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1. Full Text αv‐Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
by Taga, Takashi and Suzuki, Atsushi and Gonzalez‐Gomez, Ignacio and Gilles, Floyd H and Stins, Monique and Shimada, Hiroyuki and Barsky, Lora and Weinberg, Kenneth I and Laug, Walter E
International journal of cancer, ISSN 0020-7136, 04/2002, Volume 98, Issue 5, pp. 690 - 697
brain tumor | apoptosis | anti‐angiogenesis | αv‐integrins | xenograft | Brain tumor | Xenograft | αv-integrins | Anti-angiogenesis | Apoptosis | Receptors, Vitronectin - antagonists & inhibitors | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Peptides, Cyclic - pharmacology | Integrins - metabolism | Tenascin - metabolism | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Tumor Cells, Cultured - pathology | Flow Cytometry | Medulloblastoma - pathology | Glioblastoma - metabolism | Receptors, Vitronectin - metabolism | Snake Venoms | In Situ Nick-End Labeling | Tumor Cells, Cultured - drug effects | Tumor Cells, Cultured - metabolism | Medulloblastoma - metabolism | Cell Adhesion - drug effects | Vitronectin - metabolism | Cell Division - drug effects | Collagen - metabolism | Animals | Mice, Nude | Glioblastoma - pathology | Fluorescent Antibody Technique | Mice | Integrins - antagonists & inhibitors | Index Medicus
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2. Full Text Tumour exosome integrins determine organotropic metastasis
by Hoshino, Ayuko and Costa-Silva, Bruno and Shen, Tang-Long and Rodrigues, Goncalo and Hashimoto, Ayako and Tesic Mark, Milica and Molina, Henrik and Kohsaka, Shinji and Di Giannatale, Angela and Ceder, Sophia and Singh, Swarnima and Williams, Caitlin and Soplop, Nadine and Uryu, Kunihiro and Pharmer, Lindsay and King, Tari and Bojmar, Linda and Davies, Alexander E and Ararso, Yonathan and Zhang, Tuo and Zhang, Haiying and Hernandez, Jonathan and Weiss, Joshua M and Dumont-Cole, Vanessa D and Kramer, Kimberly and Wexler, Leonard H and Narendran, Aru and Schwartz, Gary K and Healey, John H and Sandstrom, Per and Jørgen Labori, Knut and Kure, Elin H and Grandgenett, Paul M and Hollingsworth, Michael A and De Sousa, Maria and Kaur, Sukhwinder and Jain, Maneesh and Mallya, Kavita and Batra, Surinder K and Jarnagin, William R and Brady, Mary S and Fodstad, Oystein and Muller, Volkmar and Pantel, Klaus and Minn, Andy J and Bissell, Mina J and Garcia, Benjamin A and Kang, Yibin and Rajasekhar, Vinagolu K and Ghajar, Cyrus M and Matei, Irina and Peinado, Hector and Bromberg, Jacqueline and Lyden, David and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) and Weill Cornell Medicine, New York, NY (United States) and Memorial Sloan Kettering Cancer Center, New York, NY (United States)
Nature (London), ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 329 - 335
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Exosomes - metabolism | Tropism | Phosphorylation | Epithelial Cells - metabolism | Receptors, Vitronectin - antagonists & inhibitors | Humans | Lung - cytology | Integrin beta4 - metabolism | Integrins - metabolism | Brain - metabolism | Integrin alpha6beta1 - metabolism | S100 Proteins - genetics | Neoplasm Metastasis - prevention & control | Female | Kupffer Cells - metabolism | Lung - metabolism | Receptors, Vitronectin - metabolism | Epithelial Cells - cytology | Integrin alpha6beta4 - metabolism | Fibroblasts - metabolism | Biomarkers - metabolism | Brain - cytology | Kupffer Cells - cytology | Endothelial Cells - metabolism | Liver - metabolism | Mice, Inbred C57BL | Integrin alpha6beta4 - antagonists & inhibitors | Organ Specificity | Animals | Endothelial Cells - cytology | Neoplasm Metastasis - pathology | Cell Line, Tumor | Integrin beta Chains - metabolism | Fibroblasts - cytology | Liver - cytology | Mice | Genes, src | Integrins - antagonists & inhibitors | Complications and side effects | Development and progression | Cell organelles | Metastasis | Health aspects | Integrins | Tumors | Studies | Microscopy | Liver | Melanoma | Fibroblasts | Breast cancer | Chemokines | Index Medicus | mechanisms of disease | cancer microenvironment | BASIC BIOLOGICAL SCIENCES | metastasis | 60 APPLIED LIFE SCIENCES | Medicin och hälsovetenskap
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3. Full Text A New Class of Orthosteric uPAR·uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR·Vitronectin Interaction
by Liu, Degang and Zhou, Donghui and Wang, Bo and Knabe, William Eric and Meroueh, Samy O
ACS chemical biology, ISSN 1554-8929, 06/2015, Volume 10, Issue 6, pp. 1521 - 1534
