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Immunotechnology, ISSN 1380-2933, 1995
Journal
Nature medicine, ISSN 1546-170X, 2019, Volume 25, Issue 5, pp. 767 - 775
.... Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that can mediate responses to immunotherapy... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | TUMOR-ANTIGENS | LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCR-ABL | INDUCTION | CANCER | SOMATIC MUTATIONS | CELL BIOLOGY | PEPTIDES | IMMUNOTHERAPY | BLOCKADE | Recombinant Fusion Proteins - immunology | Oncogene Proteins - genetics | Immunotherapy - methods | Humans | Proto-Oncogene Proteins c-myb - genetics | Programmed Cell Death 1 Receptor - antagonists & inhibitors | NFI Transcription Factors - genetics | Squamous Cell Carcinoma of Head and Neck - immunology | Neoplasms - therapy | Neoplasms - genetics | Nuclear Proteins - genetics | Oncogene Proteins - immunology | T-Lymphocytes, Cytotoxic - immunology | Antigens, Neoplasm - genetics | Head and Neck Neoplasms - therapy | Poly-ADP-Ribose Binding Proteins - genetics | Gene Fusion | Proto-Oncogene Proteins c-myb - immunology | Nuclear Proteins - immunology | Chromosomal Proteins, Non-Histone - genetics | Whole Genome Sequencing | Chromosomal Proteins, Non-Histone - immunology | Head and Neck Neoplasms - immunology | Squamous Cell Carcinoma of Head and Neck - genetics | Neoplasms - immunology | Recombinant Fusion Proteins - genetics | Head and Neck Neoplasms - genetics | Poly-ADP-Ribose Binding Proteins - immunology | Squamous Cell Carcinoma of Head and Neck - therapy | NFI Transcription Factors - immunology | Care and treatment | Immune response | Patient outcomes | Immunotherapy | Tumor antigens | Head and neck cancer | Genetic aspects | T cells | Identification and classification | Health aspects | Gene fusion | Antigens | Cytotoxicity | Immunosurveillance | Genomes | Lymphocytes T | Ribonucleic acid--RNA | Immunity | Metastases | Gene sequencing | Inhibitors | Immune checkpoint | Immunogenicity | Lymphocytes | Antigen (tumor-associated) | Infiltration | Mutation | Pretreatment | Tumors | Cancer | tumor-antigens | somatic mutations | bcr-abl | induction | blockade | immunotherapy | protein | peptides | cancer | Cancer and Oncology | landscape | Cancer och onkologi
Journal Article
The Journal of infectious diseases, ISSN 0022-1899, 4/2014, Volume 209, Issue 7, pp. 1116 - 1125
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2006, Volume 203, Issue 3, pp. 607 - 617
.... We are developing a protein-based approach that directly harnesses principles for generating T cell immunity... 
ADAPTIVE IMMUNITY | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | VIRUS | DNA VACCINES | TISSUE DISTRIBUTION | RECEPTOR DEC-205 | TOLERANCE | IN-VIVO | HELPER-CELLS | MONOCLONAL-ANTIBODY | IMMUNOLOGY | Recombinant Fusion Proteins - immunology | Antigens, CD - immunology | Immunity, Mucosal - immunology | Adenoviridae | Dose-Response Relationship, Immunologic | Genetic Vectors - administration & dosage | Minor Histocompatibility Antigens | Dendritic Cells - immunology | Humans | AIDS Vaccines - immunology | Lectins, C-Type - immunology | Immunologic Memory - drug effects | Lectins, C-Type - genetics | Antigens, CD - genetics | CD4-Positive T-Lymphocytes - immunology | Immunity, Mucosal - drug effects | Haplotypes - genetics | Injections, Subcutaneous | Lectins, C-Type - deficiency | Antibodies, Monoclonal - immunology | Immunologic Memory - immunology | Recombinant Fusion Proteins - administration & dosage | Gene Products, gag - immunology | Gene Products, gag - genetics | Genetic Vectors - immunology | Antigen Presentation - immunology | HIV-1 - genetics | Receptors, Cell Surface - immunology | Genetic Vectors - genetics | Mice, Inbred C3H | Mice, Knockout | Vaccinia virus | Antibodies, Monoclonal - genetics | HIV-1 - immunology | Animals | Antibodies, Monoclonal - administration & dosage | Receptors, Cell Surface - deficiency | Recombinant Fusion Proteins - genetics | AIDS Vaccines - genetics | Antigen Presentation - drug effects | Major Histocompatibility Complex - immunology | Mice | Mice, Inbred BALB C | Gene Products, gag - administration & dosage | AIDS Vaccines - administration & dosage | Haplotypes - immunology | Receptors, Cell Surface - genetics
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 1, pp. 213 - 221.e5
Journal Article
PLoS biology, ISSN 1545-7885, 2019, Volume 17, Issue 2, p. e3000164
Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory... 
