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Nature Structural and Molecular Biology, ISSN 1545-9993, 01/2012, Volume 19, Issue 1, pp. 117 - 122
The use of genetic mutations to study protein functions in vivo is a central paradigm of modern biology. Recent advances in reverse genetics such as RNA... 
TARGET | CELLS | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAP | DROSOPHILA | NONMUSCLE MYOSIN | CELL BIOLOGY | UBIQUITINATION | BIOPHYSICS | GENE | CELLULAR-PROTEINS | EFFICIENT | Drosophila melanogaster - embryology | Cytoskeletal Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Green Fluorescent Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Drosophila melanogaster - metabolism | POU Domain Factors - genetics | Proteolysis | Base Sequence | Antibodies - immunology | Cytoskeletal Proteins - metabolism | POU Domain Factors - metabolism | Wings, Animal - embryology | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Knockout Techniques | Blotting, Western | Homeodomain Proteins - genetics | Microscopy, Confocal | Wings, Animal - metabolism | Animals | Green Fluorescent Proteins - immunology | Histones - genetics | Models, Biological | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Drosophila Proteins - genetics | HeLa Cells | Histones - metabolism | Luminescent Proteins - metabolism | Ubiquitin | Physiological aspects | Research | Structure | Green fluorescent protein | Proteins | Genetics | Eukaryotes | Mutation | Insects | Molecular biology | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 09/2016, Volume 167, Issue 1, pp. 233 - 247.e17
Journal Article
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 6, pp. 569 - 576
  Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
Genetic research | Nucleases | Genetic aspects | Genetic engineering | Zinc finger proteins | Research | Biotechnology | Enzymes | Mutation | Genomics | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 609 - 621
is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity. The mechanisms of MLL fusion... 
CELLCYCLE | DNA | HUMDISEASE | RNA-POLYMERASE-II | CHROMOSOMAL TRANSLOCATIONS | TARGET GENES | STEM-CELLS | HISTONE H2B | ONCOLOGY | H3 METHYLATION | TUMOR-SUPPRESSOR PROTEIN | LEUKEMIA | EXPRESSION | TRANSCRIPTIONAL ELONGATION | CELL BIOLOGY | Myeloid Cells - cytology | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Transcriptional Activation - genetics | Protein Interaction Domains and Motifs - physiology | Humans | Leukemia - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Transfection | RNA Interference | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Leukemia - genetics | Recombinant Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Sequence Deletion - physiology | Mice, Inbred C57BL | Gene Expression Regulation | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Transcription, Genetic - physiology | Animals | Carrier Proteins - metabolism | Models, Biological | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | HL-60 Cells | Myeloid Cells - metabolism | Mice | HeLa Cells | Myeloid Ecotropic Viral Integration Site 1 Protein | Cell Transformation, Neoplastic - pathology | Protein Binding - physiology | Proteins | RNA | Gene expression | Index Medicus
Journal Article
Nature Biotechnology, ISSN 1087-0156, 06/2009, Volume 27, Issue 6, pp. 567 - 571
Journal Article