Focal Adhesion Kinase 1 - genetics | Integrin alphaVbeta3 - chemistry | Small Molecule Libraries - pharmacology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Humans | Integrins - genetics | Vitronectin - genetics | Integrins - metabolism | Vitronectin - antagonists & inhibitors | Integrin alphaVbeta3 - metabolism | Thermodynamics | Integrin alphaVbeta3 - genetics | HEK293 Cells | Urokinase-Type Plasminogen Activator - chemistry | Binding Sites | Focal Adhesion Kinase 1 - metabolism | Serine Proteinase Inhibitors - pharmacology | Integrin alphaVbeta3 - antagonists & inhibitors | Binding, Competitive | Cell Survival - drug effects | Receptors, Urokinase Plasminogen Activator - chemistry | Serine Proteinase Inhibitors - chemical synthesis | Signal Transduction | Gene Expression Regulation | Small Molecule Libraries - chemical synthesis | Urokinase-Type Plasminogen Activator - genetics | Cell Adhesion - drug effects | Vitronectin - metabolism | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Peptides - pharmacology | Receptors, Urokinase Plasminogen Activator - metabolism | Cell Movement - drug effects | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Urokinase-Type Plasminogen Activator - metabolism | Vitronectin - chemistry | Cell Line, Tumor | Protein Binding | Receptors, Urokinase Plasminogen Activator - genetics | Kinetics | rac1 GTP-Binding Protein - metabolism | Receptor Cross-Talk - drug effects | rac1 GTP-Binding Protein - genetics | Index Medicus
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4. Full Text Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization
by Sutter, Arne and Preissner, Klaus T and Jonczyk, Alfred and Hammes, Hans-Peter and Brownlee, Michael
Nature medicine, ISSN 1078-8956, 05/1996, Volume 2, Issue 5, pp. 529 - 533
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Amino Acid Sequence | Receptors, Vitronectin - antagonists & inhibitors | Mice, Inbred C57BL | Molecular Sequence Data | Peptides, Cyclic - pharmacology | Peptides, Cyclic - toxicity | Dose-Response Relationship, Drug | Animals | Injections, Subcutaneous | Peptides, Cyclic - therapeutic use | Mice | Retinal Neovascularization - drug therapy | Integrins - antagonists & inhibitors | Index Medicus
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5. Full Text Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
by Miller, William H and Alberts, Doreen P and Bhatnagar, Pradip K and Bondinell, William E and Callahan, James F and Calvo, Raul R and Cousins, Russell D and Erhard, Karl F and Heerding, Dirk A and Keenan, Richard M and Kwon, Chet and Manley, Peter J and Newlander, Kenneth A and Ross, Stephen T and Samanen, James M and Uzinskas, Irene N and Venslavsky, Joseph W and Yuan, Catherine C.-K and Haltiwanger, R. Curtis and Gowen, Maxine and Hwang, Shing-Mei and James, Ian E and Lark, Michael W and Rieman, David J and Stroup, George B and Azzarano, Leonard M and Salyers, Kevin L and Smith, Brian R and Ward, Keith W and Johanson, Kyung O and Huffman, William F
Journal of medicinal chemistry, ISSN 0022-2623, 01/2000, Volume 43, Issue 1, pp. 22 - 26
Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Cell Line | Receptors, Vitronectin - antagonists & inhibitors | Stereoisomerism | Humans | Pyridines - chemical synthesis | Half-Life | Pyridines - pharmacokinetics | Rats | Biological Availability | Benzazepines - pharmacology | Cell Adhesion - drug effects | Benzazepines - chemical synthesis | Benzazepines - pharmacokinetics | Osteoclasts - metabolism | Bone Resorption - prevention & control | Tissue Distribution | Molecular Mimicry | Animals | Pyridines - pharmacology | Osteoclasts - drug effects | Index Medicus
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6. Full Text Urokinase Receptor Regulates Adhesion of Progenitor Cardiac Cells to Vitronectin
by Dergilev, K V and Tsokolaeva, Z I and Beloglazova, I B and Zubkova, E S and Ratner, E I and Molokotina, Yu D and Parfenova, E V
Bulletin of experimental biology and medicine, ISSN 0007-4888, 7/2019, Volume 167, Issue 3, pp. 315 - 319
Biomedicine, general | Pathology | Biomedicine | vitronectin | Internal Medicine | Laboratory Medicine | urokinase receptor | adhesion | progenitor cells of the heart | Cell Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, Urokinase Plasminogen Activator - physiology | Mice, Inbred C57BL | Male | Vitronectin - metabolism | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Mice, Knockout | Myocardium - cytology | Animals | Cell Adhesion - physiology | Myocardial Infarction - pathology | Myocardium - metabolism | Stem Cells - physiology | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Viral antibodies | Antibodies | Embryonic development | Urokinase | Heart cells | Heart | Embryogenesis | Cell adhesion | Myocardium | Extracellular matrix | Vitronectin | Infarction | Matrix protein | Growth factors | U-Plasminogen activator | Index Medicus
