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Virus Research, ISSN 0168-1702, 2011, Volume 162, Issue 1, pp. 80 - 99
Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone worldwide early in life and is a leading cause of severe lower... 
RNA viruses | Paramyxoviruses | Pathogenesis | Antivirals | Replication | Pneumoviruses | Immune responses | Immune evasion | Vaccines | Epidemiology | INCREASED PHENOTYPIC STABILITY | PURIFIED-F-GLYCOPROTEIN | REPLICATION IN-VITRO | WASH IMMUNOGLOBULIN-G | SMALL HYDROPHOBIC PROTEIN | T-CELL RESPONSES | VIROLOGY | ENHANCED PULMONARY HISTOPATHOLOGY | HUMANIZED MONOCLONAL-ANTIBODY | IMMUNIZED BALB/C MICE | SITE-SPECIFIC ATTENUATION | Antibodies, Neutralizing - administration & dosage | Virus Replication - genetics | Humans | Vaccination | Viral Proteins - immunology | Antigens, Viral - genetics | Infant | Respiratory Syncytial Virus Infections - immunology | Respiratory Syncytial Virus, Human - genetics | Antibodies, Neutralizing - immunology | RNA, Viral - genetics | Respiratory Syncytial Virus Infections - drug therapy | Vaccines, Attenuated - administration & dosage | Respiratory Syncytial Virus Infections - prevention & control | Aged, 80 and over | Respiratory Syncytial Virus Infections - virology | Child | Communicable Disease Control - organization & administration | Cytokines - immunology | Viral Proteins - chemistry | Viral Proteins - genetics | Virus Replication - immunology | Immunity, Innate | Antiviral Agents - administration & dosage | Antigens, Viral - immunology | Respiratory Syncytial Virus, Human - immunology | Respiratory Syncytial Virus Vaccines - administration & dosage | Antibodies, Viral - immunology | RNA, Viral - immunology | Aged | Antibodies, Viral - genetics | Antiviral agents | Immunoglobulins | Biological products | Glycosaminoglycans | RNA | Dendritic cells | Genes | Melanoma | Infants | Biological response modifiers | HIV (Viruses) | Diseases | Virus diseases | Synthesis | Virus diseases in children | Monoclonal antibodies | Children | Tretinoin
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 31, Issue 3, pp. 524 - 532
Highlights ► This Phase 1 trial evaluated the safety and immunogenicity of an RSV (F) nanoparticle vaccine. ► The vaccine was well-tolerated and no related... 
Allergy and Immunology | Respiratory syncytial virus (RSV) | Palivizumab | Fusion protein (F protein) | Competitive ELISA | SF9 insect cell | Microneutralization | Aluminum phosphate | Anti-F IgG | Nanoparticle vaccine | UNITED-STATES | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | IMMUNE GLOBULIN | COTTON RATS | INFLUENZA | RISK | IMMUNOLOGY | F-GLYCOPROTEIN | INFANTS | INFECTION | YOUNG-CHILDREN | Recombinant Fusion Proteins - immunology | Single-Blind Method | Biotechnology | Respiratory Syncytial Virus Vaccines - immunology | Adjuvants, Immunologic - administration & dosage | Aluminum Compounds - adverse effects | Phosphates - administration & dosage | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Male | Nanoparticles - adverse effects | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Adjuvants, Immunologic - adverse effects | Young Adult | Respiratory Syncytial Virus Vaccines - adverse effects | Sf9 Cells | Technology, Pharmaceutical | Vaccines, Virosome - immunology | Vaccines, Synthetic - adverse effects | Placebos - adverse effects | Adult | Female | Placebos - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Vaccines, Virosome - administration & dosage | Vaccines, Synthetic - genetics | Vaccines, Virosome - genetics | Animals | Aluminum Compounds - administration & dosage | Phosphates - adverse effects | Vaccines, Virosome - adverse effects | Respiratory Syncytial Virus Vaccines - administration & dosage | Adolescent | Recombinant Fusion Proteins - genetics | Nanoparticles - administration & dosage | Vaccines, Synthetic - administration & dosage | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Neutralizing - blood | Virus diseases | Phosphates | Vaccines | Immunoglobulin G | Enzyme-linked immunosorbent assay | Proteins | Nanoparticles | Infections | Index Medicus
Journal Article
Virology, ISSN 0042-6822, 2016, Volume 494, pp. 215 - 224
Abstract A safe and effective vaccine against respiratory syncytial virus (RSV) should confer protection without causing vaccine-enhanced disease. Here, using... 
