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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 2868 - 2873
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane,... 
Protein delivery | Genome editing | CRISPR/Cas9 | Cre recombinase | Lipid nanoparticle | THERAPEUTICS | genome editing | COMBINATORIAL LIBRARY | VIVO | RNA | CELLS IN-VITRO | CAS9 PROTEIN | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | lipid nanoparticle | protein delivery | INTRACELLULAR DELIVERY | Endonucleases - genetics | Thalamus - metabolism | Nanoparticles - chemistry | Humans | Green Fluorescent Proteins - genetics | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Endosomes - metabolism | Drug Carriers | Luminescent Proteins - biosynthesis | RNA - genetics | Cholesterol - chemistry | Endocytosis | Lipids - chemistry | Integrases - administration & dosage | Endonucleases - administration & dosage | Recombination, Genetic | Nanoparticles - metabolism | Molecular Structure | Genes, Reporter | Genetic Engineering - methods | Bacterial Proteins - genetics | Genes, Synthetic | Ceramides - chemistry | Lipids - administration & dosage | Gene Knockout Techniques | Static Electricity | Nanoparticles - toxicity | Bacterial Proteins - administration & dosage | Animals | Hypothalamus - metabolism | Lipids - chemical synthesis | Green Fluorescent Proteins - biosynthesis | CRISPR-Cas Systems | Luminescent Proteins - genetics | Mice | Nanoparticles - administration & dosage | HeLa Cells | Integrases - genetics | Phosphatidylethanolamines - chemistry | Nanoparticles | Genetic aspects | Nucleotide sequencing | Lipid metabolism | Health aspects | Methods | DNA sequencing | Proteins | Lipids | Genomes | Ribonucleic acid--RNA | Index Medicus | CRISPR | Physical Sciences | Cas9
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e46883 - e46883
Background: Complement 3 (C3), a key component of the innate immune system, is involved in early inflammatory responses. Acylation stimulating protein (ASP;... 
COMPLEMENT C3 | IN-VITRO | OBESITY | C5A RECEPTOR C5L2 | ENERGY-EXPENDITURE | MULTIDISCIPLINARY SCIENCES | MACROPHAGE-INFILTRATION | KNOCKOUT MICE | DEFICIENCY | ADIPOSE-TISSUE | C3A ANAPHYLATOXIN | Inflammation - pathology | Insulin Resistance | Diet, High-Fat - adverse effects | Male | Adipocytes - drug effects | Recombinant Proteins - pharmacology | Gene Knockout Techniques | Recombinant Proteins - administration & dosage | Inflammation - metabolism | Animals | Complement C3 - deficiency | Intercellular Signaling Peptides and Proteins - pharmacology | Adipocytes - metabolism | Lipid Metabolism - drug effects | Female | Mice | Intercellular Signaling Peptides and Proteins - administration & dosage | Complement C3 - genetics | CC chemokine receptors | Size distribution | Adipose tissue | RANTES | Inflammatory response | Lipids | Adipocytes | Kinases | Low fat | High fat diet | Interleukin 6 | Proteins | CCR2 protein | Granulocyte colony-stimulating factor | Rodents | Lipid metabolism | Acylation | Immune system | Recombinant | Obesity | CD11c antigen | Cytokines | Secretion | Diabetes mellitus | Neutrophils | Muscles | JNK protein | Inflammation | CD36 antigen | Metabolism | Gene expression | Insulin | Fatty acids | Sensitivity | Food intake | Complement component C3 | Low fat diet | Insulin resistance | Diabetes | Cardiovascular diseases | Metabolic disorders | Monocyte chemoattractant protein 1 | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2015, Volume 112, Issue 2, pp. E156 - E165
Current treatments to control pathological or unwanted immune responses often use broadly immunosuppressive drugs. New approaches to induce antigen-specific... 
