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1. Full Text Age-related macular degeneration-emerging pathogenetic and therapeutic concepts
by Gehrs, Karen M and Anderson, Don H and Johnson, Lincoln V and Hageman, Gregory S
Annals of medicine (Helsinki), ISSN 0785-3890, 2006, Volume 38, Issue 7, pp. 450 - 471
basal laminar deposit (BLamD) | complement Factor H (CFH) | epidemiology | genetics | Age-related macular degeneration (AMD) | complement Factor B (BF) | geographic atrophy | choroidal neovascularization | inflammation | drusen | Bruch's membrane | surgery | Drusen | Choroidal neovascularization | Complement Factor B (BF) | Surgery | Geographic atrophy | Genetics | Inflammation | Basal laminar deposit (BLamD) | Epidemiology | Complement Factor H (CFH) | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Public health. Hygiene-occupational medicine | Public health. Hygiene | Biological and medical sciences | General aspects | Miscellaneous | Medical sciences | Age Factors | Blindness - physiopathology | Humans | Middle Aged | Risk Factors | Palliative Care | Dry Eye Syndromes - genetics | Complement Activation - immunology | Disease Progression | Complement Activation - genetics | Macular Degeneration - genetics | Macular Degeneration - therapy | Aged, 80 and over | Aging | Macular Degeneration - epidemiology | Aged | Retinal Drusen - complications | Blindness - etiology | Index Medicus | Bruch’s membrane
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2. Full Text Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration
by Byrne, Leah C and Dalkara, Deniz and Luna, Gabriel and Fisher, Steven K and Clérin, Emmanuelle and Sahel, Jose-Alain and Léveillard, Thierry and Flannery, John G
The Journal of clinical investigation, ISSN 0021-9738, 01/2015, Volume 125, Issue 1, pp. 105 - 116
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Dependovirus - genetics | Gene Transfer Techniques | Genetic Therapy | Gene Expression | Retinal Cone Photoreceptor Cells | Transduction, Genetic | Cell Survival | Mice, Inbred C57BL | Rhodopsin - metabolism | Retinal Degeneration - metabolism | Animals | Rhodopsin - genetics | Thioredoxins - biosynthesis | Thioredoxins - genetics | Retinal Degeneration - therapy | Evoked Potentials, Visual | Eye Proteins - genetics | Photic Stimulation | Retinal Degeneration - pathology | Eye Proteins - biosynthesis | Retinal Rod Photoreceptor Cells | Care and treatment | Physiological aspects | Retinal degeneration | Photoreceptors | Genetic aspects | Research | Gene therapy | Health aspects | Hypotheses | Rodents | Colleges & universities | Retina | Mutation | Laboratory animals | Index Medicus | Abridged Index Medicus
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3. Full Text A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies
by Khanna, H and Davis, E.E and Murga-Zamalloa, C.A and Estrada-Cuzcano, A and Lopez, I and Hollander, A.I. den and Zonneveld-Vrieling, M.N and Othman, M.I and Waseem, N and Chakarova, C and Maubaret, C and Diaz-Font, A and Macdonald, I and Muzny, D.M and Wheeler, D.A and Morgan, M and Lewis, L.R and Logan, C.V and Tan, P.L and Beer, M.A and Inglehearn, C.F and Lewis, R.A and Jacobson, S.G and Bergmann, C and Beales, P.L and Attie-Bitach, T and Johnson, C.A and Otto, E.A and Bhattacharya, S.S and Hildebrandt, F and Gibbs, R.A and Koenekoop, R.K and Swaroop, A and Katsanis, N
Nature genetics, ISSN 1061-4036, 2009, Volume 41, Issue 6, pp. 739 - 745
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Ophthalmology | Retinopathies | Retinal Degeneration - genetics | Humans | RNA, Messenger - genetics | Europe - epidemiology | Retinitis Pigmentosa - genetics | Retinal Degeneration - prevention & control | Zebrafish - genetics | Genetic Variation | Retinitis Pigmentosa - enzymology | Animals | GTP Phosphohydrolases - metabolism | Ciliary Body - physiopathology | Retinal Degeneration - epidemiology | GTP Phosphohydrolases - genetics | Adaptor Proteins, Signal Transducing - genetics | Alleles | Uveitis - epidemiology | Bardet-Biedl Syndrome - genetics | Polymorphism, Single Nucleotide | Mutation | Uveitis - genetics | Allelomorphism | Retinal degeneration | Physiological aspects | Genetic aspects | Research | Gene mutations | Studies | Genetics | Retina | Biomedical research | Index Medicus
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4. Full Text Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait
by Bhattacharya, Shomi S and Wright, Alan F and Chakarova, Christina F and Abd El-Aziz, Mai M
Nature reviews. Genetics, ISSN 1471-0056, 04/2010, Volume 11, Issue 4, pp. 273 - 284
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | RNA Processing, Post-Transcriptional | Retinal Degeneration - genetics | Humans | Stress, Physiological | Photoreceptor Cells, Vertebrate - physiology | Complement Activation - genetics | Photoreceptor Cells, Vertebrate - radiation effects | Cell Death - genetics | Energy Metabolism | Retinal Degeneration - therapy | Inflammation - genetics | Lipid Peroxidation - genetics | Retinal Degeneration - pathology | Photoreceptor Cells, Vertebrate - pathology | Macular degeneration | Care and treatment | Physiological aspects | Photoreceptors | Genetic aspects | Research | Gene therapy | Health aspects | Index Medicus
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5. Full Text CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration
by Koo, Taeyoung and Park, Sung Wook and Jo, Dong Hyun and Kim, Daesik and Kim, Jin Hyoung and Cho, Hee-Yeon and Kim, Jeungeun and Kim, Jeong Hun and Kim, Jin-Soo
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1855 - 8
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Dependovirus - genetics | Endonucleases - genetics | Genetic Vectors - administration & dosage | Intravitreal Injections | RNA, Guide - genetics | Humans | Choroidal Neovascularization - therapy | Choroidal Neovascularization - etiology | Male | Vascular Endothelial Growth Factor A - genetics | Retinal Pigment Epithelium - pathology | Choroidal Neovascularization - pathology | Endonucleases - administration & dosage | Retinal Pigment Epithelium - blood supply | Clostridiales - genetics | Retinal Pigment Epithelium - radiation effects | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Disease Models, Animal | Lasers - adverse effects | Macular Degeneration - etiology | Cell Line | Specific Pathogen-Free Organisms | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Bacterial Proteins - genetics | Treatment Outcome | Bacterial Proteins - administration & dosage | Genetic Vectors - genetics | Animals | Macular Degeneration - genetics | Macular Degeneration - therapy | Gene Editing - methods | Mice | Choroidal Neovascularization - genetics | Genetic Therapy - methods | Macular Degeneration - pathology | CRISPR | Therapeutic applications | Medical treatment | Viruses | Retina | Genomes | Ribonucleic acid--RNA | Epithelium | Age related diseases | Retinal pigment epithelium | Vascularization | Macular degeneration | Angiogenesis | Gene disruption | Hypoxia | Endonuclease | Vascular endothelial growth factor | Genetic modification | Age | Index Medicus
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