CELLS | FUSION-GLYCOPROTEIN VACCINE | HEMAGGLUTININ-STEM | HIV | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | INFECTION | RSV ANTIBODY | DEPENDENT ENHANCEMENT | DENGUE VIRUS | RESPIRATORY SYNCYTIAL VIRUS | Immunogenicity, Vaccine | Recombinant Fusion Proteins - immunology | Viral Fusion Proteins - administration & dosage | Nanoparticles - chemistry | Viral Fusion Proteins - genetics | Respiratory Syncytial Viruses - immunology | Viral Fusion Proteins - immunology | Epitopes - immunology | Viral Fusion Proteins - chemistry | Receptors, Antigen, B-Cell - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Female | Recombinant Fusion Proteins - administration & dosage | Antibodies, Viral - biosynthesis | Gene Expression | Genetic Vectors - chemistry | Respiratory Syncytial Virus Vaccines - biosynthesis | Immunization - methods | Genetic Vectors - metabolism | Antibodies, Neutralizing - genetics | Palivizumab - chemistry | Palivizumab - immunology | Recombinant Fusion Proteins - chemistry | Receptors, Antigen, B-Cell - immunology | Animals | Antibodies, Neutralizing - biosynthesis | Escherichia coli - genetics | Respiratory Syncytial Virus Vaccines - administration & dosage | Recombinant Fusion Proteins - genetics | Receptors, Antigen, B-Cell - genetics | Epitopes - chemistry | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Structural Homology, Protein | Computer-Aided Design | Antibodies, Monoclonal, Humanized - immunology | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Viral - genetics | Antibodies, Monoclonal, Humanized - chemistry | Viral antibodies | Immunogenetics | Usage | Vaccination | Analysis | Antibodies | Physiological aspects | Health aspects | Antigenic determinants | Bioengineering | Profiling | Laboratories | Pathogenesis | Viral diseases | Viruses | Infections | Zika virus | Vaccines | Immunodominance | Proteins | Design | Hierarchies | Fusion protein | Bioinformatics | Supervision | Vector-borne diseases | Dengue | Epitopes | Depth profiling | Infectious diseases | Respiratory syncytial virus | Lymphocytes B | Influenza | Neutralizing | Software | Binding sites | Neutralization | Life Sciences | Immunology
Journal Article
Blood, ISSN 1528-0020, 2015, Volume 125, Issue 10, pp. 1566 - 1577
Journal Article
Clinical and experimental immunology, ISSN 0009-9104, 2019, Volume 195, Issue 1, pp. 1 - 9
The objective of this study was to test the capacity of a newly developed fusion protein of interleukin 4 (IL-4) and IL-10... 