Nanoparticles | Rapamycin | Anti-drug antibodies | Immune tolerance | Immunotherapy | THERAPEUTICS | anti-drug antibodies | IMMUNITY | TOLEROGENIC DENDRITIC CELLS | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | FACTOR-VIII | MECHANISMS | RESPONSES | immune tolerance | IMMUNOGENICITY | nanoparticles | UNRESPONSIVENESS | immunotherapy | rapamycin | Factor VIII - immunology | Oligodeoxyribonucleotides - administration & dosage | Nanoparticles - chemistry | Ovalbumin - immunology | Immunosuppression - methods | Nanocapsules - administration & dosage | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Hypersensitivity, Delayed - immunology | Nanocapsules - chemistry | Peptides - administration & dosage | Antigens - administration & dosage | CD4-Positive T-Lymphocytes - immunology | Immunity, Humoral | Peptide Fragments - immunology | Proteins - administration & dosage | Female | Immunosuppressive Agents - administration & dosage | Disease Models, Animal | Lactic Acid - chemistry | Peptides - chemistry | Hemophilia A - immunology | Peptide Fragments - administration & dosage | Peptides - immunology | Immune Tolerance | Hemophilia A - therapy | Hypersensitivity, Delayed - therapy | Antigens - chemistry | Proteins - immunology | Encephalomyelitis, Autoimmune, Experimental - therapy | Sirolimus - administration & dosage | Animals | Ovalbumin - administration & dosage | Recombinant Proteins - immunology | Polyglycolic Acid - chemistry | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Hemocyanins - administration & dosage | Proteins - chemistry | Antigens | Usage | Research | Health aspects | Immunological tolerance | Immunological research | Immunology | Polymers | Chemical synthesis | Immune system | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
International Archives of Allergy and Immunology, ISSN 1018-2438, 04/2015, Volume 166, Issue 1, pp. 41 - 51
Background: The FAST (food allergy-specific immunotherapy) project aims at developing safe and effective subcutaneous immunotherapy for fish allergy, using... 
Original Paper | Food allergy | Carp | Toxicity | Immunotherapy | Fish | Cyprinus carpio | Allergen mutants | FAST | Parvalbumin | Recombinant hypoallergenic allergens | TOLERANCE INDUCTION | EFFICACY | SAFETY | IGE | DESENSITIZATION | VACCINATION | IMMUNOLOGY | PEANUT ORAL IMMUNOTHERAPY | ALLERGY | PURIFICATION | CALCIUM-BINDING | HYPERSENSITIVITY | Immunoglobulin G - blood | Humans | Male | Immunoglobulin E - blood | Allergens - administration & dosage | Fish Proteins - genetics | Food Hypersensitivity - immunology | Allergens - immunology | Calcium-Binding Proteins - immunology | Injections, Subcutaneous | Leukocytes, Mononuclear - immunology | Allergens - chemistry | Escherichia coli - metabolism | Parvalbumins - genetics | Female | Protein Stability | Calcium-Binding Proteins - chemistry | Rabbits | Gene Expression | Double-Blind Method | Fish Proteins - chemistry | Fish Proteins - immunology | Parvalbumins - chemistry | Recombinant Proteins - chemistry | Allergens - genetics | Recombinant Proteins - genetics | Lethal Dose 50 | Parvalbumins - immunology | Protein Folding | Recombinant Proteins - administration & dosage | Calcium-Binding Proteins - administration & dosage | Carps - immunology | Fish Proteins - administration & dosage | Leukocytes, Mononuclear - pathology | Parvalbumins - administration & dosage | Animals | Recombinant Proteins - immunology | Escherichia coli - genetics | Food Hypersensitivity - prevention & control | Mice | Food Hypersensitivity - physiopathology | Calcium-Binding Proteins - genetics | Desensitization, Immunologic - methods | Food allergies | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 25, pp. 3855 - 3863
Journal Article
Nature, ISSN 0028-0836, 07/2007, Volume 448, Issue 7149, pp. 39 - 43
A major impediment in the treatment of neurological diseases is the presence of the blood - brain barrier, which precludes the entry of therapeutic molecules... 
