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Circulation Research, ISSN 0009-7330, 04/2014, Volume 114, Issue 9, pp. 1389 - 1397
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2006, Volume 103, Issue 7, pp. 2328 - 2333
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2015, Volume 112, Issue 39, pp. 12163 - 12168
Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally... 
MiR-150 | MicroRNA | Retinopathy | Neovascularization | Endothelial cells | B-CELL DEVELOPMENT | PROLIFERATIVE RETINOPATHY | endothelial cells | ANGIOGENESIS | OXYGEN-INDUCED RETINOPATHY | MULTIDISCIPLINARY SCIENCES | neovascularization | MOUSE | C-MYB | MODEL | HYPOXIA | retinopathy | microRNA | miR-150 | INDUCED CHOROIDAL NEOVASCULARIZATION | Intravitreal Injections | Humans | 3' Untranslated Regions - genetics | Laser Capture Microdissection | Molecular Sequence Data | MicroRNAs - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Retinal Neovascularization - metabolism | MicroRNAs - pharmacology | Luciferases | Base Sequence | HEK293 Cells | Retinal Vessels - cytology | Receptors, CXCR4 - genetics | Retinal Neovascularization - genetics | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | MicroRNAs - administration & dosage | Frizzled Receptors - metabolism | Mice, Knockout | Receptors, CXCR4 - metabolism | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Animals | Choroidal Neovascularization - metabolism | Frizzled Receptors - genetics | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Choroidal Neovascularization - genetics | Physiological aspects | Genetic aspects | Blindness | Pathology | Angiogenesis | MicroRNAs | Blood vessels | Physiology | Gene expression | Index Medicus | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1855 - 8
LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that... 
CELLS | SPECIFICITIES | ENDONUCLEASE | EFFICACY | INJECTION | MULTIDISCIPLINARY SCIENCES | CPF1 | CRISPR-CAS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | NUCLEASES | Dependovirus - genetics | Endonucleases - genetics | Genetic Vectors - administration & dosage | Intravitreal Injections | RNA, Guide - genetics | Humans | Choroidal Neovascularization - therapy | Choroidal Neovascularization - etiology | Male | Vascular Endothelial Growth Factor A - genetics | Retinal Pigment Epithelium - pathology | Choroidal Neovascularization - pathology | Endonucleases - administration & dosage | Retinal Pigment Epithelium - blood supply | Clostridiales - genetics | Retinal Pigment Epithelium - radiation effects | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Disease Models, Animal | Lasers - adverse effects | Macular Degeneration - etiology | Cell Line | Specific Pathogen-Free Organisms | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Bacterial Proteins - genetics | Treatment Outcome | Bacterial Proteins - administration & dosage | Genetic Vectors - genetics | Animals | Macular Degeneration - genetics | Macular Degeneration - therapy | Gene Editing - methods | Mice | Choroidal Neovascularization - genetics | Genetic Therapy - methods | Macular Degeneration - pathology | CRISPR | Therapeutic applications | Medical treatment | Viruses | Retina | Genomes | Ribonucleic acid--RNA | Epithelium | Retinal pigment epithelium | Vascularization | Macular degeneration | Angiogenesis | Gene disruption | Hypoxia | Degeneration | Endonuclease | Vascular endothelial growth factor | Genetic modification | Age | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 04/2010, Volume 106, Issue 8, pp. 1425 - 1433
RATIONALE:Arteriovenous malformations (AVMs) result in anomalous direct blood flow between arteries and veins, bypassing the normal capillary bed. Depending on... 
