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Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2016, Volume 20, Issue 9, pp. 1651 - 1663
Among retinal macular diseases, the juvenile recessive Stargardt disease and the age‐related degenerative disease arise from carbonyl and oxidative stresses (... 
all | retinal | bisretinoid A2E | photoreceptor | phloroglucinol | retinal pigment epithelium | chromene adduct | trans | all-trans-retinal | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE-STRESS | LIPOFUSCIN | MACULAR DEGENERATION | MECHANISMS | CELL BIOLOGY | INDUCED CELL-DAMAGE | IN-VIVO | DISEASE | MICE | ACCUMULATION | BISRETINOIDS | Hydrogen Peroxide - toxicity | Retinal Pigment Epithelium - metabolism | Retinoids - metabolism | Oxidative Stress | Rats, Long-Evans | Benzopyrans - metabolism | Chromatography, High Pressure Liquid | Retinal Pigment Epithelium - pathology | Animals | Proton Magnetic Resonance Spectroscopy | Protective Agents - pharmacology | Retinaldehyde - toxicity | Cytoprotection - drug effects | Phloroglucinol - pharmacology | Cell Death - drug effects | Photoreceptor Cells, Vertebrate - metabolism | Retinal Pigment Epithelium - drug effects | Chemical inhibitors | Peroxides | Epithelium | Analysis | Retina | Photoreceptors | Toxicity | Apoptosis | Cell culture | Oxidative stress | Phosphatidylethanolamine | Reactive oxygen species | Transformation | Hydrogen peroxide | Medical treatment | Phloroglucinol | Lipid peroxidation | Lipids | Phenolic compounds | Accumulation | Retinal pigment epithelium | Organic chemistry | Cell death | Phenols | Conflicts of interest | Polyphenols | Transformations | Carbonyls | Index Medicus | Life Sciences | Cellular Biology | Human health and pathology | all‐trans‐retinal | Original
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 7, pp. 5059 - 5069
Compromised clearance of all-trans-retinal (atRAL), a component of the retinoid cycle, increases the susceptibility of mouse retina to acute light-induced... 
VISUAL CYCLE | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | 5-HT1A RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | IN-VIVO | RECESSIVE RETINITIS-PIGMENTOSA | GENE ABCR | BINDING-PROPERTIES | NEUTROPHIL NADPH-OXIDASE | Reactive Oxygen Species - metabolism | Receptor, Serotonin, 5-HT2A - genetics | Calcium - metabolism | Humans | NADPH Oxidases - metabolism | Corneal Dystrophies, Hereditary - genetics | Type C Phospholipases - metabolism | Retinaldehyde - metabolism | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - genetics | Corneal Dystrophies, Hereditary - pathology | ATP-Binding Cassette Transporters - metabolism | NADPH Oxidases - genetics | Signal Transduction | Light - adverse effects | Receptor, Muscarinic M3 - metabolism | Alcohol Oxidoreductases - metabolism | Corneal Dystrophies, Hereditary - metabolism | Receptor, Muscarinic M3 - genetics | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Mice, Knockout | Macular Degeneration - metabolism | Animals | Macular Degeneration - genetics | Type C Phospholipases - genetics | Mice | Inositol 1,4,5-Trisphosphate - genetics | Photoreceptor Cells, Vertebrate - metabolism | Receptor, Serotonin, 5-HT2A - metabolism | Inositol 1,4,5-Trisphosphate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Macular Degeneration - pathology | Index Medicus | Molecular Bases of Disease | Vitamin A | Retinal metabolism | Vision | Reactive oxygen species (ROS) | Retinoid
Journal Article
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 11/2011, Volume 119, Issue 11, pp. 1590 - 1595
Background: Palate development depends on complex events and is very sensitive to disruption. Accordingly, clefts are the most common congenital malformations... 
Cleft palate | Receptors | Palatal consonants | Bones | Palate | Retinoids | Research | Aryl hydrocarbon receptors | Epithelium | Guanine nucleotide dissociation inhibitors | Embryos | 2,3,7,8-tetrachlorodibenzo-p-dioxin tcdd | Teratogenesis | Rar | Mesenchyme | Mouse | Cleft | Retinaldehyde dehydrogenase (raldh) | Ahr | Nasal epithelium | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) | RAR | SIGNALING PATHWAYS | MOUSE EMBRYOGENESIS | CLEFT-LIP | AH RECEPTOR | AHR | cleft | nasal epithelium | retinaldehyde dehydrogenase (RALDH) | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | mouse | ENVIRONMENTAL SCIENCES | mesenchyme | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | teratogenesis | MESSENGER-RNA | METABOLISM | GENE-EXPRESSION | MICE | TOXICOLOGY | SYNTHETIC RETINOIDS | Cleft Palate - chemically induced | Retinal Dehydrogenase - metabolism | Mesoderm - drug effects | Mice, Transgenic | Receptors, Retinoic Acid - metabolism | Cleft Palate - genetics | Palate - embryology | Animals | Tretinoin - metabolism | Cleft Palate - etiology | Polychlorinated Dibenzodioxins - toxicity | Receptors, Aryl Hydrocarbon - metabolism | Models, Animal | Mesoderm - metabolism | Mice | Palate - drug effects | Real-Time Polymerase Chain Reaction | Retinoic Acid Receptor alpha | Physiological aspects | Embryonic development | Genetic aspects | Dioxin | Tretinoin | Index Medicus
Journal Article
Journal Article
Toxicology, ISSN 0300-483X, 2016, Volume 371, pp. 41 - 48
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1976 - 18
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to... 
