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American journal of hematology, ISSN 0361-8609, 03/2012, Volume 87, Issue 3, pp. 245 - 250
Chronic myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) have an inherent tendency to progress to acute myeloid leukemia (AML). Using... 
HISTONE METHYLTRANSFERASE ACTIVITY | GROUP GENE EZH2 | TARGET | COMPLEX | PROTEIN | PRC2 | MYELOPROLIFERATIVE NEOPLASMS | HEMATOLOGY | TRANSCRIPTION FACTOR | POLYCOMB | SOMATIC MUTATIONS | Oligonucleotide Array Sequence Analysis | Humans | Leukemia, Myeloid - genetics | Neoplasm Proteins - physiology | Nerve Tissue Proteins - deficiency | Transcription Factors - deficiency | Male | Myeloproliferative Disorders - genetics | DNA-Binding Proteins - deficiency | Repressor Proteins - physiology | Repressor Proteins - deficiency | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - deficiency | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Female | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Genes, Tumor Suppressor | Chromosome Deletion | Acute Disease | Nerve Tissue Proteins - physiology | Repressor Proteins - genetics | Genotype | Chromosome Mapping | Polycomb-Group Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Chromosomes, Human, Pair 6 - genetics | Disease Progression | Enhancer of Zeste Homolog 2 Protein | Carrier Proteins - genetics | Tumor Suppressor Proteins - physiology | Polycomb Repressive Complex 2 | Chromosome Aberrations | Aged | Myelodysplastic Syndromes - genetics | Neoplasm Proteins - deficiency | Chromosomes, Human, Pair 6 - ultrastructure
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7290, pp. 927 - 931
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 544, Issue 7651, pp. 503 - 507
Journal Article
PLoS pathogens, ISSN 1553-7374, 2018, Volume 14, Issue 8, p. e1007264
.... Surprisingly, using the infected cell protein 0 (ICP0)-deleted HSV1 (HSV1-dICP0), we found that asTORi markedly augment infection in cancer cells and a mouse mammary cancer xenograft... 
RAPAMYCIN | IMMUNE-RESPONSE | MESSENGER-RNA TRANSLATION | MYXOMA-VIRUS | ACTIVATION | INITIATION | ONCOLYTIC VIROTHERAPY | MICROBIOLOGY | RESISTANT | HERPES-SIMPLEX-VIRUS | INTERFERON | VIROLOGY | PARASITOLOGY | Catalytic Domain - drug effects | Humans | Cercopithecus aethiops | Eukaryotic Initiation Factor-4E - metabolism | Phosphoproteins - metabolism | Herpes Simplex - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplasms - complications | Neoplasms - virology | Neoplasms - genetics | HEK293 Cells | Immediate-Early Proteins - deficiency | Gene Expression Regulation, Neoplastic - drug effects | Organisms, Genetically Modified | Eukaryotic Initiation Factor-4E - genetics | Vero Cells | Cells, Cultured | Signal Transduction - genetics | Phosphoproteins - genetics | Herpesvirus 1, Human - drug effects | Animals | Immediate-Early Proteins - genetics | TOR Serine-Threonine Kinases - chemistry | Herpes Simplex - pathology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Herpes Simplex - complications | Herpesvirus 1, Human - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Physiological aspects | Genetic aspects | Research | Genetic regulation | Herpes simplex virus | Cancer cells | TOR protein | Transplants & implants | Funding | Xenotransplantation | Herpes simplex | Viruses | Genomes | mRNA | Infections | Biochemistry | Kinases | Proteins | Immunology | Repressors | Transformed cells | Immunotherapy | Xenografts | Oncolysis | Inhibition | Supervision | Medical research | Protein biosynthesis | Rapamycin | Pharmacology | Children & youth | Infectious diseases | Inhibitors | Protein synthesis | Herpes viruses | Replication | Initiation factor eIF-4E | Tumors | Cancer | TOR Serine-Threonine Kinases/antagonists & inhibitiors | Herpes Simplex/genetics | Herpes Simplex/pathology | Neoplasms/pathology | Eukaryotic Initiation Factor-4E/genetics | Ubiquitin-Protein Ligases/deficiency | Immediate-Early Proteins/genetics | Neoplasms/genetics | Herpes Simplex/complications | Life Sciences | Eukaryotic Initiation Factor-4E/metabolism | Neoplasms/complications | Herpesvirus 1, Human/genetics | Catalytic Domain/drug effects | Signal Transduction/genetics | Adaptator Proteins, Signal Transducing/genetics | Gene Expression Regulation, Neoplastic/drug effects | Phosphoproteins/genetics | Adaptator Proteins, Signal Transducing/metabolism | Immediate-Early Proteins/deficiency | Phosphoproteins/metabolims | TOR Serine-Threonine Kinases/chemistry | Protein Kinase Inhibitors/pharmacology | Herpesvirus 1, Human/drug effects | Ubiquitin-Protein Ligases/genetics | Neoplasms/virology
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 6, p. e97090
.... Bcl6 deficiency was accompanied by decreased hepatic expression... 
