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1. Full Text Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress
by Macheret, Morgane and Halazonetis, Thanos D
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7694, pp. 112 - 116
Oncogene-induced DNA replication stress contributes critically to the genomic instability that is present in cancer(1-4). However, elucidating how oncogenes... 
CYCLIN-E | INSTABILITY | CANCER DEVELOPMENT | INITIATION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION UNITS | FRAGILE SITES | COPY-NUMBER ALTERATION | INDUCED SENESCENCE | GENOME | Oncogene Proteins - genetics | Oncogenes - genetics | Chromosome Breakpoints | Humans | Gene Expression Regulation, Neoplastic | Cyclin E - genetics | DNA Breaks, Double-Stranded | S Phase - genetics | DNA - genetics | Replication Origin - genetics | Neoplasms - genetics | Genes, myc - genetics | Cell Line, Tumor | DNA Replication - genetics | DNA - biosynthesis | Female | Cyclin E - metabolism | G1 Phase - genetics | Transcription, Genetic - genetics | Genomic Instability - genetics | Cohort Studies | Translocation, Genetic - genetics | Genetic research | DNA replication | Genetic aspects | Research | Oncogenes | Cell cycle | Stresses | Origins | Breakpoints | Deregulation | Firing | Stability | Transcription | Genes | DNA damage | Replication initiation | Genomes | Myc protein | Stress | Genomic instability | DNA biosynthesis | Replication origins | S phase | Replication | Instability | Dihydrofolate reductase | Gene mapping | Deoxyribonucleic acid--DNA | Cancer
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2. Full Text A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan
by Kwan, Elizabeth X and Foss, Eric J and Tsuchiyama, Scott and Alvino, Gina M and Kruglyak, Leonid and Kaeberlein, Matt and Raghuraman, M.K and Brewer, Bonita J and Kennedy, Brian K and Bedalov, Antonio
PLoS Genetics, ISSN 1553-7390, 2013, Volume 9, Issue 3, p. e1003329
Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative... 
RECOMBINATION | RNA-POLYMERASE-I | GENE | BUDDING YEAST | INITIATION | RIBOSOMAL DNA REPEATS | CHROMOSOME-VI | TRANSCRIPTION | GENETICS & HEREDITY | EXTENSION | SACCHAROMYCES-CEREVISIAE | Saccharomyces cerevisiae - physiology | Caloric Restriction | Saccharomyces cerevisiae - genetics | DNA, Ribosomal - physiology | Longevity - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Polymorphism, Genetic | Saccharomyces cerevisiae - metabolism | Sirtuin 2 - genetics | Replication Origin - genetics | Aging - genetics | DNA Replication - genetics | Gene Expression Regulation, Fungal - genetics | DNA, Ribosomal - genetics | Quantitative Trait Loci - genetics | Quantitative genetics | DNA replication | Physiological aspects | Genetic aspects | Research | Recombinant DNA | Brewer's yeast | Health aspects | Genetic polymorphisms | Proteins | Yeast | Microbiology | Plasmids | Deoxyribonucleic acid | DNA | Aging
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3. Full Text Eukaryotic DNA replication origins: many choices for appropriate answers
by Méchali, Marcel
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 10/2010, Volume 11, Issue 10, pp. 728 - 738
At each cell division in humans, 30,000-50,000 DNA replication origins are activated, and it remains unclear how they are selected and recognized by... 
XENOPUS EGG EXTRACTS | FISSION YEAST | GENOME-WIDE DISTRIBUTION | RECOGNITION COMPLEX ORC | SEQUENCE SPECIFICITY | HUMAN-CELLS | VERTEBRATE S-PHASE | SACCHAROMYCES-CEREVISIAE | MAMMALIAN-CELLS | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | Cell Division - genetics | Replication Origin - genetics | Animals | Xenopus - genetics | DNA Replication | Transcription, Genetic | DNA Damage | Eukaryotic Cells - physiology | Genome | Drosophila - genetics | DNA synthesis | Eukaryotes | DNA replication | Genetic aspects | Research | Life Sciences | Genetics
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4. Full Text The origin of genetic diversity in HIV-1
by Smyth, Redmond P and Davenport, Miles P and Mak, Johnson
Virus Research, ISSN 0168-1702, 11/2012, Volume 169, Issue 2, pp. 415 - 429
► Most HIV infections are initiated from a single particle, yet near the end stages of disease the genetic diversity of the quasispecies within the infected... 
Retrovirus | Recombination | Pathogenesis | Evolution | Mutation | Diversification | Drug resistance | Immune escape | MULTIPLY INFECTED-CELLS | MACROPHAGE-TROPIC HIV-1 | MURINE LEUKEMIA-VIRUS | HUMAN-IMMUNODEFICIENCY-VIRUS | VIROLOGY | TYPE-1 REVERSE-TRANSCRIPTASE | COPY-CHOICE RECOMBINATION | VIVO MUTATION-RATE | ACTIVE ANTIRETROVIRAL THERAPY | DRUG-RESISTANCE MUTATIONS | URACIL DNA GLYCOSYLASE | Genetic Variation | Host-Pathogen Interactions | HIV Reverse Transcriptase - metabolism | HIV-1 - physiology | APOBEC-1 Deaminase | Recombination, Genetic | Cytidine Deaminase - metabolism | HIV-1 - enzymology | HIV-1 - genetics | Reverse Transcription | Influenza viruses | Genetic research | Universities and colleges | HIV (Viruses) | Health aspects | HIV infection | Biological diversity | Enzymes | RNA-directed DNA polymerase | antiretroviral therapy | Genetic diversity | Genomes | Vaccines | nucleic acids | Population genetics | Infection | Life cycle | Replication | Immune system
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5. Full Text Unearthing worm replication origins
by Sasaki, Takayo and Gilbert, David M
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2017, Volume 24, Issue 3, pp. 195 - 196
Unlike in animals in which gastrulation marks the onset of zygotic transcription and a transition from random to site-specific localization of replication... 
