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1. Full Text APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
by Parsa, Afshin and Kao, W.H. Linda and Xie, Dawei and Astor, Brad C and Li, Man and Hsu, Chi-yuan and Feldman, Harold I and Parekh, Rulan S and Kusek, John W and Greene, Tom H and Fink, Jeffrey C and Anderson, Amanda H and Choi, Michael J and Wright, Jackson T and Lash, James P and Freedman, Barry I and Ojo, Akinlolu and Winkler, Cheryl A and Raj, Dominic S and Kopp, Jeffrey B and He, Jiang and Jensvold, Nancy G and Tao, Kaixiang and Lipkowitz, Michael S and Appel, Lawrence J and AASK Study Investigators and CRIC Study Investigators
The New England Journal of Medicine, ISSN 0028-4793, 12/2013, Volume 369, Issue 23, pp. 2183 - 2196
In this study, APOL1 variants were associated with an increased risk of progression of chronic kidney disease in black patients, as compared with white... 
FUNCTION DECLINE | MEDICINE, GENERAL & INTERNAL | GFR | GENE | RACIAL-DIFFERENCES | MYH9 | INSUFFICIENCY COHORT | CKD | STAGE RENAL-DISEASE | PARTICIPANTS | BASE-LINE CHARACTERISTICS | Multivariate Analysis | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Glomerular Filtration Rate | Lipoproteins, HDL - genetics | Humans | Middle Aged | African Americans - genetics | Male | Kidney Failure, Chronic - ethnology | Disease Progression | Kidney Failure, Chronic - genetics | Renal Insufficiency, Chronic - ethnology | Apolipoproteins - genetics | Apolipoprotein L1 | Renal Insufficiency, Chronic - genetics | Creatinine - blood | Hypertension - complications | Adult | Female | Aged | Diabetes Complications - genetics | Polymorphism, Single Nucleotide | Proteinuria | Demographic aspects | Genetic variation | African Americans | Genetic aspects | Research | Kidney diseases | Apolipoproteins | Health aspects | Risk factors | Hypertension | Creatinine | End-stage renal disease | Kidneys | Epidermal growth factor receptors | Risk groups | Medical treatment | Diabetes mellitus | Glomerular filtration rate | Renal insufficiency | Diabetes
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2. Full Text Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease
by Appel, Lawrence J and Wright, Jackson T and Greene, Tom and Agodoa, Lawrence Y and Astor, Brad C and Bakris, George L and Cleveland, William H and Charleston, Jeanne and Contreras, Gabriel and Faulkner, Marquetta L and Gabbai, Francis B and Gassman, Jennifer J and Hebert, Lee A and Jamerson, Kenneth A and Kopple, Joel D and Kusek, John W and Lash, James P and Lea, Janice P and Lewis, Julia B and Lipkowitz, Michael S and Massry, Shaul G and Miller, Edgar R and Norris, Keith and Phillips, Robert A and Pogue, Velvie A and Randall, Otelio S and Rostand, Stephen G and Smogorzewski, Miroslaw J and Toto, Robert D and Wang, Xuelei and AASK Collaborative Res Grp and AASK Collaborative Research Group
The New England Journal of Medicine, ISSN 0028-4793, 09/2010, Volume 363, Issue 10, pp. 918 - 929
This trial tested whether intensive blood-pressure control retards the progression of chronic kidney disease in black patients with hypertension. Although... 
TRIAL | MEDICINE, GENERAL & INTERNAL | DESIGN | DIET | AASK | PROTEINURIA | RISK | OUTCOMES | STAGE RENAL-DISEASE | AFRICAN-AMERICAN | PROGRESSION | Blood Pressure | Renal Insufficiency, Chronic - etiology | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | African Americans | Hypertension - drug therapy | Male | Albuminuria | Antihypertensive Agents - therapeutic use | Disease Progression | Renal Insufficiency, Chronic - drug therapy | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Kidney Failure, Chronic - prevention & control | Renal Insufficiency, Chronic - ethnology | Hypertension - ethnology | Creatinine - blood | Hypertension - complications | Adult | Female | Aged | Cohort Studies | Physiological aspects | Control | Blood pressure | Kidney diseases | Health aspects | Hypertension | Diabetes | Medical treatment
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3. Full Text APOL1 variants associate with increased risk of CKD among African Americans
by Foster, Meredith C and Coresh, Josef and Fornage, Myriam and Astor, Brad C and Grams, Morgan and Franceschini, Nora and Boerwinkle, Eric and Parekh, Rulan S and Kao, W.H.L
Journal of the American Society of Nephrology, ISSN 1046-6673, 09/2013, Volume 24, Issue 9, pp. 1484 - 1491
Although case-control studies suggest that African Americans with common coding variants in the APOL1 gene are 5-29 times more likely than those individuals... 
