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EMBO molecular medicine, ISSN 1757-4676, 2012, Volume 4, Issue 10, pp. 1015 - 1028
Journal Article
Journal of thrombosis and haemostasis, ISSN 1538-7933, 2013, Volume 11, Issue 1, pp. 132 - 141
.... A recombinant FVIII–Fc fusion protein (rFVIIIFc) was molecularly engineered to increase the half... 
Fc fusion | hemophilia A | long‐acting | rFVIIIFc | Factor VIII | RFVIIIFc | Long-acting | Hemophilia A | DOMAIN | HEMOPHILIA-A | FACTOR-IX | PROLONGED ACTIVITY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | long-acting | Recombinant Fusion Proteins - pharmacology | Immunoglobulin Fc Fragments - metabolism | Factor VIII - pharmacokinetics | Humans | Half-Life | Male | Structure-Activity Relationship | Coagulants - chemistry | Neoplasm Proteins - metabolism | Cysteine Endopeptidases - metabolism | Coagulants - pharmacology | Mass Spectrometry | Cloning, Molecular | Protein Engineering | Coagulants - pharmacokinetics | Protein Stability | Binding Sites | Disease Models, Animal | von Willebrand Factor - metabolism | Amino Acid Sequence | Thrombelastography | Factor VIII - chemistry | Factor VIII - genetics | Immunoglobulin Fc Fragments - chemistry | Peptide Mapping - methods | Hemophilia A - blood | Animals | Blood Coagulation - drug effects | Partial Thromboplastin Time | Recombinant Fusion Proteins - pharmacokinetics | Factor VIII - pharmacology | Protein Conformation | Mice | Protein C - metabolism | Hemophilia A - drug therapy | Immunoglobulin Fc Fragments - genetics | Proteins | Blood coagulation factor VIII | Medical examination | Analysis | Immunoglobulin G | Questions and answers | Hemophilia | Thrombin | Liquid chromatography | Chemical properties | Mass spectrometry | Blood | Coagulation
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46039
...(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. We demonstrate that the N-terminal fused T4L is sufficiently rigid... 
COMPLEX | ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GPCR | BETA-ADRENERGIC RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Protein Engineering - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Tritium | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Sf9 Cells | Bacteriophage T4 - enzymology | Binding Sites | Binding, Competitive | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Muramidase - chemistry | Receptors, Adrenergic, beta-2 - genetics | Viral Proteins - chemistry | Muramidase - genetics | Crystallization | Models, Molecular | Viral Proteins - genetics | Muramidase - metabolism | Recombinant Fusion Proteins - chemistry | Receptors, Adrenergic, beta-2 - metabolism | Animals | Dihydroalprenolol - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Dihydroalprenolol - chemistry | Protein Conformation | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, G-Protein-Coupled - chemistry | Proteins | Lysozyme | G proteins | Protein engineering | G protein-coupled receptors | Crystal lattices | Science | Catecholamines | Crystallography | Medicine | Signaling | N-Terminus | Chemical bonds | Adrenergic receptors | Physiology | Crystal structure
Journal Article
Pharmaceutical research, ISSN 0724-8741, 12/2019, Volume 37, Issue 2, pp. 17 - 10
.... We studied the effect of low and high sialylated IL4-10 fusion protein (IL4-10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on pharmacokinetic parameters. METHODS... 
therapeutic protein | Biotechnology | sialylation | inflammation | Pharmaceutical Science | Pharmacology (medical) | pharmacokinetics | cytokines | Molecular Medicine | Pharmacology | Organic Chemistry | Cricetulus | Rats, Wistar | Recombinant Fusion Proteins - pharmacology | Anti-Inflammatory Agents - pharmacology | Humans | Mice, Inbred C57BL | Interleukin-10 - blood | Metabolic Clearance Rate | Glycosylation | Recombinant Fusion Proteins - chemistry | Interleukin-4 - chemistry | Recombinant Fusion Proteins - blood | Anti-Inflammatory Agents - blood | N-Acetylneuraminic Acid - chemistry | Interleukin-4 - blood | Interleukin-4 - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Pain - drug therapy | HEK293 Cells | Interleukin-10 - chemistry | Interleukin-10 - pharmacology | CHO Cells | Disease Models, Animal | CELLS | RECOMBINANT HUMAN INTERLEUKIN-4 | MONOCYTES | TOXICITY | CYTOKINE | CHEMISTRY, MULTIDISCIPLINARY | IL-10 | PHARMACOLOGY & PHARMACY | PSORIASIS | Glycoproteins | Analysis | Organic acids | Resveratrol | Plasma | Evaluation | Intravenous administration | Exposure | Inflammation | Injection | Biological activity | Lipopolysaccharides | Proteins | Interleukin 4 | Pain | Production methods | Cell lines | Plasma levels | Pharmacokinetics | Fusion protein | Research Paper
Journal Article
Cancer cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 664 - 678
Recurrent fusions of ETS genes are considered driving mutations in a diverse array of cancers, including Ewing's sarcoma, acute myeloid leukemia, and prostate cancer... 
