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Experimental Parasitology, ISSN 0014-4894, 04/2019, Volume 199, pp. 17 - 23
Exposing second-stage juveniles (J2) of to a phenolic compound sometimes fails to cause J2 mortality, but in tests the same compound may reduce the infectivity... 
Hydroquinone | Phenols | Root-knot nematode | Tomato | Solanum lycopersicum | ROOT-KNOT NEMATODES | RESISTANCE | NEMATOCIDAL ACTIVITY | PSI-BLAST | PARASITOLOGY | Hydroxybenzoates - administration & dosage | Tylenchoidea - drug effects | Hydroquinones - administration & dosage | Arbutin - administration & dosage | Hydroquinones - chemistry | Caffeic Acids - pharmacology | Catechols - chemistry | Glycerol - administration & dosage | Naphthols - chemistry | Hydroquinones - pharmacology | Resorcinols - administration & dosage | Arbutin - pharmacology | Resorcinols - pharmacology | Hydroxybenzoates - pharmacology | Time Factors | Hydroxybenzoates - chemistry | Catechols - pharmacology | Naphthols - administration & dosage | Glycerol - pharmacology | Glycerol - chemistry | Carbofuran - chemistry | Phenols - pharmacology | Caffeic Acids - administration & dosage | Benzaldehydes - chemistry | Carbofuran - pharmacology | Naphthols - pharmacology | Benzaldehydes - pharmacology | Caffeic Acids - chemistry | Lethal Dose 50 | Random Allocation | Arbutin - chemistry | Animals | Benzaldehydes - administration & dosage | Carbofuran - administration & dosage | Resorcinols - chemistry | Lycopersicon esculentum - parasitology | Phenols - administration & dosage | Phenols - chemistry | Catechols - administration & dosage | Plants | Tomatoes | Nematoda | Index Medicus
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2009, Volume 29, Issue 29, pp. 9148 - 9162
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited, neurodegenerative disease caused by an expansion of polyglutamine tracts in the... 
SCA1 TRANSGENIC MICE | PURKINJE-CELLS | STEREOLOGICAL ESTIMATION | RYANODINE RECEPTORS | FUNCTIONAL-CHARACTERIZATION | POLYGLUTAMINE EXPANSION | DOMINANT CEREBELLAR-ATAXIA | HUNTINGTONS-DISEASE | NEUROSCIENCES | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | TRINUCLEOTIDE REPEAT | Glycine - analogs & derivatives | Calcium - metabolism | Calcium Signaling - physiology | Nerve Degeneration - physiopathology | Cercopithecus aethiops | Motor Activity - drug effects | Resorcinols - administration & dosage | Purkinje Cells - physiology | Ataxins | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Dantrolene - administration & dosage | Cell Death - drug effects | Purkinje Cells - drug effects | Glycine - administration & dosage | Excitatory Amino Acid Agents - administration & dosage | Spinocerebellar Ataxias - genetics | Cells, Cultured | Ryanodine - administration & dosage | Mice, Transgenic | Spinocerebellar Ataxias - physiopathology | Nerve Tissue Proteins - genetics | Nerve Degeneration - pathology | Nerve Tissue Proteins - metabolism | Animals | Cell Death - physiology | Calcium Signaling - drug effects | Calcium Channel Blockers - administration & dosage | Mice | Glutamic Acid - toxicity | COS Cells | Purkinje Cells - pathology | Index Medicus | ataxin-2 | spinocerebellar ataxia type 2 | Purkinje cells | calcium signaling | SCA2 | neurodegeneration | stereology | apoptosis | dantrolene | transgenic mouse
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 834 - 843
Background and Purpose GPR18 is a recently deorphaned lipid receptor that is activated by the endogenous lipid N-arachidonoyl glycine (NAGly) as well the... 
eye | GPR | mouse | intraocular pressure | cannabinoid | THC | GPR18 | RAT | ANANDAMIDE | INTRAOCULAR-PRESSURE | IDENTIFICATION | ARRIVE GUIDELINES | MESSENGER-RNA | CANNABINOID RECEPTOR AGONISTS | PHARMACOLOGY & PHARMACY | RETINA | N-ARACHIDONOYL GLYCINE | CB1 RECEPTORS | Endocannabinoids - metabolism | Administration, Ophthalmic | Glycine - analogs & derivatives | Glycine - metabolism | Intraocular Pressure - drug effects | Receptors, G-Protein-Coupled - metabolism | Epithelium, Corneal - cytology | Male | Eye Proteins - agonists | Receptors, G-Protein-Coupled - agonists | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Resorcinols - administration & dosage | Ciliary Body - metabolism | Anterior Eye Segment - metabolism | Receptors, Cannabinoid - metabolism | Resorcinols - pharmacology | Arachidonic Acids - metabolism | Arachidonic Acids - administration & dosage | Cannabinoid Receptor Antagonists - pharmacology | Epithelium, Corneal - drug effects | Eye Proteins - antagonists & inhibitors | Eye Proteins - genetics | Glycine - administration & dosage | Receptors, Cannabinoid - chemistry | Receptors, Cannabinoid - genetics | Resorcinols - metabolism | Ciliary Body - cytology | Mice, Inbred C57BL | Anterior Eye Segment - cytology | Cannabinoid Receptor Agonists - administration & dosage | Mice, Knockout | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Eye Proteins - metabolism | Signal Transduction - drug effects | Ciliary Body - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Epithelium, Corneal - metabolism | Anterior Eye Segment - drug effects | Ligands | Cannabinoid Receptor Antagonists - administration & dosage | Mice | Receptors, G-Protein-Coupled - genetics | Immunohistochemistry | Glycine | Analysis | Glaucoma | Medical research | Index Medicus | Cannabinoids 2012, Part Two | Themed Section
Journal Article
Psychopharmacology, ISSN 0033-3158, 5/2012, Volume 221, Issue 1, pp. 91 - 100
Glutamatergic projection neurons in the medial prefrontal cortex (mPFC) are hyperexcitable in cocaine-sensitized animals, resulting in increased excitatory... 
