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Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6219, pp. 273 - 277
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination... 
GLIOBLASTOMA | REPEAT-CONTAINING RNA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | POLYMERASE | CHROMOSOME ENDS | SINGLE-STRANDED-DNA | HOMOLOGOUS RECOMBINATION | MUTATIONS | TUMORS | DISCOVERY | Osteosarcoma - drug therapy | Ataxia Telangiectasia Mutated Proteins - metabolism | RNA, Untranslated - metabolism | Humans | Homologous Recombination | X-linked Nuclear Protein | Telomere - drug effects | Sulfones - pharmacology | RNA, Untranslated - genetics | Gene Knockdown Techniques | Glioma - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Telomere - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Telomere Homeostasis | Transcription Factors - metabolism | DNA Helicases - metabolism | Cell Cycle | Cell Line, Tumor | Telomeric Repeat Binding Protein 2 - metabolism | HeLa Cells | Osteosarcoma - genetics | Pyrazines - pharmacology | Glioma - drug therapy | Promyelocytic Leukemia Protein | Apoptosis | Telomeres | Protein research | Cell research | Cancer cells | Cell cycle | Genetic aspects | Research | Health aspects | Enzymes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Proteins | Inhibitors | Deoxyribonucleic acid | Kinases | Chromosomes | Telomerase | Tumors
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2009, Volume 28, Issue 21, pp. 3413 - 3427
Homologous recombination (HR) and non‐homologous end joining (NHEJ) represent distinct pathways for repairing DNA double‐strand breaks (DSBs). Previous work... 
ataxia telangiectasia | Artemis | homologous recombination | double‐strand breaks | non‐homologous end joining | Double-strand breaks | Ataxia telangiectasia | Homologous recombination | Non-homologous end joining | BIOCHEMISTRY & MOLECULAR BIOLOGY | double-strand breaks | MAMMALIAN-CELLS | CELL BIOLOGY | REPLICATION FORKS | IN-VIVO | non-homologous end joining | GENE CONVERSION | DIRECTED REPAIR | CELL-CYCLE | END RESECTION | IONIZING-RADIATION | DSB REPAIR | SISTER-CHROMATID EXCHANGES | Humans | DNA Breaks, Double-Stranded - radiation effects | DNA-Binding Proteins - metabolism | Heterochromatin - metabolism | Gene Deletion | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | G2 Phase - radiation effects | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | DNA Helicases | Apoptosis Regulatory Proteins | BRCA2 Protein - metabolism | Fibroblasts - radiation effects | G1 Phase - radiation effects | Endonucleases | HeLa Cells | Proteins | Molecular biology | Genetic recombination | DNA repair | Radiation | Index Medicus
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2012, Volume 40, Issue 21, pp. 10780 - 10794
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2009, Volume 11, Issue 8, pp. 980 - 987
The ends of linear eukaryotic chromosomes are protected by telomeres, which serve to ensure proper chromosome replication and to prevent spurious recombination... 
REPAIR | KU HETERODIMER | COLOCALIZATION | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | S-PHASE | YEAST TELOMERES | BINDING PROTEIN | SACCHAROMYCES-CEREVISIAE | G-TAILS | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Recombinant Fusion Proteins - metabolism | DNA, Single-Stranded - genetics | Nuclear Pore Complex Proteins - genetics | Saccharomyces cerevisiae - metabolism | Haploidy | Telomere-Binding Proteins - genetics | Telomerase - genetics | Chromatin Immunoprecipitation | Rad52 DNA Repair and Recombination Protein - metabolism | Replication Protein A - genetics | S Phase | Cell Cycle Proteins - genetics | G2 Phase | Telomerase - metabolism | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Telomere - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA Repair | Adaptor Proteins, Signal Transducing - genetics | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | DNA Damage | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA replication | Research | Telomerase | DNA damage | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7275, pp. 935 - 939
Journal Article
Genes and Development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins:... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | NUCLEASE ACTIVITY | BLOOMS-SYNDROME HELICASE | HUMAN EXONUCLEASE 1 | ESCHERICHIA-COLI | MISMATCH REPAIR | DEVELOPMENTAL BIOLOGY | DOUBLE-STRAND BREAK | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | homologous recombination | GENETICS & HEREDITY | MRE11 NUCLEASE | MITOTIC RECOMBINATION | RECQ HELICASE | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Index Medicus | Research Paper
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2013, Volume 50, Issue 4, pp. 589 - 600
Replication protein A (RPA) is an essential eukaryotic single-stranded DNA binding protein with a central role in DNA metabolism. RPA directly participates in... 
POLYMERASE-DELTA | DAMAGE CHECKPOINT | BIOCHEMISTRY & MOLECULAR BIOLOGY | YEAST RAD52 PROTEIN | REPLICATION-PROTEIN-A | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | CHECKPOINT ACTIVATION | PRESYNAPTIC COMPLEX-FORMATION | SACCHAROMYCES-CEREVISIAE | MEIOTIC RECOMBINATION | CELL BIOLOGY | DNA, Fungal - genetics | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | RecQ Helicases - genetics | DNA, Fungal - chemistry | DNA Breaks, Double-Stranded | DNA-Directed DNA Polymerase - genetics | DNA, Single-Stranded - genetics | Saccharomyces cerevisiae - metabolism | Replication Protein A - genetics | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - genetics | Nucleic Acid Conformation | DNA Helicases - genetics | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | DNA, Single-Stranded - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | DNA, Single-Stranded - chemistry | DNA Helicases - metabolism | Endodeoxyribonucleases - genetics | DNA Repair | DNA, Fungal - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Luminescent Proteins - genetics | Models, Genetic | DNA-Directed DNA Polymerase - metabolism | Mutation | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA synthesis | Surgery | Genomics | DNA | Protein binding | Index Medicus
Journal Article