UNITED-STATES | APOLIPOPROTEIN L | GENE | UROLOGY & NEPHROLOGY | MYH9 | CHRONIC KIDNEY-DISEASE | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | NEPHROPATHY | STAGE RENAL-DISEASE | United States - epidemiology | Lipoproteins, HDL - genetics | Glomerulosclerosis, Focal Segmental - genetics | Humans | Middle Aged | Male | Kidney Failure, Chronic - ethnology | Case-Control Studies | AIDS-Associated Nephropathy - genetics | Renal Insufficiency, Chronic - epidemiology | Apolipoproteins - genetics | Glomerulosclerosis, Focal Segmental - ethnology | Renal Insufficiency, Chronic - genetics | Female | Genetic Predisposition to Disease - epidemiology | Genetic Predisposition to Disease - genetics | Glomerulosclerosis, Focal Segmental - epidemiology | Risk Factors | AIDS-Associated Nephropathy - epidemiology | African Americans - ethnology | Kidney Failure, Chronic - genetics | Kidney Failure, Chronic - epidemiology | Renal Insufficiency, Chronic - ethnology | AIDS-Associated Nephropathy - ethnology | Alleles | Apolipoprotein L1 | Genetic Predisposition to Disease - ethnology | Genetic Variation - genetics | Clinical Epidemiology
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4. Full Text Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function
by James P. Lash and Alan S. Go and Lawrence J. Appel and Jiang He and Akinlolu Ojo and Mahboob Rahman and Raymond R. Townsend and Dawei Xie and Denise Cifelli and Janet Cohan and Jeffrey C. Fink and Michael J. Fischer and Crystal Gadegbeku and L. Lee Hamm and John W. Kusek and J. Richard Landis and Andrew Narva and Nancy Robinson and Valerie Teal and Harold I. Feldman and Chronic Renal Insufficiency Cohort and Chronic Renal Insufficiency Cohort (CRIC) Study Group
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 08/2009, Volume 4, Issue 8, pp. 1302 - 1311
Background and objectives: The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney... 
SERUM CREATININE | NONTRADITIONAL RISK-FACTORS | CARDIOVASCULAR OUTCOMES | UROLOGY & NEPHROLOGY | CORONARY-HEART-DISEASE | HYPERTENSION | BLOOD-PRESSURE | SOCIOECONOMIC-STATUS | AFRICAN-AMERICAN | ATHEROSCLEROSIS RISK | PROGRESSION | Blood Pressure | Smoking - adverse effects | United States - epidemiology | Prospective Studies | Age Factors | Cardiovascular Diseases - ethnology | Humans | Middle Aged | Male | Educational Status | Renal Insufficiency, Chronic - complications | Kidney Failure, Chronic - ethnology | Patient Selection | Young Adult | Cardiovascular Diseases - complications | Adult | Female | Kidney - physiopathology | Proteinuria - etiology | Kidney Failure, Chronic - physiopathology | Cardiovascular Diseases - physiopathology | Glomerular Filtration Rate | Risk Assessment | Risk Factors | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Social Class | Proteinuria - physiopathology | Renal Insufficiency, Chronic - ethnology | Aged | Kidney Failure, Chronic - etiology | Original
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5. Full Text Metabolic Syndrome and Insulin Resistance as Risk Factors for Development of Chronic Kidney Disease and Rapid Decline in Renal Function in Elderly
by Cheng, Hui-Teng and Huang, Jenq-Wen and Chiang, Chih-Kang and Yen, Chung-Jen and Hung, Kuan-Yu and Wu, Kwan-Dun
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2012, Volume 97, Issue 4, pp. 1268 - 1276
Context: Studies addressing the association of metabolic syndrome and insulin resistance with the risks of incident chronic kidney disease (CKD) and the... 
