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retinoblastoma-binding protein 1 (1034) 1034
e2f transcription factors (1023) 1023
carrier proteins (982) 982
humans (903) 903
transcription factor dp1 (894) 894
cell cycle proteins (880) 880
animals (785) 785
dna-binding proteins (741) 741
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biochemistry & molecular biology (539) 539
e2f1 transcription factor (504) 504
cell biology (491) 491
mice (426) 426
transcription factors - genetics (410) 410
molecular sequence data (360) 360
retinoblastoma protein - metabolism (336) 336
cell cycle (332) 332
expression (318) 318
base sequence (310) 310
retinoblastoma protein (281) 281
index medicus (263) 263
cell line (250) 250
promoter regions, genetic (239) 239
dna-binding proteins - metabolism (234) 234
oncology (233) 233
transcription, genetic (215) 215
genetics & heredity (206) 206
phosphorylation (206) 206
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female (193) 193
proteins (188) 188
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gene expression regulation (181) 181
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e2f (174) 174
transfection (174) 174
amino acid sequence (170) 170
research article (167) 167
retinoblastoma gene-product (164) 164
cell-cycle (156) 156
nuclear proteins - metabolism (149) 149
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biological phenomena, cell phenomena, and immunity (146) 146
cells, cultured (143) 143
cyclins - metabolism (141) 141
research (139) 139
male (138) 138
protein (137) 137
gene expression (130) 130
gene (128) 128
retinoblastoma protein - genetics (128) 128
mutation (126) 126
3t3 cells (125) 125
cell division (125) 125
cyclin-dependent kinases - metabolism (125) 125
cell cycle - physiology (124) 124
in-vivo (123) 123
binding protein (120) 120
cancer (119) 119
s-phase entry (119) 119
transcription factor e2f (115) 115
rats (110) 110
transcription factor (110) 110
genetic aspects (109) 109
s phase (109) 109
transcriptional activation (107) 107
transcription (106) 106
cell cycle proteins - metabolism (105) 105
multidisciplinary sciences (102) 102
retinoblastoma (101) 101
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transcription factors - biosynthesis (100) 100
e2f4 transcription factor (98) 98
hela cells (97) 97
cyclin-dependent kinase 2 (96) 96
dna - metabolism (96) 96
retinoblastoma binding proteins - genetics (96) 96
cdc2-cdc28 kinases (94) 94
nuclear proteins - genetics (92) 92
ubiquitin-protein ligases - genetics (91) 91
retinoblastoma-like protein p107 (90) 90
binding (88) 88
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genes (80) 80
p53 (80) 80
protein-serine-threonine kinases - metabolism (78) 78
histones - metabolism (77) 77
identification (77) 77
retinoblastoma-like protein p130 (75) 75
differentiation (74) 74
gene-product (74) 74
recombinant fusion proteins - metabolism (73) 73
tumor suppressor protein p53 - metabolism (73) 73
cells (72) 72
cyclin-dependent kinase inhibitor p21 (72) 72
developmental biology (72) 72
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Biochemical Society Symposium, ISSN 0067-8694, 06/2013, Volume 41, Issue 3, pp. 727 - 740
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates... 
DNA methylation | Epigenetics | DNA demethylation | Chromatin | Transcription | CpG island | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | TRANSCRIPTIONAL REPRESSION | chromatin | H3-LYS METHYLTRANSFERASE COMPLEX | epigenetics | FINGER PROTEIN-1 | EMBRYONIC STEM-CELLS | MIXED-LINEAGE-LEUKEMIA | GENOME-WIDE ANALYSIS | POSTNATAL-DEVELOPMENT | HISTONE H3 ACETYLATION | Amino Acid Sequence | Chromatin - metabolism | DNA-Binding Proteins - physiology | Humans | Models, Molecular | Molecular Sequence Data | DNA Methylation - genetics | Protein Structure, Tertiary - genetics | DNA - metabolism | CpG Islands - physiology | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | CpG Islands - genetics | Zinc Fingers - genetics | DNA Methylation - physiology | Protein Binding - physiology | MBD, methyl-CpG-binding domain | PRC, polycomb group repressive complex | IDAX, inhibition of the Dvl and axin complex protein | ESC, embryonic stem cell | RING, really interesting new gene | CFP1, CxxC finger protein 1 | JmjC, Jumonji C | PHD, plant homeodomain | Biochemical Society Annual Symposium No. 80 | 5mC, 5-methylcytosine | CGBP, CpG-binding protein | 5hmC, 5-hydroxymethylcytosine | DNMT1, DNA methyltransferase 1 | FBXL19, F-box and leucine-rich repeat protein 19 | RFTS, replication foci-targeting sequence | WDR, WD40 repeat | DPY-30, dosage compensation protein 30 | AF9, ALL1–fused gene from chromosome 9 protein | ChIP-seq, chromatin immunoprecipitation sequencing | HDAC, histone deacetylase | YY1, Yin and Yang 1 | RbBP5, retinoblastoma-binding protein 5 | ZF-CxxC, zinc finger-CxxC | BAH, bromo-adjacent homology | ASH2L, absent, small or homeotic 2-like | SETD1, SET domain 1 | TET, ten-eleven translocation | SEC, super-elongation complex | MLL, mixed lineage leukaemia protein | CGI, CpG island | ENL, eleven-nineteen leukaemia | shRNA, short hairpin RNA | KDM, lysine demethylase | RNAPII, RNA polymerase II
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 02/2011, Volume 20, Issue 4, pp. 731 - 751
Mammalian circadian rhythms are synchronized to the external time by daily resetting of the suprachiasmatic nucleus (SCN) in response to light. As the master... 
