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Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 484, Issue 7397, pp. 195 - 202
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2405 - 2416
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 234 - 237
Journal Article
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2513 - 2526
While the cytosolic events of Wnt/β‐catenin signaling (canonical Wnt signaling) pathway have been widely studied, only little is known about the molecular... 
plasma membrane lipid | canonical Wnt | lipid raft | membrane trafficking | Wnt/β‐catenin pathway | Wnt/β-catenin pathway | FC-EPSILON-RI | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Wnt/beta-catenin pathway | FLUORESCENCE CORRELATION SPECTROSCOPY | DETERGENT-RESISTANT MEMBRANES | SIGNAL-TRANSDUCTION | B-VIRUS INFECTION | SPIM-FCS | PATHWAY | LIPID RAFTS | IN-VIVO | Wnt3A Protein - metabolism | Cricetulus | Cytoskeletal Proteins - genetics | Membrane Microdomains - metabolism | Humans | Embryo, Nonmammalian - metabolism | Receptors, Wnt - metabolism | Wnt Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Wnt3 Protein - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Wnt Proteins - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Wnt3 Protein - metabolism | Cell Membrane - metabolism | Genes, Reporter | Wnt Signaling Pathway | CHO Cells | Wnt3A Protein - genetics | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Cells, Cultured | Niemann-Pick Diseases - metabolism | Niemann-Pick Diseases - pathology | Receptors, Wnt - agonists | Zebrafish - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - agonists | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Zebrafish - metabolism | Cell Line, Tumor | Luminescent Proteins - genetics | Zebrafish Proteins - genetics | Luminescent Proteins - metabolism | Lipids | Cell membranes | Binding | Niemann-Pick disease | Plasma | Wnt protein | β-catenin | Receptors | Molecular modelling | Ligands | Membrane trafficking | Coordination compounds | Molecular biology | Plasmas (physics) | Wnt | Original | β‐catenin pathway
Journal Article