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1. Full Text Tumour exosome integrins determine organotropic metastasis
by Hoshino, Ayuko and Costa-Silva, Bruno and Shen, Tang-Long and Rodrigues, Goncalo and Hashimoto, Ayako and Tesic Mark, Milica and Molina, Henrik and Kohsaka, Shinji and Di Giannatale, Angela and Ceder, Sophia and Singh, Swarnima and Williams, Caitlin and Soplop, Nadine and Uryu, Kunihiro and Pharmer, Lindsay and King, Tari and Bojmar, Linda and Davies, Alexander E and Ararso, Yonathan and Zhang, Tuo and Zhang, Haiying and Hernandez, Jonathan and Weiss, Joshua M and Dumont-Cole, Vanessa D and Kramer, Kimberly and Wexler, Leonard H and Narendran, Aru and Schwartz, Gary K and Healey, John H and Sandstrom, Per and Jørgen Labori, Knut and Kure, Elin H and Grandgenett, Paul M and Hollingsworth, Michael A and De Sousa, Maria and Kaur, Sukhwinder and Jain, Maneesh and Mallya, Kavita and Batra, Surinder K and Jarnagin, William R and Brady, Mary S and Fodstad, Oystein and Muller, Volkmar and Pantel, Klaus and Minn, Andy J and Bissell, Mina J and Garcia, Benjamin A and Kang, Yibin and Rajasekhar, Vinagolu K and Ghajar, Cyrus M and Matei, Irina and Peinado, Hector and Bromberg, Jacqueline and Lyden, David and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) and Weill Cornell Medicine, New York, NY (United States) and Memorial Sloan Kettering Cancer Center, New York, NY (United States) and Medicinska fakulteten and Region Östergötland and Kirurgiska kliniken US and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Avdelningen för kliniska vetenskaper and Centrum för kirurgi, ortopedi och cancervård
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 329 - 335
Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from... 
CELLS | BONE METASTASES | VESICLES | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | NICHE | MICROVESICLES | PROTEINS | PROTEOMICS | Exosomes - metabolism | Tropism | Phosphorylation | Epithelial Cells - metabolism | Receptors, Vitronectin - antagonists & inhibitors | Humans | Lung - cytology | Integrin beta4 - metabolism | Integrins - metabolism | Brain - metabolism | Integrin alpha6beta1 - metabolism | S100 Proteins - genetics | Neoplasm Metastasis - prevention & control | Female | Kupffer Cells - metabolism | Lung - metabolism | Receptors, Vitronectin - metabolism | Epithelial Cells - cytology | Integrin alpha6beta4 - metabolism | Fibroblasts - metabolism | Biomarkers - metabolism | Brain - cytology | Kupffer Cells - cytology | Endothelial Cells - metabolism | Liver - metabolism | Mice, Inbred C57BL | Integrin alpha6beta4 - antagonists & inhibitors | Organ Specificity | Animals | Endothelial Cells - cytology | Neoplasm Metastasis - pathology | Cell Line, Tumor | Integrin beta Chains - metabolism | Fibroblasts - cytology | Liver - cytology | Mice | Genes, src | Integrins - antagonists & inhibitors | Complications and side effects | Development and progression | Cell organelles | Metastasis | Health aspects | Integrins | Tumors | Studies | Microscopy | Liver | Melanoma | Fibroblasts | Breast cancer | Chemokines | Index Medicus | mechanisms of disease | cancer microenvironment | BASIC BIOLOGICAL SCIENCES | metastasis | 60 APPLIED LIFE SCIENCES | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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2. Full Text αv‐Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
by Taga, Takashi and Suzuki, Atsushi and Gonzalez‐Gomez, Ignacio and Gilles, Floyd H and Stins, Monique and Shimada, Hiroyuki and Barsky, Lora and Weinberg, Kenneth I and Laug, Walter E
International Journal of Cancer, ISSN 0020-7136, 04/2002, Volume 98, Issue 5, pp. 690 - 697
Orthotopic brain tumor growth is inhibited in athymic mice by the daily systemic administration of the α v ‐integrin antagonist EMD 121974. This compound, a... 