RESPONSE ELEMENT | POLY(A) BINDING-PROTEIN | MESSENGER-RNA | RETT-SYNDROME | SUPRACHIASMATIC NUCLEUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SLEEP PHASE SYNDROME | GENETICS & HEREDITY | GENE-EXPRESSION | POLY(A)-BINDING PROTEIN | HISTONE ACETYLTRANSFERASE | ACTIVE GENES | NIH 3T3 Cells | Humans | Methyl-CpG-Binding Protein 2 - metabolism | Chromatin Assembly and Disassembly - genetics | MicroRNAs - metabolism | E1A-Associated p300 Protein - metabolism | Chromatin Assembly and Disassembly - drug effects | Retinoblastoma-Binding Protein 2 - metabolism | Immediate-Early Proteins - metabolism | Period Circadian Proteins - genetics | Light | HEK293 Cells | Suprachiasmatic Nucleus - metabolism | DNA-Binding Proteins | Tumor Suppressor Proteins - metabolism | Signal Transduction | Mice, Inbred C57BL | Circadian Rhythm - genetics | Computational Biology | Gene Expression Regulation | Mice, Transgenic | RNA Stability | Animals | Period Circadian Proteins - metabolism | Mice | MicroRNAs - genetics | Jumonji Domain-Containing Histone Demethylases | Suprachiasmatic nucleus | Calcium | Transcription | CLOCK protein | BTG2 protein | Period 1 protein | Methyl-CpG binding protein | Entrainment | miRNA | Period 2 protein | Circadian rhythms | Obesity | Translation | mRNA turnover | Cyclic AMP | Light effects | Oscillators | Promoters | Chromatin remodeling | Neurological diseases | Period protein | Sleep | MeCP2 protein | Workers | Pacemakers | Cardiovascular diseases | Cancer
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2011, Volume 21, Issue 2, pp. 275 - 289
Journal Article
Nature Genetics, ISSN 1061-4036, 07/2000, Volume 25, Issue 3, pp. 338 - 342
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2000, Volume 97, Issue 23, pp. 12513 - 12518
Most cervical carcinomas express high-risk human papillomaviruses (HPVs) E6 and E7 proteins, which neutralize cellular tumor suppressor function. To determine... 
