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Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 09/2012, Volume 53, Issue 10, pp. 6314 - 6323
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 1999, Volume 93, Issue 1, pp. 126 - 138
Vasoactive intestinal peptide (VIP) is a neuropeptide present in the lymphoid microenvironment with a multiplicity of actions. Two sources for VIP have been... 
Lymphoid organs | Lymphocyte | Neuroimmunomodulation | Vasoactive intestinal peptide | ELISA | CHROMAFFIN CELLS | VASOACTIVE-INTESTINAL-PEPTIDE | IMMUNOREACTIVE GROWTH-HORMONE | RAT THYMUS | lymphoid organs | DEPENDENT PROTEIN-KINASE | IMMUNOLOGY | NEUROSCIENCES | lymphocyte | vasoactive intestinal peptide | neuroimmunomodulation | IMMUNE-SYSTEM | MESSENGER-RNA | GENE-EXPRESSION | T-LYMPHOCYTES | Neuroimmunomodulation - immunology | Vasoactive Intestinal Peptide - metabolism | Granulocytes - cytology | Spleen - immunology | Tetradecanoylphorbol Acetate - pharmacology | Mitogens - pharmacology | Rats, Wistar | Male | Macrophages, Peritoneal - cytology | Enzyme-Linked Immunosorbent Assay - standards | Vasoactive Intestinal Peptide - biosynthesis | Carcinogens - pharmacology | Dexamethasone - pharmacology | Flow Cytometry | Isoquinolines - pharmacology | Cell Division - immunology | Peritoneum - cytology | Sensitivity and Specificity | Mast Cells - metabolism | Peritoneum - immunology | Granulocytes - metabolism | Colforsin - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Thymus Gland - cytology | Rats | Feedback - physiology | Spleen - cytology | Lymph Nodes - immunology | Lymph Nodes - cytology | Cell Division - drug effects | Interleukin-1 - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Interleukin-6 - pharmacology | Sulfonamides | Retinaldehyde - pharmacology | Glucocorticoids - pharmacology | Interleukin-2 - pharmacology | Mast Cells - cytology | Thymus Gland - immunology | Macrophages, Peritoneal - metabolism | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1976 - 18
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to... 
RESCUE | MUTANT RHODOPSIN | PHARMACOLOGICAL CHAPERONES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DOMINANT | MUTATIONS | MONOCLONAL-ANTIBODIES | RETINITIS-PIGMENTOSA | STARGARDT-DISEASE | CELL-DEATH | Neuroprotective Agents - therapeutic use | NIH 3T3 Cells | Retinaldehyde - therapeutic use | Thiophenes - therapeutic use | Humans | Male | Retinal Degeneration - etiology | Protein Transport - drug effects | Retinal Rod Photoreceptor Cells - metabolism | Rhodopsin - metabolism | Alcohol Oxidoreductases - genetics | Neuroprotective Agents - pharmacology | Rhodopsin - agonists | ATP-Binding Cassette Transporters - genetics | Protein Folding - drug effects | HEK293 Cells | Female | Retinal Rod Photoreceptor Cells - drug effects | Disease Models, Animal | Retinal Rod Photoreceptor Cells - radiation effects | Retinal Degeneration - drug therapy | Light - adverse effects | Mice, Inbred C57BL | Thiophenes - pharmacology | Treatment Outcome | Protein Transport - genetics | Mice, Knockout | Animals | High-Throughput Screening Assays | Rhodopsin - genetics | Rhodopsin - antagonists & inhibitors | Retinaldehyde - pharmacology | Cell Line, Tumor | Mice | Mutation | Retinal Degeneration - pathology | Retinal Rod Photoreceptor Cells - pathology | Rhodopsin | Cell survival | Toxicity | Retinitis pigmentosa | Homeostasis | Cytotoxicity | Retina | Pharmacology | Light effects | Molecular chains | Mutants | Mammalian cells | Retinal degeneration | Photoreceptors | Retinitis | Degeneration | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2781 - 2794
Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-related macular degeneration (AMD). This molecule has been... 