brain tumor | apoptosis | anti‐angiogenesis | αv‐integrins | xenograft | Brain tumor | Xenograft | αv-integrins | Anti-angiogenesis | Apoptosis | Receptors, Vitronectin - antagonists & inhibitors | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Peptides, Cyclic - pharmacology | Integrins - metabolism | Tenascin - metabolism | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Tumor Cells, Cultured - pathology | Flow Cytometry | Medulloblastoma - pathology | Glioblastoma - metabolism | Receptors, Vitronectin - metabolism | In Situ Nick-End Labeling | Tumor Cells, Cultured - drug effects | Tumor Cells, Cultured - metabolism | Medulloblastoma - metabolism | Cell Adhesion - drug effects | Vitronectin - metabolism | Cell Division - drug effects | Collagen - metabolism | Animals | Mice, Nude | Glioblastoma - pathology | Fluorescent Antibody Technique | Mice | Integrins - antagonists & inhibitors | Index Medicus
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3. Full Text Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction
by Sarrazy, Vincent and Koehler, Anne and Chow, Melissa L and Zimina, Elena and Li, Chen X and Kato, Hideyuki and Caldarone, Christopher A and Hinz, Boris
Cardiovascular Research, ISSN 0008-6363, 06/2014, Volume 102, Issue 3, pp. 407 - 417
Pathological tissue remodelling by myofibroblast contraction is a hallmark of cardiac fibrosis. Myofibroblasts differentiate from cardiac fibroblasts under the... 
Cardiac fibrosis | Cardiac repair | Mechanical stress | Myofibroblast | Myofibroblasts - pathology | Receptors, Vitronectin - antagonists & inhibitors | Humans | Cells, Cultured | Male | Myocardium - pathology | Transforming Growth Factor beta1 - physiology | Animals | Swine | Actins - analysis | Fibrosis | Receptors, Vitronectin - physiology | Adult | Integrin alphaVbeta3 - physiology | Cell Differentiation | Integrin alphaVbeta3 - antagonists & inhibitors | Index Medicus | Original
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4. Full Text A New Class of Orthosteric uPAR·uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR·Vitronectin Interaction
by Liu, Degang and Zhou, Donghui and Wang, Bo and Knabe, William Eric and Meroueh, Samy O
ACS Chemical Biology, ISSN 1554-8929, 06/2015, Volume 10, Issue 6, pp. 1521 - 1534
The urokinase receptor (uPAR) is a GPI-anchored cell surface receptor that is at the center of an intricate network of protein-protein interactions. Its... 
Focal Adhesion Kinase 1 - genetics | Integrin alphaVbeta3 - chemistry | Small Molecule Libraries - pharmacology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Humans | Integrins - genetics | Vitronectin - genetics | Integrins - metabolism | Vitronectin - antagonists & inhibitors | Integrin alphaVbeta3 - metabolism | Thermodynamics | Integrin alphaVbeta3 - genetics | HEK293 Cells | Urokinase-Type Plasminogen Activator - chemistry | Binding Sites | Focal Adhesion Kinase 1 - metabolism | Serine Proteinase Inhibitors - pharmacology | Integrin alphaVbeta3 - antagonists & inhibitors | Binding, Competitive | Cell Survival - drug effects | Receptors, Urokinase Plasminogen Activator - chemistry | Serine Proteinase Inhibitors - chemical synthesis | Signal Transduction | Gene Expression Regulation | Small Molecule Libraries - chemical synthesis | Urokinase-Type Plasminogen Activator - genetics | Cell Adhesion - drug effects | Vitronectin - metabolism | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Peptides - pharmacology | Receptors, Urokinase Plasminogen Activator - metabolism | Cell Movement - drug effects | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Urokinase-Type Plasminogen Activator - metabolism | Vitronectin - chemistry | Cell Line, Tumor | Protein Binding | Receptors, Urokinase Plasminogen Activator - genetics | Kinetics | rac1 GTP-Binding Protein - metabolism | Receptor Cross-Talk - drug effects | rac1 GTP-Binding Protein - genetics | Index Medicus
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5. Full Text The αvβ1 integrin plays a critical in vivo role in tissue fibrosis
by Reed, Nilgun I and Jo, Hyunil and Chen, Chun and Tsujino, Kazuyuki and Arnold, Thomas D and DeGrado, William F and Sheppard, Dean
Science Translational Medicine, ISSN 1946-6234, 05/2015, Volume 7, Issue 288, pp. 288 - ra79
Integrins are transmembrane heterodimeric receptors that contribute to diverse biological functions and play critical roles in many human diseases. Studies... 