INDIVIDUALS | TRIGLYCERIDE | CHOLESTEROL | ENDOCRINOLOGY & METABOLISM | INSUFFICIENCY | US ADULTS | PROTEINURIA | PREVALENCE | HYPERTENSION | PROGRESSION | PROGRAM | Prevalence | Prospective Studies | Follow-Up Studies | Renal Insufficiency, Chronic - etiology | Humans | Male | Metabolic Syndrome - metabolism | Kidney Failure, Chronic - ethnology | Metabolic Syndrome - urine | Incidence | Renal Insufficiency, Chronic - epidemiology | Metabolic Syndrome - ethnology | Metabolic Syndrome - physiopathology | Aged, 80 and over | Female | Proteinuria - etiology | Proteinuria - epidemiology | Glomerular Filtration Rate | Aging - ethnology | Risk Factors | Hospitals, University | Proportional Hazards Models | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Proteinuria - ethnology | Kidney Failure, Chronic - epidemiology | Renal Insufficiency, Chronic - ethnology | Taiwan - epidemiology | Aged | Cohort Studies | Insulin Resistance - ethnology | Kidney Failure, Chronic - etiology
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6. Full Text Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans
by Naik, Rakhi P and Derebail, Vimal K and Grams, Morgan E and Franceschini, Nora and Auer, Paul L and Peloso, Gina M and Young, Bessie A and Lettre, Guillaume and Peralta, Carmen A and Katz, Ronit and Hyacinth, Hyacinth I and Quarells, Rakale C and Grove, Megan L and Bick, Alexander G and Fontanillas, Pierre and Rich, Stephen S and Smith, Joshua D and Boerwinkle, Eric and Rosamond, Wayne D and Ito, Kaoru and Lanzkron, Sophie and Coresh, Josef and Correa, Adolfo and Sarto, Gloria E and Key, Nigel S and Jacobs, David R and Kathiresan, Sekar and Bibbins-Domingo, Kirsten and Kshirsagar, Abhijit V and Wilson, James G and Reiner, Alexander P
JAMA, ISSN 0098-7484, 11/2014, Volume 312, Issue 20, pp. 2115 - 2125
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To describe the relationship between SCT... 
MEDICINE, GENERAL & INTERNAL | DESIGN | PREVALENCE | VARIANTS | RACIAL-DIFFERENCES | STAGE RENAL-DISEASE | Albuminuria - epidemiology | United States - epidemiology | Glomerular Filtration Rate | Prospective Studies | Sickle Cell Trait - ethnology | Humans | Middle Aged | Albuminuria - ethnology | Male | Risk | Albuminuria - genetics | Renal Insufficiency, Chronic - epidemiology | Young Adult | African Americans - statistics & numerical data | Renal Insufficiency, Chronic - ethnology | Renal Insufficiency, Chronic - genetics | Adult | Female | Aged | Sickle Cell Trait - epidemiology | Cohort Studies | Complications and side effects | Analysis | Sickle cell trait | African Americans | Albuminuria | Kidney diseases | Health aspects | Risk factors | Glomerular filtration rate | Sickle cell disease
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7. Full Text Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants
by Ito, Kaoru and Bick, Alexander G and Flannick, Jason and Friedman, David J and Genovese, Giulio and Parfenov, Michael G and DePalma, Steven R and Gupta, Namrata and Gabriel, Stacey B and Taylor, Herman A and Fox, Ervin R and Newton-Cheh, Christopher and Kathiresan, Sekar and Hirschhorn, Joel N and Altshuler, David M and Pollak, Martin R and Wilson, James G and Seidman, J.G and Seidman, Christine
Circulation Research, ISSN 0009-7330, 02/2014, Volume 114, Issue 5, pp. 845 - 850
RATIONALE:Two distinct alleles in the gene encoding apolipoprotein L1 (APOL1), a major component of high-density lipoprotein, confer protection against... 
