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Genes and Development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins:... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | NUCLEASE ACTIVITY | BLOOMS-SYNDROME HELICASE | HUMAN EXONUCLEASE 1 | ESCHERICHIA-COLI | MISMATCH REPAIR | DEVELOPMENTAL BIOLOGY | DOUBLE-STRAND BREAK | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | homologous recombination | GENETICS & HEREDITY | MRE11 NUCLEASE | MITOTIC RECOMBINATION | RECQ HELICASE | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Research Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. E3495 - E3504
Damage repair mechanisms at transcriptionally active sites during the G0/G1 phase are largely unknown. To elucidate these mechanisms, we introduced genome... 
Dna damage | Recombination | CSB | Transcription | RNA polymerase II | COMPLEX | recombination | PROTEIN | transcription | DNA damage | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | PREFERENTIAL REPAIR | CHROMOSOMES | 8-OXOGUANINE | GENE | DEGRADATION | Cell Cycle - genetics | Antigens, Nuclear - metabolism | Humans | DNA Repair Enzymes - genetics | Homologous Recombination | RNA - genetics | Cockayne Syndrome - pathology | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | RNA Interference | Rad52 DNA Repair and Recombination Protein - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | HEK293 Cells | Cell Cycle Proteins - genetics | Transcription, Genetic | G1 Phase - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RNA - metabolism | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | Cockayne Syndrome - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Blotting, Western | Rad52 DNA Repair and Recombination Protein - genetics | DNA Helicases - metabolism | Microscopy, Confocal | Antigens, Nuclear - genetics | Resting Phase, Cell Cycle - genetics | Ku Autoantigen | DNA Repair | Cockayne Syndrome - genetics | Cell Line, Tumor | Models, Genetic | DNA Damage | HeLa Cells | Physiological aspects | Observations | Genetic recombination | RNA polymerases | Biological Sciences | PNAS Plus
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2013, Volume 50, Issue 4, pp. 589 - 600
Replication protein A (RPA) is an essential eukaryotic single-stranded DNA binding protein with a central role in DNA metabolism. RPA directly participates in... 
POLYMERASE-DELTA | DAMAGE CHECKPOINT | BIOCHEMISTRY & MOLECULAR BIOLOGY | YEAST RAD52 PROTEIN | REPLICATION-PROTEIN-A | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | CHECKPOINT ACTIVATION | PRESYNAPTIC COMPLEX-FORMATION | SACCHAROMYCES-CEREVISIAE | MEIOTIC RECOMBINATION | CELL BIOLOGY | DNA, Fungal - genetics | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | RecQ Helicases - genetics | DNA, Fungal - chemistry | DNA Breaks, Double-Stranded | DNA-Directed DNA Polymerase - genetics | DNA, Single-Stranded - genetics | Saccharomyces cerevisiae - metabolism | Replication Protein A - genetics | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - genetics | Nucleic Acid Conformation | DNA Helicases - genetics | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | DNA, Single-Stranded - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | DNA, Single-Stranded - chemistry | DNA Helicases - metabolism | Endodeoxyribonucleases - genetics | DNA Repair | DNA, Fungal - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Luminescent Proteins - genetics | Models, Genetic | DNA-Directed DNA Polymerase - metabolism | Mutation | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA synthesis | Surgery | Genomics | DNA | Protein binding
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 01/2014, Volume 204, Issue 1, pp. 45 - 59
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2009, Volume 11, Issue 8, pp. 980 - 987
The ends of linear eukaryotic chromosomes are protected by telomeres, which serve to ensure proper chromosome replication and to prevent spurious recombination... 
REPAIR | KU HETERODIMER | COLOCALIZATION | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | S-PHASE | YEAST TELOMERES | BINDING PROTEIN | SACCHAROMYCES-CEREVISIAE | G-TAILS | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Recombinant Fusion Proteins - metabolism | DNA, Single-Stranded - genetics | Nuclear Pore Complex Proteins - genetics | Saccharomyces cerevisiae - metabolism | Haploidy | Telomere-Binding Proteins - genetics | Telomerase - genetics | Chromatin Immunoprecipitation | Rad52 DNA Repair and Recombination Protein - metabolism | Replication Protein A - genetics | S Phase | Cell Cycle Proteins - genetics | G2 Phase | Telomerase - metabolism | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Telomere - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA Repair | Adaptor Proteins, Signal Transducing - genetics | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | DNA Damage | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA replication | Research | Telomerase | DNA damage | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 206, Issue 4, pp. 493 - 507
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 5, pp. 622 - 634.e8
RFWD3 is a recently identified Fanconi anemia protein FANCW whose E3 ligase activity toward RPA is essential in homologous recombination (HR) repair. However,... 
RPA | RAD51 | Fanconi anemia | homologous recombination | RFWD3 | ICL repair | BRCA2 | E3 LIGASE | REPLICATION FORK STABILITY | COMPLEX | FANCD2 | CROSS-LINK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | UBIQUITYLATION | PROTEIN-A RPA | END RESECTION | FANCONI-ANEMIA | ASSOCIATION | CELL BIOLOGY | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Minichromosome Maintenance Proteins - metabolism | Valosin Containing Protein | Ubiquitination | Transfection | RNA Interference | Fanconi Anemia - enzymology | Proteolysis | Replication Protein A - genetics | Cell Cycle Proteins - genetics | Fanconi Anemia - genetics | Binding Sites | Chromatin - drug effects | Recombinational DNA Repair - drug effects | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Replication Protein A - metabolism | DNA - metabolism | Mitomycin - pharmacology | DNA - genetics | Chromatin - radiation effects | Cell Line, Tumor | Protein Binding | Recombinational DNA Repair - radiation effects | Chromatin - enzymology | Adenosine Triphosphatases - genetics | DNA Damage | Mutation | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Chromatin - genetics | Ubiquitin | Biotechnology | Medical colleges | Chromatin | Mitomycin | Ligases | DNA damage | DNA | Physiological aspects | Genetic research | Fanconi's anemia
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 19, pp. 2452 - 2462
Journal Article