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1. Full Text Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses
by Ecoeur, F and Weiss, J and Kaupmann, K and Hintermann, S and Orain, D and Guntermann, C
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 03/2019, Volume 10, p. 577
The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (ROR gamma t) is the key transcription factor required for Th17 cell... 
VITAMIN-D | T helper 17 differentiation | NUCLEAR RECEPTORS | 25-HYDROXYVITAMIN D | keratinocytes | INNATE LYMPHOID-CELLS | ANKYLOSING-SPONDYLITIS | IMMUNOLOGY | ROR-ALPHA | T(H)17 CELLS | autoimmunity | nuclear hormone receptor | IL-17 | retinoic acid receptor-related-orphan-receptor-gamma t | DIFFERENTIATION | skin inflammation | PSORIASIS | TH17 CELLS | Transcription factors | Immune response | Keratinocytes | Dosage and administration | Research | Gene expression | Tretinoin
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2. Full Text Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss
by Tome, Saki and Sasaki, Tetsuya and Takahashi, Satoru and Takei, Yosuke
Experimental animals, ISSN 1341-1357, 06/2019, Volume 68, Issue 4, pp. 491 - 497
T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation... 
polyinosinic-polycytidylic acid [poly(I:C)] | abortion | retinoic acid-related orphan receptor gamma-t (ROR gamma t) | CELL PARADIGM | PREGNANCY LOSS | CADHERIN | ZOOLOGY | PATHWAY | INCREASE | IL-17 | maternal immune activation | VETERINARY SCIENCES | TH17 CELLS | polyinosinic-polycytidylic acid [poly:(IC)] | Original | retinoic acid-related orphan receptor gamma-t (RORγt)
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3. Full Text Targeting inflammatory T helper cells via retinoic acid-related orphan receptor gamma t is ineffective to prevent allo-response-driven colitis
by Buchele, Vera and Abendroth, Benjamin and Büttner-Herold, Maike and Vogler, Tina and Rothamer, Johanna and Ghimire, Sakhila and Ullrich, Evelyn and Holler, Ernst and Neurath, Markus F and Hildner, Kai
Frontiers in Immunology, ISSN 1664-3224, 05/2018, Volume 9, Issue MAY, p. 1138
Intestinal graft-versus-host disease (GvHD) is a life-threatening, inflammatory donor T cell-mediated complication of allogeneic hematopoietic stem cell... 
Interleukin-23 receptor | Granulocyte-macrophage colony-stimulating factor | Basic leucine zipper transcription factor ATF-like | Retinoic acid-related orphan receptor gamma t | Colitis | T helper 17 cells | Intestinal graft-versus-host disease | Usage | Graft versus host reaction | Transplantation | Diagnosis | Research | T cells | Risk factors | Hematopoietic stem cells | interleukin-23 receptor | granulocyte-macrophage colony-stimulating factor | basic leucine zipper transcription factor ATF-like | retinoic acid-related orphan receptor gamma t | intestinal graft-versus-host disease
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4. Full Text Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
by Lu, Zhonghui and Duan, James J.-W and Xiao, Haiyun and Neels, James and Wu, Dauh-Rurng and Weigelt, Carolyn A and Sack, John S and Khan, Javed and Ruzanov, Max and An, Yongmi and Yarde, Melissa and Karmakar, Ananta and Vishwakrishnan, Sureshbabu and Baratam, Venkata and Shankarappa, Harisha and Vanteru, Sridhar and Babu, Venkatesh and Basha, Mushkin and Kumar Gupta, Arun and Kumaravel, Selvakumar and Mathur, Arvind and Zhao, Qihong and Salter-Cid, Luisa M and Carter, Percy H and Murali Dhar, T.G
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2265 - 2269
An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that the cyclohexane... 
Th17 | Inverse agonist | Retinoic acid-related orphan receptor gamma t | IL-17 | RORγt | AUTOIMMUNE | DESIGN | CHEMISTRY, MEDICINAL | ROR gamma t | CHEMISTRY, ORGANIC | PSORIASIS | DISCOVERY
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5. Full Text Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T(H)17 cell polarization
by Tamehiro, N and Nishida, K and Sugita, Y and Hayakawa, K and Oda, H and Nitta, T and Nakano, M and Nishioka, A and Yanobu-Takanashi, R and Goto, M and Okamura, T and Adachi, R and Kondo, K and Morita, A and Suzuki, H
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 05/2019, Volume 143, Issue 5, pp. 1878 - 1891
Background: Ras homolog gene family H (RhoH) is a membrane-bound adaptor protein involved in proximal T-cell receptor signaling. Therefore RhoH plays critical... 
