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Nature, ISSN 0028-0836, 2013, Volume 494, Issue 7436, pp. 201 - 206
The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly,... 
PATHOGENESIS | LOCALIZES | COMPLEX | PROTEIN | BECLIN-1 | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | BINDING | Apoptosis Regulatory Proteins - pharmacology | Recombinant Fusion Proteins - pharmacology | Humans | Cell Membrane Permeability | Molecular Sequence Data | Peptide Fragments - pharmacology | Membrane Proteins - pharmacology | Membrane Proteins - therapeutic use | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | HIV-1 - physiology | nef Gene Products, Human Immunodeficiency Virus - metabolism | Membrane Proteins - metabolism | Beclin-1 | Amino Acid Sequence | HIV-1 - metabolism | Virus Replication - drug effects | Peptide Fragments - metabolism | HIV-1 - drug effects | tat Gene Products, Human Immunodeficiency Virus - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | West Nile virus - drug effects | Macrophages - cytology | Recombinant Fusion Proteins - chemistry | Apoptosis Regulatory Proteins - metabolism | Chikungunya virus - drug effects | Peptide Fragments - chemistry | Animals | Membrane Proteins - chemistry | Mice | HeLa Cells | Apoptosis Regulatory Proteins - therapeutic use | tat Gene Products, Human Immunodeficiency Virus - metabolism | Proteins | Peptides | Microscopy | Rodents | Mortality | Amino acids | Infections | Autophagy | Index Medicus
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 01/2013, Volume 11, Issue 1, pp. 132 - 141
Background:  Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half‐life... 
Fc fusion | hemophilia A | long‐acting | rFVIIIFc | Factor VIII | RFVIIIFc | Long-acting | Hemophilia A | DOMAIN | HEMOPHILIA-A | FACTOR-IX | PROLONGED ACTIVITY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | long-acting | Recombinant Fusion Proteins - pharmacology | Immunoglobulin Fc Fragments - metabolism | Factor VIII - pharmacokinetics | Humans | Half-Life | Male | Structure-Activity Relationship | Coagulants - chemistry | Neoplasm Proteins - metabolism | Cysteine Endopeptidases - metabolism | Coagulants - pharmacology | Mass Spectrometry | Cloning, Molecular | Protein Engineering | Coagulants - pharmacokinetics | Protein Stability | Binding Sites | Disease Models, Animal | von Willebrand Factor - metabolism | Amino Acid Sequence | Thrombelastography | Factor VIII - chemistry | Factor VIII - genetics | Immunoglobulin Fc Fragments - chemistry | Peptide Mapping - methods | Hemophilia A - blood | Animals | Blood Coagulation - drug effects | Partial Thromboplastin Time | Recombinant Fusion Proteins - pharmacokinetics | Factor VIII - pharmacology | Protein Conformation | Mice | Protein C - metabolism | Hemophilia A - drug therapy | Immunoglobulin Fc Fragments - genetics | Proteins | Blood coagulation factor VIII | Medical examination | Analysis | Immunoglobulin G | Questions and answers | Hemophilia | Thrombin | Liquid chromatography | Chemical properties | Mass spectrometry | Blood | Index Medicus | Coagulation
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 521 - n/a
Synthetic biology aims to systematically design and construct novel biological systems that address energy, environment, and health issues. Herein, we describe... 
synthetic biology | Pseudomonas aeruginosa | pyocin | quorum sensing | genetic circuits | CELLS | BACTERIA | PROTEIN | SENSITIVE METHOD | SPECIFICITY | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMID | OTITIS | PERACETIC-ACID | BINDING | Recombinant Fusion Proteins - pharmacology | Humans | Pseudomonas aeruginosa - growth & development | Biofilms - growth & development | Escherichia coli - pathogenicity | Escherichia coli - metabolism | Homoserine - pharmacology | Homoserine - analogs & derivatives | Organisms, Genetically Modified - genetics | Genes, Reporter | Biofilms - drug effects | Recombinant Fusion Proteins - biosynthesis | Green Fluorescent Proteins - analysis | Quorum Sensing - drug effects | Pseudomonas Infections - drug therapy | 4-Butyrolactone - pharmacology | Pyocins - biosynthesis | Pseudomonas aeruginosa - drug effects | Escherichia coli - chemistry | Pseudomonas Infections - microbiology | Gene Expression Regulation, Bacterial - drug effects | Bacterial Proteins - pharmacology | Pyocins - pharmacology | Escherichia coli - genetics | Green Fluorescent Proteins - biosynthesis | Plasmids | Synthetic Biology - methods | Biosensing Techniques - methods | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - biosynthesis | 4-Butyrolactone - analogs & derivatives | Antibiosis - genetics | Chassis | Water-borne diseases | Cell culture | Mixed culture | Escherichia coli | Fluorescence | Confocal microscopy | Infections | Biology | E7 protein | Devices | Matrix methods | Antiinfectives and antibacterials | Proteins | Engineering | Microorganisms | Microbiota | Biological weapons | E coli | Helicobacter pylori | Mathematical analysis | Bacteria | Synthetic biology | Inhibition | Public health | Killing | Pathogens | Escherichia | Damage assessment | Empirical equations | Transfer functions | Data processing | Membrane proteins | Biofilms | Infectious diseases | Antibiotics | Microscopy | Lysis | Green fluorescent protein | Strategy | Cholera | Detection | Index Medicus
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6028, pp. 478 - 484
The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain... 
