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Journal of Controlled Release, ISSN 0168-3659, 11/2013, Volume 172, Issue 1, pp. 144 - 151
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 11/2014, Volume 12, Issue 11, pp. 1788 - 1800
BackgroundRoutine prophylaxis with replacement factorVIII (FVIII) - the standard of care for severe hemophiliaA - often requires frequent intravenous infusions... 
Drug | Administration schedule | Pharmacokinetics | Recombinant fusion proteins | Hemophilia A | Factor VIII | SEVERE HEMOPHILIA-A | SAFETY | PROLONGED ACTIVITY | CARE | drug | factorVIII | PROPHYLACTIC TREATMENT | recombinant fusion proteins | BLOOD-GROUP | ON-DEMAND | pharmacokinetics | PERIPHERAL VASCULAR DISEASE | administration schedule | hemophiliaA | COAGULATION-FACTOR VIII | HEMATOLOGY | PRACTICE PATTERNS | Recombinant Fusion Proteins - adverse effects | Factor VIII - pharmacokinetics | Humans | Half-Life | Male | Hemorrhage - prevention & control | Immunoglobulin Fc Fragments - administration & dosage | Young Adult | Time Factors | Computer Simulation | Coagulants - administration & dosage | Adult | Factor VIII - adverse effects | Coagulants - pharmacokinetics | Hemophilia A - diagnosis | Immunoglobulin Fc Fragments - adverse effects | Immunoglobulin Fc Fragments - blood | Recombinant Fusion Proteins - administration & dosage | von Willebrand Factor - metabolism | Hemostasis - drug effects | Severity of Illness Index | Drug Administration Schedule | Treatment Outcome | Biomarkers - blood | Coagulants - blood | Hemophilia A - blood | Recombinant Fusion Proteins - blood | Models, Biological | Recombinant Fusion Proteins - pharmacokinetics | Adolescent | Factor VIII - administration & dosage | Hemorrhage - chemically induced | Infusions, Intravenous | Coagulants - adverse effects | Drug Monitoring | Hemophilia A - drug therapy | Proteins | Blood coagulation factor VIII | Analysis | Von Willebrand factor | Hemophilia
Journal Article
Advanced Materials, ISSN 0935-9648, 12/2015, Volume 27, Issue 45, pp. 7320 - 7324
Genetic fusion of elastin‐like polypeptide (ELP) to the C‐terminus of interferon alpha (IFN) generates a well‐defined IFN‐ELP fusion protein with high yield... 
pharmacokinetics | cancer therapy | interferon | elastin‐like polypeptides | protein delivery | elastin-like polypeptides | POLYMERS | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | ALBINTERFERON ALPHA-2B | DRUG-DELIVERY | PROTEIN PEGYLATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHRONIC HEPATITIS-C | CHEMISTRY, PHYSICAL | RANDOMIZED-TRIAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | PEGINTERFERON ALPHA-2A | CHEMISTRY | BINDING-SITE | Recombinant Fusion Proteins - biosynthesis | Elastin - metabolism | Interferon-alpha - metabolism | Humans | Peptides - genetics | Half-Life | Antineoplastic Agents - therapeutic use | Recombinant Fusion Proteins - blood | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Tissue Distribution | Animals | Peptides - metabolism | Elastin - genetics | Interferon-alpha - genetics | Interferon-alpha - blood | Recombinant Fusion Proteins - pharmacokinetics | Escherichia coli - metabolism | Antineoplastic Agents - pharmacokinetics | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Circular Dichroism | Dynamic Light Scattering | Drug therapy | Biological response modifiers | Elastin | Interferon alpha | Tumors | Proteins | Polypeptides | Effectiveness | Genetics | Interferon | Biochemistry | Anticancer properties
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 38, pp. 16363 - 16368
Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, doseescalation clinical trial of a... 
T lymphocytes | Genetic vectors | Neutralizing antibodies | Enzyme linked immunosorbent assay | Antibodies | Clinical trials | Capsid | Transgenes | Gene therapy | Blood | CTL | Immune response | AAV | Pulmonary | MULTIDISCIPLINARY SCIENCES | pulmonary | gene therapy | NEUTROPHIL ELASTASE | VIRAL VECTORS | DEFICIENCY | SKELETAL-MUSCLE | PHARMACOKINETICS | immune response | INTRAMUSCULAR INJECTION | IMMUNE-RESPONSES | ADENOASSOCIATED VIRUS VECTORS | ALPHA-1-ANTITRYPSIN GENE | AUGMENTATION THERAPY | CD8-Positive T-Lymphocytes - cytology | Dependovirus - genetics | Genetic Vectors - administration & dosage | Humans | Middle Aged | Male | Capsid - enzymology | Antibodies, Viral - blood | Recombinant Fusion Proteins - metabolism | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes - metabolism | Time Factors | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | alpha 1-Antitrypsin Deficiency - genetics | Cell Line | Gene Expression | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin Deficiency - therapy | Enzyme-Linked Immunosorbent Assay | alpha 1-Antitrypsin - blood | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Dependovirus - immunology | Injections, Intramuscular | Genetic Vectors - genetics | Recombinant Fusion Proteins - blood | Capsid - immunology | T-Lymphocytes - cytology | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | alpha 1-Antitrypsin - metabolism | CD8-Positive T-Lymphocytes - immunology | Genetic Therapy - methods | Biological Sciences
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2015, Volume 33, Issue 30, pp. 3431 - 3438
Journal Article
Circulation, ISSN 0009-7322, 07/2003, Volume 107, Issue 25, pp. 3133 - 3140
Journal Article
Journal Article
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