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Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2014, Volume 32, Issue 3, pp. 436 - 444
The aim of this study was to determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic profile of E7107 in patients with advanced... 
E7107 | Phase I | Medicine & Public Health | Advanced solid tumors | Pharmacodynamic | Oncology | Pharmacology/Toxicology | Pharmacokinetic | RING SIDEROBLASTS | DOMINANT RETINITIS-PIGMENTOSA | PLADIENOLIDE D | GENE | ONCOLOGY | RP11 | PHARMACOLOGY & PHARMACY | MUTATIONS | SPLICING FACTOR | Neoplasms - metabolism | Leukocytes, Mononuclear - metabolism | Nausea - chemically induced | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Diarrhea - chemically induced | RNA, Messenger - metabolism | Epoxy Compounds - pharmacokinetics | Macrolides - pharmacokinetics | Antineoplastic Agents - adverse effects | Epoxy Compounds - administration & dosage | Vision Disorders - chemically induced | Female | Antineoplastic Agents - pharmacokinetics | Spliceosomes | RNA Splicing - drug effects | Leukocytes, Mononuclear - drug effects | Macrolides - administration & dosage | Neoplasms - drug therapy | Macrolides - adverse effects | Vomiting - chemically induced | Maximum Tolerated Dose | Aged | Infusions, Intravenous | Epoxy Compounds - adverse effects | Antimitotic agents | Complications and side effects | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Pharmacokinetics | Drug therapy | Tumors | Statistical analysis | Research & development--R&D | Patients | Cancer therapies | Drug dosages | Pharmaceuticals | Index Medicus
Journal Article
Diabetologia, ISSN 0012-186X, 12/2010, Volume 53, Issue 12, pp. 2656 - 2666
Up-regulation of the receptor for AGEs (RAGE) and its ligands in diabetes has been observed in various tissues. Here, we sought to determine levels of RAGE and... 
Diabetic retinopathy | Medicine & Public Health | Human Physiology | Müller glia | Metabolic Diseases | Cytokine | Internal Medicine | Inflammation | RAGE | MAPK | S100B | Muller glia | ACTIVATION | RAT RETINA | MACULAR DEGENERATION | NEURODEGENERATION | FACTOR-KAPPA-B | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | EXPERIMENTAL DIABETIC-RETINOPATHY | GROWTH-FACTOR | PROTEINS | EXPRESSION | Retina - metabolism | Receptors, Immunologic - physiology | Neuroglia - pathology | Streptozocin | Humans | Hyperglycemia - complications | Male | Diabetic Retinopathy - pathology | Retinitis - genetics | Retina - cytology | Hyperglycemia - pathology | Inflammation Mediators - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | Retinitis - etiology | Receptor for Advanced Glycation End Products | Cell Line | Glucose - adverse effects | Rats | Glucose - pharmacology | Rats, Sprague-Dawley | Diabetic Retinopathy - metabolism | Hyperglycemia - metabolism | Animals | Diabetic Neuropathies - pathology | Diabetes Mellitus, Experimental - pathology | Neuroglia - metabolism | Hyperglycemia - etiology | Diabetic Neuropathies - metabolism | Receptors, Immunologic - genetics | Retina - pathology | Receptors, Immunologic - metabolism | Retinitis - metabolism | RNA | Development and progression | Ophthalmology | Glucose | Intermediate filament proteins | Protein kinases | Enzyme-linked immunosorbent assay | Dextrose | Glucose metabolism | Hyperglycemia | Mitogens | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 234 - 243
Revascularization of ischemic tissue is a highly desirable outcome in multiple diseases, including cardiovascular diseases and ischemic retinopathies.... 
