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Virology, ISSN 0042-6822, 2016, Volume 494, pp. 215 - 224
Abstract A safe and effective vaccine against respiratory syncytial virus (RSV) should confer protection without causing vaccine-enhanced disease. Here, using... 
Infectious Disease | Virus-like particle | Respiratory syncytial virus | Safety | Cotton rats | Protection | Vaccines, DNA - genetics | Respiratory Syncytial Virus Vaccines - immunology | Viral Fusion Proteins - genetics | Respiratory Syncytial Viruses - immunology | Vaccines, DNA - immunology | Respiratory Syncytial Virus Infections - immunology | Vaccines, DNA - administration & dosage | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus Vaccines - adverse effects | Antibodies, Neutralizing - immunology | Vaccines, Virus-Like Particle - genetics | Immunoglobulin G - immunology | Respiratory Syncytial Virus Infections - prevention & control | Respiratory Syncytial Virus Infections - virology | Disease Models, Animal | Vaccines, Virus-Like Particle - adverse effects | Immunization | Viral Envelope Proteins - genetics | Cytokines - metabolism | Rats | Sigmodontinae | Vaccines, Virus-Like Particle - administration & dosage | Animals | Respiratory Syncytial Virus Vaccines - administration & dosage | Respiratory Syncytial Viruses - genetics | Vaccines, DNA - adverse effects | Antibodies, Viral - immunology | Vaccines, Virus-Like Particle - immunology | Viral Envelope Proteins - immunology | Respiratory Syncytial Virus Infections - pathology | Respiratory Syncytial Virus Vaccines - genetics | Glycoproteins | Health aspects | DNA | Vaccination | Formaldehyde | Histochemistry | Medical research | Medicine, Experimental | ANTIBODIES | PLASMIDS | EOSINOPHILS | LUNGS | GLYCOPROTEINS | RATS | 60 APPLIED LIFE SCIENCES | LYMPHOKINES | INFLAMMATION | VIRAL DISEASES | FORMALDEHYDE | COTTON | VIRUSES | VACCINES
Journal Article
Science Translational Medicine, ISSN 1946-6234, 08/2015, Volume 7, Issue 300, pp. 300ra126 - 300ra126
Journal Article
Journal of Virology, ISSN 0022-538X, 05/2017, Volume 91, Issue 10
Journal Article
Journal of Virology, ISSN 0022-538X, 05/2017, Volume 91, Issue 10
Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and elderly people, and no marketed vaccine exists. In this... 
Live vectors | Replication deficient | Sendai vector | Respiratory syncytial virus | Sendai virus (SeV) | Viral vector | Genetic stability | Vaccine | RSV F protein | Paramyxovirus | EFFICIENT GENE-TRANSFER | genetic stability | NEUTRALIZING ANTIBODIES | CANDIDATE | viral vector | RSV VACCINE | F-GLYCOPROTEIN | LIVE | IMMUNIZATION | vaccine | IMMUNOGENICITY | VIROLOGY | replication deficient | live vectors | respiratory syncytial virus | CELL | paramyxovirus | MUCOSAL DELIVERY | Respiratory Syncytial Virus Vaccines - immunology | Immunoglobulin G - blood | Viral Fusion Proteins - genetics | Vaccines, Subunit - genetics | Respiratory Syncytial Virus Vaccines - chemistry | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus, Human - genetics | Antibodies, Neutralizing - immunology | Respiratory Syncytial Virus Infections - prevention & control | Female | Respiratory Syncytial Virus Infections - virology | Immunization | Vaccines, Subunit - chemistry | Sendai virus - immunology | Vaccines, Subunit - immunology | Sendai virus - genetics | Animals | Virus Replication | Respiratory Syncytial Virus, Human - immunology | Vaccines, Subunit - administration & dosage | Immunoglobulin A - immunology | Respiratory Syncytial Virus Vaccines - administration & dosage | Respiratory Syncytial Virus, Human - physiology | Vaccines, Attenuated | Antibodies, Viral - immunology | Mice | Mice, Inbred BALB C | Genetic Vectors | Respiratory Syncytial Virus Vaccines - genetics
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 31, Issue 3, pp. 524 - 532
Highlights ► This Phase 1 trial evaluated the safety and immunogenicity of an RSV (F) nanoparticle vaccine. ► The vaccine was well-tolerated and no related... 