TRANSITION | BIOPHYSICS | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SPECIFICATION | LOCUS | GENOME | DNA-REPLICATION | CELL BIOLOGY | Animals | Caenorhabditis elegans - genetics | Gene Expression Regulation, Developmental | Models, Biological | Replication Origin | DNA Replication | Caenorhabditis elegans - embryology | Animal development | DNA replication | Gastrulation | Genetic research | Models | Genetic aspects | Research | Animal reproduction | Worms
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6. Full Text Conserved nucleosome positioning defines replication origins
by Eaton, Matthew L and Galani, Kyriaki and Kang, Sukhyun and Bell, Stephen P and MacAlpine, David M
Genes and Development, ISSN 0890-9369, 04/2010, Volume 24, Issue 8, pp. 748 - 753
The origin recognition complex (ORC) specifies replication origin location. The Saccharomyces cerevisiae ORC recognizes the ARS (autonomously replicating... 
Chromatin | DNA replication | Nucleosome | Origin recognition complex (ORC) | ORC | COMPLEX | MCM PROTEINS | CHROMATIN-STRUCTURE | INITIATION | origin recognition complex (ORC) | DEVELOPMENTAL BIOLOGY | chromatin | SACCHAROMYCES-CEREVISIAE | GENOME | DNA-REPLICATION | CELL BIOLOGY | SEQUENCE | GENETICS & HEREDITY | nucleosome | BINDING | Nucleosomes - genetics | Replication Origin - genetics | Sequence Analysis | Chromosomes, Fungal - genetics | Genome, Fungal - genetics | Saccharomyces cerevisiae - genetics | Usage | Yeast fungi | Nucleosomes | Genetic aspects | Research | Nucleotide sequencing | Research Communication
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7. Full Text Genetic and epigenetic determinants of DNA replication origins, position and activation
by Méchali, Marcel and Yoshida, Kazumasa and Coulombe, Philippe and Pasero, Philippe
Current Opinion in Genetics & Development, ISSN 0959-437X, 2013, Volume 23, Issue 2, pp. 124 - 131
In the genome of eukaryotic cells, DNA synthesis is initiated at multiple sites called origins of DNA replication. Origins must fire only once per cell cycle... 
Medical Education | RECOGNITION COMPLEX | CHROMOSOME | TIMING DOMAINS | PROTEIN | CHROMATIN | INITIATION | HETEROCHROMATIN | GENETICS & HEREDITY | GENOME-WIDE | BAH DOMAIN | REVEALS | CELL BIOLOGY | Saccharomyces cerevisiae - metabolism | Replication Origin - genetics | Eukaryota - genetics | Cell Cycle | Epigenesis, Genetic - genetics | Saccharomyces cerevisiae - genetics | Humans | DNA Replication - genetics | Nucleosomes - genetics | Genome | Chromatin - genetics | Replicon - genetics | Genetic research | DNA synthesis | DNA replication | Genomics | DNA | Life Sciences | Genetics
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8. Full Text Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
by Besnard, Emilie and Babled, Amélie and Lapasset, Laure and Milhavet, Ollivier and Parrinello, Hugues and Dantec, Christelle and Marin, Jean-Michel and Lemaitre, Jean-Marc
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2012, Volume 19, Issue 8, pp. 837 - 844
DNA replication is highly regulated, ensuring faithful inheritance of genetic information through each cell cycle. In metazoans, this process is initiated at... 
ACTIVATION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | EUKARYOTIC DNA-REPLICATION | PATTERNS | REPLICON | LOCUS | CELL BIOLOGY | ORGANIZATION | BIOPHYSICS | SEQUENCE | GENOME-WIDE | Consensus Sequence | Cell Line | Replication Origin - genetics | Nucleotide Motifs | Base Sequence | Humans | DNA Replication - genetics | G-Quadruplexes | Chromosome Mapping | DNA Primers - genetics | HeLa Cells | Genome, Human | Physiological aspects | DNA replication | Research | G proteins | Molecular genetics | DNA | Genetics | DNA repair | Cells | Statistics | Mathematics
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9. Full Text The gastrula transition reorganizes replication-origin selection in Caenorhabditis elegans
by Rodríguez-Martínez, Marta and Pinzón, Natalia and Ghommidh, Charles and Beyne, Emmanuelle and Seitz, Hervé and Cayrou, Christelle and Méchali, Marcel
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2017, Volume 24, Issue 3, pp. 290 - 299
Although some features underlying replication-origin activation in metazoan cells have been determined, little is known about their regulation during metazoan... 
DROSOPHILA-MELANOGASTER | RESTRICTION FRAGMENTS | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-REPLICATION | CELL BIOLOGY | TO-ZYGOTIC TRANSITION | BIOPHYSICS | START SITES | S-PHASE | C-ELEGANS | COMPLEX GENOMES | RNA-POLYMERASE | Inverted Repeat Sequences - genetics | Chromatin - metabolism | Caenorhabditis elegans - metabolism | Embryo, Nonmammalian - metabolism | Embryonic Development - genetics | Caenorhabditis elegans - embryology | Operon - genetics | Replication Origin - genetics | Animals | Base Sequence | Chromosomes - metabolism | CpG Islands - genetics | DNA Replication - genetics | Gastrula - metabolism | Transcription, Genetic | Enhancer Elements, Genetic - genetics | Histones - metabolism | Embryonic development | Caenorhabditis elegans | Gastrulation | Synthesis | Genetic research | Genetic aspects | Research | Nucleic acids | Observations | Cellular biology | Embryos | Genes | Life Sciences | Genetics
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