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by Hoshino, Ayuko and Costa-Silva, Bruno and Shen, Tang-Long and Rodrigues, Goncalo and Hashimoto, Ayako and Tesic Mark, Milica and Molina, Henrik and Kohsaka, Shinji and Di Giannatale, Angela and Ceder, Sophia and Singh, Swarnima and Williams, Caitlin and Soplop, Nadine and Uryu, Kunihiro and Pharmer, Lindsay and King, Tari and Bojmar, Linda and Davies, Alexander E and Ararso, Yonathan and Zhang, Tuo and Zhang, Haiying and Hernandez, Jonathan and Weiss, Joshua M and Dumont-Cole, Vanessa D and Kramer, Kimberly and Wexler, Leonard H and Narendran, Aru and Schwartz, Gary K and Healey, John H and Sandstrom, Per and Jørgen Labori, Knut and Kure, Elin H and Grandgenett, Paul M and Hollingsworth, Michael A and De Sousa, Maria and Kaur, Sukhwinder and Jain, Maneesh and Mallya, Kavita and Batra, Surinder K and Jarnagin, William R and Brady, Mary S and Fodstad, Oystein and Muller, Volkmar and Pantel, Klaus and Minn, Andy J and Bissell, Mina J and Garcia, Benjamin A and Kang, Yibin and Rajasekhar, Vinagolu K and Ghajar, Cyrus M and Matei, Irina and Peinado, Hector and Bromberg, Jacqueline and Lyden, David and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) and Weill Cornell Medicine, New York, NY (United States) and Memorial Sloan Kettering Cancer Center, New York, NY (United States) and Medicinska fakulteten and Region Östergötland and Kirurgiska kliniken US and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Avdelningen för kliniska vetenskaper and Centrum för kirurgi, ortopedi och cancervård
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 329 - 335
Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from... 
CELLS | BONE METASTASES | VESICLES | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | NICHE | MICROVESICLES | PROTEINS | PROTEOMICS | Exosomes - metabolism | Tropism | Phosphorylation | Epithelial Cells - metabolism | Receptors, Vitronectin - antagonists & inhibitors | Humans | Lung - cytology | Integrin beta4 - metabolism | Integrins - metabolism | Brain - metabolism | Integrin alpha6beta1 - metabolism | S100 Proteins - genetics | Neoplasm Metastasis - prevention & control | Female | Kupffer Cells - metabolism | Lung - metabolism | Receptors, Vitronectin - metabolism | Epithelial Cells - cytology | Integrin alpha6beta4 - metabolism | Fibroblasts - metabolism | Biomarkers - metabolism | Brain - cytology | Kupffer Cells - cytology | Endothelial Cells - metabolism | Liver - metabolism | Mice, Inbred C57BL | Integrin alpha6beta4 - antagonists & inhibitors | Organ Specificity | Animals | Endothelial Cells - cytology | Neoplasm Metastasis - pathology | Cell Line, Tumor | Integrin beta Chains - metabolism | Fibroblasts - cytology | Liver - cytology | Mice | Genes, src | Integrins - antagonists & inhibitors | Complications and side effects | Development and progression | Cell organelles | Metastasis | Health aspects | Integrins | Tumors | Studies | Microscopy | Liver | Melanoma | Fibroblasts | Breast cancer | Chemokines | Index Medicus | mechanisms of disease | cancer microenvironment | BASIC BIOLOGICAL SCIENCES | metastasis | 60 APPLIED LIFE SCIENCES | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 06/2015, Volume 10, Issue 6, pp. 1521 - 1534
The urokinase receptor (uPAR) is a GPI-anchored cell surface receptor that is at the center of an intricate network of protein-protein interactions. Its... 
Focal Adhesion Kinase 1 - genetics | Integrin alphaVbeta3 - chemistry | Small Molecule Libraries - pharmacology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Humans | Integrins - genetics | Vitronectin - genetics | Integrins - metabolism | Vitronectin - antagonists & inhibitors | Integrin alphaVbeta3 - metabolism | Thermodynamics | Integrin alphaVbeta3 - genetics | HEK293 Cells | Urokinase-Type Plasminogen Activator - chemistry | Binding Sites | Focal Adhesion Kinase 1 - metabolism | Serine Proteinase Inhibitors - pharmacology | Integrin alphaVbeta3 - antagonists & inhibitors | Binding, Competitive | Cell Survival - drug effects | Receptors, Urokinase Plasminogen Activator - chemistry | Serine Proteinase Inhibitors - chemical synthesis | Signal Transduction | Gene Expression Regulation | Small Molecule Libraries - chemical synthesis | Urokinase-Type Plasminogen Activator - genetics | Cell Adhesion - drug effects | Vitronectin - metabolism | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Peptides - pharmacology | Receptors, Urokinase Plasminogen Activator - metabolism | Cell Movement - drug effects | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Urokinase-Type Plasminogen Activator - metabolism | Vitronectin - chemistry | Cell Line, Tumor | Protein Binding | Receptors, Urokinase Plasminogen Activator - genetics | Kinetics | rac1 GTP-Binding Protein - metabolism | Receptor Cross-Talk - drug effects | rac1 GTP-Binding Protein - genetics | Index Medicus
Journal Article
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2016, Volume 15, Issue 7, pp. 1602 - 1613
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 07/2017, Volume 28, Issue 7, pp. 1998 - 2005
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 07/2015, Volume 55, Issue 7, pp. 815 - 824
Cilengitide (EMD 121974, manufactured by Merck KGaA, Darmstadt, Germany) is an αv-integrin receptor antagonist showing high affinity for αvβ3 and αvβ5.This... 
