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Journal Article
Journal of thrombosis and haemostasis, ISSN 1538-7933, 11/2014, Volume 12, Issue 11, pp. 1788 - 1800
...‐life could reduce infusion frequency. The A‐LONG study established the safety, efficacy and prolonged pharmacokinetics of recombinant FVIII Fc fusion protein (rFVIIIFc... 
pharmacokinetics | factor VIII | hemophilia A | administration schedule | recombinant fusion proteins | drug | Drug | Administration schedule | Pharmacokinetics | Recombinant fusion proteins | Hemophilia A | Factor VIII | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Recombinant Fusion Proteins - adverse effects | Factor VIII - pharmacokinetics | Humans | Half-Life | Male | Hemorrhage - prevention & control | Immunoglobulin Fc Fragments - administration & dosage | Young Adult | Time Factors | Computer Simulation | Coagulants - administration & dosage | Adult | Factor VIII - adverse effects | Coagulants - pharmacokinetics | Hemophilia A - diagnosis | Immunoglobulin Fc Fragments - adverse effects | Immunoglobulin Fc Fragments - blood | Recombinant Fusion Proteins - administration & dosage | von Willebrand Factor - metabolism | Hemostasis - drug effects | Severity of Illness Index | Drug Administration Schedule | Treatment Outcome | Biomarkers - blood | Coagulants - blood | Hemophilia A - blood | Recombinant Fusion Proteins - blood | Models, Biological | Recombinant Fusion Proteins - pharmacokinetics | Adolescent | Factor VIII - administration & dosage | Hemorrhage - chemically induced | Infusions, Intravenous | Coagulants - adverse effects | Drug Monitoring | Hemophilia A - drug therapy | Proteins | Blood coagulation factor VIII | Analysis | Von Willebrand factor | Hemophilia | Index Medicus
Journal Article
Blood, ISSN 1528-0020, 06/2014, Volume 123, Issue 25, pp. 3855 - 3863
Journal Article
Vaccine, ISSN 0264-410X, 01/2013, Volume 31, Issue 3, pp. 524 - 532
Highlights ► This Phase 1 trial evaluated the safety and immunogenicity of an RSV (F) nanoparticle vaccine. ► The vaccine was well-tolerated and no related... 
Allergy and Immunology | Respiratory syncytial virus (RSV) | Palivizumab | Fusion protein (F protein) | Competitive ELISA | SF9 insect cell | Microneutralization | Aluminum phosphate | Anti-F IgG | Nanoparticle vaccine | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Fusion Proteins - immunology | Single-Blind Method | Biotechnology | Respiratory Syncytial Virus Vaccines - immunology | Adjuvants, Immunologic - administration & dosage | Aluminum Compounds - adverse effects | Phosphates - administration & dosage | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Male | Nanoparticles - adverse effects | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Adjuvants, Immunologic - adverse effects | Young Adult | Respiratory Syncytial Virus Vaccines - adverse effects | Sf9 Cells | Technology, Pharmaceutical | Vaccines, Virosome - immunology | Vaccines, Synthetic - adverse effects | Placebos - adverse effects | Adult | Female | Placebos - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Vaccines, Virosome - administration & dosage | Vaccines, Synthetic - genetics | Vaccines, Virosome - genetics | Animals | Aluminum Compounds - administration & dosage | Phosphates - adverse effects | Vaccines, Virosome - adverse effects | Respiratory Syncytial Virus Vaccines - administration & dosage | Adolescent | Recombinant Fusion Proteins - genetics | Nanoparticles - administration & dosage | Vaccines, Synthetic - administration & dosage | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Neutralizing - blood | Virus diseases | Phosphates | Vaccines | Immunoglobulin G | Enzyme-linked immunosorbent assay | Proteins | Nanoparticles | Infections | Index Medicus
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 10/2012, Volume 32, Issue 10, pp. 1933 - 1938
...), designated as cTfRMAb-TNFR fusion protein. The cTfRMAb domain of the fusion protein acts as a molecular Trojan horse to deliver the fused TNFR across the BBB... 
