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Neuron, ISSN 0896-6273, 2010, Volume 68, Issue 1, pp. 113 - 126
Endocannabinoids and their receptor CB1 play key roles in brain function. Astrocytes express CB1Rs that are activated by endocannabinoids released by neurons.... 
ENDOGENOUS CANNABINOIDS | ACTIVATION | CA1 PYRAMIDAL CELLS | EXCITATORY SYNAPSES | NEURONS | LONG-TERM POTENTIATION | GLIAL-CELLS | NEUROSCIENCES | MODULATION | HIPPOCAMPAL SYNAPSES | PLASTICITY | Cannabinoid Receptor Modulators - metabolism | Cannabinoid Receptor Modulators - pharmacology | Glycine - analogs & derivatives | Synaptic Transmission - physiology | Synaptic Transmission - genetics | Calcium - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Resorcinols - pharmacology | Drug Interactions | Photolysis | Piperidines - pharmacology | Pyramidal Cells - physiology | Egtazic Acid - analogs & derivatives | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Electric Stimulation - methods | Endocannabinoids | Excitatory Postsynaptic Potentials - genetics | Pyrazoles - pharmacology | Animals, Newborn | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Chelating Agents - pharmacology | Hippocampus - cytology | Mice, Knockout | Astrocytes - physiology | Animals | Egtazic Acid - pharmacology | Glycine - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Benzoates - pharmacology | Thapsigargin - pharmacology | Mice | Pyridines - pharmacology | Receptor, Cannabinoid, CB1 - deficiency | In Vitro Techniques | Glutamate | Neurons | Studies | Retina | Transmitters | Index Medicus | Potentiation | Brain | Neurotransmitter release | Astrocytes | Glutamic acid receptors | Cannabinoid CB1 receptors | synaptic depression | Calcium signalling | Pyramidal cells | Synaptic transmission | Endogenous stimuli | Receptor mechanisms | Glutamic acid receptors (metabotropic) | Hippocampus | Neurotransmission
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2007, Volume 321, Issue 3, pp. 930 - 937
We have previously shown that the endocannabinoid anandamide and its metabolically stable analog ( R )-methanandamide produce vasorelaxation in rabbit aortic... 
SYNTHASE | 4,5-DIAMINOFLUORESCEIN DIACETATE | VASORELAXATION | CB1 | PHOSPHORYLATION | PROTEIN-KINASE | PHARMACOLOGY | ENDOCANNABINOIDS | PHARMACOLOGY & PHARMACY | MESENTERIC-ARTERY | COMBINATION | Cannabinoid Receptor Modulators - pharmacology | Receptor, Cannabinoid, CB2 - physiology | Receptor, Cannabinoid, CB2 - agonists | Bornanes - pharmacology | Benzofurans - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Dose-Response Relationship, Drug | Resorcinols - pharmacology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Cyclohexanols - pharmacology | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Endocannabinoids | Pertussis Toxin - pharmacology | Pyrazoles - pharmacology | Rabbits | Endothelial Cells - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Animals | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Endothelial Cells - cytology | Benzoxazines - pharmacology | Polyunsaturated Alkamides - pharmacology | Signal Transduction - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Nitric Oxide - metabolism | Endothelial Cells - drug effects | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2004, Volume 24, Issue 28, pp. 6352 - 6361
Hippocampal long-term depression (LTD) is a long-lasting decrease in synaptic strength that is most commonly studied at glutamatergic inputs to pyramidal cells... 