RESCUE | MUTANT RHODOPSIN | PHARMACOLOGICAL CHAPERONES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DOMINANT | MUTATIONS | MONOCLONAL-ANTIBODIES | RETINITIS-PIGMENTOSA | STARGARDT-DISEASE | CELL-DEATH | Neuroprotective Agents - therapeutic use | NIH 3T3 Cells | Retinaldehyde - therapeutic use | Thiophenes - therapeutic use | Humans | Male | Retinal Degeneration - etiology | Protein Transport - drug effects | Retinal Rod Photoreceptor Cells - metabolism | Rhodopsin - metabolism | Alcohol Oxidoreductases - genetics | Neuroprotective Agents - pharmacology | Rhodopsin - agonists | ATP-Binding Cassette Transporters - genetics | Protein Folding - drug effects | HEK293 Cells | Female | Retinal Rod Photoreceptor Cells - drug effects | Disease Models, Animal | Retinal Rod Photoreceptor Cells - radiation effects | Retinal Degeneration - drug therapy | Light - adverse effects | Mice, Inbred C57BL | Thiophenes - pharmacology | Treatment Outcome | Protein Transport - genetics | Mice, Knockout | Animals | High-Throughput Screening Assays | Rhodopsin - genetics | Rhodopsin - antagonists & inhibitors | Retinaldehyde - pharmacology | Cell Line, Tumor | Mice | Mutation | Retinal Degeneration - pathology | Retinal Rod Photoreceptor Cells - pathology | Rhodopsin | Cell survival | Toxicity | Retinitis pigmentosa | Homeostasis | Cytotoxicity | Retina | Pharmacology | Light effects | Molecular chains | Mutants | Mammalian cells | Retinal degeneration | Photoreceptors | Retinitis | Degeneration | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2781 - 2794
Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-related macular degeneration (AMD). This molecule has been... 
LIPOFUSCIN FLUOROPHORE | MEDICINE, RESEARCH & EXPERIMENTAL | LEBER CONGENITAL AMAUROSIS | DENSITY MAPS | CONE PHOTORECEPTORS | PROTEIN-COUPLED RECEPTOR | PIGMENT EPITHELIUM | CRYSTAL-STRUCTURE | STARGARDT DISEASE | MACULAR DEGENERATION | VISUAL CYCLE MODULATOR | Free Radical Scavengers - pharmacology | Propanolamines - metabolism | Free Radical Scavengers - chemistry | Stereoisomerism | Retinaldehyde - chemistry | Crystallography, X-Ray | Male | Retinaldehyde - metabolism | Retinal Degeneration - metabolism | Macular Degeneration - drug therapy | Retinal Degeneration - prevention & control | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Phenyl Ethers - chemistry | ATP-Binding Cassette Transporters - genetics | Cattle | cis-trans-Isomerases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Female | cis-trans-Isomerases - metabolism | Catalytic Domain | Enzyme Inhibitors - metabolism | Free Radical Scavengers - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Models, Molecular | Phenyl Ethers - pharmacology | Mice, Knockout | cis-trans-Isomerases - chemistry | Macular Degeneration - metabolism | Animals | Retinaldehyde - toxicity | Propanolamines - chemistry | Mice | Mice, Inbred BALB C | Schiff Bases - metabolism | Phenyl Ethers - metabolism | Propanolamines - pharmacology | Retinal Degeneration - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Vitamin A | Laboratories | Light | Pigments | Data collection | Retina | Cytotoxicity | Photoreceptors | Index Medicus | Abridged Index Medicus
Journal Article
Aquatic Toxicology, ISSN 0166-445X, 2007, Volume 82, Issue 4, pp. 281 - 295
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2018, Volume 141, Issue 1, pp. 163 - 170
Induction of oral tolerance to haptens is an efficient way to prevent allergic contact dermatitis (ACD) in mice. Toll-like receptor (TLR)–mediated sensing of... 
microbiota | contact dermatitis | dendritic cells | Oral tolerance | Toll-like receptor 4 | ACTIVATION | RETINOIC-ACID | INDUCTION | IMMUNOLOGY | BETA | ALLERGY | IN-VIVO | REGULATORY T-CELLS | SKIN INFLAMMATION | INNATE IMMUNITY | ANTIGEN | HYPERSENSITIVITY | Dermatitis, Allergic Contact - immunology | Intestines - pathology | Dendritic Cells - immunology | Dermatitis, Allergic Contact - genetics | Dendritic Cells - pathology | Immune Tolerance | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Dermatitis, Allergic Contact - pathology | Intestines - immunology | T-Lymphocytes, Regulatory - pathology | Mice, Knockout | T-Lymphocytes, Regulatory - immunology | Animals | Dinitrofluorobenzene - toxicity | Interferon-gamma - immunology | Mice | Gastrointestinal Microbiome - immunology | Interferon-gamma - genetics | Homeostasis | Gram-positive bacteria | Effector cells | Cytotoxicity | Lymphocytes T | Haptens | Licensing | Dermatitis | Adoptive transfer | Lymph nodes | Proteins | Microbiota | CD103 antigen | Metabolites | Lymphocytes | Intestine | Rodents | Gastroenterology | Bone marrow | Toll-like receptors | Forkhead protein | Chimeras | Conditioning | Digestive tract | Antigens | CD11b antigen | Gnotobiotics | Dendritic cells | Digestive system | Hypersensitivity | Dinitrofluorobenzene | T cell receptors | Retinaldehyde | Conversion | Immunological tolerance | Hemopoiesis | Immune systems | Studies | Probiotics | Contact dermatitis | γ-Interferon | Skin | Interferon | Index Medicus | Abridged Index Medicus | Life Sciences
Journal Article