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The Plant Cell, ISSN 1040-4651, 11/2012, Volume 24, Issue 11, pp. 4465 - 4482
Supramolecular organization of enzymes is proposed to orchestrate metabolic complexity and help channel intermediates in different pathways. Phenylpropanoid... 
Proteins | Enzymes | Lignin | Protein metabolism | Sterols | RESEARCH ARTICLES | Hematocrit | Fluorescence | Cytochromes | Plants | Plant cells | ENDOPLASMIC-RETICULUM MEMBRANE | MOLECULAR-INTERACTIONS | ARABIDOPSIS-THALIANA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CINNAMIC ACID | PHENYLALANINE AMMONIA-LYASE | CYTOCHROME P450 REDUCTASE | PLANT SCIENCES | CELL BIOLOGY | PHENYLPROPANOID PATHWAY | TANDEM AFFINITY PURIFICATION | ENZYME COMPLEXES | BINDING PROTEIN-1 | Green Fluorescent Proteins | Protein Multimerization | Cytochrome P-450 Enzyme System - metabolism | Endoplasmic Reticulum - metabolism | Trans-Cinnamate 4-Monooxygenase - genetics | Acyltransferases - metabolism | Recombinant Fusion Proteins | Coenzyme A Ligases - metabolism | Arabidopsis Proteins - metabolism | Trans-Cinnamate 4-Monooxygenase - metabolism | Lignin - metabolism | Plants, Genetically Modified | Membrane Proteins - metabolism | Transgenes | Acyl Coenzyme A - metabolism | Arabidopsis Proteins - genetics | Hydroxylation | Hydroxybenzoates - metabolism | Membrane Proteins - genetics | Tobacco - metabolism | Arabidopsis - metabolism | Protein Interaction Mapping | Arabidopsis - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Tobacco - genetics | Cytochrome P-450 Enzyme System - genetics | Phytochemistry | Physiological aspects | Biosynthesis | Research | Protein-protein interactions | Membrane proteins | Life Sciences | Molecular biology | Cellular Biology | Biochemistry, Molecular Biology
Journal Article
2010, 1. Aufl., ISBN 0470411961, xxii, 486
This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the... 
Development | Pharmacology | Drug Discovery | MEDICAL | Protein drugs | Aggregation (Chemistry)
Book
Journal Article
Nature Biotechnology, ISSN 1087-0156, 06/2002, Volume 20, Issue 6, pp. 619 - 622
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2003, Volume 75, Issue 18, pp. 4740 - 4746
The creation and characterization of histidine-tagged fusion protein arrays using nitrilotriacetic acid (NTA) capture probes on gold thin films for the study... 
CHEMISTRY, ANALYTICAL | FILMS | MALTOSE-BINDING PROTEIN | SPR | RECOMBINANT PROTEINS | TATA BOX | PURIFICATION | TIME SAMPLING ELECTRONICS | MICROARRAYS | MONOLAYERS | IMMOBILIZATION | Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Histidine - chemistry | Base Sequence | Proteins | Nitrilotriacetic acid | Research
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
by Ge, H
Nucleic acids research, ISSN 1362-4962, 2000, Volume 28, Issue 2, pp. e3 - 3
Protein-protein interactions have been widely used to study gene expression pathways and may be considered as a new approach to drug discovery. Here I report... 
Molecular Probes | DNA Probes | Escherichia coli | Humans | Biological Assay - methods | DNA - metabolism | Recombinant Fusion Proteins - metabolism | RNA Probes | Adaptor Proteins, Signal Transducing | Trans-Activators - genetics | Protein Binding | Ligands | Trans-Activators - metabolism | Transcription Factors | HeLa Cells | RNA - metabolism | NAR Methods Online
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2013, Volume 288, Issue 3, pp. 1856 - 1870
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2012, Volume 366, Issue 22, pp. 2055 - 2064
Journal Article