LIPOFUSCIN FLUOROPHORE | MEDICINE, RESEARCH & EXPERIMENTAL | LEBER CONGENITAL AMAUROSIS | DENSITY MAPS | CONE PHOTORECEPTORS | PROTEIN-COUPLED RECEPTOR | PIGMENT EPITHELIUM | CRYSTAL-STRUCTURE | STARGARDT DISEASE | MACULAR DEGENERATION | VISUAL CYCLE MODULATOR | Free Radical Scavengers - pharmacology | Propanolamines - metabolism | Free Radical Scavengers - chemistry | Stereoisomerism | Retinaldehyde - chemistry | Crystallography, X-Ray | Male | Retinaldehyde - metabolism | Retinal Degeneration - metabolism | Macular Degeneration - drug therapy | Retinal Degeneration - prevention & control | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Phenyl Ethers - chemistry | ATP-Binding Cassette Transporters - genetics | Cattle | cis-trans-Isomerases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Female | cis-trans-Isomerases - metabolism | Catalytic Domain | Enzyme Inhibitors - metabolism | Free Radical Scavengers - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Models, Molecular | Phenyl Ethers - pharmacology | Mice, Knockout | cis-trans-Isomerases - chemistry | Macular Degeneration - metabolism | Animals | Retinaldehyde - toxicity | Propanolamines - chemistry | Mice | Mice, Inbred BALB C | Schiff Bases - metabolism | Phenyl Ethers - metabolism | Propanolamines - pharmacology | Retinal Degeneration - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Vitamin A | Laboratories | Light | Pigments | Data collection | Retina | Cytotoxicity | Photoreceptors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2012, Volume 3, pp. 58 - 58
Several aldo keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K-m and k(cat) values. Only AKR1B10 and... 
Retinaldehyde | Retinoic acid | Aldo-keto reductase | Cancer | Retinol | retinol | PHARMACOLOGY & PHARMACY | retinoic acid | cancer | aldo-keto reductase | retinaldehyde
Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 83, pp. 219 - 232
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12710 - 12715
Inward rectifying potassium (Kir) channels participate in regulating potassium concentration (K⁺) in the central nervous system (CNS), including in the retina.... 
Neuroscience | Neurons | Neuroglia | Antibodies | Rats | Amacrine cells | Retina | Cell membranes | Electric current | Potassium | Peptide carrier | Müller cells | Pep-1 | Kir | Retinal bipolar cells | ADAPTED CAT RETINA | NEGATIVE RESPONSE | PROTEIN-KINASE-C | MULTIDISCIPLINARY SCIENCES | ROD BIPOLAR CELLS | VERTEBRATE RETINA | GLIAL-CELLS | Muller cells | RCS RAT | PROXIMAL PORTION | retinal bipolar cells | peptide carrier | SCOTOPIC THRESHOLD RESPONSE | Potassium - metabolism | Retina - drug effects | Retina - metabolism | Central Nervous System - metabolism | Antibodies - metabolism | Potassium Channels - physiology | Barium - metabolism | Cytoplasm - metabolism | Retinaldehyde - metabolism | Antibodies - physiology | Nerve Degeneration - metabolism | Central Nervous System - physiology | Potassium Channels - metabolism | Rats, Mutant Strains | Retinaldehyde - physiology | Electroretinography | Potassium Channels - pharmacology | Potassium Channels, Inwardly Rectifying | Neuroglia - physiology | Barium - pharmacology | Barium - physiology | Cytoplasm - physiology | Potassium - pharmacology | Antibodies - pharmacology | Retina - physiology | Patch-Clamp Techniques | Potassium - physiology | Animals | Retinaldehyde - pharmacology | Neuroglia - metabolism | Viral antibodies | Nervous system | Degeneration | Research | Potassium channels | Observations | Health aspects | Retinal diseases | Peptides | Rodents | Cells | Index Medicus | Biological Sciences
Journal Article