epidemiology | risk factors | genetics | renal insufficiency | Atherosclerosis | continental population groups | chronic | atherosclerosis | KIDNEY-DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | RISK | PLAQUE | IMPACT | PERIPHERAL VASCULAR DISEASE | AFRICAN | HEMATOLOGY | ASSOCIATION | Genetic Predisposition to Disease - genetics | Lipoproteins, HDL - genetics | Atherosclerosis - genetics | Humans | Middle Aged | Risk Factors | African Americans - genetics | Male | Atherosclerosis - ethnology | Incidence | Genetic Variation | African Americans - statistics & numerical data | Renal Insufficiency, Chronic - ethnology | Apolipoproteins - genetics | Apolipoprotein L1 | Renal Insufficiency, Chronic - genetics | Adult | Female | Genetic Predisposition to Disease - ethnology | Aged | chronic kidney disease | race | ethnicity | genetic association | Genetics | cardiovascular genomics
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8. Full Text Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar
by Wen, Chi Pang and Matsushita, Kunihiro and Coresh, Josef and Iseki, Kunitoshi and Islam, Muhammad and Katz, Ronit and McClellan, William and Peralta, Carmen A and Wang, HaiYan and de Zeeuw, Dick and Astor, Brad C and Gansevoort, Ron T and Levey, Andrew S and Levin, Adeera and Chronic Kidney Dis Prognosis and Chronic Kidney Disease Prognosis Consortium
Kidney International, ISSN 0085-2538, 10/2014, Volume 86, Issue 4, pp. 819 - 827
Some suggest race-specific cutpoints for kidney measures to define and stage chronic kidney disease (CKD), but evidence for race-specific clinical impact is... 
chronic kidney disease | epidemiology and outcomes | ethnicity | end-stage renal disease | mortality risk | ASSOCIATIONS | PROTEINURIA | PREVALENCE | COLLABORATIVE METAANALYSIS | CKD-EPI EQUATION | INDIVIDUALS | GLOMERULAR-FILTRATION-RATE | ALL-CAUSE | CREATININE | UROLOGY & NEPHROLOGY | HIGHER ALBUMINURIA | Kidney Failure, Chronic - physiopathology | Glomerular Filtration Rate | Cardiovascular Diseases - ethnology | Humans | Middle Aged | Risk Factors | Albuminuria - ethnology | European Continental Ancestry Group - statistics & numerical data | Male | Creatinine - urine | Kidney Failure, Chronic - ethnology | Renal Insufficiency, Chronic - physiopathology | African Continental Ancestry Group - statistics & numerical data | Renal Insufficiency, Chronic - ethnology | Aged, 80 and over | Cardiovascular Diseases - mortality | Renal Insufficiency, Chronic - mortality | Adult | Female | Aged | Odds Ratio | Asian Continental Ancestry Group - statistics & numerical data | Cohort Studies
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9. Full Text Cytosine methylation predicts renal function decline in American Indians
by Qiu, Chengxiang and Hanson, Robert L and Fufaa, Gudeta and Kobes, Sayuko and Gluck, Caroline and Huang, Jing and Chen, Yong and Raj, Dominic and Nelson, Robert G and Knowler, William C and Susztak, Katalin
Kidney International, ISSN 0085-2538, 06/2018, Volume 93, Issue 6, pp. 1417 - 1431
Diabetic nephropathy accounts for most of the excess mortality in individuals with diabetes, but the molecular mechanisms by which nephropathy develops are... 