Liver - pathology | Receptors, Vitronectin - antagonists & inhibitors | Molecular Targeted Therapy | Liver Cirrhosis, Experimental - prevention & control | Bleomycin | Liver - drug effects | Drug Design | Liver Cirrhosis, Experimental - pathology | Lung - metabolism | Pulmonary Fibrosis - metabolism | Receptors, Vitronectin - metabolism | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Fibroblasts - metabolism | Chemical and Drug Induced Liver Injury - prevention & control | Lung - pathology | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Pulmonary Fibrosis - pathology | Fibroblasts - pathology | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Fibroblasts - drug effects | Liver Cirrhosis, Experimental - chemically induced | Lung - drug effects | Pulmonary Fibrosis - prevention & control | Pulmonary Fibrosis - chemically induced | Mice | Hydrocarbons, Brominated | Transforming Growth Factor beta - metabolism | Liver Cirrhosis, Experimental - metabolism | Index Medicus
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6. Full Text Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule‐dependency
by Mikkelsen, Tom and Brodie, Chaya and Finniss, Susan and Berens, Michael E and Rennert, Jessica L and Nelson, Kevin and Lemke, Nancy and Brown, Stephen L and Hahn, Diane and Neuteboom, Berend and Goodman, Simon L
International Journal of Cancer, ISSN 0020-7136, 06/2009, Volume 124, Issue 11, pp. 2719 - 2727
We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific... 
glioma | cilengitide | integrin | animal model | radiation | Animal model | Cilengitide | Integrin | Glioma | Radiation | SURVIVAL | CELLS | SOLID TUMORS | ANGIOGENESIS | VITRONECTIN | ALPHA(V)BETA INTEGRIN | MALIGNANT GLIOMA | INVASION | ONCOLOGY | NF-KAPPA-B | BRAIN | Transcription Factor RelA - physiology | Cell Adhesion - radiation effects | Oligonucleotide Array Sequence Analysis | Rats, Wistar | Receptors, Vitronectin - antagonists & inhibitors | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Radiation-Sensitizing Agents - pharmacology | Rats | Endothelial Cells - radiation effects | Cell Adhesion - drug effects | Glioblastoma - radiotherapy | Xenograft Model Antitumor Assays | Integrin alphaVbeta3 - analysis | Receptors, Vitronectin - analysis | Animals | Snake Venoms - pharmacokinetics | Snake Venoms - pharmacology | Glioblastoma - pathology | Cell Line, Tumor | Integrin alphaVbeta3 - antagonists & inhibitors | Index Medicus
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7. Full Text Antagonists of IGF:Vitronectin interactions inhibit IGF-I-Induced breast cancer cell functions
by Kashyap, Abhishek S and Shooter, Gary K and Shokoohmand, Ali and McGovern, Jacqui and Sivaramakrishnan, Manaswini and Croll, Tristan I and Cane, Gaëlle and Leavesley, David I and Söderberg, Ola and Upton, Zee and Hollier, Brett G and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Molekylära verktyg
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2016, Volume 15, Issue 7, pp. 1602 - 1613
We provide proof-of-concept evidence for a new class of therapeutics that target growth factor: extracellular matrix (GF: ECM) interactions for the management... 
