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Experimental animals, ISSN 1341-1357, 06/2019, Volume 68, Issue 4, pp. 491 - 497
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2265 - 2269
An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that the cyclohexane... 
Th17 | Inverse agonist | Retinoic acid-related orphan receptor gamma t | IL-17 | RORγt | AUTOIMMUNE | DESIGN | CHEMISTRY, MEDICINAL | ROR gamma t | CHEMISTRY, ORGANIC | PSORIASIS | DISCOVERY
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 05/2019, Volume 143, Issue 5, pp. 1878 - 1891
Background: Ras homolog gene family H (RhoH) is a membrane-bound adaptor protein involved in proximal T-cell receptor signaling. Therefore RhoH plays critical... 
Nr2f6 | TCR | Psoriasis | T cell | IFN-GAMMA | SUSCEPTIBILITY | DELTA T-CELLS | INTERLEUKIN-22 | IMMUNOLOGY | ARTHRITIS | IL-22 | retinoic acid-related orphan receptor gamma t | ALLERGY | INFLAMMATION | T(H)17 | T-cell receptor signaling | IL-22 binding protein | PAPILLOMAVIRUS TYPE 5 | CYCLOSPORINE
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2018, Volume 495, Issue 2, pp. 1890 - 1895
Journal Article
Assay and Drug Development Technologies, ISSN 1540-658X, 05/2018, Volume 16, Issue 4, pp. 194 - 204
The retinoic acid-related orphan receptor gamma T (RORγt) plays an important role in Th17 cell proliferation and functionality. Thus, RORγt inverse agonists... 
cholesterol | inverse agonist | retinoic acid-related orphan receptor gamma T | high-throughput screening | RORγt
Journal Article
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, ISSN 1540-658X, 06/2018, Volume 16, Issue 4, pp. 194 - 204
The retinoic acid-related orphan receptor gamma T (RORt) plays an important role in Th17 cell proliferation and functionality. Thus, RORt inverse agonists are... 
CELLS | inverse agonist | NUCLEAR RECEPTORS | CRYSTAL-STRUCTURE | high-throughput screening | ROR gamma t | X-RAY-STRUCTURE | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | GAMMA-T | retinoic acid-related orphan receptor gamma T | ORPHAN RECEPTOR-ALPHA | cholesterol | PHARMACOLOGY & PHARMACY | LIGAND-BINDING DOMAIN | NATURAL LIGANDS | AUTOIMMUNE-DISEASE
Journal Article
Journal Article
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2011, Volume 11, Issue 11, pp. 1780 - 1788
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2010, Volume 43, Issue 5, pp. 520 - 529
We previously reported that Fms-like tyrosine kinase 3 ligand (Flt3-L) reversed airway hyperresponsiveness (AHR) and airway inflammation, and increased the... 
T helper cell type 17 | Suppressors of cytokine signaling | House dust mite | Retinoic acid-related orphan receptor-γt | Airway hyperresponsiveness | suppressors of cytokine signaling | airway hyperresponsiveness | retinoic acid-related orphan receptor-gamma t | house dust mite | COLONY-STIMULATING FACTOR | ALLERGEN EXPOSURE | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLT3 LIGAND | NEUTROPHIL RECRUITMENT | CELL BIOLOGY | SOCS PROTEINS | RESPIRATORY SYSTEM | INSULIN-RESISTANCE | GROWTH-FACTOR | TH17 CELLS | Bronchial Hyperreactivity - immunology | Cell Count | Membrane Proteins - pharmacology | Th2 Cells - immunology | RNA, Messenger - metabolism | Th2 Cells - drug effects | Receptors, Interleukin - metabolism | T-Lymphocytes, Helper-Inducer - drug effects | T-Lymphocytes, Helper-Inducer - immunology | Methacholine Chloride - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Pyroglyphidae - drug effects | T-Lymphocytes, Helper-Inducer - cytology | Bronchoalveolar Lavage Fluid - cytology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Immunization | Lung - pathology | Cell Separation | Lung - parasitology | RNA, Messenger - genetics | Gene Expression Regulation - drug effects | Bronchial Hyperreactivity - pathology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Lung - drug effects | Mice | Mice, Inbred BALB C | Suppressor of Cytokine Signaling Proteins - metabolism | Cytokines - biosynthesis | Lung - immunology | CD4 Antigens - metabolism | Pyroglyphidae - immunology | retinoic acid–related orphan receptor–γt
Journal Article
Journal of Pharmacy and Bioallied Sciences, ISSN 0976-4879, 08/2015, Volume 7, Issue 6, pp. S672 - S676
Journal Article
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 08/2017, Volume 16, Issue 2, pp. 1207 - 1215
3O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol, or Astragaloside IV (AST), is one of the major active ingredients isolated from Astragalus... 
Astragaloside I V | Forkhead box protein 3 | Allergic rhinitis | Forkhead box protein 3/retinoic acid-related orphan nuclear receptor γt | GATA-3 | T-box protein expressed in T cells | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | MECHANISM | forkhead box protein 3/retinoic acid-related orphan nuclear receptor gamma t | TH1 LINEAGE COMMITMENT | T-BET/GATA-3 | forkhead box protein 3 | IN-VITRO | ONCOLOGY | INFLAMMATION | astragaloside IV | GENE-EXPRESSION | ASTHMA | allergic rhinitis | TRANSCRIPTION FACTOR | MODULATION | T-Lymphocyte Subsets - immunology | Spleen - immunology | Triterpenes - pharmacology | Male | Rhinitis, Allergic - metabolism | RNA, Messenger - metabolism | Rhinitis, Allergic - diagnosis | Immunoglobulin E - blood | Dexamethasone - pharmacology | Immunoglobulin E - immunology | Allergens - immunology | Protective Agents - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Ovalbumin - adverse effects | Female | Nasal Mucosa - metabolism | GATA3 Transcription Factor - metabolism | Disease Models, Animal | RNA, Messenger - genetics | Nuclear Proteins - metabolism | T-Box Domain Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Spleen - metabolism | Nasal Mucosa - immunology | T-Lymphocyte Subsets - metabolism | Rhinitis, Allergic - etiology | Biomarkers | Mice | Rhinitis, Allergic - drug therapy | Saponins - pharmacology
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1463 - 1470
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma... 
Retinoic acid-related orphan nuclear receptor gamma t | Th17 | Inverse agonist | IL-17 | RORγt | gamma t | CHEMISTRY, MEDICINAL | LIGANDS | PATHWAY | ROR gamma t | CHEMISTRY, ORGANIC | Retinoic acid-related orphan nuclear receptor
Journal Article