Neurosciences | mPFC | Biomedicine | Microinjection | Behavioral sensitization | Cocaine | DHPG | Pharmacology/Toxicology | Glutamate | Psychiatry | mGluR5 | REPEATED EXPOSURE | PSYCHIATRY | DRUG-SEEKING | NEUROSCIENCES | EXTRACELLULAR GLUTAMATE | VENTRAL TEGMENTAL AREA | PYRAMIDAL NEURONS | TRANSMISSION | DOPAMINE | PHARMACOLOGY & PHARMACY | ANTAGONISTS | MODULATION | Glycine - analogs & derivatives | Motor Activity - physiology | Motor Activity - drug effects | Receptors, Metabotropic Glutamate - physiology | Male | Thiazoles - administration & dosage | Ventral Tegmental Area - physiology | Cocaine - agonists | Resorcinols - administration & dosage | Resorcinols - pharmacology | Drug Interactions | Prefrontal Cortex - drug effects | Benzimidazoles - administration & dosage | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Receptor, Metabotropic Glutamate 5 | Central Nervous System Sensitization - drug effects | Cocaine - antagonists & inhibitors | Glycine - administration & dosage | Ventral Tegmental Area - drug effects | Pyridines - administration & dosage | Microinjections | Excitatory Amino Acid Antagonists - administration & dosage | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Rats, Sprague-Dawley | 6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage | Excitatory Amino Acid Agonists - administration & dosage | Cocaine - pharmacology | Animals | Glycine - pharmacology | Benzimidazoles - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Central Nervous System Sensitization - physiology | Receptors, Metabotropic Glutamate - agonists | Prefrontal Cortex - physiology | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Receptors, AMPA - antagonists & inhibitors | Amino acids | Pyridine | Brain | Neurons | Psychopharmacology | Rodents | Nucleus accumbens | Ventral tegmentum | alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors | Cortex (prefrontal) | Excitability | Data processing | Glutamic acid receptors | Glutamic acid receptors (metabotropic) | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 12/2017, Volume 411, pp. 19 - 26
Small cell lung cancer (SCLC) cannot be efficiently controlled using existing chemotherapy and radiotherapy approaches, indicating the need for new therapeutic... 
Small cell lung cancer | Combination therapy | HSP90 inhibitor | BCL-2 inhibitor | PATHWAYS | INDUCED APOPTOSIS | PHOSPHORYLATION | MCL-1 | DEATH | FAMILY | ONCOLOGY | RESISTANCE | LEUKEMIA | Piperazines - administration & dosage | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Resorcinols - administration & dosage | Small Cell Lung Carcinoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Resorcinols - pharmacology | Small Cell Lung Carcinoma - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Signal Transduction | Nitrophenols - administration & dosage | Random Allocation | Sulfonamides - pharmacology | Piperazines - pharmacology | Isoxazoles - administration & dosage | Drug Synergism | Isoxazoles - pharmacology | Xenograft Model Antitumor Assays | Small Cell Lung Carcinoma - pathology | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Biphenyl Compounds - administration & dosage | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Sulfonamides - administration & dosage | Heat shock proteins | Medical colleges | Lung cancer, Small cell | Chemotherapy | Lymphomas | Cancer | Hsp90 protein | Phosphorylation | Substance abuse treatment | Bcl-2 protein | Toxicity | Leukemia | Lung cancer | Clinical trials | Cytotoxicity | AKT protein | Phosphatase | Cancer therapies | Anticancer properties | Signal transduction | Biocompatibility | NF-κB protein | Immunoglobulins | Extracellular signal-regulated kinase | Radiation therapy | Gene expression | Lymphoma | Mcl-1 protein | Inhibitors | Lymphocytes B | In vivo methods and tests | Synergistic effect | Apoptosis | Heat shock | B-cell lymphoma | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2014, Volume 75, pp. 132 - 142
Resorcinolic lipids have important biological actions, including anti-carcinogenic activity. Therefore, we evaluated the mutagenic, genotoxic, immunomodulatory... 