MIGRATION | FUTURE-DIRECTIONS | ONCOLOGY | COACTIVATION | FIBRONECTIN | CARCINOMAS | RECEPTOR | GROWTH-FACTOR-II | IDENTIFICATION | EXPRESSION | BINDING-PROTEINS | Immunohistochemistry | Somatomedins - chemistry | Insulin-Like Growth Factor I - chemistry | Insulin-Like Growth Factor Binding Protein 3 - chemistry | Humans | Peptide Fragments - pharmacology | Breast Neoplasms - metabolism | Multiprotein Complexes - metabolism | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Protein Binding - drug effects | Female | Protein Interaction Domains and Motifs | Somatomedins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Models, Molecular | Vitronectin - metabolism | Cell Movement - drug effects | Peptide Fragments - chemistry | Vitronectin - chemistry | Cell Line, Tumor | Ligands | Protein Conformation | Cell Proliferation - drug effects | Insulin-Like Growth Factor I - metabolism | Index Medicus | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
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8. Full Text Pharmacologic Blockade of alpha v beta 1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo
by Chang, YG and Lau, WL and Jo, H and Tsujino, K and Gewin, L and Reed, NI and Atakilit, A and Nunes, ACF and DeGrado, WF and Sheppard, D
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 07/2017, Volume 28, Issue 7, pp. 1998 - 2005
Activated fibroblasts are deemed the main executors of organ fibrosis. However, regulation of the pathologic functions of these cells in vivo is poorly... 
ADHESION | ACTIVATES LATENT TGF-BETA-1 | INJURY | UROLOGY & NEPHROLOGY | EXTRACELLULAR-MATRIX | MICE | EXPRESSION | MURINE | Kidney - pathology | Receptors, Vitronectin - antagonists & inhibitors | Guanidines - pharmacology | Male | Renal Insufficiency - prevention & control | Sulfonamides - pharmacology | Renal Insufficiency - etiology | Animals | Sulfonamides - therapeutic use | Fibrosis - etiology | Receptors, Vitronectin - physiology | Mice | Fibrosis - prevention & control | Guanidines - therapeutic use
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9. Full Text Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of αvβ5 integrin
by Ruffini, Federica and Graziani, Grazia and Levati, Lauretta and Tentori, Lucio and D'Atri, Stefania and Lacal, Pedro M
International Journal of Cancer, ISSN 0020-7136, 03/2015, Volume 136, Issue 6, pp. E545 - E558
During melanoma progression, tumour cells show increased adhesiveness to the vascular wall, invade the extracellular matrix (ECM) and frequently form... 
neuropilin 1 | melanoma | integrins | cilengitide | vasculogenic mimicry | Cilengitide | Melanoma | Integrins | Neuropilin 1 | Vasculogenic mimicry | Receptors, Vitronectin - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - analysis | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Neoplasm Invasiveness | Humans | Melanoma - pathology | Neuropilin-1 - physiology | Snake Venoms - pharmacology | Melanoma - drug therapy | Cell Line, Tumor | Receptors, Vitronectin - physiology | Neuropilin-1 - analysis | Melanoma - chemistry | Index Medicus
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10. Full Text Cross Talk between Engulfment Receptors Stabilin-2 and Integrin αvβ5 Orchestrates Engulfment of Phosphatidylserine-Exposed Erythrocytes
by Soyoun Kim and Seung-Yoon Park and Sang-Yeob Kim and Dong-Jun Bae and Jae-Hoon Pyo and Mina Hong and In-San Kim
Molecular and Cellular Biology, ISSN 0270-7306, 07/2012, Volume 32, Issue 14, pp. 2698 - 2708
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
RNA, Small Interfering - genetics | Receptors, Vitronectin - antagonists & inhibitors | Humans | rac GTP-Binding Proteins - metabolism | L Cells (Cell Line) | DNA Primers - genetics | Erythrocyte Aging | Gene Knockdown Techniques | rac GTP-Binding Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | rac GTP-Binding Proteins - genetics | Base Sequence | Erythrocytes - cytology | Cell Adhesion Molecules, Neuronal - metabolism | Receptors, Vitronectin - genetics | Receptors, Vitronectin - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Adhesion Molecules, Neuronal - chemistry | Receptor Cross-Talk | Phosphatidylserines - metabolism | Antibodies, Blocking | Phagocytosis - physiology | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cell Adhesion Molecules, Neuronal - genetics | Animals | Models, Biological | Adaptor Proteins, Signal Transducing - genetics | Erythrocytes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Apoptosis | Index Medicus
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11. Full Text Metabolism and disposition of the αv‐integrin ß3/ß5 receptor antagonist cilengitide, a cyclic polypeptide, in humans
by Becker, Andreas and von Richter, Oliver and Kovar, Andreas and Scheible, Holger and van Lier, Jan J and Johne, Andreas
The Journal of Clinical Pharmacology, ISSN 0091-2700, 07/2015, Volume 55, Issue 7, pp. 815 - 824
Cilengitide (EMD 121974, manufactured by Merck KGaA, Darmstadt, Germany) is an αv-integrin receptor antagonist showing high affinity for αvβ3 and αvβ5.This... 