CA1 | Phosphorylation | Protein kinase | Hippocampus | Synaptic plasticity | Translation initiation | MAMMALIAN TARGET | MESSENGER-RNA TRANSLATION | hippocampus | PHOSPHATIDYLINOSITOL 3-KINASE | translation initiation | HIPPOCAMPAL CA1 REGION | AREA CA1 | NEUROSCIENCES | protein kinase | X MENTAL-RETARDATION | PROTEIN-KINASE B | P70 S6 KINASE | synaptic plasticity | phosphorylation | DHPG-INDUCED LTD | Glycine - analogs & derivatives | Pyramidal Cells - metabolism | Synaptosomes - drug effects | Receptors, Metabotropic Glutamate - physiology | Male | Tacrolimus - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Resorcinols - pharmacology | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Tacrolimus - pharmacology | Receptor, Metabotropic Glutamate 5 | Pyramidal Cells - drug effects | Phosphorylation - drug effects | Chromones - pharmacology | Pyramidal Cells - ultrastructure | 3-Phosphoinositide-Dependent Protein Kinases | Dendrites - drug effects | Dendrites - metabolism | Long-Term Synaptic Depression - physiology | Protein Kinases - drug effects | Protein-Serine-Threonine Kinases - physiology | Synaptosomes - physiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Hippocampus - cytology | Sirolimus - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Androstadienes - pharmacology | Glycine - pharmacology | Signal Transduction - drug effects | Protein Kinases - physiology | Wortmannin | Proto-Oncogene Proteins - physiology | Benzoates - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Mice | Pyridines - pharmacology | TOR Serine-Threonine Kinases | Hippocampus - physiology | Receptors, Metabotropic Glutamate - agonists | Index Medicus | Cellular | Molecular
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 09/2003, Volume 18, Issue 5, pp. 1155 - 1168
Tonic impulse flow in the septohippocampal GABAergic pathway is essential for normal cognitive functioning and is sustained, in part, by acetylcholine (ACh)... 
Learning and memory | Septum | Metabotropic | Cognition | Theta rhythm | Glutamate | DIAGONAL BAND COMPLEX | PARVALBUMIN | CA1 INTERNEURONS | cognition | ALZHEIMERS-DISEASE | IMPULSE FLOW | metabotropic | NEUROSCIENCES | septum | theta rhythm | ACETYLCHOLINE-RECEPTORS | learning and memory | MEDIAL SEPTAL AREA | CENTRAL-NERVOUS-SYSTEM | BASAL FOREBRAIN | RAT HIPPOCAMPUS | glutamate | Muscarinic Agonists - pharmacology | gamma-Aminobutyric Acid - metabolism | Cell Count | Septum of Brain - physiology | Parvalbumins - metabolism | Male | Nicotinic Antagonists - pharmacology | Drug Interactions | Neuroprotective Agents - pharmacology | Septum of Brain - ultrastructure | Vesicular Glutamate Transport Protein 2 | Muscarinic Antagonists - pharmacology | Hippocampus - ultrastructure | Tetrodotoxin - pharmacology | Chromones - pharmacology | Animals, Newborn | Membrane Potentials - drug effects | Drug Administration Routes | Acyclovir - pharmacology | Rats | Atropine - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Immunohistochemistry - methods | Glycine - pharmacology | Microscopy, Electron - methods | Muscarine - pharmacology | Glycine - analogs & derivatives | Electric Conductivity | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Nicotine - pharmacology | Dose-Response Relationship, Drug | Resorcinols - pharmacology | Cycloleucine - pharmacology | Tubocurarine - pharmacology | Synapses - metabolism | Neurons - physiology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Neurons - drug effects | Nicotinic Agonists - pharmacology | Vesicular Transport Proteins | Acyclovir - analogs & derivatives | Valine - analogs & derivatives | Aconitine - analogs & derivatives | Aconitine - pharmacology | Hippocampus - cytology | Membrane Potentials - physiology | Animals | Carrier Proteins - metabolism | Membrane Transport Proteins | Choline - pharmacology | Microscopy, Electron - instrumentation | Valine - pharmacology | In Vitro Techniques | Cycloleucine - analogs & derivatives | Bungarotoxins - pharmacology | Index Medicus
Journal Article
Gastric Cancer, ISSN 1436-3291, 1/2016, Volume 19, Issue 1, pp. 53 - 62
Up to 10 % of primary gastric cancers are characterized by FGFR2 amplification, and fibroblast growth factor receptor (FGFR) inhibitors may represent... 
