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Journal of the American Society of Nephrology, ISSN 1046-6673, 12/2015, Volume 26, Issue 12, pp. 2963 - 2977
Expression of thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidoreductase thioredoxin, is augmented by high glucose (HG) and... 
OXIDATIVE STRESS | INFLAMMASOME ACTIVATION | MITOCHONDRIAL-FUNCTION | MESANGIAL CELLS | HIGH GLUCOSE | UROLOGY & NEPHROLOGY | COMPLICATIONS | BETA-CELL MASS | KIDNEY | EXPRESSION | NADPH OXIDASES | Oxidative Stress | Apoptosis - drug effects | Cystatin C - blood | Streptozocin | NADPH Oxidases - metabolism | RNA, Messenger - analysis | Apoptosis - genetics | Interleukin-1beta - genetics | Repressor Proteins - analysis | Membrane Proteins - analysis | Oxygen - metabolism | Thioredoxins - genetics | Mitochondria - genetics | Glomerular Basement Membrane - pathology | NADPH Oxidases - genetics | Thioredoxins - metabolism | Diabetes Mellitus, Experimental - chemically induced | Transforming Growth Factor beta1 - analysis | Diabetes Mellitus, Experimental - metabolism | Podocytes - chemistry | Antigens, Differentiation - analysis | Albuminuria - etiology | Diabetic Nephropathies - metabolism | Cells, Cultured | Glucose - pharmacology | Mitochondria - metabolism | Kidney Glomerulus - pathology | Mitochondria - drug effects | NADPH Oxidase 4 | Podocytes - pathology | Collagen Type IV - analysis | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Podocytes - drug effects | Fibrosis | Creatinine - blood | Mice | Kidney Glomerulus - chemistry | Index Medicus | Life Sciences | diabetes mellitus | diabetic nephropathy | oxidative stress | Basic Research
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7651, pp. 503 - 507
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7415, pp. 313 - 317
Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL1,2 for... 
SISTER-CHROMATID COHESION | NIPPED-B | COMPLEX | NIPBL | HUMAN GENOME | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | X-CHROMOSOME-INACTIVATION | S-PHASE | PROTEINS | BINDING | Chromatin - metabolism | Chondroitin Sulfate Proteoglycans - chemistry | Humans | Crystallography, X-Ray | Male | Phosphoproteins - metabolism | Cell Cycle Proteins - chemistry | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | De Lange Syndrome - metabolism | Fibroblasts | Female | Transcription, Genetic | Acetylation | Binding Sites | Repressor Proteins - metabolism | De Lange Syndrome - genetics | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | Histone Deacetylases - genetics | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Histone Deacetylases - chemistry | Histone Deacetylases - deficiency | Mutant Proteins - genetics | Prophase | Models, Molecular | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Mutation - genetics | Proteins - genetics | Mutant Proteins - chemistry | Protein Conformation | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Anaphase | Chromatin - genetics | Chromosomal Proteins, Non-Histone - chemistry | Genetics | De Lange syndrome | Genetic aspects | Research | Mutation (Biology) | Proteins | Cell culture | Genes | Cell cycle | Mutation | Females | Chromosomes | Crystal structure | Index Medicus | Chromatin | Repressor Proteins | Life Sciences | Phosphoproteins | Chromosomal Proteins, Non-Histone | Histone Deacetylases | De Lange Syndrome | Chondroitin Sulfate Proteoglycans | Nuclear Proteins | Mutant Proteins | Adaptor Proteins, Signal Transducing | Development Biology | Cell Cycle Proteins
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7396, pp. 123 - 127
Journal Article
American Journal of Hematology, ISSN 0361-8609, 03/2012, Volume 87, Issue 3, pp. 245 - 250
Chronic myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) have an inherent tendency to progress to acute myeloid leukemia (AML). Using... 
HISTONE METHYLTRANSFERASE ACTIVITY | GROUP GENE EZH2 | MOUSE DEVELOPMENT | TARGET | PRC2 | H3 LYSINE-27 METHYLATION | MYELOPROLIFERATIVE NEOPLASMS | PROTEIN COMPLEXES | HEMATOLOGY | TRANSCRIPTION FACTOR | SOMATIC MUTATIONS | Oligonucleotide Array Sequence Analysis | Humans | Leukemia, Myeloid - genetics | Neoplasm Proteins - physiology | Nerve Tissue Proteins - deficiency | Transcription Factors - deficiency | Male | Myeloproliferative Disorders - genetics | DNA-Binding Proteins - deficiency | Repressor Proteins - physiology | Repressor Proteins - deficiency | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - deficiency | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Female | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Genes, Tumor Suppressor | Chromosome Deletion | Acute Disease | Nerve Tissue Proteins - physiology | Repressor Proteins - genetics | Genotype | Chromosome Mapping | Polycomb-Group Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Chromosomes, Human, Pair 6 - genetics | Disease Progression | Enhancer of Zeste Homolog 2 Protein | Carrier Proteins - genetics | Tumor Suppressor Proteins - physiology | Polycomb Repressive Complex 2 | Chromosome Aberrations | Aged | Myelodysplastic Syndromes - genetics | Neoplasm Proteins - deficiency | Chromosomes, Human, Pair 6 - ultrastructure | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 438 - 442
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated... 
ENCEPHALOPATHY | COMPLEX | SZT2 | RAG GTPASES | GENE | SIGNALING PATHWAY | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | MUTATIONS | FOCAL EPILEPSIES | Lysosomes | Physiological aspects | Protein research | Research | Biological control systems | Protein-protein interactions | Proteins | Amino acids | Phosphorylation | Mutation | Glucose | Molecular weight | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2013, Volume 210, Issue 12, pp. 2641 - 2659
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7649, pp. 245 - 249
Journal Article