blood-brain barrier | TNFa inhibitors | monoclonal antibody | stroke | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Neuroprotective Agents - therapeutic use | Recombinant Fusion Proteins - immunology | Infarction, Middle Cerebral Artery - prevention & control | Neuroprotective Agents - immunology | Humans | Recombinant Fusion Proteins - therapeutic use | Antibodies, Monoclonal - therapeutic use | Receptors, Tumor Necrosis Factor - therapeutic use | Stroke - pathology | Neuroprotective Agents - administration & dosage | Antibodies, Monoclonal - immunology | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Cricetinae | Stroke - prevention & control | Receptors, Tumor Necrosis Factor - administration & dosage | Infarction, Middle Cerebral Artery - pathology | Brain - drug effects | Immunoglobulin gamma-Chains - therapeutic use | Administration, Intravenous | Animals | Immunoglobulin gamma-Chains - immunology | Antibodies, Monoclonal - administration & dosage | Receptors, Transferrin - immunology | Brain - pathology | Mice | Receptors, Tumor Necrosis Factor - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Immunoglobulin gamma-Chains - administration & dosage | Index Medicus | Drugs | Tumor necrosis factor receptors | Brain | Neuroprotection | Stroke | Intravenous administration | etanercept | Blood-brain barrier | Ischemia | Cerebral blood flow | Tumor necrosis factor | Monoclonal antibodies | Genetic engineering | Fusion protein | Transferrin receptors | Tumor necrosis factor- alpha | Apoptosis | blood–brain barrier | TNFα inhibitors, monoclonal antibody | Original
Journal Article
PLoS biology, ISSN 1545-7885, 02/2019, Volume 17, Issue 2, pp. e3000164 - e3000164
Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory... 
Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Immunogenicity, Vaccine | Recombinant Fusion Proteins - immunology | Viral Fusion Proteins - administration & dosage | Nanoparticles - chemistry | Viral Fusion Proteins - genetics | Respiratory Syncytial Viruses - immunology | Viral Fusion Proteins - immunology | Epitopes - immunology | Viral Fusion Proteins - chemistry | Receptors, Antigen, B-Cell - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Female | Recombinant Fusion Proteins - administration & dosage | Antibodies, Viral - biosynthesis | Gene Expression | Genetic Vectors - chemistry | Respiratory Syncytial Virus Vaccines - biosynthesis | Immunization - methods | Genetic Vectors - metabolism | Antibodies, Neutralizing - genetics | Palivizumab - chemistry | Palivizumab - immunology | Recombinant Fusion Proteins - chemistry | Receptors, Antigen, B-Cell - immunology | Animals | Antibodies, Neutralizing - biosynthesis | Escherichia coli - genetics | Respiratory Syncytial Virus Vaccines - administration & dosage | Recombinant Fusion Proteins - genetics | Receptors, Antigen, B-Cell - genetics | Epitopes - chemistry | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Structural Homology, Protein | Computer-Aided Design | Antibodies, Monoclonal, Humanized - immunology | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Viral - genetics | Antibodies, Monoclonal, Humanized - chemistry | Viral antibodies | Immunogenetics | Usage | Vaccination | Analysis | Antibodies | Physiological aspects | Health aspects | Antigenic determinants | Bioengineering | Profiling | Laboratories | Pathogenesis | Viral diseases | Viruses | Infections | Zika virus | Vaccines | Immunodominance | Proteins | Design | Hierarchies | Fusion protein | Bioinformatics | Supervision | Vector-borne diseases | Dengue | Epitopes | Depth profiling | Infectious diseases | Respiratory syncytial virus | Lymphocytes B | Influenza | Neutralizing | Software | Binding sites | Neutralization | Index Medicus | Life Sciences | Immunology
Journal Article