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7. Full Text αvβ5/β6 integrin suppression leads to a stimulation of α2β1 dependent cell migration resistant to PI3K/Akt inhibition
by Defilles, Céline and Lissitzky, Jean-Claude and Montero, Marie-Pierre and André, Frédéric and Prévot, Charles and Delamarre, Estelle and Marrakchi, Naziha and Luis, José and Rigot, Véronique
Experimental cell research, ISSN 0014-4827, 2009, Volume 315, Issue 11, pp. 1840 - 1849
Colon adenocarcinoma | PI3K | Crosstalk | PKC | Cell migration | Integrin signaling | Integrins | Collagen Type I/metabolism | Integrins/antagonists & inhibitors | Receptors, Vitronectin/genetics | Antigens, Neoplasm/physiology | Cell Movement/drug effects | RNA, Small Interfering/genetics | Humans | Focal Adhesions | Oncogene Protein v-akt/physiology | Oncogene Protein v-akt/genetics | Life Sciences | Oncogene Protein v-akt/antagonists & inhibitors | Receptors, Vitronectin/antagonists & inhibitors | Receptors, Vitronectin/physiology | Signal Transduction | Integrin alpha2beta1/physiology | Integrin alpha2beta1/genetics | Phosphatidylinositol 3-Kinases/physiology | Integrin alpha2beta1/antagonists & inhibitors | Integrins/genetics | Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Cell Movement/physiology | Antigens, Neoplasm/genetics | Cell Line, Tumor | Protein Kinase Inhibitors/pharmacology | Integrins/physiology
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8. Full Text Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages
by Bae, Hong-Beom and Tadie, Jean-Marc and Jiang, Shaoning and Park, Dae Won and Bell, Celeste P and Thompson, Lawrence C and Peterson, Cynthia B and Thannickal, Victor J and Abraham, Edward and Zmijewski, Jaroslaw W
The Journal of immunology (1950), ISSN 0022-1767, 03/2013, Volume 190, Issue 5, pp. 2273 - 2281
Life Sciences & Biomedicine | Immunology | Science & Technology | Apoptosis - drug effects | Receptors, Urokinase Plasminogen Activator - immunology | Cell Count | Coculture Techniques | Macrophages, Peritoneal - pathology | Bronchoalveolar Lavage Fluid - immunology | Male | Vitronectin - genetics | Lipopolysaccharides | Vitronectin - deficiency | Female | Acute Lung Injury - metabolism | Macrophages, Peritoneal - drug effects | Neutrophils - pathology | Phagocytosis - drug effects | Vitronectin - immunology | Mice, Inbred C57BL | Neutrophils - drug effects | Neutrophils - immunology | Phagocytosis - immunology | Macrophages, Peritoneal - immunology | Acute Lung Injury - pathology | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Mice, Knockout | Thymocytes - immunology | Antibodies - pharmacology | Animals | Apoptosis - immunology | Acute Lung Injury - chemically induced | Plasminogen Activator Inhibitor 1 - pharmacology | Acute Lung Injury - immunology | Thymocytes - drug effects | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Bronchoalveolar Lavage Fluid - chemistry | Thymocytes - pathology | Index Medicus | Abridged Index Medicus
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9. Full Text Discovery of new small molecules targeting the vitronectin-binding site of the urokinase receptor that block cancer cell invasion
by Rea, Vincenza Elena Anna and Lavecchia, Antonio and Di Giovanni, Carmen and Rossi, Francesca Wanda and Gorrasi, Anna and Pesapane, Ada and De Paulis, Amato and Ragno, Pia and Montuori, Nunzia
Molecular cancer therapeutics, ISSN 1535-7163, 08/2013, Volume 12, Issue 8, pp. 1402 - 1416
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator - chemistry | Neoplasm Invasiveness | Humans | Molecular Conformation | Models, Molecular | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Cell Adhesion - drug effects | Vitronectin - metabolism | Drug Discovery | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Receptors, Urokinase Plasminogen Activator - metabolism | Signal Transduction - drug effects | Protein Binding - drug effects | Cell Line, Tumor | Ligands | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Binding Sites | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text The αvβ1 integrin plays a critical in vivo role in tissue fibrosis
by Reed, Nilgun I and Jo, Hyunil and Chen, Chun and Tsujino, Kazuyuki and Arnold, Thomas D and DeGrado, William F and Sheppard, Dean
Science translational medicine, ISSN 1946-6234, 05/2015, Volume 7, Issue 288, pp. 288 - ra79