Allergy and Immunology | Respiratory syncytial virus (RSV) | Palivizumab | Fusion protein (F protein) | Competitive ELISA | SF9 insect cell | Microneutralization | Aluminum phosphate | Anti-F IgG | Nanoparticle vaccine | UNITED-STATES | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | IMMUNE GLOBULIN | COTTON RATS | INFLUENZA | RISK | IMMUNOLOGY | F-GLYCOPROTEIN | INFANTS | INFECTION | YOUNG-CHILDREN | Recombinant Fusion Proteins - immunology | Single-Blind Method | Biotechnology | Respiratory Syncytial Virus Vaccines - immunology | Adjuvants, Immunologic - administration & dosage | Aluminum Compounds - adverse effects | Phosphates - administration & dosage | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Male | Nanoparticles - adverse effects | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Adjuvants, Immunologic - adverse effects | Young Adult | Respiratory Syncytial Virus Vaccines - adverse effects | Sf9 Cells | Technology, Pharmaceutical | Vaccines, Virosome - immunology | Vaccines, Synthetic - adverse effects | Placebos - adverse effects | Adult | Female | Placebos - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Vaccines, Virosome - administration & dosage | Vaccines, Synthetic - genetics | Vaccines, Virosome - genetics | Animals | Aluminum Compounds - administration & dosage | Phosphates - adverse effects | Vaccines, Virosome - adverse effects | Respiratory Syncytial Virus Vaccines - administration & dosage | Adolescent | Recombinant Fusion Proteins - genetics | Nanoparticles - administration & dosage | Vaccines, Synthetic - administration & dosage | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Neutralizing - blood | Virus diseases | Phosphates | Vaccines | Immunoglobulin G | Enzyme-linked immunosorbent assay | Proteins | Nanoparticles | Infections | Index Medicus
Journal Article
Vaccine, ISSN 0264-410X, 2016, Volume 35, Issue 5, pp. 757 - 766
Highlights • A single dose of 3 × 105 CFUs of rBCG-N-hRSV cGMP elicits T-cell memory against hRSV. • rBCG-N-hRSV cGMP elicits a strong antiviral TH1/TH17... 
Allergy and Immunology | Human respiratory syncytial virus | Pulmonary inflammation | Bacillus Calmette et Guerin | T cells | Th1 | Viral infection | Th17 | Recombinant vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | RECRUITMENT | DENDRITIC CELLS | ENHANCED DISEASE | INFLUENZA | IMMUNOLOGY | PULMONARY EOSINOPHILIA | RESPONSES | INFANTS | ALVEOLAR MACROPHAGES | EXPRESSION | YOUNG-CHILDREN | Immunogenicity, Vaccine | Respiratory Syncytial Virus Vaccines - immunology | Humans | Nucleoproteins - genetics | Interleukin-17 - immunology | Viral Proteins - immunology | Th1 Cells - immunology | Respiratory Syncytial Virus Infections - immunology | Th17 Cells - virology | Th1 Cells - virology | BCG Vaccine - genetics | Lung - virology | Th17 Cells - drug effects | Immunity, Cellular - drug effects | Respiratory Syncytial Virus Infections - prevention & control | Immunization Schedule | Respiratory Syncytial Virus Infections - virology | Respiratory Syncytial Virus, Human - pathogenicity | Nucleoproteins - immunology | Th1 Cells - drug effects | Respiratory Syncytial Virus, Human - drug effects | Viral Proteins - genetics | Interleukin-17 - biosynthesis | Animals | CD8-Positive T-Lymphocytes - virology | Lymphocyte Activation - drug effects | Respiratory Syncytial Virus, Human - immunology | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Lung - drug effects | Respiratory Syncytial Virus Vaccines - administration & dosage | BCG Vaccine - immunology | Th17 Cells - immunology | Vaccines, Synthetic | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Respiratory Syncytial Virus Vaccines - genetics | BCG Vaccine - administration & dosage | Interferon-gamma - biosynthesis | Lung - immunology | Virus diseases | Prevention | Vaccines | Health aspects | Antigens | Pneumonia | Vaccination | Bacterial pneumonia | Disease susceptibility | Epidemics | Pathogenesis | Neutrophils | Viruses | T cell receptors | Infections | Pathology | Immunology | Respiratory syncytial virus | Lungs | Lymphocytes | Laboratory animals | Public health | Life Sciences | Human health and pathology
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 16, pp. 7508 - 7518
Journal Article
Journal of Virology, ISSN 0022-538X, 11/2017, Volume 91, Issue 22
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1904 - 10
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 2014, Volume 88, Issue 8, pp. 4237 - 4250
A recombinant chimeric bovine/human parainfluenza type 3 virus (rB/HPIV3) vector expressing the respiratory syncytial virus (RSV) fusion F glycoprotein... 
LIVE-ATTENUATED VACCINE | INACTIVATED VIRUS | VIROLOGY | HEMAGGLUTININ-NEURAMINIDASE | RHESUS-MONKEYS | ENHANCED PULMONARY PATHOLOGY | HUMAN METAPNEUMOVIRUS | COTTON RATS | GENE-EXPRESSION | YOUNG-CHILDREN | ANTIGEN INSERTION | Viral Fusion Proteins - administration & dosage | Respiratory Syncytial Virus Vaccines - immunology | Viral Fusion Proteins - genetics | Humans | Respiratory Syncytial Virus Vaccines - chemistry | Respiratory Syncytial Viruses - immunology | Parainfluenza Virus 3, Bovine - genetics | Respiratory Syncytial Virus Infections - immunology | Viral Fusion Proteins - immunology | Respiratory Syncytial Virus, Human - genetics | Parainfluenza Virus 3, Human - genetics | Viral Fusion Proteins - chemistry | Mesocricetus | Protein Engineering | Respiratory Syncytial Virus Infections - prevention & control | Respiratory Syncytial Virus Infections - virology | Cricetinae | Parainfluenza Virus 3, Bovine - physiology | Parainfluenza Virus 3, Human - physiology | Genetic Vectors - metabolism | Genetic Vectors - genetics | Animals | Virus Replication | Respiratory Syncytial Virus, Human - immunology | Respiratory Syncytial Virus Vaccines - administration & dosage | Respiratory Syncytial Viruses - genetics | Antibodies, Viral - immunology | Respiratory Syncytial Virus Vaccines - genetics | Vaccines and Antiviral Agents
Journal Article