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Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2016, Volume 44, Issue 4, pp. 495 - 504
Journal Article
Journal Article
Toxicology Letters, ISSN 0378-4274, 04/2018, Volume 286, pp. 10 - 21
In the present study, we show the value of combining toxico-dynamic and -kinetic approaches for embryotoxicity testing of azoles. Both the whole embryo culture... 
Biomarkers | Embryotoxicity | Azoles | Whole embryo culture | Stem cell test | Placental transfer | RAT | DEVELOPMENTAL TOXICITY | RETINOIC ACID | DIFFERENTIATION ASSAY | IN-VIVO | TEST EST | TOXICOLOGY | ALTERNATIVE METHODS | TRANSPORT MODEL | RISK-ASSESSMENT | Embryo, Mammalian - drug effects | Teratogens - toxicity | Sterol 14-Demethylase - genetics | Humans | Mixed Function Oxygenases - metabolism | Embryo Culture Techniques | Retinoic Acid 4-Hydroxylase - metabolism | Retinoic Acid 4-Hydroxylase - genetics | Embryo, Mammalian - metabolism | Mouse Embryonic Stem Cells - drug effects | Mouse Embryonic Stem Cells - metabolism | Alcohol Oxidoreductases - genetics | Dose-Response Relationship, Drug | Biological Transport | Biological Assay | Female | Toxicity Tests - methods | Azoles - toxicity | Mouse Embryonic Stem Cells - pathology | Cell Line | Reproducibility of Results | Embryo, Mammalian - pathology | Risk Assessment | Gene Expression Regulation, Developmental - drug effects | Alcohol Oxidoreductases - metabolism | Placenta - drug effects | Placenta - metabolism | Pregnancy | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Placenta - pathology | Myocytes, Cardiac - metabolism | Mice | Sterol 14-Demethylase - metabolism | Kinetics | Mixed Function Oxygenases - genetics | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 02/2018, Volume 233, Issue 2, pp. 1129 - 1145
ATRA may activate the expression of RARα/RXRα and induce terminal differentiation of antler chondrocytes through BMP2‐WNT4‐RUNX1 pathway. CRABP2 can enhance... 
ATRA signaling | BMP2 | antler chondrocyte terminal differentiation | RUNX1 | WNT4 | ENDOCHONDRAL OSSIFICATION | PHYSIOLOGY | PROLIFERATION | TRANS-RETINOIC ACID | INDUCTION | BETA | CELL BIOLOGY | METABOLISM | PATHWAY | DECIDUALIZATION | CELL-DIFFERENTIATION | CHONDROGENESIS | Antlers - drug effects | Antlers - metabolism | Chondrogenesis - drug effects | Wnt4 Protein - metabolism | Retinoic Acid 4-Hydroxylase - metabolism | Retinoic Acid 4-Hydroxylase - genetics | Receptors, Retinoic Acid - genetics | Wnt4 Protein - genetics | Chondrocytes - drug effects | Collagen Type X - metabolism | Transfection | RNA Interference | Time Factors | Bone Morphogenetic Protein 2 - metabolism | Receptors, Retinoic Acid - agonists | Chondrocytes - metabolism | Tretinoin - pharmacology | Bone Morphogenetic Protein 2 - genetics | Core Binding Factor Alpha 2 Subunit - metabolism | Matrix Metalloproteinase 13 - genetics | Cells, Cultured | Gene Expression Regulation | Collagen Type X - genetics | Receptors, Retinoic Acid - metabolism | Deer | Matrix Metalloproteinase 13 - metabolism | Animals | Wnt Signaling Pathway - drug effects | Antlers - cytology | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Core Binding Factor Alpha 2 Subunit - genetics | Bone morphogenetic proteins | Analysis | Cytochrome P-450 | Sensitivity analysis | Bone morphogenetic protein 2 | Wnt protein | Downstream effects | Crosstalk | Runx1 protein | siRNA | Retinoid X receptors | Collagenase 3 | Eutrophication | Signaling | Chondrocytes | Differentiation | Chondrogenesis | Index Medicus
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 9/2018, Volume 55, Issue 9, pp. 7187 - 7200
Angelman syndrome (AS) is a complex genetic disorder that affects the nervous system. AS affects an estimated 1 in 12,000 to 20,000 individuals. Characteristic... 
E6AP | Hormone | Brain | Estrogen receptor | Neurosciences | Transcription | Neurobiology | Coactivator | UBE3A | Cell Biology | Neurology | Angelman syndrome | CYP26B1 | Biomedicine | Neuron | Retinoic acid | DIFFERENTIAL EXPRESSION | MECHANISM | NEUROSCIENCES | RECEPTOR-ALPHA | DEVELOPING BRAIN | ESTRADIOL | MICE | LONG-TERM POTENTIATION | LIGASE | Neurons - pathology | Receptors, Estrogen - metabolism | Humans | RNA, Messenger - metabolism | Retinoic Acid 4-Hydroxylase - metabolism | Promoter Regions, Genetic - genetics | Retinoic Acid 4-Hydroxylase - genetics | Angelman Syndrome - pathology | Cell Nucleus - metabolism | Tretinoin - metabolism | Base Sequence | Angelman Syndrome - genetics | Transcription, Genetic | Epigenesis, Genetic - drug effects | Neurons - metabolism | Response Elements - genetics | Estrogens - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Signal Transduction - genetics | Animals | Signal Transduction - drug effects | Models, Biological | HeLa Cells | Neurons | Analysis | Estrogen | Phenols | Genetic aspects | Genetic transcription | Tretinoin | Ubiquitin | Deregulation | Gene regulation | Estrogens | Memory | Estrogen receptors | Nervous system | Proteins | Learning | Rodents | Ataxia | Chromosome 15 | Ubiquitin-protein ligase | Seizures | Gene expression | ErbB-2 protein | Autism | Microencephaly | Acids | Speech | Mice | Hippocampus | Index Medicus
Journal Article