disposition | cilengitide | mass balance | human | Human | Mass balance | Disposition | Cilengitide | Young Adult | Snake Venoms - pharmacokinetics | Receptors, Vitronectin - antagonists & inhibitors | Humans | Snake Venoms - administration & dosage | Adult | Male | Infusions, Intravenous | Integrin alphaVbeta3 - antagonists & inhibitors | Index Medicus
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12. Full Text Thiophene-based vitronectin receptor antagonists
by Bubenik, Monica and Meerovitch, Karen and Bergeron, Frédéric and Attardo, Giorgio and Chan, Laval
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2003, Volume 13, Issue 3, pp. 503 - 506
A series of α β antagonists based on a thiophene scaffold were synthesized via two routes and evaluated for in vitro biological activity. We have identified... 
BREAST-CANCER | POTENT | CHEMISTRY, MEDICINAL | ANGIOGENESIS | GUANIDINES | GROWTH | VASCULAR INTEGRIN ALPHA(V)BETA | CHEMISTRY, ORGANIC | Vascular Endothelial Growth Factor A | Receptors, Vitronectin - antagonists & inhibitors | Vascular Endothelial Growth Factors | Humans | Angiogenesis Inhibitors - pharmacology | Thiophenes - pharmacology | Guanidines - pharmacology | Chorion - ultrastructure | Endothelial Growth Factors - pharmacology | Structure-Activity Relationship | Chick Embryo | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Endothelial Growth Factors - antagonists & inhibitors | Animals | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphokines - antagonists & inhibitors | K562 Cells | Guanidines - chemical synthesis | Chorion - drug effects | Lymphokines - pharmacology | Oligopeptides - pharmacology | Angiogenesis Inhibitors - chemical synthesis | Integrin alphaVbeta3 - antagonists & inhibitors | Index Medicus
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13. Full Text Radiolabeled divalent peptidomimetic vitronectin receptor antagonists as potential tumor radiotherapeutic and imaging agents
by Harris, Thomas D and Cheesman, Edward and Harris, Anthony R and Sachleben, Richard and Edwards, D. Scott and Liu, Shuang and Bartis, Judit and Ellars, Charles and Onthank, Dave and Yalamanchili, Padmaja and Heminway, Stuart and Silva, Paula and Robinson, Simon and Lazewatsky, Joel and Rajopadhye, Milind and Barrett, John
Bioconjugate Chemistry, ISSN 1043-1802, 07/2007, Volume 18, Issue 4, pp. 1266 - 1279
The integrin receptor alpha(v)beta(3) is overexpressed on the endothelial cells of growing tumors and on some tumor cells themselves. A radiolabeled... 