IN-VIVO DELIVERY | VIRUS | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR DELIVERY | CELL-PENETRATING PEPTIDES | GENE-THERAPY | RECEPTORS | MODIFIED SIRNAS | BRAIN | INHIBITS TUMOR-GROWTH | RNA, Small Interfering - genetics | Superoxide Dismutase - genetics | Encephalitis Virus, Japanese | Humans | Glycoproteins - metabolism | Brain - virology | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Viral Proteins - metabolism | Drug Delivery Systems | Brain - metabolism | Lentivirus - genetics | Viral Proteins - administration & dosage | Neurons - metabolism | Glycoproteins - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Neurons - virology | Rabies virus - physiology | Receptors, Nicotinic - metabolism | Mice, Inbred C57BL | Oligopeptides - genetics | Gene Silencing | Viral Proteins - genetics | Recombinant Proteins - genetics | Mice, SCID | Genetic Vectors - genetics | Glycoproteins - administration & dosage | Recombinant Proteins - administration & dosage | Rabies virus - genetics | Animals | Encephalitis, Japanese - prevention & control | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | HeLa Cells | Liposomes | Superoxide Dismutase-1 | RNA, Small Interfering - administration & dosage | Blood-Brain Barrier | RNA, Small Interfering - metabolism | Brain cells | Research | Brain | Nervous system | Amino acids | Peptides | Neurological disorders | Blood | Blood-brain barrier | Ribonucleic acids | Cytokines | Genes | Central nervous system | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2015, Volume 11, Issue 5, pp. e1004896 - e1004896
Clostridium perfringens epsilon-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with... 
NERVOUS-SYSTEM | MDCK CELLS | MICROBIOLOGY | PLASMA-MEMBRANE | INTESTINAL INFECTIONS | DARBY CANINE KIDNEY | VIROLOGY | PORE-FORMING TOXIN | APICAL SORTING MACHINERY | RAFT-ASSOCIATED PROTEIN | HUMAN T-LYMPHOCYTES | PARASITOLOGY | INFLUENZA-VIRUS HEMAGGLUTININ | Injections, Intravenous | Cricetulus | Myelin and Lymphocyte-Associated Proteolipid Proteins - metabolism | Humans | Bacterial Toxins - toxicity | Recombinant Fusion Proteins - metabolism | Tissue Distribution | Protein Precursors - toxicity | Bacterial Toxins - genetics | Clostridium perfringens - metabolism | Protein Interaction Domains and Motifs | Cell Death - drug effects | Binding Sites | Clostridium perfringens - pathogenicity | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Recombinant Proteins - metabolism | Protein Precursors - genetics | Protein Precursors - administration & dosage | Mice, Inbred C57BL | Rats | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - toxicity | Recombinant Fusion Proteins - chemistry | Recombinant Proteins - administration & dosage | Mice, Knockout | Protein Precursors - metabolism | Toxicokinetics | Bacterial Toxins - metabolism | Animals | Myelin and Lymphocyte-Associated Proteolipid Proteins - chemistry | Recombinant Proteins - toxicity | Ligands | Mutagenesis, Insertional | Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics | Index Medicus
Journal Article
Diabetes Care, ISSN 0149-5992, 2014, Volume 37, Issue 8, pp. 2159 - 2167
OBJECTIVE To compare the efficacy and safety of dulaglutide, a once-weekly GLP-1 receptor agonist, with placebo and exenatide in type 2 diabetic patients. The... 
GLYCEMIC CONTROL | GLUCAGON-LIKE PEPTIDE-1 | EXENDIN-4 | SITAGLIPTIN | ENDOCRINOLOGY & METABOLISM | ANALOG LIRAGLUTIDE | OPEN-LABEL | LY2189265 | TREATED PATIENTS | Recombinant Fusion Proteins - adverse effects | Glucagon-Like Peptides - administration & dosage | Humans | Middle Aged | Male | Immunoglobulin Fc Fragments - administration & dosage | Thiazolidinediones - administration & dosage | Metformin - adverse effects | Peptides - administration & dosage | Hypoglycemic Agents - administration & dosage | Venoms - administration & dosage | Female | Metformin - administration & dosage | Drug Therapy, Combination | Glucagon-Like Peptides - analogs & derivatives | Immunoglobulin Fc Fragments - adverse effects | Recombinant Fusion Proteins - administration & dosage | Drug Administration Schedule | Venoms - adverse effects | Hypoglycemia - drug therapy | Thiazolidinediones - adverse effects | Blood Glucose - drug effects | Glucagon-Like Peptides - adverse effects | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Peptides - adverse effects | Type 2 diabetes | Care and treatment | Safety and security measures | Dosage and administration | Metformin | Comparative analysis | Exenatide | Clinical trials | Hemoglobin | Diabetes | Product safety | Drug dosages | Placebo effect | Index Medicus
Journal Article