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PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0133349
Esophageal squamous cell carcinomas (ESCC) have become a severe threat to health and the current treatments for ESCC are frequently not effective. Recent... 
CANCER-CELLS | PROSTATE | APOPTOSIS | CISPLATIN | ANGIOGENESIS | SIGNALING PATHWAY | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PROLIFERATION | INDUCTION | Cyclin D1 - metabolism | AMP-Activated Protein Kinases - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Male | Esophageal Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Esophageal Neoplasms - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Survival - drug effects | Metformin - pharmacology | Tumor Suppressor Protein p53 - metabolism | Enzyme Activation - drug effects | Blotting, Western | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Resting Phase, Cell Cycle - drug effects | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Esophageal Neoplasms - drug therapy | Diabetics | Squamous cell carcinoma | Growth | Cell cycle | Metformin | Tumor proteins | Health aspects | Esophageal cancer | Flow cytometry | Regulations | p53 Protein | Colorectal cancer | Kinases | Epidemiology | Anticancer properties | Angiogenesis | Cell activation | Cell growth | Gastroenterology | Xenografts | Tumorigenesis | Inhibition | Growth factors | G1 phase | Esophageal carcinoma | Enzymes | Adenosine | Diabetes mellitus | Cyclin-dependent kinases | Health risks | Risk reduction | Cell division | Cultures | Metabolism | Esophagus | Cyclin-dependent kinase inhibitor p21 | Hospitals | Cell lines | Cyclin-dependent kinase inhibitor p27 | Antitumor activity | Hypoxia | Cancer
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2014, Volume 4, Issue 1, p. 4012
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2011, Volume 65, Issue 7, pp. 467 - 473
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e98207
Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation... 
PROSTATE | OBESITY | ACTIVATED PROTEIN-KINASE | INHIBITION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | AKT | AUTOPHAGY | TUMOR SUPPRESSORS | AMP-Activated Protein Kinases - metabolism | Oxidants - pharmacology | Hydrogen - pharmacology | Apoptosis - drug effects | Humans | Metformin - pharmacology | Enzyme Activation - drug effects | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | Hypoglycemic Agents - pharmacology | Breast Neoplasms - pathology | Forkhead Transcription Factors - metabolism | Cell Line, Tumor | Female | Resting Phase, Cell Cycle - drug effects | Oxidative Stress - drug effects | Forkhead Box Protein O3 | G1 Phase Cell Cycle Checkpoints - drug effects | AMP-Activated Protein Kinases - genetics | Oxidative stress | Cancer cells | Cell cycle | Breast cancer | Metformin | Diabetes therapy | Apoptosis | Flow cytometry | Cell culture | Phosphorylation | Hydrogen peroxide | Bax protein | Bcl-2 protein | AKT protein | Superoxide dismutase | Biology | Activation | Kinases | Caspase-3 | Cancer therapies | Western blotting | Necrosis | Proteins | Signal transduction | Cell growth | Catalase | Penicillin | FOXO3 protein | G1 phase | Diabetes mellitus | Extracellular signal-regulated kinase | Caspase | MAP kinase | Pharmacology | Gene expression | Insulin | Zinc | Polymerase chain reaction | Cytometry | Molecular modelling | Cell number | Diabetes | Viability | Prostate | Cancer
Journal Article
Journal Article
International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, 2012, Volume 5, Issue 8, pp. 796 - 805
Journal Article
Science, ISSN 0036-8075, 04/2016, Volume 352, Issue 6284, pp. 453 - 459
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e41693
Journal Article