Infectious Disease | Virus-like particle | Respiratory syncytial virus | Safety | Cotton rats | Protection | Vaccines, DNA - genetics | Respiratory Syncytial Virus Vaccines - immunology | Viral Fusion Proteins - genetics | Respiratory Syncytial Viruses - immunology | Vaccines, DNA - immunology | Respiratory Syncytial Virus Infections - immunology | Vaccines, DNA - administration & dosage | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus Vaccines - adverse effects | Antibodies, Neutralizing - immunology | Vaccines, Virus-Like Particle - genetics | Immunoglobulin G - immunology | Respiratory Syncytial Virus Infections - prevention & control | Respiratory Syncytial Virus Infections - virology | Disease Models, Animal | Vaccines, Virus-Like Particle - adverse effects | Immunization | Viral Envelope Proteins - genetics | Cytokines - metabolism | Rats | Sigmodontinae | Vaccines, Virus-Like Particle - administration & dosage | Animals | Respiratory Syncytial Virus Vaccines - administration & dosage | Respiratory Syncytial Viruses - genetics | Vaccines, DNA - adverse effects | Antibodies, Viral - immunology | Vaccines, Virus-Like Particle - immunology | Viral Envelope Proteins - immunology | Respiratory Syncytial Virus Infections - pathology | Respiratory Syncytial Virus Vaccines - genetics | Glycoproteins | Health aspects | DNA | Vaccination | Formaldehyde | Histochemistry | Medical research | Medicine, Experimental | ANTIBODIES | PLASMIDS | EOSINOPHILS | LUNGS | GLYCOPROTEINS | RATS | 60 APPLIED LIFE SCIENCES | LYMPHOKINES | INFLAMMATION | VIRAL DISEASES | FORMALDEHYDE | COTTON | VIRUSES | VACCINES
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 4/2005, Volume 191, Issue 7, pp. 1093 - 1104
Background. Recombination technology can be used to create live attenuated respiratory syncytial virus (RSV) vaccines that contain combinations of known... 
Human respiratory syncytial virus | Transcriptional regulatory elements | Respiratory syncytial virus vaccines | Vaccination | Antibodies | Viruses | Infants | Children | Dosage | Genetic mutation | INFECTIOUS DISEASES | IN-VITRO | INFLUENZA-A VIRUS | SERONEGATIVE CHIMPANZEES | SH GENE | MUTATIONS | REVERSE GENETICS | RSV VACCINE | TEMPERATURE SENSITIVITY | INACTIVATED VACCINE | YOUNG-CHILDREN | Respiratory Syncytial Virus Vaccines - immunology | Respiratory Syncytial Viruses - physiology | Humans | Respiratory Syncytial Viruses - immunology | Child, Preschool | Infant | Virus Shedding | Mutation, Missense | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Respiratory Syncytial Virus Vaccines - adverse effects | Vaccines, Synthetic - adverse effects | Vaccines, Attenuated - administration & dosage | Genes, Viral | Respiratory Syncytial Virus Infections - prevention & control | Adult | Viral Nonstructural Proteins - immunology | Double-Blind Method | Vaccines, Synthetic - virology | DNA-Directed RNA Polymerases - immunology | Viral Nonstructural Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Vaccines, Attenuated - immunology | Virus Replication | Respiratory Syncytial Virus Vaccines - administration & dosage | Respiratory Syncytial Viruses - genetics | Vaccines, Synthetic - administration & dosage | Vaccines, Attenuated - adverse effects | Amino Acid Substitution | Vaccines, Attenuated - genetics | Care and treatment | Respiratory syncytial virus infection | Diagnosis | Health aspects
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 01/2017, Volume 215, Issue 1, pp. 24 - 33
Journal Article
Vaccine, ISSN 0264-410X, 2016, Volume 35, Issue 5, pp. 757 - 766
Highlights • A single dose of 3 × 105 CFUs of rBCG-N-hRSV cGMP elicits T-cell memory against hRSV. • rBCG-N-hRSV cGMP elicits a strong antiviral TH1/TH17... 
