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Stem Cells, ISSN 1066-5099, 10/2009, Volume 27, Issue 10, pp. 2427 - 2434
Human induced pluripotent stem cells (iPSCs) have great promise for cellular therapy, but it is unclear if they have the same potential as human embryonic stem... 
Retinal pigmented epithelium | Age-related macular degeneration | Induced pluripotent stem cells | Retinitis pigmentosa | ISOMEROHYDROLASE | ROD OUTER SEGMENTS | PHAGOCYTOSIS | MACULAR DEGENERATION | retinal pigmented epithelium | IPS CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MICROSOMAL PROTEIN | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | retinitis pigmentosa | induced pluripotent stem cells | RPE CELLS | DIFFERENTIATION | HEMATOLOGY | age-related macular degeneration | EYE DEVELOPMENT | EXPRESSION | Retinal Pigment Epithelium - metabolism | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - analysis | Retinal Diseases - therapy | RNA, Messenger - analysis | Retinal Rod Photoreceptor Cells - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | SOXB1 Transcription Factors - pharmacology | Homeodomain Proteins - pharmacology | Cell Differentiation - physiology | Integrin alphaV - metabolism | Biomarkers - metabolism | Cell Line | Nanog Homeobox Protein | Pluripotent Stem Cells - cytology | Biomarkers - analysis | Octamer Transcription Factor-3 - pharmacology | Phagocytosis - physiology | Regeneration - physiology | Nerve Tissue Proteins - metabolism | Pluripotent Stem Cells - metabolism | Phenotype | Regeneration - drug effects | Cell Differentiation - drug effects | Octamer Transcription Factor-3 - metabolism | Pluripotent Stem Cells - drug effects | Retinal Rod Photoreceptor Cells - cytology | Cell Polarity - physiology | Brain Tissue Transplantation - methods | Retinal Pigment Epithelium - cytology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8518 - 8523
Progress in retinal-cell therapy derived from human pluripotent stem cells currently faces technical challenges that require the development of easy and... 
Epithelial cells | Induced pluripotent stem cells | Stem cells | Cell lines | Photoreceptors | Neural stem cells | Cultured cells | Pluripotent stem cells | Embryonic stem cells | Cellular differentiation | Cones | Retinal ganglion cells | Rods | DIRECTED DIFFERENTIATION | VESICLE-LIKE STRUCTURES | MULTIDISCIPLINARY SCIENCES | MOUSE | INDUCTION | FATE | PLURIPOTENT STEM-CELLS | cones | GROWTH | rods | retinal ganglion cells | GENERATION | EXPRESSION | REVEALS | Immunohistochemistry | Retinal Pigment Epithelium - metabolism | Homeodomain Proteins - metabolism | Humans | Multipotent Stem Cells - metabolism | Retinal Neurons - cytology | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Transfection | SOXB1 Transcription Factors - genetics | Adult | Cell Differentiation | Cell Culture Techniques | Dermis - cytology | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Cell Line | Gene Expression | Nanog Homeobox Protein | Photoreceptor Cells - cytology | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Retinal Neurons - metabolism | Multipotent Stem Cells - cytology | Octamer Transcription Factor-3 - metabolism | Photoreceptor Cells - metabolism | Fibroblasts - cytology | Microscopy, Fluorescence | Retinal Pigment Epithelium - cytology | Physiological aspects | Retina | Tissue | Molecules | Cellular biology | Index Medicus | Biological Sciences
Journal Article
STEM CELLS Translational Medicine, ISSN 2157-6564, 05/2013, Volume 2, Issue 5, pp. 384 - 393
Although protocols to generate retinal pigmented epithelium (RPE) from human pluripotent stem cells have become more efficient since the first report in 2004,... 