Angiogenesis | Mouse models of cardiovascular disease | Endothelial cells | mouse models of cardiovascular disease | RETINAL VASCULATURE | endothelial cells | CARDIAC & CARDIOVASCULAR SYSTEMS | HEREDITARY HEMORRHAGIC TELANGIECTASIA | ENDOTHELIAL-CELL PROLIFERATION | MICE LACKING ENDOGLIN | angiogenesis | BETA RECEPTOR | RECEPTOR-LIKE KINASE-1 | MORPHOGENESIS | VESSELS | GENE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Cell Proliferation | Capillaries - pathology | Retinal Neovascularization - metabolism | Antigens, CD - genetics | Arteriovenous Malformations - physiopathology | Neovascularization, Pathologic - pathology | Intracellular Signaling Peptides and Proteins - deficiency | Endoglin | Microcirculation | Arteriovenous Malformations - pathology | Aging | Neovascularization, Pathologic - physiopathology | Retinal Neovascularization - genetics | Cadherins - genetics | Capillaries - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Endothelial Cells - metabolism | Mice, Transgenic | Regional Blood Flow | Mice, Knockout | Animals | Arteriovenous Malformations - genetics | Arteriovenous Malformations - metabolism | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Mutation | Endothelial Cells - pathology | Retinal Neovascularization - physiopathology | Angiogenic Proteins - metabolism | Integrases - genetics | Retinal Neovascularization - pathology | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 03/2010, Volume 106, Issue 5, pp. 932 - 940
RATIONALE:Pathological neovascularization is a critical component of diseases such as proliferative retinopathies, cancer and rheumatoid arthritis, yet much... 
Tnfα-convertase | Metalloproteinase-disintegrins | Pathological neovascularization | Adams | Proliferative retinopathy | SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | metalloproteinase-disintegrins | pathological neovascularization | HB-EGF | TNF alpha-convertase | NECROSIS-FACTOR-ALPHA | RETINAL NEOVASCULARIZATION | ADAMs | TISSUE INHIBITOR | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | GROWTH-FACTOR | HEMATOLOGY | proliferative retinopathy | TRANSGENIC MICE | CONVERTASE TACE | ADAM17 Protein | Cell Proliferation | Receptor, TIE-2 | Actins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Pericytes - enzymology | Intercellular Signaling Peptides and Proteins - metabolism | Neovascularization, Pathologic - enzymology | Melanoma, Experimental - prevention & control | Time Factors | Swine | Retinal Neovascularization - enzymology | Retinal Neovascularization - prevention & control | Neovascularization, Pathologic - prevention & control | Retinal Neovascularization - genetics | Disease Models, Animal | Promoter Regions, Genetic | Melanoma, Experimental - blood supply | Mice, Inbred C57BL | Cells, Cultured | ADAM Proteins - deficiency | Melanoma, Experimental - pathology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Tumor Burden | Mice, Knockout | Heparin-binding EGF-like Growth Factor | Animals | Receptor Protein-Tyrosine Kinases - genetics | Neovascularization, Pathologic - genetics | Mice | ADAM Proteins - genetics | Endothelial Cells - enzymology | Integrases - genetics | Cell Movement | Index Medicus | Angiogenesis | Animal models of human disease | Vascular Biology | TNFα-convertase
Journal Article
Diabetes, ISSN 0012-1797, 02/2011, Volume 60, Issue 2, pp. 614 - 624
OBJECTIVE-Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation... 
EPITHELIUM-DERIVED FACTOR | NAD(P)H OXIDASE | PROSTATE-CANCER CELLS | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | SMOOTH-MUSCLE-CELLS | ANGIOTENSIN-II | TUMOR ANGIOGENESIS | LEUKOCYTE-TYPE | ENDOTHELIAL GROWTH-FACTOR | 12/15-LIPOXYGENASE | Immunohistochemistry | Arachidonate 12-Lipoxygenase - metabolism | Humans | Nerve Growth Factors - metabolism | Retinal Neovascularization - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Vitreous Body - metabolism | Mass Spectrometry | Retinal Neovascularization - genetics | Eye Proteins - genetics | Serpins - genetics | Enzyme-Linked Immunosorbent Assay | Retinal Vessels - metabolism | Serpins - metabolism | Flavanones - pharmacology | Enzyme Inhibitors - pharmacology | Ischemia - metabolism | Retinal Vessels - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - genetics | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Analysis of Variance | Eye Proteins - metabolism | Nerve Growth Factors - genetics | Mice | Diabetic retinopathy | Physiological aspects | Development and progression | Genetic aspects | Research | Neovascularization | Vascular endothelial growth factor | Risk factors | Index Medicus | Abridged Index Medicus | Complications
Journal Article
Immunology, ISSN 0019-2805, 04/2016, Volume 147, Issue 4, pp. 414 - 428
Neovascularization ( NV ), as a cardinal complication of several ocular diseases, has been intensively studied, and research has shown its close association... 