Liver - pathology | Receptors, Vitronectin - antagonists & inhibitors | Molecular Targeted Therapy | Liver Cirrhosis, Experimental - prevention & control | Bleomycin | Liver - drug effects | Drug Design | Liver Cirrhosis, Experimental - pathology | Lung - metabolism | Pulmonary Fibrosis - metabolism | Receptors, Vitronectin - metabolism | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Fibroblasts - metabolism | Chemical and Drug Induced Liver Injury - prevention & control | Lung - pathology | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Pulmonary Fibrosis - pathology | Fibroblasts - pathology | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Fibroblasts - drug effects | Liver Cirrhosis, Experimental - chemically induced | Lung - drug effects | Pulmonary Fibrosis - prevention & control | Pulmonary Fibrosis - chemically induced | Mice | Hydrocarbons, Brominated | Transforming Growth Factor beta - metabolism | Liver Cirrhosis, Experimental - metabolism | Index Medicus
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11. Full Text Cross Talk between Engulfment Receptors Stabilin-2 and Integrin αvβ5 Orchestrates Engulfment of Phosphatidylserine-Exposed Erythrocytes
by Soyoun Kim and Seung-Yoon Park and Sang-Yeob Kim and Dong-Jun Bae and Jae-Hoon Pyo and Mina Hong and In-San Kim
Molecular and Cellular Biology, ISSN 0270-7306, 07/2012, Volume 32, Issue 14, pp. 2698 - 2708
RNA, Small Interfering - genetics | Receptors, Vitronectin - antagonists & inhibitors | Humans | rac GTP-Binding Proteins - metabolism | L Cells (Cell Line) | DNA Primers - genetics | Erythrocyte Aging | Gene Knockdown Techniques | rac GTP-Binding Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | rac GTP-Binding Proteins - genetics | Base Sequence | Erythrocytes - cytology | Cell Adhesion Molecules, Neuronal - metabolism | Receptors, Vitronectin - genetics | Receptors, Vitronectin - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Adhesion Molecules, Neuronal - chemistry | Receptor Cross-Talk | Phosphatidylserines - metabolism | Antibodies, Blocking | Phagocytosis - physiology | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cell Adhesion Molecules, Neuronal - genetics | Animals | Models, Biological | Adaptor Proteins, Signal Transducing - genetics | Erythrocytes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Apoptosis | Index Medicus
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12. Full Text Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides
by Urbahns, Klaus and Härter, Michael and Albers, Markus and Schmidt, Delf and Stelte-Ludwig, Beatrix and Brüggemeier, Ulf and Vaupel, Andrea and Keldenich, Jörg and Lustig, Klemens and Tsujishita, Hideki and Gerdes, Christoph
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2007, Volume 17, Issue 22, pp. 6151 - 6154
Restenosis | Smooth muscle cell | Urea | Squaric acid amide | Arginine | α Vβ 3 | Biphenyl | Vitronectin | Guanidine mimetic | RGD | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Miscellaneous | Medical sciences | Pharmacology. Drug treatments | Protein Structure, Tertiary | Receptors, Vitronectin - antagonists & inhibitors | Sulfonamides - chemistry | Humans | Models, Molecular | Structure-Activity Relationship | Sulfonamides - pharmacology | Biphenyl Compounds - pharmacology | Cyclobutanes - pharmacology | Ligands | Molecular Structure | Biphenyl Compounds - chemistry | Cyclobutanes - chemistry | Binding Sites - drug effects | Receptors, Vitronectin - chemistry | Index Medicus
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13. Small molecule integrin antagonists in cancer therapy
by Paolillo, Mayra and Russo, Marika A and Serra, Massimo and Colombo, Lino and Schinelli, Sergio
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2009, Volume 9, Issue 12, pp. 1439 - 1446
Anoikis | RGD-peptides | Metastasis | Integrin antagonists | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Integrin alphaVbeta3 - chemistry | Peptides - chemistry | Receptors, Vitronectin - antagonists & inhibitors | Signal Transduction | Sulfonamides - chemistry | Humans | Integrins - chemistry | Snake Venoms - chemistry | Sulfonamides - pharmacology | Integrins - metabolism | Integrin alphaVbeta3 - metabolism | Neoplasms - drug therapy | Peptides - pharmacology | Snake Venoms - pharmacology | Indoles - pharmacology | Receptors, Vitronectin - metabolism | Indoles - chemistry | Integrins - antagonists & inhibitors | Receptors, Vitronectin - chemistry | Integrin alphaVbeta3 - antagonists & inhibitors
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14. Full Text Radiolabeled Divalent Peptidomimetic Vitronectin Receptor Antagonists as Potential Tumor Radiotherapeutic and Imaging Agents