Cartilage | Immunization | Antiinflammatories | Medical treatment | REPORTS | Collagens | Antibodies | Bones | Arthritis | Mice | Inflammation | TUMOR-NECROSIS-FACTOR | GENE | MULTIDISCIPLINARY SCIENCES | HOST-DEFENSE | DEGRADATION | OLIGOMERIC MATRIX PROTEIN | GRANULIN-EPITHELIN PRECURSOR | ADAMTS-7 | MUTATIONS | TRANSCRIPTION FACTOR | PSEUDOACHONDROPLASIA | Recombinant Proteins - therapeutic use | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Recombinant Fusion Proteins - pharmacology | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Intercellular Signaling Peptides and Proteins - chemistry | Male | Receptors, Tumor Necrosis Factor, Type I - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | T-Lymphocytes, Regulatory - immunology | Arthritis, Experimental - pathology | Young Adult | Intercellular Signaling Peptides and Proteins - metabolism | Cartilage, Articular - metabolism | Receptors, Tumor Necrosis Factor, Type II - metabolism | Adult | Female | Protein Interaction Domains and Motifs | Anti-Inflammatory Agents, Non-Steroidal - metabolism | T-Lymphocytes, Regulatory - physiology | Arthritis, Experimental - physiopathology | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Arthritis, Experimental - immunology | Mice, Inbred Strains | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Cartilage, Articular - pathology | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Ligands | Aged | Intercellular Signaling Peptides and Proteins - therapeutic use | Care and treatment | Genetic aspects | Properties | Tumor necrosis factor | Growth factors | Index Medicus | Binding | Pathology | Receptors | Pathogenesis
Journal Article
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 05/2010, Volume 26, Issue 4, pp. 287 - 296
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 26, pp. 6307 - 6316
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2014, Volume 192, Issue 3, pp. 1120 - 1129
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 10, pp. 904 - 913
In this study of perinatal and infantile hypophosphatasia, patients received ENB-0040, a bone-targeted, recombinant, human tissue-nonspecific isozyme of... 
MEDICINE, GENERAL & INTERNAL | INFANTILE HYPOPHOSPHATASIA | GENE | NONSPECIFIC ALKALINE-PHOSPHATASE | DISEASE | MINERALIZATION | PYRIDOXAL-5'-PHOSPHATE | MURINE HYPOPHOSPHATASIA | BONE | INTRAVENOUS-INFUSION | TRANSPLANTATION | Recombinant Fusion Proteins - pharmacology | Rickets - diagnostic imaging | Humans | Recombinant Fusion Proteins - therapeutic use | Child, Preschool | Biological Availability | Infant | Male | Injections, Subcutaneous - adverse effects | Bone and Bones - drug effects | Enzyme Replacement Therapy - adverse effects | Bone and Bones - diagnostic imaging | Immunoglobulin G - pharmacology | Female | Infant, Newborn | Recombinant Fusion Proteins - administration & dosage | Alkaline Phosphatase - pharmacology | Immunoglobulin G - therapeutic use | Treatment Outcome | Immunoglobulin G - administration & dosage | Alkaline Phosphatase - therapeutic use | Hypophosphatasia - complications | Radiography | Rickets - drug therapy | Alkaline Phosphatase - administration & dosage | Hypophosphatasia - drug therapy | Infusions, Intravenous | Rickets - etiology | Enzymes | Care and treatment | Usage | Patient outcomes | Hypophosphatasia | Health aspects | Risk factors | Calcification (ectopic) | Alkaline phosphatase | Respiratory function | Lung | Cognitive ability | Infants | Bone diseases | Phosphatase | Rickets | Mineralization | Supplementation | Children | Osteomalacia | Parathyroid | Hypocalcemia | Age | Calcium (dietary) | Pharmacodynamics | Statistical analysis | Dietary supplements | Metabolism | Patients | Studies | Parathyroid hormone | Collaboration | Calcification | Plasma levels | Pharmacokinetics | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2016, Volume 291, Issue 46, pp. 23869 - 23881
IL-15 and its receptor (IL-15R) are co-expressed on antigen-presenting cells, allowing transpresentation of IL-15 to immune cells bearing IL-2R(C) and... 
IMMUNE-RESPONSE | CELLS | COMPLEX | antibody | FAB FRAGMENT | PROTECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | fusion protein | FC-RECEPTOR | RITUXIMAB | immunotherapy | scaffold protein | interleukin | </