GERMINAL CENTER FORMATION | PPAR-ALPHA | ACID SYNTHASE PROMOTER | GROWTH-HORMONE | REGULATED TRANSCRIPTION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ADIPOCYTE DIFFERENTIATION | ELEMENT-BINDING PROTEIN | HEPATIC STEATOSIS | Serum - metabolism | Male | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Lipogenesis - genetics | Repressor Proteins - deficiency | Fasting - blood | Female | Lipid Metabolism - genetics | Transcription, Genetic | Nuclear Proteins - genetics | Fatty Acids - metabolism | Repressor Proteins - metabolism | Oxidation-Reduction | Liver - metabolism | Adipose Tissue - pathology | Gene Expression Regulation | Organ Size | Suppressor of Cytokine Signaling Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | Metabolome - genetics | Mice, Knockout | Triglycerides - metabolism | Transcription Factors - metabolism | Animals | Suppressor of Cytokine Signaling Proteins - metabolism | Proto-Oncogene Proteins c-bcl-6 | Adipose tissues | Enzymes | Synthesis | Physiological aspects | Lymphomas | Genetic aspects | Triglycerides | B cells | Genetic transcription | Fatty acids | Protein binding | Transcription factors | Adipose tissue | Liver | Genes | Lipids | Biosynthesis | Adipocytes | Desaturase | Thymus | Proteins | Immunology | Rodents | Animal tissues | Physiology | Lipid metabolism | Spleen | Carbohydrates | Cytokines | Immunoregulation | Muscles | Stearoyl-CoA desaturase | Metabolism | Gene expression | Lymphoma | Fatty-acid synthase | Signaling | Lymphocytes B | Mice | Molecular biology | Bcl-6 protein
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 485, Issue 7396, pp. 123 - 127
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 544, Issue 7649, pp. 245 - 249
Normal differentiation and induced reprogramming require the activation of target cell programs and silencing of donor cell programs(1,2). In reprogramming,... 
FINGER TRANSCRIPTION FACTORS | NERVOUS-SYSTEM | CELLS | MULTIDISCIPLINARY SCIENCES | GENES | DIFFERENTIATION | LATERAL INHIBITION | EXPRESSION | BINDING | FIBROBLASTS | FAMILY | Chromatin - metabolism | Brain - embryology | Humans | Nerve Tissue Proteins - deficiency | Transcription Factors - deficiency | Neurons - cytology | Brain - metabolism | Neurogenesis - genetics | Organ Specificity - genetics | Repressor Proteins - deficiency | Protein Domains | Neurons - metabolism | Receptors, Notch - deficiency | Cellular Reprogramming - genetics | Cell Lineage - genetics | Repressor Proteins - metabolism | Fibroblasts - metabolism | Animals, Newborn | Brain - cytology | Repressor Proteins - chemistry | Signal Transduction | Cells, Cultured | Gene Silencing | Transcription Factor HES-1 - deficiency | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Fibroblasts - cytology | Mice | Chromatin - genetics | Protein research | Research | Genetic transcription | Neurons | Myelin proteins | Proteins | Studies | Transcription factors | Ontology | Fibroblasts | Physiology | Mutation | Gene expression | Growth factors | Binding sites | Deoxyribonucleic acid--DNA | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 489, Issue 7415, pp. 313 - 317
Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL1,2 for nearly 60... 
SISTER-CHROMATID COHESION | NIPPED-B | COMPLEX | NIPBL | HUMAN GENOME | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | X-CHROMOSOME-INACTIVATION | S-PHASE | PROTEINS | BINDING | Chromatin - metabolism | Chondroitin Sulfate Proteoglycans - chemistry | Humans | Crystallography, X-Ray | Male | Phosphoproteins - metabolism | Cell Cycle Proteins - chemistry | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | De Lange Syndrome - metabolism | Fibroblasts | Female | Transcription, Genetic | Acetylation | Binding Sites | Repressor Proteins - metabolism | De Lange Syndrome - genetics | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | Histone Deacetylases - genetics | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Histone Deacetylases - chemistry | Histone Deacetylases - deficiency | Mutant Proteins - genetics | Prophase | Models, Molecular | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Mutation - genetics | Proteins - genetics | Mutant Proteins - chemistry | Protein Conformation | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Anaphase | Chromatin - genetics | Chromosomal Proteins, Non-Histone - chemistry | Genetics | De Lange syndrome | Genetic aspects | Research | Mutation (Biology) | Proteins | Cell culture | Genes | Cell cycle | Mutation | Females | Chromosomes | Crystal structure | Chromatin | Repressor Proteins | Life Sciences | Phosphoproteins | Chromosomal Proteins, Non-Histone | Histone Deacetylases | De Lange Syndrome | Chondroitin Sulfate Proteoglycans | Nuclear Proteins | Mutant Proteins | Adaptor Proteins, Signal Transducing | Development Biology | Cell Cycle Proteins
Journal Article
Journal Article