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Clinical Cancer Research, ISSN 1078-0432, 04/2006, Volume 12, Issue 7, pp. 2109 - 2116
Purpose: Aberrant promoter hypermethylation of Wnt-antagonist genes contributes to the pathogenesis of several cancers. We hypothesized that combined... 
secreted frizzled-related protein-1, 2, 4 and 5 | Wnt inhibitory factor-1 | Dickkopf family proteins-3 | bladder cancer | methylation | INACTIVATION | HUMAN PROSTATE-CANCER | PROMOTER HYPERMETHYLATION | SFRP GENES | METHYLATION | INHIBITORY FACTOR-I | ONCOLOGY | SIGNALING PATHWAY | COLORECTAL-CANCER | TUMOR-SUPPRESSOR GENES | URINE | Intercellular Signaling Peptides and Proteins - analysis | Multivariate Analysis | Carrier Proteins - urine | Urinary Bladder Neoplasms - diagnosis | Carcinoma, Transitional Cell - urine | Humans | Proto-Oncogene Proteins - urine | Membrane Proteins - urine | Repressor Proteins - analysis | Membrane Proteins - analysis | DNA Methylation | Urinary Bladder Neoplasms - genetics | Biomarkers, Tumor - urine | Proto-Oncogene Proteins - analysis | Sensitivity and Specificity | Eye Proteins - genetics | Carrier Proteins - analysis | Carcinoma, Transitional Cell - genetics | Repressor Proteins - urine | Urinary Bladder Neoplasms - urine | Biomarkers, Tumor - analysis | Membrane Proteins - genetics | Carcinoma, Transitional Cell - diagnosis | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Intercellular Signaling Peptides and Proteins - urine | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Eye Proteins - analysis | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Biomarkers, Tumor - genetics | Eye Proteins - urine | Urinary Bladder - physiology
Journal Article
Genetics in Medicine, ISSN 1098-3600, 02/2017, Volume 19, Issue 2, pp. 256 - 263
Cerebral creatine deficiency syndromes are neurometabolic conditions characterized by intellectual disability, seizures, speech delay, and behavioral... 
GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | ARGININEGLYCINE AMIDINOTRANSFERASE | neurometabolic disorders | CLINICAL-FEATURES | creatine deficiency | TANDEM MASS-SPECTROMETRY | INBORN ERROR | interpretation and reporting | AMIDINOTRANSFERASE AGAT DEFICIENCY | SLC6A8 DEFICIENCY | GAMT DEFICIENCY | LINKED MENTAL-RETARDATION | ACMG laboratory guideline | clinical biochemical genetic testing | GENETICS & HEREDITY | TRANSPORTER DEFICIENCY | Creatine - cerebrospinal fluid | Plasma Membrane Neurotransmitter Transport Proteins - blood | Intellectual Disability - cerebrospinal fluid | Mental Retardation, X-Linked - cerebrospinal fluid | Genomics | Humans | Amino Acid Metabolism, Inborn Errors - cerebrospinal fluid | Amidinotransferases - genetics | Intellectual Disability - urine | Plasma Membrane Neurotransmitter Transport Proteins - cerebrospinal fluid | Intellectual Disability - blood | Amidinotransferases - cerebrospinal fluid | Amino Acid Metabolism, Inborn Errors - genetics | Guanidinoacetate N-Methyltransferase - urine | Amidinotransferases - blood | Developmental Disabilities - cerebrospinal fluid | Brain Diseases, Metabolic, Inborn - genetics | Speech Disorders - blood | Repressor Proteins - urine | Language Development Disorders - cerebrospinal fluid | Creatine - genetics | Genetic Testing - standards | Mental Retardation, X-Linked - blood | Brain Diseases, Metabolic, Inborn - cerebrospinal fluid | Repressor Proteins - genetics | Movement Disorders - blood | Amino Acid Metabolism, Inborn Errors - blood | Developmental Disabilities - urine | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Amidinotransferases - urine | Movement Disorders - genetics | Speech Disorders - cerebrospinal fluid | Brain Diseases, Metabolic, Inborn - blood | Developmental Disabilities - blood | Mental Retardation, X-Linked - urine | Guidelines as Topic | Language Development Disorders - blood | Genetics, Medical - standards | Guanidinoacetate N-Methyltransferase - genetics | Movement Disorders - urine | Developmental Disabilities - genetics | Creatine - blood | Intellectual Disability - genetics | Mental Retardation, X-Linked - genetics | Guanidinoacetate N-Methyltransferase - cerebrospinal fluid | Speech Disorders - urine | Amino Acid Metabolism, Inborn Errors - urine | Creatine - metabolism | Creatine - deficiency | Guanidinoacetate N-Methyltransferase - blood | Plasma Membrane Neurotransmitter Transport Proteins - deficiency | Amidinotransferases - deficiency | Movement Disorders - cerebrospinal fluid | Creatine - urine | Language Development Disorders - genetics | Brain Diseases, Metabolic, Inborn - urine | Repressor Proteins - blood | Speech Disorders - genetics | Language Development Disorders - urine | Plasma Membrane Neurotransmitter Transport Proteins - urine | Repressor Proteins - cerebrospinal fluid | Clinical Laboratory Techniques - methods | Guanidinoacetate N-Methyltransferase - deficiency | Movement Disorders - congenital