AZD4547 | Medicine & Public Health | Gastroenterology | BGJ398 | Abdominal Surgery | Oncology | Cancer Research | Epithelial–mesenchymal transition | Drug resistance | Surgical Oncology | Fibroblast growth factor receptor | Fibroblast growth factor receptor inhibitor | TGF-BETA | SENSITIVITY | E-CADHERIN | ANTITUMOR-ACTIVITY | EMT | LINES | Epithelial-mesenchymal transition | POTENT | ONCOLOGY | GROWTH | MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | EXPOSURE | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Transforming Growth Factor beta1 - metabolism | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Epithelial-Mesenchymal Transition - drug effects | Stomach Neoplasms - pathology | Pyrimidines - pharmacology | Stomach Neoplasms - drug therapy | Piperazines - pharmacology | Isoxazoles - pharmacology | Resorcinols - pharmacology | Triazoles - pharmacology | Cell Line, Tumor | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Oxazoles - pharmacology | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Molecular Targeted Therapy - methods | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Transforming Growth Factor beta1 - pharmacology | Drug Resistance, Neoplasm - drug effects | Pyrazoles - pharmacology | Proteins | Stem cells | Heat shock proteins | Stomach cancer | Growth factors | Cancer | Index Medicus | Original
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 12/2010, Volume 15, Issue 10, pp. 1238 - 1247
Recently, new technologies based on biosensors and called label free have been developed. These technologies eliminate the need for using markers and dyes. The... 
impedance | mGluR1 | CB2 | label-free technology | assay | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | TRAFFICKING | LABEL-FREE | CB2 RECEPTORS | SENSOR ARRAYS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ASSAYS | Analgesics - pharmacology | Glycine - analogs & derivatives | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Calcium - metabolism | Receptors, Metabotropic Glutamate - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Quinolines - pharmacology | Resorcinols - pharmacology | Cycloleucine - pharmacology | Neuroprotective Agents - pharmacology | Biological Assay | Indoles - pharmacology | Cyclohexanols - pharmacology | Cyclic AMP - metabolism | CHO Cells | Cricetinae | Glutamic Acid - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Electric Impedance | Cannabinoids - pharmacology | Naphthalenes - pharmacology | Receptor, Cannabinoid, CB2 - metabolism | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Benzimidazoles - pharmacology | Signal Transduction - physiology | Glutamic Acid - metabolism | Thiazoles - pharmacology | Receptors, Metabotropic Glutamate - agonists | Cycloleucine - analogs & derivatives | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Chromones | Quisqualic Acid - pharmacology | Index Medicus | Life Sciences | Other
Journal Article
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 08/2015, Volume 789-790, pp. 7 - 27
Journal Article
Neuroscience, ISSN 0306-4522, 2001, Volume 106, Issue 3, pp. 579 - 587
Medium spiny neurons were recorded from striatal slices obtained from mice lacking the group I metabotropic glutamate receptor (mGluR) subtype 1 or subtype 5.... 
basal ganglia | knockout mice | electrophysiology | striatum | excitotoxicity | metabotropic glutamate receptor | Electrophysiology | Striatum | Basal ganglia | Knockout mice | Excitotoxicity | Metabotropic glutamate receptor | ACTIVATION | NMDA-RESPONSES | SYNAPTIC PLASTICITY | NEUROSCIENCES | MGLUR1 MUTANT MICE | QUINOLINIC ACID | SUBUNIT MESSENGER-RNAS | (S)-4C3HPG PROTECTS | LONG-TERM POTENTIATION | RAT HIPPOCAMPAL SLICES | HUNTINGTONS-DISEASE | Receptors, Metabotropic Glutamate - drug effects | Glycine - analogs & derivatives | Synaptic Transmission - physiology | Muscarinic Agonists - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Neurons - cytology | Anticonvulsants - pharmacology | N-Methylaspartate - pharmacology | Resorcinols - pharmacology | (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride - pharmacology | Neostriatum - drug effects | Receptors, Metabotropic Glutamate - genetics | Receptor, Metabotropic Glutamate 5 | Neostriatum - metabolism | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | Receptors, Metabotropic Glutamate - deficiency | Action Potentials - drug effects | Cyclopropanes - pharmacology | Receptors, N-Methyl-D-Aspartate - drug effects | Benzoates | Neostriatum - cytology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Action Potentials - physiology | Animals | Glycine - pharmacology | Muscarine - pharmacology | Glutamic Acid - metabolism | Mice | Pyridines - pharmacology | Phenylacetates - pharmacology | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 825 - 831
Journal Article
British Journal of Haematology, ISSN 0007-1048, 02/2013, Volume 160, Issue 4, pp. 465 - 476
The heat shock transcription factor 1 ( HSF 1) has recently been reported to promote malignant transformation and growth. Here we provide experimental evidence... 