METASTASIS | HUMAN SKIN | ANGIOGENESIS | INTEGRIN ALPHA(V)BETA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CANCER | CHEMISTRY, MULTIDISCIPLINARY | MULTIMERIC LIGANDS | RGD-PEPTIDE | IN-111 COMPLEXES | ALPHA-V-BETA-3 | CARCINOMA | Radioisotopes - pharmacokinetics | Peptides - pharmacokinetics | Integrin alphaVbeta3 - metabolism | Breast Neoplasms - metabolism | Tissue Distribution | Adenocarcinoma - metabolism | Heterocyclic Compounds, 1-Ring - chemistry | Female | Lutetium - chemistry | Breast Neoplasms - diagnostic imaging | Lutetium - therapeutic use | Adenocarcinoma - radiotherapy | Integrin alphaVbeta3 - antagonists & inhibitors | Binding, Competitive | Lutetium - pharmacokinetics | Radioisotopes - therapeutic use | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Peptides - chemistry | Sulfonamides - chemistry | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Indium Radioisotopes - chemistry | Indium Radioisotopes - pharmacokinetics | Sulfonamides - pharmacokinetics | Diagnostic Imaging | Breast Neoplasms - radiotherapy | Animals | Sulfonamides - therapeutic use | Radionuclide Imaging | Heterocyclic Compounds, 1-Ring - therapeutic use | Indium Radioisotopes - therapeutic use | Mice | Adenocarcinoma - diagnostic imaging | Peptides - therapeutic use | Radioisotopes - chemistry | Radiopharmaceuticals - therapeutic use | Cell growth | Peptides | Rodents | T cell receptors | Models | Radiation therapy | Drug therapy | Tumors | Index Medicus
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14. Full Text Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides
by Urbahns, Klaus and Härter, Michael and Albers, Markus and Schmidt, Delf and Stelte-Ludwig, Beatrix and Brüggemeier, Ulf and Vaupel, Andrea and Keldenich, Jörg and Lustig, Klemens and Tsujishita, Hideki and Gerdes, Christoph
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 22, pp. 6151 - 6154
Vitronectin receptor (α β ) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we... 
Restenosis | Smooth muscle cell | Urea | Squaric acid amide | Arginine | α Vβ 3 | Biphenyl | Vitronectin | Guanidine mimetic | RGD | restenosis | DESIGN | CHEMISTRY, MEDICINAL | smooth muscle cell | INTEGRIN | CHEMISTRY, ORGANIC | urea | squaric acid amide | biphenyl | vitronectin | arginine | alpha nu beta | ALPHA(V)BETA | LIGANDS | guanidine mimetic | SELECTIVITY | Protein Structure, Tertiary | Receptors, Vitronectin - antagonists & inhibitors | Sulfonamides - chemistry | Humans | Models, Molecular | Structure-Activity Relationship | Sulfonamides - pharmacology | Biphenyl Compounds - pharmacology | Cyclobutanes - pharmacology | Ligands | Molecular Structure | Biphenyl Compounds - chemistry | Cyclobutanes - chemistry | Binding Sites - drug effects | Receptors, Vitronectin - chemistry | Index Medicus
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15. Full Text A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells
by RUSSO, MARIKA A and PAOLILLO, MAYRA and SANCHEZ-HERNANDEZ, YULY and CURTI, DANIELA and CIUSANI, EMILIO and SERRA, MASSIMO and COLOMBO, LINO and SCHINELLI, SERGIO
International Journal of Oncology, ISSN 1019-6439, 1/2013, Volume 42, Issue 1, pp. 83 - 92
In cancer cells integrins modulate important cellular events that regulate the metastasic cascade which involves detachment from the tumor mass, dissemination... 
migration | anoikis | integrins | glioblastoma | Anoikis | Migration | Glioblastoma | Integrins | GLIOMA-CELLS | APOPTOSIS | ALPHA(V)BETA | ANGIOGENESIS | ONCOLOGY | PENTAPEPTIDE MIMICS | GROWTH | CILENGITIDE | Receptors, Vitronectin - antagonists & inhibitors | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Integrin alphaVbeta3 - metabolism | Integrin alphaVbeta3 - genetics | Actin Cytoskeleton - drug effects | Glioblastoma - metabolism | Phosphorylation - drug effects | Receptors, Vitronectin - genetics | Receptors, Vitronectin - metabolism | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Integrin alphaVbeta3 - antagonists & inhibitors | Enzyme-Linked Immunosorbent Assay | Focal Adhesion Protein-Tyrosine Kinases - metabolism | RNA, Messenger - genetics | Brain Neoplasms - drug therapy | Cell Adhesion - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Focal Adhesion Protein-Tyrosine Kinases - genetics | Cell Movement - drug effects | Signal Transduction - drug effects | Glioblastoma - pathology | Anoikis - drug effects | Cell Proliferation - drug effects | Glioblastoma - drug therapy | Oligopeptides - pharmacology | Drugs | Cell culture | Peptides | Brain cancer | Metastasis | Kinases | Cancer therapies | Cell adhesion & migration | Studies | Medical prognosis | Rodents | Ligands | Apoptosis
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