Journal Article
Clinical Genitourinary Cancer, ISSN 1558-7673, 2012, Volume 10, Issue 2, pp. 106 - 113
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0176783 - e0176783
There is a growing body of evidence demonstrating an association between smoking and DNA methylation. Accordingly, DNA methylation is now considered a... 
CIGARETTE-SMOKING | METABOLITES | SERUM COTININE | LUNG-CANCER DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | BLOOD DNA | TOBACCO-SMOKE | RECEPTOR | RISK | SELF-REPORTED SMOKING | DIFFERENTIAL DNA METHYLATION | Multivariate Analysis | Biomarkers - urine | Lung Neoplasms - urine | Prospective Studies | Area Under Curve | Humans | Middle Aged | Male | Risk | DNA Methylation | Aged, 80 and over | Female | Republic of Korea - epidemiology | Cotinine - urine | Receptors, Thrombin - blood | Lung Neoplasms - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Smoking - blood | Self Report | Basic Helix-Loop-Helix Transcription Factors - blood | Repressor Proteins - blood | Repressor Proteins - genetics | Logistic Models | Smoking - genetics | Biomarkers - blood | Lung Neoplasms - epidemiology | Receptors, Thrombin - genetics | Smoking - epidemiology | ROC Curve | Aged | Lung Neoplasms - blood | Smoking - urine | DNA | Lung cancer | Research | Biological markers | Cotinine | Methylation | Risk factors | Smoking | Disease | Laboratories | Hydrocarbons | Genomes | Multivariate analysis | DNA methylation | Population | Genetics | Physiology | Deoxyribonucleic acid--DNA | Urine | Medical research | Health risks | Exposure | Regression analysis | Gene expression | Disease prevention | Medicine | Studies | Tobacco | Hospitals | Biomarkers | Adults | Genetic testing | Health risk assessment | Cancer | Index Medicus | Deoxyribonucleic acid
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2017, Volume 127, Issue 11, pp. 3954 - 3969
Uromodulin-associated kidney disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form of UMOD protein, which is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CASPASE-12 ACTIVATION | UNFOLDED PROTEIN RESPONSE | UMOD GENE | MOUSE MODEL | ENDOPLASMIC-RETICULUM STRESS | FOXO TRANSCRIPTION FACTORS | NF-KAPPA-B | JUVENILE HYPERURICEMIC NEPHROPATHY | TAMM-HORSFALL GLYCOPROTEIN | CELL-DEATH | Tumor Necrosis Factor-alpha - metabolism | Humans | Male | Mutation, Missense | Autophagy | Base Sequence | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Renal Insufficiency - immunology | Uromodulin - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Renal Insufficiency - genetics | Genetic Association Studies | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Uromodulin - metabolism | Mice, Transgenic | Immunity, Innate | Disease Progression | Point Mutation | Animals | Renal Insufficiency - pathology | Endoplasmic Reticulum Stress | Apoptosis | Care and treatment | Gene mutations | Epithelial cells | Glycoproteins | Kidney diseases | Diagnosis | Research | TOR protein | Tumor necrosis factor receptors | Syngeneic grafts | Kinases | Caspase-3 | Proteins | Neurodegeneration | Protein folding | Rodents | Tumor necrosis factor-TNF | Fusion protein | Urine | Activating transcription factor 4 | Caspase | Tumor necrosis factor-α | Epithelium | Nephrons | Fc receptors | Cell death | Point mutation | Renal failure | TRAIL protein | Mutation | Endoplasmic reticulum | Phagocytosis | Kidney transplantation
Journal Article
Kidney International, ISSN 0085-2538, 06/2018, Volume 93, Issue 6, pp. 1308 - 1319
In diseases of many parenchymatous organs, heterogeneous deterioration of individual functional units determines the clinical prognosis. However, the molecular... 