Cell Proliferation | Immunotherapy/methods | Humans | autoinflammatory diseases | Interleukin-4/genetics | Journal Article | Inflammation/immunology | Th1/Th2 cells | Flow Cytometry | Immunology | inflammation | Interleukin-10/immunology | Female | cytokines | Synovial Membrane/metabolism | Arthritis, Rheumatoid/chemically induced | Disease Models, Animal | Recombinant Fusion Proteins/genetics | Proteoglycans | Immunomodulation | Cells, Cultured | Lipopolysaccharides/immunology | Animals | arthritis | Research Support, Non-U.S. Gov't | Leukocytes, Mononuclear/immunology | Mice | Mice, Inbred BALB C | Immunology and Allergy | RHEUMATOID-ARTHRITIS | SYNERGIZE | MONOCYTES | IMMUNOLOGY | IL-10 | Immunotherapy - methods | Recombinant Fusion Proteins - therapeutic use | Synovial Membrane - pathology | Lipopolysaccharides - immunology | Leukocytes, Mononuclear - immunology | Interleukin-4 - genetics | Inflammation - immunology | Arthritis, Rheumatoid - chemically induced | Synovial Membrane - metabolism | Arthritis, Rheumatoid - therapy | Inflammation - therapy | Recombinant Fusion Proteins - genetics | Arthritis, Rheumatoid - immunology | Interleukin-4 - therapeutic use | Interleukin-10 - immunology | Tumor necrosis factor receptors | Animal models | Interleukin | Lymphocytes T | Arthritis | Cell fusion | Inflammatory diseases | Proteins | Signal transduction | Receptors | Interleukin 4 | Lymphocytes | Foxp3 protein | Tumor necrosis factor-TNF | Inhibition | Fusion protein | Immunoglobulins | Cytokines | Immunoregulation | Fc receptors | Lymphocytes B | Tumor necrosis factor | Rheumatoid arthritis | Interleukin 10 | Tumors | Editor's Choice | Th1 | Th2 cells | Original
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2016, Volume 60, Issue 1, pp. 6 - 13
Respiratory syncytial virus (RSV) is an important causative agent of lower respiratory tract infections in infants and elderly individuals. Its fusion (F... 
EPITHELIAL-CELLS | RSV | ANTIGENIC STRUCTURE | IN-VIVO | PALIVIZUMAB | HUMANIZED MONOCLONAL-ANTIBODY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | FUSION GLYCOPROTEIN | MOTAVIZUMAB | SINGLE-DOMAIN ANTIBODY | NEUTRALIZATION | Palivizumab - pharmacology | Humans | Respiratory Syncytial Viruses - immunology | Male | Antiviral Agents - metabolism | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus Infections - drug therapy | Nasal Cavity - virology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Gene Expression | Respiratory Syncytial Viruses - drug effects | Models, Molecular | Rats | Recombinant Proteins - chemistry | Lung - drug effects | Pichia - genetics | Respiratory Syncytial Virus Infections - pathology | Viral Load - drug effects | Respiratory Syncytial Viruses - pathogenicity | Antibodies, Viral - pharmacology | Viral Fusion Proteins - genetics | Antiviral Agents - immunology | Neutralization Tests | Respiratory Syncytial Virus Infections - immunology | Single-Domain Antibodies - immunology | Antibodies, Neutralizing - immunology | Lung - virology | Pichia - metabolism | Viral Fusion Proteins - chemistry | Female | Nasal Cavity - drug effects | Respiratory Syncytial Virus Infections - virology | Nasal Cavity - immunology | Antibodies, Viral - biosynthesis | Palivizumab - biosynthesis | Administration, Inhalation | Antibodies, Neutralizing - pharmacology | Palivizumab - immunology | Recombinant Proteins - genetics | Single-Domain Antibodies - pharmacology | Sigmodontinae | Animals | Recombinant Proteins - immunology | Antibodies, Neutralizing - biosynthesis | Antibodies, Viral - immunology | Viral Fusion Proteins - antagonists & inhibitors | Single-Domain Antibodies - biosynthesis | Lung - immunology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 17, pp. 5533 - 5538
...). A gene encoding a fungal PG was fused with a gene encoding a plant polygalacturonase-inhibiting protein (PGIP... 
