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1. Full Text Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin
by Stier, Matthew T., BS and Bloodworth, Melissa H., BS and Toki, Shinji, PhD and Newcomb, Dawn C., PhD and Goleniewska, Kasia, MS and Boyd, Kelli L., DVM, PhD and Quitalig, Marc and Hotard, Anne L., PhD and Moore, Martin L., PhD and Hartert, Tina V., MD, MPH and Zhou, Baohua, PhD and McKenzie, Andrew N., PhD and Peebles, R. Stokes, MD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2016, Volume 138, Issue 3, pp. 814 - 824.e11
Allergy and Immunology | Group 2 innate lymphoid cells | thymic stromal lymphopoietin | IL-13 | type 2 immunity (TH2) | IL-33 | respiratory syncytial virus | type 2 immunity (T | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Interleukin-13 - immunology | Interleukin-33 - immunology | Respiratory Syncytial Virus Infections - immunology | Viral Load | Mice, Knockout | Lung - virology | Animals | Lymphocytes - immunology | Female | Mucus - metabolism | Lung - metabolism | Mice, Inbred BALB C | Respiratory Syncytial Virus Infections - virology | Cytokines - genetics | Lung - immunology | Cytokines - immunology | Virus diseases | Medical colleges | Infants | Health aspects | Mortality | Analysis | Asthma | Proteins | Ostomy | Disease | Lungs | Cytokines | Viruses | Infections | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | MFI, Mean fluorescence intensity | BAL, Bronchoalveolar lavage | WT, Wild-type | TSLP, Thymic stromal lymphopoietin | KO, Knockout | INSPIRE, Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure | PAS, Periodic acid–Schiff | ILC2, Group 2 innate lymphoid cell | TSLPR, Thymic stromal lymphopoietin receptor | ILC, Innate lymphoid cell | RSV, Respiratory syncytial virus | PFU, Plaque-forming units
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2. Full Text Respiratory Syncytial Virus Increases the Virulence of Streptococcus pneumoniae by Binding to Penicillin Binding Protein 1a A New Paradigm in Respiratory Infection
by Smith, Claire M and Sanini, Sara and Datta, Sumit and Freestone, Primrose and Shafeeq, Sulman and Radhakrishnan, Priya and Williams, Gwyneth and Glenn, Sarah M and Kuipers, Oscar P and Hirst, Robert A and Easton, Anew J and Anew, Peter W and O'Callaghan, Christopher
American journal of respiratory and critical care medicine, ISSN 1073-449X, 07/2014, Volume 190, Issue 2, pp. 196 - 207
INVASIVE-PNEUMOCOCCAL-DISEASE | BEAT FREQUENCY | PNEUMOLYSIN | CHILDREN | pneumococcus | PRIMARY CILIARY DYSKINESIA | IMMUNIZATION | virulence | EPITHELIAL-CELLS | NITRIC-OXIDE | cilia | MICE | GLYCOPROTEIN | respiratory syncytial virus | G protein | Respiratory syncytial virus | Pneumococcus | Virulence | Cilia | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Viral diseases of the respiratory system and ent viral diseases | Infectious diseases | Bacterial diseases | Human bacterial diseases | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Viral diseases | Staphylococcal infections, streptococcal infections, pneumococcal infections | Biological and medical sciences | Intensive care medicine | Medical sciences | Human viral diseases | Pneumology | Up-Regulation | Epithelial Cells - metabolism | Viral Fusion Proteins - metabolism | Humans | Transcriptome | Respiratory Syncytial Virus Infections - metabolism | Respiratory Syncytial Virus Infections - microbiology | Respiratory Mucosa - microbiology | Streptococcus pneumoniae - pathogenicity | Streptococcus pneumoniae - metabolism | Streptococcus pneumoniae - genetics | Female | Real-Time Polymerase Chain Reaction | Respiratory Syncytial Viruses - metabolism | Biomarkers - metabolism | Pneumonia, Pneumococcal - microbiology | Streptococcus pneumoniae - virology | Cells, Cultured | Coinfection - metabolism | Penicillin-Binding Proteins - metabolism | Blotting, Western | Bacterial Adhesion | Microscopy, Confocal | Pneumonia, Pneumococcal - metabolism | Coinfection - microbiology | Pneumonia, Pneumococcal - virology | Animals | Epithelial Cells - microbiology | Mice | Respiratory Mucosa - metabolism | Gene Expression Regulation, Bacterial | Index Medicus | Abridged Index Medicus | Original
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3. Full Text Thymic stromal lymphopoietin is induced by respiratory syncytial virus–infected airway epithelial cells and promotes a type 2 response to infection
by Lee, Hai-Chon, PhD and Headley, Mark B., PhD and Loo, Yueh-Ming, PhD and Berlin, Aaron, BS and Gale, Michael, PhD and Debley, Jason S., MD and Lukacs, Nicholas W., PhD and Ziegler, Steven F., PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 130, Issue 5, pp. 1187 - 1196.e5
