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Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1844 - 12
Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1... 
COMPLEX | REPLICATION | INTEGRATION | STRUCTURAL BASIS | PROTEIN-SYNTHESIS SYSTEM | MULTIDISCIPLINARY SCIENCES | INHIBITORS | HIV-1 INFECTION | CELL | EXPRESSION | IMMUNODEFICIENCY-VIRUS VPX | Humans | Proto-Oncogene Proteins c-pim-1 - metabolism | Pyridazines - pharmacology | Proto-Oncogene Proteins c-pim-1 - immunology | Host-Pathogen Interactions - immunology | Recombinant Proteins - isolation & purification | HIV Infections - immunology | Proteolysis - drug effects | Biphenyl Compounds - pharmacology | Protein Processing, Post-Translational - drug effects | SAM Domain and HD Domain-Containing Protein 1 - immunology | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Protein Binding - drug effects | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - immunology | Phosphorylation - immunology | Protein Processing, Post-Translational - immunology | Thiazolidines - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Viral Regulatory and Accessory Proteins - isolation & purification | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Virus Replication - drug effects | SAM Domain and HD Domain-Containing Protein 1 - metabolism | HIV Infections - virology | Immune Tolerance | Virus Replication - immunology | Imidazoles - pharmacology | Protein Binding - immunology | Serine - metabolism | Molecular Dynamics Simulation | Viral Regulatory and Accessory Proteins - metabolism | SAM Domain and HD Domain-Containing Protein 1 - chemistry | Monocytes | Protein Kinase Inhibitors - therapeutic use | HIV-2 - immunology | Proteomics | Cell Line, Tumor | HIV Infections - drug therapy | Protein-Serine-Threonine Kinases - immunology | Protein Kinase Inhibitors - pharmacology | Viral Regulatory and Accessory Proteins - chemistry | Ubiquitin | Phosphorylation | Threonine | Serine | Viruses | Functional analysis | Promotion | Kinases | Proteins | Protein X | Restoration | Proteolysis | Human immunodeficiency virus--HIV | Infectivity | Antiviral activity | Proteasomes
Journal Article
Nature cell biology, ISSN 1476-4679, 2011, Volume 13, Issue 10, pp. 1265 - 1271
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2014, Volume 171, Issue 3, pp. 772 - 788
Background and Purpose Receptor activity‐modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor‐like receptor (CLR... 
GPCR | adrenomedullin | RAMP | CGRP | receptor activity‐modifying protein | receptor activity-modifying protein | CRYSTAL-STRUCTURE | EXTRACELLULAR DOMAIN | N-TERMINUS | FAMILY | CORTICOTROPIN-RELEASING-FACTOR | STRUCTURAL BASIS | MOLECULAR RECOGNITION | PHARMACOLOGY & PHARMACY | CLASS-B GPCR | COUPLED-RECEPTOR | BINDING | Receptors, Adrenomedullin - chemistry | Humans | Adrenomedullin - chemistry | Cercopithecus aethiops | Receptor Activity-Modifying Protein 1 - chemistry | Receptor Activity-Modifying Protein 2 - chemistry | Receptor Activity-Modifying Protein 3 - genetics | Calcitonin Gene-Related Peptide - chemistry | Receptors, Calcitonin Gene-Related Peptide - metabolism | Recombinant Fusion Proteins - metabolism | Peptide Hormones - metabolism | Receptors, Calcitonin Gene-Related Peptide - chemistry | Peptide Hormones - chemistry | Protein Interaction Domains and Motifs | Calcitonin Gene-Related Peptide - metabolism | Cyclic AMP - metabolism | Peptide Fragments - genetics | Second Messenger Systems | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Receptors, Adrenomedullin - metabolism | Calcitonin Receptor-Like Protein - chemistry | Models, Molecular | Rats | Receptor Activity-Modifying Protein 1 - metabolism | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Receptor Activity-Modifying Protein 2 - metabolism | Adrenomedullin - metabolism | Receptor Activity-Modifying Protein 1 - genetics | Recombinant Fusion Proteins - chemistry | Calcitonin Receptor-Like Protein - metabolism | Peptide Fragments - chemistry | Animals | Receptor Activity-Modifying Protein 3 - chemistry | Calcitonin Receptor-Like Protein - genetics | Mutant Proteins - chemistry | Receptor Activity-Modifying Protein 3 - metabolism | Receptor Activity-Modifying Protein 2 - genetics | COS Cells | Proteins | Genetic research | Pharmacology | Genetic aspects | Algorithms | Analysis | Peptides | Mutation | Calcitonin gene-related peptide | G protein-coupled receptors | Adrenomedullin | Receptor activity modifying proteins | Cell surface | Mutants | Research Papers
Journal Article
Pharmacological reviews, ISSN 1521-0081, 2015, Volume 67, Issue 2, pp. 389 - 440
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
ACTIVATION | MEK INHIBITION | DETERMINANTS | RAF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | DEFICIENCY | Signal transduction | Kinetics | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e29828
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein... 
CHRONIC MYELOGENOUS LEUKEMIA | CHRONIC PHASE | COMPLEX | C-ABL | ACTIVE-SITE | SRC | MULTIDISCIPLINARY SCIENCES | ELECTRIC-FIELDS | IMATINIB | MUTATION | CLINICAL RESISTANCE | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Spectroscopic analysis | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Resistant mutant | Binding sites
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
... studies have demonstrated the importance of many of these residues in SERT pharmacology (9-12,15,20,21). By tracking the binding constant ([K.sub.d])of [[sup.3]H... 
NEUROTRANSMITTER | HIGH-AFFINITY RECOGNITION | MECHANISM | DETERMINANTS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | HUMAN SEROTONIN TRANSPORTER | CHLORIDE | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 494, Issue 7436, pp. 201 - 206
.... Here we show that a peptide, Tat-beclin 1-derived from a region of the autophagy protein, beclin 1, which binds human immunodeficiency virus (HIV... 
Ordered by external client | PATHOGENESIS | LOCALIZES | COMPLEX | PROTEIN | BECLIN-1 | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | BINDING | Apoptosis Regulatory Proteins - pharmacology | Recombinant Fusion Proteins - pharmacology | Humans | Cell Membrane Permeability | Molecular Sequence Data | Peptide Fragments - pharmacology | Membrane Proteins - pharmacology | Membrane Proteins - therapeutic use | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | HIV-1 - physiology | nef Gene Products, Human Immunodeficiency Virus - metabolism | Membrane Proteins - metabolism | Beclin-1 | Amino Acid Sequence | HIV-1 - metabolism | Virus Replication - drug effects | Peptide Fragments - metabolism | HIV-1 - drug effects | tat Gene Products, Human Immunodeficiency Virus - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | West Nile virus - drug effects | Macrophages - cytology | Recombinant Fusion Proteins - chemistry | Apoptosis Regulatory Proteins - metabolism | Chikungunya virus - drug effects | Peptide Fragments - chemistry | Animals | Membrane Proteins - chemistry | Mice | HeLa Cells | Apoptosis Regulatory Proteins - therapeutic use | tat Gene Products, Human Immunodeficiency Virus - metabolism | Proteins | Peptides | Microscopy | Rodents | Mortality | Amino acids | Infections | Autophagy
Journal Article