Allergy and Immunology | Human respiratory syncytial virus | Pulmonary inflammation | Bacillus Calmette et Guerin | T cells | Th1 | Viral infection | Th17 | Recombinant vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | RECRUITMENT | DENDRITIC CELLS | ENHANCED DISEASE | INFLUENZA | IMMUNOLOGY | PULMONARY EOSINOPHILIA | RESPONSES | INFANTS | ALVEOLAR MACROPHAGES | EXPRESSION | YOUNG-CHILDREN | Immunogenicity, Vaccine | Respiratory Syncytial Virus Vaccines - immunology | Humans | Nucleoproteins - genetics | Interleukin-17 - immunology | Viral Proteins - immunology | Th1 Cells - immunology | Respiratory Syncytial Virus Infections - immunology | Th17 Cells - virology | Th1 Cells - virology | BCG Vaccine - genetics | Lung - virology | Th17 Cells - drug effects | Immunity, Cellular - drug effects | Respiratory Syncytial Virus Infections - prevention & control | Immunization Schedule | Respiratory Syncytial Virus Infections - virology | Respiratory Syncytial Virus, Human - pathogenicity | Nucleoproteins - immunology | Th1 Cells - drug effects | Respiratory Syncytial Virus, Human - drug effects | Viral Proteins - genetics | Interleukin-17 - biosynthesis | Animals | CD8-Positive T-Lymphocytes - virology | Lymphocyte Activation - drug effects | Respiratory Syncytial Virus, Human - immunology | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Lung - drug effects | Respiratory Syncytial Virus Vaccines - administration & dosage | BCG Vaccine - immunology | Th17 Cells - immunology | Vaccines, Synthetic | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Respiratory Syncytial Virus Vaccines - genetics | BCG Vaccine - administration & dosage | Interferon-gamma - biosynthesis | Lung - immunology | Virus diseases | Prevention | Vaccines | Health aspects | Antigens | Pneumonia | Vaccination | Bacterial pneumonia | Disease susceptibility | Epidemics | Pathogenesis | Neutrophils | Viruses | T cell receptors | Infections | Pathology | Immunology | Respiratory syncytial virus | Lungs | Lymphocytes | Laboratory animals | Public health | Life Sciences | Human health and pathology
Journal Article
Journal of Virology, ISSN 0022-538X, 05/2017, Volume 91, Issue 10
Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and elderly people, and no marketed vaccine exists. In this... 
Live vectors | Replication deficient | Sendai vector | Respiratory syncytial virus | Sendai virus (SeV) | Viral vector | Genetic stability | Vaccine | RSV F protein | Paramyxovirus | EFFICIENT GENE-TRANSFER | genetic stability | NEUTRALIZING ANTIBODIES | CANDIDATE | viral vector | RSV VACCINE | F-GLYCOPROTEIN | LIVE | IMMUNIZATION | vaccine | IMMUNOGENICITY | VIROLOGY | replication deficient | live vectors | respiratory syncytial virus | CELL | paramyxovirus | MUCOSAL DELIVERY | Respiratory Syncytial Virus Vaccines - immunology | Immunoglobulin G - blood | Viral Fusion Proteins - genetics | Vaccines, Subunit - genetics | Respiratory Syncytial Virus Vaccines - chemistry | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus, Human - genetics | Antibodies, Neutralizing - immunology | Respiratory Syncytial Virus Infections - prevention & control | Female | Respiratory Syncytial Virus Infections - virology | Immunization | Vaccines, Subunit - chemistry | Sendai virus - immunology | Vaccines, Subunit - immunology | Sendai virus - genetics | Animals | Virus Replication | Respiratory Syncytial Virus, Human - immunology | Vaccines, Subunit - administration & dosage | Immunoglobulin A - immunology | Respiratory Syncytial Virus Vaccines - administration & dosage | Respiratory Syncytial Virus, Human - physiology | Vaccines, Attenuated | Antibodies, Viral - immunology | Mice | Mice, Inbred BALB C | Genetic Vectors | Respiratory Syncytial Virus Vaccines - genetics
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 16, pp. 7508 - 7518
Journal Article