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Journal Article
Nature neuroscience, ISSN 1546-1726, 04/2008, Volume 11, Issue 6, pp. 667 - 675
.... To restore photosensitivity, we genetically targeted a light-activated cation channel, channelrhodopsin-2, to second-order neurons, ON bipolar cells, of degenerated retinas in vivo in the Pde6b(rd1) (also known as rd1) mouse model... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Motor Activity - physiology | Retinal Bipolar Cells - radiation effects | Visual Pathways - radiation effects | Vision, Ocular - radiation effects | Behavior, Animal | Quinoxalines - pharmacology | Vision, Ocular - physiology | Visual Pathways - physiology | Motor Activity - radiation effects | Evoked Potentials, Visual - physiology | Retinal Bipolar Cells - physiology | Time Factors | Light | Rhodopsin - physiology | Disease Models, Animal | Retinal Ganglion Cells - physiology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Mice, Transgenic | Excitatory Amino Acid Antagonists - pharmacology | Retinal Degeneration - physiopathology | Electroporation - methods | Piperazines - pharmacology | Patch-Clamp Techniques | Animals | Visual Pathways - drug effects | Evoked Potentials, Visual - drug effects | Photic Stimulation - methods | Retinal Degeneration - therapy | Luminescent Proteins - genetics | Mice | Evoked Potentials, Visual - radiation effects | Retinal Degeneration - pathology | Luminescent Proteins - metabolism | Physiological aspects | Retinal degeneration | Photoreceptors | Genetic aspects | Ion channels | Research | Risk factors | Index Medicus
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