Biological Sciences | Carcinoma | Messenger RNA | RNA | DNA | Cell lines | Cell cycle | HeLa cells | Infections | Repression | Cyclins | HPV18 REGULATORY REGION | GROWTH ARREST | MULTIDISCIPLINARY SCIENCES | RETINOBLASTOMA GENE-PRODUCT | CYCLE PROGRESSION | FAMILY PROTEINS | BINDING-SITES | E2 PROTEIN | P53 | Uterine Cervical Neoplasms | Tumor Suppressor Protein p53 - biosynthesis | Humans | E2F Transcription Factors | Papillomavirus E7 Proteins | Retinoblastoma-Like Protein p107 | Proto-Oncogene Proteins - biosynthesis | Viral Proteins - metabolism | Papillomaviridae - genetics | Bovine papillomavirus 1 - genetics | DNA-Binding Proteins - metabolism | Proteins | Cyclins - biosynthesis | Cattle | DNA - biosynthesis | Female | Oncogene Proteins, Viral - genetics | Bovine papillomavirus 1 - metabolism | Nuclear Proteins - genetics | Genes, Tumor Suppressor | Oncogenes | Repressor Proteins - metabolism | Carrier Proteins | Signal Transduction | Cyclin-Dependent Kinase Inhibitor p21 | Repressor Proteins - genetics | Viral Proteins - genetics | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Transcription Factor DP1 | Transcription Factors - metabolism | Proto-Oncogene Proteins c-mdm2 | Animals | Gene Expression Regulation, Viral | Retinoblastoma Protein - genetics | Retinoblastoma-Like Protein p130 | HeLa Cells | Retinoblastoma-Binding Protein 1 | Cell Cycle Proteins | Papillomaviruses | Tumor suppressor genes | Genetic aspects | Analysis | Cervical cancer
Journal Article
Nature genetics, ISSN 1061-4036, 2000, Volume 26, Issue 3, pp. 291 - 299
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest... 
LYMPHOMAGENESIS | APOPTOSIS | STABILIZES P53 | AMPLIFICATION | INK4A LOCUS | GENETICS & HEREDITY | C-MYC | MDM2 | GENE FAMILY | CELL-CYCLE ARREST | ARF TUMOR-SUPPRESSOR | T-Box Domain Proteins - physiology | Protein Biosynthesis | Humans | E2F Transcription Factors | Cyclin-Dependent Kinase Inhibitor p16 | T-Box Domain Proteins - isolation & purification | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | Gene Deletion | Repressor Proteins - isolation & purification | Neoplastic Syndromes, Hereditary - genetics | Genes, BRCA1 | Neoplasm Proteins - genetics | Tumor Suppressor Protein p14ARF | Oncogenes | DNA-Binding Proteins | Fibroblasts - metabolism | Cell Cycle Proteins - isolation & purification | Repressor Proteins - genetics | Transcription Factor DP1 | Breast Neoplasms - genetics | Polycomb Repressive Complex 1 | Neoplasm Proteins - isolation & purification | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Fibroblasts - cytology | Mice | COS Cells | Cell Cycle Proteins - physiology | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Chromosomes, Human, Pair 17 - genetics | Breast Neoplasms - metabolism | Repressor Proteins - physiology | Transfection | Cell Cycle Proteins - genetics | Female | Adenocarcinoma - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Cellular Senescence - genetics | Promoter Regions, Genetic | E2F1 Transcription Factor | Neoplasm Proteins - biosynthesis | Cells, Cultured | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | T-Box Domain Proteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Animals | Gene Amplification | Retinoblastoma-Binding Protein 1 | Fibroblasts | Physiological aspects | Development and progression | Breast cancer | Genetic aspects | Research | Risk factors
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2018, Volume 110, Issue 4, pp. 400 - 410
Background: Despite the benefit of endocrine therapy, acquired resistance during or after treatment still remains a major challenge in estrogen receptor... 
ENDOCRINE RESISTANCE | ACTIVATION | GENE | ONCOLOGY | GROWTH | TRANSCRIPTIONAL REPRESSION | HISTONE DEMETHYLASE RBP2 | H3K4 DEMETHYLASE | PROTEINS | TUMORS | ESTROGEN-RECEPTOR BINDING | Receptor, IGF Type 1 - metabolism | Receptors, Estrogen - metabolism | Humans | Neoplasm Proteins - physiology | Receptor, ErbB-2 - metabolism | Colorimetry | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Carcinoma, Ductal, Breast - chemistry | Breast Neoplasms - metabolism | Retinoblastoma-Binding Protein 2 - metabolism | Breast Neoplasms - chemistry | Carcinoma, Ductal, Breast - drug therapy | Heterografts | MCF-7 Cells | Antineoplastic Agents, Hormonal - therapeutic use | Carcinoma, Ductal, Breast - pathology | Female | Carcinoma, Ductal, Breast - metabolism | Retinoblastoma-Binding Protein 2 - physiology | Kaplan-Meier Estimate | Nuclear Proteins - metabolism | Neoplastic Stem Cells | Tumor Burden | Mice, SCID | Breast Neoplasms - drug therapy | Nuclear Receptor Interacting Protein 1 | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Carrier Proteins - metabolism | Analysis of Variance | Breast Neoplasms - pathology | Tamoxifen - therapeutic use | Mice, Inbred NOD | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cohort Studies
Journal Article