Allergy and Immunology | asthma | epithelium | TSLP | RSV | TH2 | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Viral diseases of the respiratory system and ent viral diseases | Infectious diseases | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Viral diseases | Biological and medical sciences | Medical sciences | Human viral diseases | Humans | Respiratory Syncytial Viruses - immunology | Th1-Th2 Balance | Respiratory Mucosa - virology | Th2 Cells - immunology | Respiratory Syncytial Virus Infections - immunology | Signal Transduction - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Asthma - etiology | Membrane Proteins - metabolism | Child | Cytokines - genetics | Respiratory Syncytial Virus Infections - complications | Cell Line | Cytokines - metabolism | Membrane Proteins - genetics | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Mice | Mice, Inbred BALB C | Adaptor Proteins, Signal Transducing - metabolism | Virus diseases | Medical colleges | Virus diseases in children | Respiratory agents | Children | Health aspects | Asthma | Diseases | Cell culture | Fluids | Epidermal growth factor | Cytokines | Rodents | Nitric oxide | Viral infections | Index Medicus | Abridged Index Medicus
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4. Full Text Late therapeutic intervention with a respiratory syncytial virus L‐protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium
by Brookes, Daniel W and Coates, Matthew and Allen, Heather and Daly, Leah and Constant, Samuel and Huang, Song and Hows, Mark and Davis, Amanda and Cass, Lindsey and Ayrton, John and Knowles, Ian and Strong, Pete and Rapeport, Garth and Ito, Kazuhiro
British journal of pharmacology, ISSN 0007-1188, 06/2018, Volume 175, Issue 12, pp. 2520 - 2534
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Epithelium - drug effects | Virus Replication - drug effects | Antiviral Agents - pharmacology | Respiratory Mucosa - drug effects | Respiratory Syncytial Virus, Human - drug effects | DNA-Directed RNA Polymerases - antagonists & inhibitors | Epithelium - metabolism | Humans | Respiratory Mucosa - virology | Respiratory Syncytial Virus Infections - metabolism | Structure-Activity Relationship | Epithelium - virology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Antiviral Agents - chemistry | Respiratory Syncytial Virus Infections - drug therapy | HeLa Cells | Respiratory Mucosa - metabolism | DNA-Directed RNA Polymerases - metabolism | Spiro Compounds - chemistry | Spiro Compounds - pharmacology | Intervention | Peak load | Wash load | Viruses | Infections | Pharmacology | Epithelium | Chemical compounds | Mucous membrane | Respiratory tract | Proteins | Polymerase | Inoculation | Mucin | Respiratory syncytial virus | Inhibitors | Biomarkers | Plaque assay | Fusion protein | Nucleoside analogs | Deoxyribonucleic acid--DNA | Research Papers | Research Paper
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5. Full Text Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection
by Weiss, Kayla A and Christiaansen, Allison F and Fulton, Ross B and Meyerholz, David K and Varga, Steven M
The Journal of immunology (1950), ISSN 0022-1767, 09/2011, Volume 187, Issue 6, pp. 3145 - 3154
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Enzyme-Linked Immunosorbent Assay | Respiratory Syncytial Viruses - immunology | CD4-Positive T-Lymphocytes - metabolism | Immunologic Factors - immunology | Bronchoalveolar Lavage Fluid - immunology | Respiratory Syncytial Virus Infections - metabolism | Respiratory Syncytial Virus Infections - immunology | CD4-Positive T-Lymphocytes - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-10 - metabolism | Female | Mice | Mice, Inbred BALB C | Bronchoalveolar Lavage Fluid - chemistry | Immunologic Factors - metabolism | Respiratory Syncytial Virus Infections - pathology | Interleukin-10 - immunology | Index Medicus | Abridged Index Medicus
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6. Full Text Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection
by Kolli, Deepthi and Gupta, Meera R and Sbrana, Elena and Velayutham, Thangam S and Chao, Hong and Casola, Antonella and Garofalo, Roberto P
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 10/2014, Volume 51, Issue 4, pp. 502 - 515