glomerulus proteomic analysis | albuminuria | focal segmental glomerulosclerosis | proximal tubule | podocyte | ANALYSIS REVEALS | QUANTIFICATION | VALIDATION | CLASSIFICATION | IDENTIFICATION | ENDOCYTOSIS | PODOCYTES | PHOSPHOPROTEOMIC ANALYSIS | COMPUTATIONAL PLATFORM | UROLOGY & NEPHROLOGY | CATHEPSIN-B | Proteostasis | Humans | Nephrotic Syndrome - metabolism | Male | Nephrotic Syndrome - genetics | Proteinuria - pathology | Glomerulonephritis - metabolism | Nephrons - pathology | Tandem Mass Spectrometry | Nephrons - physiopathology | Proteomics - methods | Glomerulonephritis - physiopathology | Extracellular Matrix Proteins - metabolism | Repressor Proteins - metabolism | Disease Models, Animal | Biomarkers - metabolism | Reproducibility of Results | Lysosome-Associated Membrane Glycoproteins - metabolism | Podocytes - metabolism | Glomerulonephritis - genetics | Nephrotic Syndrome - pathology | Proteinuria - metabolism | Repressor Proteins - genetics | Proteome | Podocytes - pathology | Proteinuria - genetics | Biological Variation, Individual | Mice, Knockout | Proteinuria - physiopathology | Animals | Nephrotic Syndrome - physiopathology | Glomerulonephritis - pathology | Lysosome-Associated Membrane Glycoproteins - genetics | Mice | Nephrons - metabolism | Serum Albumin - metabolism | Animal models | Transcription factors | Peptides | Homeostasis | Sclerosis | Datasets | Proteins | Lasers | Rodents | Extracellular matrix | Matrix protein | Chronic illnesses | Urine | Kidneys | Tubules | Mass spectroscopy | Histology | Patients | Biopsy | Morphology | Proteomics | Protein expression | Mutation | Kidney diseases | Lysosomal protein | Proteinuria
Journal Article
Journal of Nutrition, ISSN 0022-3166, 2014, Volume 144, Issue 8, pp. 1150 - 1157
This study was conducted to examine whether oligonol, a low-molecular-weight polyphenol derived from lychee fruit, has an ameliorative effect on... 
APOPTOSIS | OXIDATIVE STRESS | NUTRITION & DIETETICS | MECHANISM | GLYCOLALDEHYDE | INFLAMMATION | GLUCOSE | COMPLICATIONS | PROTEINS | IDENTIFICATION | NEPHROPATHY | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Plant Extracts - pharmacology | Blood Urea Nitrogen | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | NADPH Oxidases - metabolism | Polyphenols - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Kidney - metabolism | Caspase 3 - genetics | NADPH Oxidases - genetics | Inhibitor of Apoptosis Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Catechin - pharmacology | Kidney - physiopathology | Repressor Proteins - metabolism | bcl-2-Associated X Protein - genetics | Phenols - pharmacology | Kidney - drug effects | Fruit - chemistry | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Repressor Proteins - genetics | NADPH Oxidase 4 | Creatinine - urine | Organ Size - drug effects | Animals | Glycation End Products, Advanced - metabolism | Creatinine - blood | Catechin - analogs & derivatives | Mice | Oxidative Stress - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Litchi - chemistry | Prevention | Polyphenols | Eye diseases | Health aspects | Soapberries
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99771
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131416
Journal Article