PGIP | Polygalacturonase | Oligogalacturonides | Plant immunity | DAMPs | POLYGALACTURONASE-INHIBITING PROTEIN | ARABIDOPSIS-THALIANA | DEFENSE RESPONSES | BOTRYTIS-CINEREA | MULTIDISCIPLINARY SCIENCES | TRANSLATIONAL INHIBITION | oligogalacturonides | SALICYLIC-ACID | SIGNALING PATHWAY | ELICITORS | polygalacturonase | RESISTANCE | HOST-PATHOGEN INTERACTIONS | plant immunity | Recombinant Fusion Proteins - immunology | Plant Immunity | Fungal Proteins - biosynthesis | Pseudomonas syringae - growth & development | Plant Diseases - immunology | Polygalacturonase - immunology | Arabidopsis - immunology | Plant Diseases - microbiology | Fungal Proteins - immunology | Arabidopsis Proteins - biosynthesis | Hexuronic Acids - immunology | Plant Diseases - genetics | Polygalacturonase - genetics | Pectobacterium carotovorum - growth & development | Botrytis - immunology | Botrytis - growth & development | Pectobacterium carotovorum - immunology | Recombinant Fusion Proteins - biosynthesis | Arabidopsis Proteins - genetics | Pseudomonas syringae - immunology | Mice, Transgenic | Plant Proteins - immunology | Fungal Proteins - genetics | Arabidopsis Proteins - immunology | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis - microbiology | Plant Proteins - genetics | Polygalacturonase - biosynthesis | Animals | Recombinant Fusion Proteins - genetics | Plant Proteins - biosynthesis | Hexuronic Acids - metabolism | Enzymes | Botanical research | Pectin | Disease susceptibility | Regulation | Research | Properties | Gene expression | Observations | Biological Sciences
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 5, pp. 1207 - 1217.e11
..., and Phl p 6 by using a peptide-carrier approach. Methods Fusion proteins consisting of nonallergenic peptides from the 4 major timothy grass pollen allergens... 
Allergy and Immunology | allergen | Grass pollen allergy | recombinant allergen | recombinant hypoallergenic allergen derivative | peptide-carrier technology | allergen-specific immunotherapy | P 2 | RECOGNITION | IGE | BLOCKING ANTIBODIES | IMMUNOLOGY | IMMUNOGENICITY | ALLERGY | IMMUNOTHERAPY | EXTRACTS | PHLEUM-PRATENSE POLLEN | IMMUNOGLOBULIN-E | EPITOPES | Hepatitis B Surface Antigens - genetics | Recombinant Fusion Proteins - immunology | Recombinant Fusion Proteins - isolation & purification | Humans | Poaceae | Vaccines, Synthetic - immunology | Pollen - immunology | Immunoglobulin E - blood | Lymphocyte Activation - immunology | Immunoglobulin E - immunology | Lymphocytes - immunology | Allergens - immunology | Immunoglobulin G - immunology | Basophils - immunology | Inflammation Mediators - metabolism | Protein Engineering | Female | Disease Models, Animal | Hepatitis B Surface Antigens - chemistry | Lymphocytes - metabolism | Peptides - immunology | Vaccines, Subunit - immunology | Recombinant Fusion Proteins - chemistry | Rhinitis, Allergic, Seasonal - prevention & control | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | Basophils - metabolism | Cytokines - biosynthesis | Allergy | Vaccines | Peptides | Allergic reaction | Proteins | Immunization | Cytokines | E coli | Pollen | Grasses | Patients | Allergies | Binding sites | Quality of life | SIT, Allergen-specific immunotherapy | CFA, Complete Freund adjuvant | Rhinitis, Sinusitis, and Upper Airway Disease | KLH, Keyhole limpet hemocyanin
Journal Article