Respiratory syncytial virus | Pathogenesis | Alveolar macrophages | Viral infection | Human metapneumovirus | Respiratory System | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Pneumonia - physiopathology | Humans | Respiratory Syncytial Viruses - immunology | Respiratory Syncytial Virus Infections - metabolism | Respiratory Syncytial Virus Infections - immunology | Airway Obstruction - virology | Paramyxoviridae Infections - physiopathology | Lung - virology | Paramyxoviridae Infections - virology | Time Factors | Airway Obstruction - immunology | Respiratory Syncytial Virus Infections - physiopathology | Inflammation Mediators - metabolism | Respiratory Syncytial Virus Infections - prevention & control | Pneumonia - immunology | Lung - metabolism | Respiratory Syncytial Virus Infections - virology | Macrophages, Alveolar - immunology | Disease Models, Animal | Macrophages, Alveolar - virology | Metapneumovirus - immunology | Cytokines - metabolism | Paramyxoviridae Infections - metabolism | Metapneumovirus - pathogenicity | Airway Obstruction - physiopathology | Cells, Cultured | Lung - physiopathology | Pneumonia - virology | Paramyxoviridae Infections - immunology | Animals | Virus Replication | Mice, Inbred BALB C | Macrophages, Alveolar - metabolism | Lung - immunology | Respiratory Syncytial Viruses - pathogenicity | Studies | Airway management | Disease | Lungs | Rodents | Infections | Viral infections | Immune system | Apoptosis | Index Medicus | pathogenesis | viral infection | human metapneumovirus | Original Research | respiratory syncytial virus | alveolar macrophages
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7. Full Text Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection
by Fulton, Ross B and Meyerholz, David K and Varga, Steven M
The Journal of immunology (1950), ISSN 0022-1767, 08/2010, Volume 185, Issue 4, pp. 2382 - 2392
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | T-Lymphocytes, Regulatory - metabolism | Respiratory Syncytial Viruses - physiology | Humans | Respiratory Syncytial Viruses - immunology | Respiratory Syncytial Virus Infections - immunology | T-Lymphocytes, Regulatory - pathology | Host-Pathogen Interactions - immunology | T-Lymphocytes, Regulatory - immunology | Lung - virology | Forkhead Transcription Factors - metabolism | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Bronchoalveolar Lavage Fluid - cytology | Respiratory Syncytial Virus Infections - virology | Interleukin-2 Receptor alpha Subunit - immunology | Lung - pathology | Bronchoalveolar Lavage Fluid - virology | Inflammation - virology | Inflammation - immunology | Hep G2 Cells | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Lymphocyte Count | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Index Medicus | Abridged Index Medicus | Virus | T cells | Rodent | Lung | Treg
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8. Full Text Contribution of Fcγ receptors to human respiratory syncytial virus pathogenesis and the impairment of T‐cell activation by dendritic cells
by Gómez, Roberto S and Ramirez, Bruno A and Céspedes, Pablo F and Cautivo, Kelly M and Riquelme, Sebastián A and Prado, Carolina E and González, Pablo A and Kalergis, Alexis M
Immunology, ISSN 0019-2805, 01/2016, Volume 147, Issue 1, pp. 55 - 72
neutralizing antibodies | dendritic cells | human respiratory syncytial virus | Fcγ receptors | palivizumab | immune complexes | Human respiratory syncytial virus | Palivizumab | Dendritic cells | Immune complexes | Neutralizing antibodies | Life Sciences & Biomedicine | Immunology | Science & Technology | Antibodies, Viral - metabolism | Palivizumab - pharmacology | Coculture Techniques | Dendritic Cells - immunology | Receptors, IgG - deficiency | Respiratory Syncytial Virus Infections - metabolism | Respiratory Syncytial Virus Infections - immunology | Receptors, IgG - metabolism | T-Lymphocytes - virology | Viral Load | Lung - virology | Receptors, IgG - genetics | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Respiratory Syncytial Virus Infections - drug therapy | T-Lymphocytes - drug effects | Dendritic Cells - drug effects | Lung - metabolism | Dendritic Cells - virology | Respiratory Syncytial Virus Infections - virology | Respiratory Syncytial Virus, Human - pathogenicity | Dendritic Cells - metabolism | Disease Models, Animal | Adaptive Immunity | Antiviral Agents - pharmacology | Respiratory Syncytial Virus, Human - drug effects | Cytokines - metabolism | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Respiratory Syncytial Virus Infections - genetics | Antibodies, Neutralizing - pharmacology | Receptors, IgG - immunology | Mice, Knockout | Animals | Virus Replication | Lymphocyte Activation - drug effects | Respiratory Syncytial Virus, Human - immunology | Lung - drug effects | Antibodies, Viral - immunology | T-Lymphocytes - immunology | Lung - immunology | Immunoglobulin G - metabolism | Index Medicus | Life Sciences | Human health and pathology | Original
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