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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 02/2011, Volume 89, Issue 2, pp. 183 - 198
In HIV patients, antiretroviral medications trigger metabolic abnormalities, including insulin resistance. In addition, the inflammatory cytokine tumor... 
IGF‐I | FOXO3a | neuronal apoptosis | ROS | HIV encephalitis | IGF-I | Neuronal apoptosis | OXIDATIVE STRESS | HIV-1-INFECTED PATIENTS | FACTOR RECEPTOR | NEUROSCIENCES | PROTEASE INHIBITORS | HIV-INFECTED PATIENTS | DIABETES-MELLITUS | ACTIVE ANTIRETROVIRAL THERAPY | HOMOLOGOUS RECOMBINATION | NF-KAPPA-B | In Situ Nick-End Labeling | Proto-Oncogene Proteins - metabolism | Tumor Necrosis Factor-alpha - metabolism | Neurons - pathology | Reactive Oxygen Species - metabolism | Rats | Reverse Transcriptase Polymerase Chain Reaction | PC12 Cells | Rats, Sprague-Dawley | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | AIDS Dementia Complex - metabolism | Animals | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Fluorescent Antibody Technique | Glucose - metabolism | Membrane Potential, Mitochondrial - physiology | Membrane Proteins - metabolism | Neurons - metabolism | Apoptosis - physiology | Forkhead Box Protein O3 | Insulin-Like Growth Factor I - metabolism | Index Medicus | Antiviral agents | Brain | Cell culture | Encephalitis | Reactive oxygen species | Transcription factors | Cytokines | Insulin-like growth factor I | Neurons | Cortex | Nervous system | Inflammation | Glucose | Metabolism | Insulin | Nuclear transport | Disease resistance | Mitochondria | Pheochromocytoma cells | Forkhead protein | BIM protein | Tumor necrosis factor- alpha | Apoptosis | FOXO3 protein
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 9/2009, Volume 49, Issue 5, pp. 682 - 690
Journal Article
Annals of Internal Medicine, ISSN 0003-4819, 08/2014, Volume 161, Issue 4, pp. 249 - 260
Journal Article
Cancer, ISSN 0008-543X, 10/2014, Volume 120, Issue 19, pp. 2980 - 2985
Simultaneous targeting of the IGF‐1R and EGFR signaling pathways for more effective downstream inhibition of proliferation and survival did not improve... 
pancreatic cancer | erlotinib signaling | randomized phase II | IGF‐1R | cixutumumab | EGFR | targeted treatment | Erlotinib signaling | Targeted treatment | Randomized phase II | Pancreatic cancer | Cixutumumab | IGF-1R | CARCINOMA-CELLS | DUCTAL ADENOCARCINOMA | MONOCLONAL-ANTIBODY | SINGLE-AGENT CETUXIMAB | BREAST-CANCER | INHIBITION | K-RAS | ONCOLOGY | THERAPEUTIC TARGET | C-MET | RESISTANCE | Erlotinib Hydrochloride | Pancreatic Neoplasms - metabolism | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptor, Epidermal Growth Factor - drug effects | Male | Insulin-Like Growth Factor I - drug effects | Pancreatic Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | Adult | Deoxycytidine - adverse effects | Female | Quinazolines - administration & dosage | Drug Administration Schedule | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Treatment Outcome | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease-Free Survival | Signal Transduction - drug effects | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - adverse effects | Aged | Deoxycytidine - analogs & derivatives | Insulin-Like Growth Factor I - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Annals of Internal Medicine, ISSN 0003-4819, 07/2006, Volume 145, Issue 1, pp. 1 - 11
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2013, Volume 61, Issue 17, pp. 1777 - 1786
Objectives: This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in... 
coronary heart disease | ethnicity | incidence | stroke | INDIVIDUALS | MORTALITY | CARDIAC & CARDIOVASCULAR SYSTEMS | COUNTRIES | MYOCARDIAL-INFARCTION | CORONARY-HEART-DISEASE | BLOOD-PRESSURE | EPIDEMIOLOGY | Myocardial Infarction - blood | Prospective Studies | Dyslipidemias - complications | Follow-Up Studies | Dyslipidemias - ethnology | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Acute Coronary Syndrome - ethnology | Coronary Artery Disease - blood | Incidence | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Odds Ratio | Waist-Hip Ratio | Body Mass Index | Caribbean Region - ethnology | Risk Factors | Adipose Tissue - pathology | Diabetes Complications - blood | Coronary Artery Disease - ethnology | Cholesterol, HDL - blood | Stroke - ethnology | Blood Glucose - metabolism | Asian Continental Ancestry Group - statistics & numerical data | Myocardial Infarction - ethnology | Smoking - adverse effects | Age Factors | Cardiovascular Diseases - ethnology | Insulin - blood | Asia, Southeastern | Dyslipidemias - blood | Adult | Cholesterol, LDL - blood | Female | Stroke - epidemiology | Surveys and Questionnaires | Diabetes Complications - ethnology | Proportional Hazards Models | European Continental Ancestry Group - statistics & numerical data | Feeding Behavior | Acute Coronary Syndrome - blood | African Continental Ancestry Group - statistics & numerical data | Stroke - blood | Sex Factors | Triglycerides - blood | Aged | United Kingdom - epidemiology | Index Medicus | Abridged Index Medicus | CVD, cardiovascular disease | Clinical Research | SHR, subhazard ratio | CHD, coronary heart disease | ICD, International Classification of Diseases | IR, insulin resistance | HDL, high-density lipoprotein | LDL, low-density lipoprotein
Journal Article
The Plant Cell, ISSN 1040-4651, 10/2011, Volume 23, Issue 10, pp. 3824 - 3841
Necrotrophic pathogens are important plant pathogens that cause many devastating plant diseases. Despite their impact, our understanding of the plant defense... 
Proteins | Pathogens | Yeasts | RNA | DNA | Genes | Infections | Plants | Transgenic plants | Plant cells |