disposition | cilengitide | mass balance | human | Human | Mass balance | Disposition | Cilengitide | Young Adult | Snake Venoms - pharmacokinetics | Receptors, Vitronectin - antagonists & inhibitors | Humans | Snake Venoms - administration & dosage | Adult | Male | Infusions, Intravenous | Integrin alphaVbeta3 - antagonists & inhibitors | Index Medicus
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 07/2007, Volume 18, Issue 4, pp. 1266 - 1279
The integrin receptor alpha(v)beta(3) is overexpressed on the endothelial cells of growing tumors and on some tumor cells themselves. A radiolabeled... 
METASTASIS | HUMAN SKIN | ANGIOGENESIS | INTEGRIN ALPHA(V)BETA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CANCER | CHEMISTRY, MULTIDISCIPLINARY | MULTIMERIC LIGANDS | RGD-PEPTIDE | IN-111 COMPLEXES | ALPHA-V-BETA-3 | CARCINOMA | Radioisotopes - pharmacokinetics | Peptides - pharmacokinetics | Integrin alphaVbeta3 - metabolism | Breast Neoplasms - metabolism | Tissue Distribution | Adenocarcinoma - metabolism | Heterocyclic Compounds, 1-Ring - chemistry | Female | Lutetium - chemistry | Breast Neoplasms - diagnostic imaging | Lutetium - therapeutic use | Adenocarcinoma - radiotherapy | Integrin alphaVbeta3 - antagonists & inhibitors | Binding, Competitive | Lutetium - pharmacokinetics | Radioisotopes - therapeutic use | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Peptides - chemistry | Sulfonamides - chemistry | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Indium Radioisotopes - chemistry | Indium Radioisotopes - pharmacokinetics | Sulfonamides - pharmacokinetics | Diagnostic Imaging | Breast Neoplasms - radiotherapy | Animals | Sulfonamides - therapeutic use | Radionuclide Imaging | Heterocyclic Compounds, 1-Ring - therapeutic use | Indium Radioisotopes - therapeutic use | Mice | Adenocarcinoma - diagnostic imaging | Peptides - therapeutic use | Radioisotopes - chemistry | Radiopharmaceuticals - therapeutic use | Cell growth | Peptides | Rodents | T cell receptors | Models | Radiation therapy | Drug therapy | Tumors | Index Medicus
Journal Article
International Journal of Oncology, ISSN 1019-6439, 1/2013, Volume 42, Issue 1, pp. 83 - 92
In cancer cells integrins modulate important cellular events that regulate the metastasic cascade which involves detachment from the tumor mass, dissemination... 
migration | anoikis | integrins | glioblastoma | Anoikis | Migration | Glioblastoma | Integrins | GLIOMA-CELLS | APOPTOSIS | ALPHA(V)BETA | ANGIOGENESIS | ONCOLOGY | PENTAPEPTIDE MIMICS | GROWTH | CILENGITIDE | Receptors, Vitronectin - antagonists & inhibitors | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Integrin alphaVbeta3 - metabolism | Integrin alphaVbeta3 - genetics | Actin Cytoskeleton - drug effects | Glioblastoma - metabolism | Phosphorylation - drug effects | Receptors, Vitronectin - genetics | Receptors, Vitronectin - metabolism | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Integrin alphaVbeta3 - antagonists & inhibitors | Enzyme-Linked Immunosorbent Assay | Focal Adhesion Protein-Tyrosine Kinases - metabolism | RNA, Messenger - genetics | Brain Neoplasms - drug therapy | Cell Adhesion - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Focal Adhesion Protein-Tyrosine Kinases - genetics | Cell Movement - drug effects | Signal Transduction - drug effects | Glioblastoma - pathology | Anoikis - drug effects | Cell Proliferation - drug effects | Glioblastoma - drug therapy | Oligopeptides - pharmacology | Drugs | Cell culture | Peptides | Brain cancer | Metastasis | Kinases | Cancer therapies | Cell adhesion & migration | Studies | Medical prognosis | Rodents | Ligands | Apoptosis
Journal Article