diabetic nephropathy | gene expression | Cell Cycle - genetics | Prognosis | Kidney - pathology | Epigenesis, Genetic | Humans | Middle Aged | Apoptosis - genetics | Male | Diabetic Nephropathies - diagnosis | Kidney Failure, Chronic - ethnology | Case-Control Studies | Albuminuria - physiopathology | DNA Methylation | Diabetic Nephropathies - physiopathology | Renal Insufficiency, Chronic - genetics | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Cytosine | Glomerular Filtration Rate - genetics | Energy Metabolism - genetics | Kidney - physiopathology | Kidney Failure, Chronic - physiopathology | Genetic Predisposition to Disease | Kidney Failure, Chronic - diagnosis | Risk Factors | Albuminuria - ethnology | Diabetic Nephropathies - genetics | Diabetic Nephropathies - ethnology | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Albuminuria - genetics | Kidney Failure, Chronic - genetics | Phenotype | Renal Insufficiency, Chronic - ethnology | Fibrosis | Indians, North American - genetics | CpG Islands | Aged | Renal function | Pathogenesis | Regulatory sequences | Hyperglycemia | Renal insufficiency | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | CpG islands | Creatinine | Kidneys | Epidermal growth factor receptors | DNA probes | Diabetes mellitus | Metabolism | Gene expression | Glomerular filtration rate | Studies | Molecular modelling | Nephropathy | Epigenetics | Diabetes | Kidney diseases | Methylation | Apoptosis | Diabetic nephropathy
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10. Full Text The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease
by Bosworth, Cortney R and Levin, Gregory and Robinson-Cohen, Cassianne and Hoofnagle, Andrew N and Ruzinski, John and Young, Bessie and Schwartz, Stephen M and Himmelfarb, Jonathan and Kestenbaum, Bryan and de Boer, Ian H
Kidney International, ISSN 0085-2538, 09/2012, Volume 82, Issue 6, pp. 693 - 700
Chronic kidney disease is characterized, in part, as a state of decreased production of 1,25-dihydroxyvitamin D (1,25(OH) D); however, this paradigm overlooks... 
chronic kidney disease | vitamin D | mineral metabolism | RAT | D METABOLISM | 1,25-DIHYDROXYCHOLECALCIFEROL | DYSREGULATION | UROLOGY & NEPHROLOGY | BIOLOGICAL ACTIVITY | 1,25-DIHYDROXYVITAMIN-D | 25-HYDROXYVITAMIN-D3 | EXPRESSION | CHRONIC-RENAL-FAILURE | Multivariate Analysis | Steroid Hydroxylases - metabolism | Prognosis | Humans | Middle Aged | African Americans | Male | Parathyroid Hormone - blood | Washington - epidemiology | Hyperparathyroidism, Secondary - ethnology | Mass Spectrometry | Renal Insufficiency, Chronic - mortality | Female | Kidney - physiopathology | Glomerular Filtration Rate | Cross-Sectional Studies | Risk Assessment | Comorbidity | Down-Regulation | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Linear Models | Vitamin D3 24-Hydroxylase | Biomarkers - blood | Renal Insufficiency, Chronic - physiopathology | Vitamin D - blood | Renal Insufficiency, Chronic - blood | Hyperparathyroidism, Secondary - blood | Hyperparathyroidism, Secondary - mortality | Renal Insufficiency, Chronic - ethnology | Vitamin D - analogs & derivatives | Aged
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11. Full Text Prevalence and correlates of CKD in hispanics/latinos in the United States
by Ricardo, Ana C and Flessner, Michael F and Eckfeldt, John H and Eggers, Paul W and Franceschini, Nora and Go, Alan S and Gotman, Nathan M and Kramer, Holly J and Kusek, John W and Loehr, Laura R and Melamed, Michal L and Peralta, Carmen A and Raij, Leopoldo and Rosas, Sylvia E and Talavera, Gregory A and Lash, James P
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 10/2015, Volume 10, Issue 10, pp. 1757 - 1766
Background and objectives The prevalence of ESRD among Hispanics/Latinos is 2-fold higher than in non-Hispanic whites. However, little is known about the... 
CREATININE | UROLOGY & NEPHROLOGY | RENAL-INSUFFICIENCY COHORT | US ADULTS | AMERICANS | AFRICAN | HEALTH | CHRONIC KIDNEY-DISEASE | AWARENESS | PROGRESSION | CARDIOVASCULAR RISK-FACTORS | United States - epidemiology | Puerto Rico - ethnology | Central America - ethnology | Prevalence | Prospective Studies | Cardiovascular Diseases - ethnology | Nutrition Surveys | Humans | Middle Aged | Hispanic Americans - statistics & numerical data | Male | Renal Insufficiency, Chronic - epidemiology | Young Adult | Mexico - ethnology | South America - ethnology | Adult | Female | Glomerular Filtration Rate | Poverty | Cross-Sectional Studies | Cuba - ethnology | Risk Factors | European Continental Ancestry Group - statistics & numerical data | Dominican Republic - ethnology | Renal Insufficiency, Chronic - physiopathology | Renal Insufficiency, Chronic - ethnology | Adolescent | Sex Factors | Diabetes Mellitus - ethnology | Aged | prevalence | Original | CKD | Hispanics
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