X Protein - metabolism | Rats | Schwann Cells - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | bcl-2-Associated X Protein - drug effects | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Apoptosis - physiology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Vasoactive Intestinal Peptide - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Culture Media, Serum-Free - toxicity | Prevention | Adenylate cyclase | Polypeptides | Analysis | Vasoactive intestinal peptides | Gene expression | Index Medicus
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2013, Volume 54, Issue 4, pp. 2872 - 2884
PURPOSE. To determine the intracellular signaling pathways that vasoactive intestinal peptide (VIP) uses to stimulate high molecular weight glycoconjugate... 
Goblet cells | Conjunctiva | Intracellular Ca | ERK | intracellular Ca2 | ACTIVATION | STIMULATION | EGF | conjunctiva | DEPENDENT PROTEIN-KINASE | CHOLINERGIC AGONISTS | CYCLIC-AMP | RECEPTOR SUBTYPES | goblet cells | PATHWAY | VASOACTIVE INTESTINAL POLYPEPTIDE | CALCIUM | OPHTHALMOLOGY | Vasoactive Intestinal Peptide - metabolism | Glycoconjugates - metabolism | MAP Kinase Signaling System - physiology | Calcium - metabolism | Receptors, Vasoactive Intestinal Peptide, Type II - agonists | DNA, Complementary - genetics | Goblet Cells - drug effects | Male | Mucin 5AC - secretion | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Vasoactive Intestinal Peptide - pharmacology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Parasympathetic Nervous System - metabolism | Organ Culture Techniques | Conjunctiva - cytology | Cyclic AMP-Dependent Protein Kinases - metabolism | Goblet Cells - secretion | Receptors, Vasoactive Intestinal Peptide, Type II - metabolism | Cells, Cultured | Rats | Conjunctiva - secretion | Goblet Cells - metabolism | Rats, Sprague-Dawley | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Glycoconjugates - secretion | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Conjunctiva - innervation | Mucin 5AC - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2013, Volume 713, Issue 1-3, pp. 25 - 30
Journal Article
Neuropharmacology, ISSN 0028-3908, 2006, Volume 51, Issue 6, pp. 1086 - 1098
Journal Article
Brain Research, ISSN 0006-8993, 2016, Volume 1657, pp. 297 - 303
Highlights • We examined the effect of VPAC1, a receptor for PACAP, on nucleus ambiguus. • VPAC1 agonist increases cytosolic Ca2+ , produces depolarization and... 
Neurology | Calcium signaling | Bradycardia | Autonomic cardiac tone | PACAP | VASOACTIVE-INTESTINAL-PEPTIDE | RECEPTOR | NEUROSCIENCES | PARASYMPATHETIC NEURONS | INHIBITION | CARDIAC VAGAL NEURONS | CALCIUM | ADENYLATE-CYCLASE | POLYPEPTIDE | Calcium - metabolism | Calcium Signaling - physiology | Neuroanatomical Tract-Tracing Techniques | Endoplasmic Reticulum - metabolism | Vagus Nerve - drug effects | Male | Neurons - cytology | Heart Rate - drug effects | Medulla Oblongata - cytology | Bradycardia - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Endoplasmic Reticulum - drug effects | Heart Rate - physiology | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Neurons - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Neurons - drug effects | Membrane Potentials - drug effects | Vagus Nerve - metabolism | Medulla Oblongata - drug effects | Cells, Cultured | Medulla Oblongata - metabolism | Membrane Potentials - physiology | Parasympatholytics - pharmacology | Rats, Sprague-Dawley | Vagus Nerve - cytology | Bradycardia - chemically induced | Animals | Calcium Signaling - drug effects | Neurons | Medical colleges | Inositol | Heart beat | Analysis | G proteins | Cardiology | Index Medicus | autonomic cardiac tone | bradycardia | calcium signaling
Journal Article
Journal Article