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American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 06/2015, Volume 308, Issue 11, pp. L1102 - L1113
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3786 - 3799
The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1... 
MONOSODIUM URATE CRYSTALS | MEDICINE, RESEARCH & EXPERIMENTAL | INTERLEUKIN-1 RECEPTOR ANTAGONIST | INDUCED CYTOKINE | INDUCED LUNG INJURY | AIRWAY INFLAMMATION | BLEOMYCIN-INDUCED PNEUMONOPATHY | DEFICIENT MICE | ONSET STILLS-DISEASE | NF-KAPPA-B | CUTTING EDGE | Respiratory Distress Syndrome, Adult - pathology | Interleukin-8 - genetics | Sialoglycoproteins - genetics | Interleukin-1beta - pharmacology | Antibiotics, Antineoplastic - toxicity | Humans | Sialoglycoproteins - metabolism | Pneumonia - pathology | Respiratory Distress Syndrome, Adult - metabolism | Receptors, Interleukin-1 Type I - metabolism | Receptors, Interleukin-1 Type I - antagonists & inhibitors | Respiratory Distress Syndrome, Adult - genetics | Lymphokines - genetics | Pneumonia - chemically induced | Bone Marrow Transplantation | Lymphokines - metabolism | Pulmonary Fibrosis - metabolism | Interleukin 1 Receptor Antagonist Protein - pharmacology | Interleukin-8 - metabolism | Bleomycin - toxicity | Disease Models, Animal | Pneumonia - genetics | Receptors, Interleukin-1 Type I - agonists | Respiratory Distress Syndrome, Adult - chemically induced | Myeloid Differentiation Factor 88 - genetics | Pulmonary Fibrosis - pathology | Signal Transduction - genetics | Recombinant Proteins - pharmacology | Mice, Knockout | Transplantation Chimera - genetics | Transplantation Chimera - metabolism | Animals | Signal Transduction - drug effects | Receptors, Interleukin-1 Type I - genetics | Pulmonary Fibrosis - chemically induced | Mice | Pneumonia - metabolism | Chronic Disease | Myeloid Differentiation Factor 88 - metabolism | Complications and side effects | Bleomycin | Pulmonary fibrosis | Dosage and administration | Research | Health aspects | Risk factors | Apoptosis | Index Medicus | Abridged Index Medicus | Pneumonia | Respiratory Distress Syndrome, Adult | Signal Transduction | Interleukin-1beta | Antibiotics, Antineoplastic | Myeloid Differentiation Factor 88 | Recombinant Proteins | Transplantation Chimera | Interleukin-8 | Lymphokines | Life Sciences | Sialoglycoproteins | Immunology | Pulmonary Fibrosis | Interleukin 1 Receptor Antagonist Protein | Receptors, Interleukin-1 Type I
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2012, Volume 185, Issue 11, pp. 1225 - 1234
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 652 - 664
Vascular endothelial barrier dysfunction underlies diseases such as acute respiratory distress syndrome (ARDS), characterized by edema and inflammatory cell... 
MEDICINE, RESEARCH & EXPERIMENTAL | HYPOXIA-INDUCIBLE FACTOR | ALVEOLAR HYPOXIA | FACTOR 1-ALPHA | ENDOTHELIAL-CELLS | IN-VIVO | LEUKOCYTE EXTRAVASATION | BARRIER FUNCTION | VE-CADHERIN | VASCULAR-PERMEABILITY | RESPIRATORY-DISTRESS-SYNDROME | Respiratory Distress Syndrome, Adult - pathology | Cadherins - metabolism | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Respiratory Distress Syndrome, Adult - metabolism | Antigens, CD - genetics | Adherens Junctions - metabolism | Antigens, CD - metabolism | Phosphorylation - genetics | Respiratory Distress Syndrome, Adult - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acute Lung Injury - metabolism | Cadherins - genetics | Adherens Junctions - genetics | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - biosynthesis | Signal Transduction | Endothelial Cells - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Acute Lung Injury - pathology | Adherens Junctions - pathology | Mice, Knockout | Animals | Gene Expression Regulation, Enzymologic - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Mice | Endothelial Cells - pathology | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2017, Volume 313, Issue 6, pp. L1016 - L1029
There is no therapeutic intervention proven to prevent acute respiratory distress syndrome (ARDS). Novel mechanistic insights into the pathophysiology of ARDS... 
Acute respiratory distress syndrome | Platelets | Mouse models | Alveolar macrophages | mouse models | PHYSIOLOGY | DENDRITIC CELLS | alveolar macrophages | PULMONARY INFLAMMATION | ASPIRIN | platelets | RESPIRATORY-DISTRESS-SYNDROME | RESPONSES | RESPIRATORY SYSTEM | acute respiratory distress syndrome | HOST-DEFENSE | THROMBOCYTOPENIA | MICE | EXPRESSION | AGGREGATION | Blood Platelets - pathology | Respiratory Distress Syndrome, Adult - pathology | Lung Injury - pathology | Blood Platelets - immunology | Lipopolysaccharides - toxicity | Macrophages, Alveolar - pathology | Respiratory Distress Syndrome, Adult - chemically induced | Lectins, C-Type - immunology | Mice, Transgenic | Signal Transduction - genetics | Lectins, C-Type - genetics | Membrane Glycoproteins - genetics | Respiratory Distress Syndrome, Adult - immunology | Signal Transduction - immunology | Lung Injury - genetics | Respiratory Distress Syndrome, Adult - genetics | Animals | Gene Deletion | Mice | Membrane Glycoproteins - immunology | Lung Injury - chemically induced | Lung Injury - immunology | Macrophages, Alveolar - immunology | Prevention | Physiological aspects | Blood platelets | Macrophages | Ligands (Biochemistry) | Intervention | Respiratory function | Lung | Oxygen content | Lipopolysaccharides | Clonal deletion | Bronchoalveolar lavage | Rodents | Deletion | Alveoli | Trachea | Saturation | Bronchus | Leukocytes (neutrophilic) | Inflammation | Cells | Hemopoiesis | Signaling | Respiratory distress syndrome | Ligands | Chemokines | Index Medicus
Journal Article
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2018, Volume 197, Issue 11, pp. 1421 - 1432
Journal Article