apoptosis | multiple myeloma | heat shock proteins | oncogenic signalling | Heat shock proteins | Oncogenic signalling | Multiple myeloma | Apoptosis | MOLECULAR CHAPERONES | CANCER | DOSE-ESCALATION | IN-VITRO | INHIBITOR | STRESS | PROTEINS | HEMATOLOGY | MARROW STROMAL CELLS | TRIPTOLIDE | FACTOR HSF1 | Immunohistochemistry | Neoplasm Transplantation | Apoptosis - drug effects | Humans | Transplantation, Heterologous | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Gene Knockdown Techniques | Heat Shock Transcription Factors | Resorcinols - pharmacology | Multiple Myeloma - drug therapy | Epoxy Compounds - pharmacology | Proteasome Endopeptidase Complex - drug effects | Female | Plasma Cells - metabolism | Antineoplastic Agents - pharmacology | Diterpenes - pharmacology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Bortezomib | DNA-Binding Proteins - antagonists & inhibitors | Down-Regulation | Heat-Shock Proteins - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Transcription Factors - antagonists & inhibitors | Blotting, Western | Isoxazoles - pharmacology | Phenanthrenes - pharmacology | Animals | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | Pyrazines - pharmacology | Boronic Acids - pharmacology | Proteins | Health aspects | Drugs | Hsp90 protein | Transformation | proteasomes | Data processing | proteasome inhibitors | triptolide | Hsp70 protein | Hsp40 protein | Drug development | Hsp27 protein | HSF1 protein | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 317 - 329
Plastic changes in the amygdala and limbic cortex networks have been widely shown in chronic pain. We have here investigated the role of group I metabotropic... 
Basolateral amygdala | Prefrontal cortex | Rat | Inflammatory pain | mGluRs | ACTIVATION | STIMULATION | FRONTAL-CORTEX | NEUROSCIENCES | ORGANIZATION | DECISION-MAKING | SENSITIZATION | NEURONS | PHARMACOLOGY & PHARMACY | PROJECTIONS | MODULATION | PLASTICITY | Glycine - analogs & derivatives | Amygdala - drug effects | Neural Pathways - drug effects | Gene Expression - drug effects | Rats, Wistar | Neuronal Plasticity - drug effects | Receptors, Metabotropic Glutamate - physiology | Male | Chromones - administration & dosage | Resorcinols - administration & dosage | Resorcinols - pharmacology | Neural Inhibition - physiology | Neuronal Plasticity - physiology | Prefrontal Cortex - drug effects | Gene Expression - physiology | Pyramidal Cells - physiology | Receptor, Metabotropic Glutamate 5 | Pyramidal Cells - drug effects | Neural Pathways - physiopathology | Chromones - pharmacology | Electric Stimulation - methods | Action Potentials - drug effects | Glycine - administration & dosage | Disease Models, Animal | Pyridines - administration & dosage | Formaldehyde - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Receptors, Metabotropic Glutamate - biosynthesis | Bicuculline - pharmacology | GABA Antagonists - pharmacology | Physical Stimulation - methods | Action Potentials - physiology | Animals | Glycine - pharmacology | Pain - physiopathology | Pyridines - pharmacology | Carrageenan | Amygdala - physiology | Neural Inhibition - drug effects | Prefrontal Cortex - physiology | GABA | Carrageenin | Glutamate | Neurons | Chronic pain | Index Medicus | Amygdala
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2014, Volume 79, pp. 59 - 65
Journal Article