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Science, ISSN 0036-8075, 11/2013, Volume 342, Issue 6160, pp. 866 - 871
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30875
The human respiratory tract is heavily exposed to microorganisms. Viral respiratory tract pathogens, like RSV, influenza and rhinoviruses cause major morbidity... 
POLYOMAVIRUS | COMMON COLD | RNA | MULTIDISCIPLINARY SCIENCES | RHINOVIRUS SPECIES C | SAMPLES | VIRUS TTV | SYNCYTIAL VIRUS | IDENTIFICATION | YOUNG-CHILDREN | GENOME | Metagenomics | Picornaviridae - genetics | Humans | Influenza A virus - genetics | Middle Aged | Paramyxoviridae Infections - genetics | Phylogeny | Paramyxoviridae Infections - diagnosis | Respiratory Tract Infections - genetics | Picornaviridae Infections - virology | Young Adult | Metagenome - genetics | Paramyxoviridae Infections - virology | Nasopharynx - virology | Aged, 80 and over | Adult | Influenza, Human - diagnosis | Influenza, Human - virology | Picornaviridae Infections - genetics | Respiratory Tract Infections - virology | Child | Picornaviridae - isolation & purification | Influenza A virus - isolation & purification | Paramyxoviridae - genetics | Picornaviridae Infections - diagnosis | Respiratory Tract Infections - diagnosis | Influenza, Human - genetics | Adolescent | Aged | Paramyxoviridae - isolation & purification | Care and treatment | Diseases | Library collections | Pathogens | Laboratories | Fragments | Science | Viruses | Infections | Genomes | Tissues | Disease control | Patients | Morbidity | Pathogenicity | Respiratory tract | Microorganisms | Disease transmission | Influenza | Respiratory tract diseases | Molecular biology | Bioinformatics | Deoxyribonucleic acid--DNA | Biological Sciences | Naturvetenskap | Natural Sciences | Bioinformatik och systembiologi | Bioinformatics and Systems Biology | Biologiska vetenskaper | Deoxyribonucleic acid | DNA
Journal Article
Lancet, The, ISSN 0140-6736, 2013, Volume 382, Issue 9909, pp. 1993 - 2002
Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | CT | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Genome biology, ISSN 1474-760X, 01/2017, Volume 18, Issue 1, pp. 12 - 17
Background: Respiratory illness caused by viral infection is associated with the development and exacerbation of childhood asthma. Little is known about the... 
Host response | Infection | Virus | RNA-seq | Transcriptome | Asymptomatic | Airway epithelium | Children | Host-virus interactions | Asthma | SYNCYTIAL VIRUS BRONCHIOLITIS | PATHWAYS | SUBPHENOTYPES | RHINOVIRUS | POLYADENYLATION | SYMPTOMS | IDENTIFICATION | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFLAMMATION | GENETICS & HEREDITY | ENRICHMENT | Humans | Gene Expression Profiling | Respiratory Mucosa - virology | Respiratory Tract Infections - genetics | Case-Control Studies | Host-Pathogen Interactions - immunology | Respiratory Mucosa - immunology | Asthma - immunology | RNA Virus Infections - complications | Respiratory Tract Infections - complications | Respiratory Tract Infections - virology | RNA Virus Infections - immunology | Child | RNA Virus Infections - genetics | RNA Viruses - genetics | RNA Virus Infections - virology | Asthma - genetics | Sequence Analysis, RNA | Host-Pathogen Interactions - genetics | Asthma - complications | Gene Expression Regulation, Viral | Respiratory Tract Infections - immunology | High-Throughput Nucleotide Sequencing | Respiratory Mucosa - metabolism | RNA viruses | Viruses | Infections | Genomes | Gene expression | Ribonucleic acid--RNA | Respiratory tract | Illnesses | Respiratory diseases | CXCL11 protein | Bioinformatics | Deoxyribonucleic acid--DNA | Methods | Viral infections | Cilia
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