vascular endothelial cells | M1, M2 macrophage polarization | interleukin‐17A | vascular endothelial growth factor | ocular neovascularization | Vascular endothelial cells | Interleukin-17A | Ocular neovascularization | Vascular endothelial growth factor | IL-17 RECEPTOR | ANGIOGENESIS | IMMUNOLOGY | CHOROIDAL NEOVASCULARIZATION | INHIBITION | vascular endothelial growth actor | SQUAMOUS-CELL CARCINOMA | interleukin-17A | TUMOR-ASSOCIATED MACROPHAGES | RETINOPATHY | ocular eovascularization | EXPRESSION | T-CELLS | ENDOTHELIAL GROWTH-FACTOR | Retina - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Retinal Neovascularization - immunology | Retina - immunology | Retinal Neovascularization - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Choroidal Neovascularization - pathology | Inflammation Mediators - metabolism | Retinal Neovascularization - genetics | Cytokines - genetics | Macrophages - immunology | Disease Models, Animal | Cell Line | Gene Expression | Cytokines - metabolism | Signal Transduction | Antibodies, Monoclonal - pharmacology | Choroidal Neovascularization - immunology | Antibodies, Neutralizing - pharmacology | Mice, Transgenic | Interleukin-17 - deficiency | Disease Progression | Interleukin-17 - metabolism | Macrophages - metabolism | Phenotype | Animals | Choroidal Neovascularization - metabolism | Interleukin-17 - antagonists & inhibitors | Mice | Choroidal Neovascularization - genetics | Retina - pathology | Retinal Neovascularization - pathology | Neovascularization | Interleukins | Macrophages | Endothelium | Angiogenesis | Cytokines | Rodents | Index Medicus | Original
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2016, Volume 36, Issue 9, pp. 1919 - 1927
OBJECTIVE—Pathological ocular neovascularization is a major cause of blindness. Increased dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA)... 
Diabetic retinopathy | Choroidal neovascularization | Arachidonic acid | Docosahexaenoic acid | CYP2C inhibitor | Neovascularization, Physiologic - drug effects | Humans | Retinopathy of Prematurity - genetics | Quinolines - pharmacology | Retinopathy of Prematurity - physiopathology | Fatty Acids, Omega-3 - pharmacology | Lasers | Hyperoxia - complications | Retinopathy of Prematurity - enzymology | Retinal Neovascularization - enzymology | Retinal Neovascularization - prevention & control | Retinal Neovascularization - genetics | Cytochrome P-450 CYP2C8 - metabolism | Aorta - enzymology | Disease Models, Animal | Cytochrome P-450 CYP2C8 Inhibitors - pharmacology | Fatty Acids, Omega-3 - metabolism | Tissue Culture Techniques | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Choroidal Neovascularization - enzymology | Angiogenesis Inhibitors - pharmacology | Genotype | Mice, Transgenic | Choroidal Neovascularization - prevention & control | Choroidal Neovascularization - physiopathology | Phenotype | Animals | Retinopathy of Prematurity - prevention & control | Acetates - pharmacology | Cytochrome P-450 CYP2C8 - genetics | Retinal Neovascularization - physiopathology | Choroidal Neovascularization - genetics | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Index Medicus | pathological angiogenesis | ω-3 LCPUFA
Journal Article