TRANSCRIPTION FACTORS | ANDROGEN RECEPTOR | EWS GENE | ONCOLOGY | TMPRSS2-ERG FUSION | EWINGS-SARCOMA TRANSLOCATION | DNA-LIGASE IV | ERG | EXPRESSION | TUMORS | PROGRESSION | CELL BIOLOGY | Oncogene Proteins, Fusion - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Male | Recombinant Fusion Proteins - metabolism | Oncogene Proteins, Fusion - chemistry | Prostatic Neoplasms - genetics | Transfection | Chromatin Immunoprecipitation | RNA Interference | Time Factors | DNA-Activated Protein Kinase - metabolism | Mass Spectrometry | HEK293 Cells | Antineoplastic Agents - pharmacology | Genes, Reporter | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Catalytic Domain | Neoplasm Invasiveness | Enzyme Inhibitors - pharmacology | Models, Molecular | Gene Fusion | Tumor Burden | Mice, SCID | Chick Embryo | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Protein Conformation | Mice | Mice, Inbred BALB C | DNA Damage | Poly (ADP-Ribose) Polymerase-1 | Cell Movement | Enzymes | Sarcoma | Leukemia | DNA | Genetic aspects | Prostate cancer | Protein kinases | Cancer | DNA-PKcs | PARP1 | TMPRSS2 | Prostate | Rearrangement
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 11/2014, Volume 111, Issue 11, pp. 2317 - 2325
...). To enable BBB penetration, IDS has been re‐engineered as an IgG‐IDS fusion protein, where the IgG domain is a monoclonal antibody (MAb... 
blood‐brain barrier | drug delivery | monoclonal antibody | lysosomal enzyme | Lysosomal enzyme | Drug delivery | Monoclonal antibody | Blood-brain barrier | blood-brain barrier | MONOCLONAL-ANTIBODY | II HUNTER-SYNDROME | IDURONATE-2-SULFATASE | IDURSULFASE | BLOOD-BRAIN-BARRIER | DELIVERY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TRANSCYTOSIS | DISEASE | IDURONIDASE | ENZYME REPLACEMENT THERAPY | Glycoproteins - genetics | Antigens, CD - immunology | Recombinant Fusion Proteins - adverse effects | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - pharmacokinetics | Glycoproteins - adverse effects | Metabolic Clearance Rate | Macaca mulatta | Glycoproteins - administration & dosage | Drug-Related Side Effects and Adverse Reactions - epidemiology | Drug-Related Side Effects and Adverse Reactions - pathology | Antibodies, Monoclonal - genetics | Animals | Antibodies, Monoclonal - administration & dosage | Plasma - chemistry | Recombinant Fusion Proteins - pharmacokinetics | Recombinant Fusion Proteins - genetics | Glycoproteins - pharmacokinetics | Infusions, Intravenous | Receptor, Insulin - immunology | Recombinant Fusion Proteins - administration & dosage | Viral antibodies | Safety and security measures | Antibodies | Pharmacology | Insulin | Biopharmaceutics | Diabetes therapy | Proteins | Brain | Enzymes | Receptors | Monkeys | Transport
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e29828
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein... 
CHRONIC MYELOGENOUS LEUKEMIA | CHRONIC PHASE | COMPLEX | C-ABL | ACTIVE-SITE | SRC | MULTIDISCIPLINARY SCIENCES | ELECTRIC-FIELDS | IMATINIB | MUTATION | CLINICAL RESISTANCE | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Spectroscopic analysis | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Resistant mutant | Binding sites
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2016, Volume 60, Issue 1, pp. 6 - 13
Respiratory syncytial virus (RSV) is an important causative agent of lower respiratory tract infections in infants and elderly individuals. Its fusion (F... 
EPITHELIAL-CELLS | RSV | ANTIGENIC STRUCTURE | IN-VIVO | PALIVIZUMAB | HUMANIZED MONOCLONAL-ANTIBODY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | FUSION GLYCOPROTEIN | MOTAVIZUMAB | SINGLE-DOMAIN ANTIBODY | NEUTRALIZATION | Palivizumab - pharmacology | Humans | Respiratory Syncytial Viruses - immunology | Male | Antiviral Agents - metabolism | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus Infections - drug therapy | Nasal Cavity - virology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Gene Expression | Respiratory Syncytial Viruses - drug effects | Models, Molecular | Rats | Recombinant Proteins - chemistry | Lung - drug effects | Pichia - genetics | Respiratory Syncytial Virus Infections - pathology | Viral Load - drug effects | Respiratory Syncytial Viruses - pathogenicity | Antibodies, Viral - pharmacology | Viral Fusion Proteins - genetics | Antiviral Agents - immunology | Neutralization Tests | Respiratory Syncytial Virus Infections - immunology | Single-Domain Antibodies - immunology | Antibodies, Neutralizing - immunology | Lung - virology | Pichia - metabolism | Viral Fusion Proteins - chemistry | Female | Nasal Cavity - drug effects | Respiratory Syncytial Virus Infections - virology | Nasal Cavity - immunology | Antibodies, Viral - biosynthesis | Palivizumab - biosynthesis | Administration, Inhalation | Antibodies, Neutralizing - pharmacology | Palivizumab - immunology | Recombinant Proteins - genetics | Single-Domain Antibodies - pharmacology | Sigmodontinae | Animals | Recombinant Proteins - immunology | Antibodies, Neutralizing - biosynthesis | Antibodies, Viral - immunology | Viral Fusion Proteins - antagonists & inhibitors | Single-Domain Antibodies - biosynthesis | Lung - immunology
Journal Article