Angiogenesis | Oxidative stress | Inflammation | Ischemia | Nrf2 | NADPH oxidase | DIABETIC-RETINOPATHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOTENSIN-II | RETINAL ISCHEMIA-REPERFUSION | NAD(P)H OXIDASE | PROTECTIVE ROLE | ENDOCRINOLOGY & METABOLISM | ANIMAL-MODEL | VESSEL LOSS | NEOVASCULARIZATION | PREMATURITY | Retina - drug effects | Retinitis - chemically induced | Retina - metabolism | Oxidative Stress | Receptors, Notch - metabolism | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Ischemia - genetics | Oxygen - adverse effects | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Retinitis - genetics | NF-E2-Related Factor 2 - genetics | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Ischemia - pathology | Animals, Newborn | Retinitis - pathology | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Ischemia - metabolism | Neovascularization, Pathologic - chemically induced | NF-E2-Related Factor 2 - deficiency | Mice, Knockout | Animals | NADPH Oxidase 2 - metabolism | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | NADPH Oxidase 2 - genetics | Retina - pathology | Retinitis - metabolism | Oxidases | Medical colleges | Ophthalmology | Vascular endothelial growth factor | Analysis | Endothelial growth factors | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2016, Volume 374, Issue 3, pp. 296 - 297
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 1, pp. E81 - E90
Journal Article
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 04/2016, Volume 57, Issue 4, pp. 1553 - 1562
Journal Article
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2010, Volume 115, Issue 4, pp. 930 - 940
P>Photoreceptor degeneration is the hallmark of a group of inherited blinding diseases collectively termed retinitis pigmentosa (RP); a major cause of... 
CAST | apoptosis | CNX295 | calcium | retina | Retina | Calcium | Apoptosis | RETINAL DEGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | RD1 MOUSE | CELL-DEATH | PATHOLOGICAL APOPTOSIS | CROSS-TALK | CYCLIC GUANOSINE-MONOPHOSPHATE | GENE-EXPRESSION | MU-CALPAIN | MOUSE RETINA | RETINITIS-PIGMENTOSA | Calpain - metabolism | Glycoproteins - therapeutic use | Humans | Photoreceptor Cells, Vertebrate - drug effects | Mice, Transgenic | Calcium-Binding Proteins - therapeutic use | Mice, Inbred C3H | Retinal Degeneration - prevention & control | Photoreceptor Cells, Vertebrate - enzymology | Retinitis Pigmentosa - chemically induced | Retinitis Pigmentosa - prevention & control | Retinitis Pigmentosa - enzymology | Animals | Cell Death - physiology | Glycoproteins - toxicity | Mice | Retinal Degeneration - chemically induced | Cell Death - drug effects | Retinal Degeneration - pathology | Photoreceptor Cells, Vertebrate - pathology | Retinal Degeneration - enzymology | Retinitis Pigmentosa - pathology | Calpain - antagonists & inhibitors | Organ Culture Techniques | Neurosciences | Peptides | Cell death | Analysis | Blindness | Calpain | Ophthalmology | Neurochemistry | Inhibitor drugs | Toxicity | Proteases | Index Medicus | Explants | Animal models | retinal degeneration | Calpastatin | Cell survival | Retinitis pigmentosa | Proteinase | Cell activation | Neurodegeneration | Photoreceptors | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
by Curran M and Noble S
Drugs, ISSN 0012-6667, 2001, Volume 61, Issue 8, pp. 1145 - 1150
Valganciclovir is a prodrug of ganciclovir which has been developed for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. Oral... 
New drug profiles | Retinitis, treatment | Antivirals, general | Cytomegalovirus infections, treatment | Research and development | Valganciclovir, general | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | PHARMACOKINETICS | ERA | DISEASE | GANCICLOVIR | AIDS | PHARMACOLOGY & PHARMACY | CYTOMEGALOVIRUS-INFECTION | ANTIRETROVIRAL THERAPY | UPDATE | TOXICOLOGY | TRANSPLANT RECIPIENTS | RETINITIS | Prodrugs - administration & dosage | Peripheral Nervous System Diseases - chemically induced | Antiviral Agents - pharmacokinetics | Ganciclovir - adverse effects | Humans | Ganciclovir - analogs & derivatives | Biological Availability | Retinal Detachment - chemically induced | Ganciclovir - pharmacokinetics | Fever - chemically induced | Sleep Initiation and Maintenance Disorders - chemically induced | Cytomegalovirus Retinitis - drug therapy | Ganciclovir - pharmacology | Neutropenia - chemically induced | Headache - chemically induced | Paresthesia - chemically induced | Antiviral Agents - pharmacology | Administration, Oral | Anemia - chemically induced | Thrombocytopenia - chemically induced | Antiviral Agents - administration & dosage | Randomized Controlled Trials as Topic | Prodrugs - adverse effects | Prodrugs - pharmacokinetics | Antiviral Agents - adverse effects | Infusions, Intravenous | Acquired Immunodeficiency Syndrome - complications | Prodrugs - pharmacology | Ganciclovir - administration & dosage | Gastrointestinal Diseases - chemically induced | Index Medicus
Journal Article
Journal Article