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Nature (London), ISSN 1476-4687, 2014, Volume 514, Issue 7522, pp. 385 - 388
Journal Article
Genes & development, ISSN 0890-9369, 07/2010, Volume 24, Issue 13, pp. 1377 - 1388
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 481, Issue 7381, pp. 329 - 334
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly... 
ANEUPLOIDY | CELLS | GENE | TYROSINE KINASE | MCL-1 | MULTIDISCIPLINARY SCIENCES | GROWTH | TUMOR | SYK INHIBITOR | CANCER | Retinoblastoma - genetics | Protein-Tyrosine Kinases - metabolism | Genomics | Humans | Retinoblastoma - drug therapy | Gene Expression Regulation, Neoplastic | Aneuploidy | Intracellular Signaling Peptides and Proteins - metabolism | Genes, Retinoblastoma - genetics | Molecular Targeted Therapy | Retinoblastoma - pathology | Protein-Tyrosine Kinases - genetics | Cell Death - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Cell Line | Cell Survival - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Retinoblastoma Protein - deficiency | Mutation - genetics | Sequence Analysis, DNA | Xenograft Model Antitumor Assays | Chromosomal Instability - genetics | Animals | Epigenesis, Genetic - genetics | Protein Kinase Inhibitors - therapeutic use | Retinoblastoma Protein - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Research | Retinoblastoma | Gene therapy | Health aspects | Risk factors | Studies | Human subjects | Epigenetics | DNA methylation | Genomes | Mutation | Kinases | Experiments | Chromosomes | Cancer | Children & youth | Apoptosis
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2005, Volume 65, Issue 22, pp. 10243 - 10254
Because each change in the evolution of a cancer is predicated on the effects of previous events, a full understanding of selective changes and their effect on... 
ADVANCED-STAGE | SUPPRESSOR GENE | ONCOLOGY | CYCLIN D1 | IN-VIVO | PTEN | ALLELIC LOSS | MICE | TRANSGENIC MOUSE MODEL | RETINOBLASTOMA GENE | PROGRESSION | Prostatic Neoplasms - metabolism | Adenocarcinoma - pathology | Epithelial Cells - metabolism | PTEN Phosphohydrolase - physiology | Male | Retinoblastoma-Like Protein p107 - genetics | Retinoblastoma-Like Protein p130 - antagonists & inhibitors | Retinoblastoma-Like Protein p107 - antagonists & inhibitors | PTEN Phosphohydrolase - antagonists & inhibitors | Adenocarcinoma - metabolism | Prostatic Neoplasms - genetics | Retinoblastoma-Like Protein p130 - metabolism | Cell Transformation, Neoplastic - genetics | Female | Adenocarcinoma - genetics | Retinoblastoma Protein - physiology | Retinoblastoma-Like Protein p107 - physiology | Disease Models, Animal | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Retinoblastoma-Like Protein p130 - physiology | Retinoblastoma-Like Protein p107 - metabolism | Retinoblastoma Protein - metabolism | PTEN Phosphohydrolase - metabolism | Epithelial Cells - pathology | Mice, Transgenic | Cell Transformation, Neoplastic - metabolism | Disease Progression | Animals | Retinoblastoma Protein - genetics | Retinoblastoma Protein - antagonists & inhibitors | Mice | Apoptosis - physiology | Cell Transformation, Neoplastic - pathology | Retinoblastoma-Like Protein p130 - genetics
Journal Article
Oncogene, ISSN 1476-5594, 2013, Volume 33, Issue 5, pp. 556 - 566
Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancers. Rb functions to inhibit cell cycle progression in part... 
Metabolism | Cancer | Glutamine | Retinoblastoma Protein | Tumor Suppressor | retinoblastoma protein | APOPTOSIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | G CONTROL | tumor suppressor | CELL-PROLIFERATION | FACTOR-I | glutamine | CELL BIOLOGY | GLYCOLYSIS | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | metabolism | cancer | GROWTH-FACTOR | ENERGY-METABOLISM | Cell Proliferation | Reactive Oxygen Species - metabolism | Glutamate-Cysteine Ligase - biosynthesis | Minor Histocompatibility Antigens | Glutamine - metabolism | Retinoblastoma-Like Protein p107 - genetics | Adenosine Triphosphate - biosynthesis | Oxygen - metabolism | Glutathione - biosynthesis | RNA Interference | Retinoblastoma-Like Protein p130 - metabolism | Fibroblasts | Biological Transport - genetics | Amino Acid Transport System ASC - genetics | Ketoglutaric Acids - metabolism | Glutaminase - biosynthesis | Promoter Regions, Genetic | Retinoblastoma-Like Protein p107 - metabolism | Retinoblastoma Protein - metabolism | Cells, Cultured | Amino Acid Transport System ASC - metabolism | Glutaminase - metabolism | Mice, Knockout | Animals | E2F3 Transcription Factor - biosynthesis | Cell Cycle | Retinoblastoma Protein - genetics | E2F3 Transcription Factor - metabolism | Mice | RNA, Small Interfering | Retinoblastoma-Like Protein p130 - genetics | Amino Acid Transport System ASC - biosynthesis | Glutaminase - genetics | Oncology, Experimental | Physiological aspects | Genetic research | Tumor suppressor genes | Genetic aspects | Research | Studies | Oncology | Tumors
Journal Article