Chemotherapy | Immunomodulation | Cytosporone | Comet assay | Micronucleus | ANTIMUTAGENIC ACTIVITY | CHEMISTRY, MEDICINAL | ANACARDIUM-OCCIDENTALE | ORPHAN-RECEPTOR NUR77 | PERIPHERAL-BLOOD | CELL-LINES | MICRONUCLEUS ASSAY | IN-VITRO | HUMAN HEPATOCELLULAR-CARCINOMA | PHENOLIC AMPHIPHILES | CYTOSPORONES | Cyclophosphamide - administration & dosage | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Mutagens - chemical synthesis | Male | Mutagens - administration & dosage | Antineoplastic Agents - administration & dosage | Immunologic Factors - chemical synthesis | Resorcinols - administration & dosage | Resorcinols - pharmacology | Lipids - chemistry | Lipids - pharmacology | Antineoplastic Agents - pharmacology | Resorcinols - chemical synthesis | Mutagens - chemistry | Immunologic Factors - chemistry | Immunologic Factors - administration & dosage | Mutagens - pharmacology | Antineoplastic Combined Chemotherapy Protocols | Lipids - administration & dosage | Antineoplastic Agents - chemistry | Comet Assay | Neoplasms - drug therapy | Animals | Lipids - chemical synthesis | Resorcinols - chemistry | Cyclophosphamide - pharmacology | Mice | Immunologic Factors - pharmacology | Antimitotic agents | Cyclophosphamide | Analysis | Lipids | Antineoplastic agents | Apoptosis | Cancer | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2001, Volume 21, Issue 22, pp. 9043 - 9052
The present study aimed to characterize a functional role for group I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens and the capacity of... 
Nucleus accumbens | Locomotion | Microdialysis | Homer | Cocaine | Glutamate | mGluR | EXTRACELLULAR DOPAMINE | cocaine | SPINAL-CORD MOTONEURONS | locomotion | N-TYPE CALCIUM | nucleus accumbens | NEUROSCIENCES | EXCITATORY AMINO-ACIDS | NUCLEUS-ACCUMBENS | AMPA RESPONSES | POSTSYNAPTIC DENSITY PROTEINS | microdialysis | SENSITIZATION | INDUCED LOCOMOTION | RAT-BRAIN | glutamate | Brain Chemistry - drug effects | Glycine - analogs & derivatives | Nucleus Accumbens - metabolism | Motor Activity - drug effects | Male | Receptors, Metabotropic Glutamate - metabolism | Rats, Inbred Strains | Resorcinols - pharmacology | Extracellular Space - metabolism | Homer Scaffolding Proteins | Receptor, Metabotropic Glutamate 5 | Receptors, AMPA - metabolism | Drug Administration Schedule | Tetrodotoxin - administration & dosage | Drug Tolerance | Rats | Neuropeptides - metabolism | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Rats, Sprague-Dawley | Cocaine - administration & dosage | Animals | Carrier Proteins - metabolism | Glycine - pharmacology | Extracellular Space - chemistry | Glutamic Acid - metabolism | Nucleus Accumbens - drug effects | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Ecology, ISSN 0012-9658, 8/2006, Volume 87, Issue 8, pp. 2103 - 2112
Most herbivores eat more and survive better when they have access to a variety of foods. One explanation involves the detoxification of plant secondary... 
Animal feeding behavior | Enzymes | Diet | Food intake | Opossums | Oxidation | Wetland ecology | Herbivores | Chemical ecology | Food | detoxification limitation hypothesis | glycine | diet mixing | plant secondary metabolites | glucuronic acid (GA) | generalist herbivore | Australia | Trichosurus vulpecula | common brushtail possum | diet choice | Plant secondary metabolites | Diet choice | Common brushtail possum | Diet mixing | Generalist herbivore | Glucuronic acid (GA) | Glycine | Detoxification limitation hypothesis | MICROSOMAL METABOLISM | TRICHOSURUS-VULPECULA | ACID | FOOD-INTAKE | TOXINS | 1,8-CINEOLE | HERBIVORE | CYTOCHROME-P450 ENZYMES | ECOLOGY | VARIED DIETS | Eating | Cyclohexanols - pharmacokinetics | Resorcinols - pharmacokinetics | Sodium Benzoate - pharmacokinetics | Benzyl Alcohols - administration & dosage | Feeding Behavior | Male | Trichosurus - physiology | Sodium Benzoate - administration & dosage | Trichosurus - metabolism | Resorcinols - administration & dosage | Monoterpenes - pharmacokinetics | Plants - metabolism | Rutin - pharmacokinetics | Animals | Rutin - administration & dosage | Monoterpenes - administration & dosage | Benzyl Alcohols - pharmacokinetics | Cyclohexanols - administration & dosage | Glucosides | Metabolic conjugation | Research | Flowers & plants | Acids | Animal behavior | Index Medicus
Journal Article
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 10/2017, Volume 137, Issue 10, pp. 2110 - 2119
Journal Article