Differentiation | Embryonic stem cells | Pluripotent stem cells | Retinal pigmented epithelium | Induced pluripotent stem cells | Cellular therapy | PATHWAYS | TRANSLOCATION | TRANSCRIPTION | MACULAR DEGENERATION | DEATH | INDUCTION | CULTURE | CELL & TISSUE ENGINEERING | ROCK INHIBITOR | DISEASE | GROWTH-FACTOR | Cell Line | Retinal Pigment Epithelium - metabolism | Pluripotent Stem Cells - cytology | Humans | RNA, Messenger - genetics | Cells, Cultured | Visual Fields - drug effects | RNA, Messenger - metabolism | Cell Lineage - drug effects | Gene Expression Regulation - drug effects | Pluripotent Stem Cells - metabolism | Cell Differentiation - genetics | Pyrroles - pharmacology | Activins - pharmacology | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Cell Differentiation - drug effects | Pluripotent Stem Cells - drug effects | Cell Proliferation - drug effects | Niacinamide - pharmacology | Retinal Pigment Epithelium - cytology | Retinal Pigment Epithelium - drug effects | Phenotypes | Data analysis | Clinical trials | Retina | Transplantation | Research | Epithelium | Cell differentiation | Experiments | Retinal pigment epithelium | Cell adhesion & migration | Macular degeneration | Efficiency | Stem cells | Fibroblasts | Growth factors | Pluripotency | Index Medicus | Protocols and Manufacturing for Cell-Based Therapies
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2011, Volume 108, Issue 28, pp. E279 - E287
Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1–40 (Aβ40) and Aβ1–42 (Aβ42), have been... 
DRUSEN FORMATION | COMPLEMENT FACTOR-H | TARGETED REPLACEMENT | DIETARY-FAT | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | APOLIPOPROTEIN-E GENE | MOUSE MODEL | BETA IMMUNIZATION | MICROARRAY ANALYSIS | TRANSGENIC MICE | Retinal Pigment Epithelium - metabolism | Vision, Low - prevention & control | Apolipoprotein E4 - genetics | Dose-Response Relationship, Immunologic | Humans | Male | Complement System Proteins - metabolism | Retinal Pigment Epithelium - pathology | Antibodies, Bispecific - administration & dosage | Immunotherapy | Peptide Fragments - immunology | Amyloid beta-Peptides - metabolism | Dietary Fats - administration & dosage | Female | Disease Models, Animal | Macular Degeneration - etiology | Vision, Low - physiopathology | Macular Degeneration - physiopathology | Mice, Transgenic | Mice, Knockout | Antibodies, Bispecific - therapeutic use | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Macular Degeneration - therapy | Peptide Fragments - antagonists & inhibitors | Amyloid beta-Peptides - immunology | Mice | Mice, Inbred BALB C | Macular Degeneration - pathology | Macular degeneration | Retina | Rodents | Cells | Blindness | Animal models | Deposits | Neurodegenerative diseases | Preservation | Cognitive ability | Antibodies | beta -Amyloid | Visual perception | Diets | Apolipoprotein E | Vision | Amyloid | retinal pigment epithelium | Alzheimer's disease | Age | Plaques | Index Medicus | PNAS Plus | Biological Sciences
Journal Article
Journal Article
BMC Biology, ISSN 1741-7007, 04/2014, Volume 12, Issue 1, pp. 28 - 28
Background: One of the promises in regenerative medicine is to regenerate or replace damaged tissues. The embryonic chick can regenerate its retina by... 
Regeneration | Retina | Transdifferentiation | LET-7 MICRORNA | DOWN-REGULATION | PAX6 | PLURIPOTENT STEM-CELLS | MESSENGER-RNAS | OPTIC CUP | BIOLOGY | HUMAN FIBROBLASTS | NEURAL RETINA | EXPRESSION | Retinal Pigment Epithelium - metabolism | Transcription, Genetic - drug effects | Homeodomain Proteins - metabolism | Fibroblast Growth Factor 2 - pharmacology | Stem Cells - metabolism | Chickens - metabolism | Retinal Pigment Epithelium - pathology | Cell Transdifferentiation - drug effects | Cilia - drug effects | Repressor Proteins - metabolism | Retinal Pigment Epithelium - drug effects | Avian Proteins - metabolism | Cell Dedifferentiation - drug effects | Alternative Splicing - genetics | PAX6 Transcription Factor | Cilia - metabolism | Cellular Reprogramming - drug effects | Alternative Splicing - drug effects | Animals | Eye Proteins - metabolism | Models, Biological | Retinal Pigment Epithelium - embryology | Stem Cells - drug effects | Cell Cycle - drug effects | Paired Box Transcription Factors - metabolism | Avian Proteins - genetics | Complications and side effects | Care and treatment | Patient outcomes | Physiological aspects | Development and progression | Fibroblast growth factors | Research | Epithelium | Retinal diseases | Risk factors | Instrument industry | Polymerase chain reaction | Stem cells | Colleges & universities | Technological change | Software | Histology | Kinases | Mammals | Gene expression | Experiments | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 05/2017, Volume 35, Issue 5, pp. 1176 - 1188
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 2014, Volume 10, Issue 5, pp. e1004360 - e1004360
Journal Article