Nr2f6 | TCR | Psoriasis | T cell | IFN-GAMMA | SUSCEPTIBILITY | DELTA T-CELLS | INTERLEUKIN-22 | IMMUNOLOGY | ARTHRITIS | IL-22 | retinoic acid-related orphan receptor gamma t | ALLERGY | INFLAMMATION | T(H)17 | T-cell receptor signaling | IL-22 binding protein | PAPILLOMAVIRUS TYPE 5 | CYCLOSPORINE
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6. Full Text Wnt/β-catenin pathway promotes acute lung injury induced by LPS through driving the Th17 response in mice
by Cheng, Li and Zhao, Yan and Qi, Di and Li, Wen and Wang, Daoxin
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2018, Volume 495, Issue 2, pp. 1890 - 1895
T helper cell 17 (Th17), one type of CD4 T cell, plays an important role in regulating the acute lung injury (ALI) inflammatory response. Recent studies showed... 
β-catenin | Retinoic acid related orphan receptor-γt (RORγt) | T helper cell 17 (Th17) | Acute lung injury (ALI) | beta-catenin | Retinoic acid related orphan receptor-gamma t (RORyt) | RECRUITMENT | ACTIVATION | NEUTROPHIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | MESENCHYMAL STEM-CELLS | RESPIRATORY-DISTRESS-SYNDROME | BIOPHYSICS | SIGNALING PATHWAY | INFLAMMATION | REGULATORY T-CELLS | LIPOPOLYSACCHARIDE
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7. Full Text Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases
by Rutz, Sascha and Eidenschenk, Celine and Kiefer, James R and Ouyang, Wenjun
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2016, Volume 30, pp. 1 - 17
Graphical abstract Post-translational regulation of RORγt. 
Advanced Basic Science | Retinoic acid-related orphan receptor gamma | Nuclear receptor | Interleukin-17 | Inverse agonist | Posttranslational regulation | Ubiquitinylation | LONG NONCODING RNAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Retinoic acid-related orphan receptor | MEDIATED TRANSCRIPTIONAL ACTIVATION | THYMOCYTE SURVIVAL | ORPHAN NUCLEAR RECEPTOR | CELL BIOLOGY | RETINOIC ACID | REV-ERB-ALPHA | AMINO-TERMINAL DOMAINS | LIGAND-BINDING DOMAIN | T(H)17 CELL-DIFFERENTIATION | gamma | TH17 CELLS
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8. Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening
by Koyama, Ryokichi and Fukuda, Yasunori and Kamada, Yusuke and Nakagawa, Hideyuki and Witmer, Darbi and Ambrus-Aikelin, Geza and Sang, Bi-Ching and Nakayama, Masaharu and Iwata, Hidehisa
Assay and Drug Development Technologies, ISSN 1540-658X, 05/2018, Volume 16, Issue 4, pp. 194 - 204
The retinoic acid-related orphan receptor gamma T (RORγt) plays an important role in Th17 cell proliferation and functionality. Thus, RORγt inverse agonists... 
cholesterol | inverse agonist | retinoic acid-related orphan receptor gamma T | high-throughput screening | RORγt
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9. Cholesterol Unbound RORt Protein Enables a Sensitive Inverse Agonist Screening
by Koyama, R and Fukuda, Y and Kamada, Y and Nakagawa, H and Witmer, D and Ambrus-Aikelin, G and Sang, BC and Nakayama, M and Iwata, H
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, ISSN 1540-658X, 06/2018, Volume 16, Issue 4, pp. 194 - 204
The retinoic acid-related orphan receptor gamma T (RORt) plays an important role in Th17 cell proliferation and functionality. Thus, RORt inverse agonists are... 
CELLS | inverse agonist | NUCLEAR RECEPTORS | CRYSTAL-STRUCTURE | high-throughput screening | ROR gamma t | X-RAY-STRUCTURE | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | GAMMA-T | retinoic acid-related orphan receptor gamma T | ORPHAN RECEPTOR-ALPHA | cholesterol | PHARMACOLOGY & PHARMACY | LIGAND-BINDING DOMAIN | NATURAL LIGANDS | AUTOIMMUNE-DISEASE
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10. Full Text MiR-200a expression in CD4+ T cells correlates with the expression of Th17/Treg cells and relevant cytokines in psoriasis vulgaris: A case control study
by Wang, Xiao-Yan and Chen, Xing-Yu and Li, Jun and Zhang, Hong-Ying and Liu, Juan and Sun, Le-Dong
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 09/2017, Volume 93, pp. 1158 - 1164
The main aim of this study is to investigate the underlying relationship shared between microRNA-200a (miR-200a) and its link to concentrations of Th17 and... 
MicroRNA-200a | Retinoic acid-related orphan receptor γt | Psoriasis vulgaris | CD4+ T cell | Th17 cell | Cytokines | Treg cell | IL-17 | TGF-β | IL-23 | CD4 | T cell | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PROLIFERATION | BREAST-CANCER | PATHOGENESIS | TGF-beta | Retinoic acid-related orphan receptor gamma t | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | DYSFUNCTION | SKIN | CD4(+) T cell | TH17 | T-Lymphocytes, Regulatory - metabolism | Cytokines - metabolism | Humans | CD4-Positive T-Lymphocytes - metabolism | Male | MicroRNAs - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Th17 Cells - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Up-Regulation - physiology | Psoriasis - metabolism | Adult | Female | Transforming Growth Factor beta - metabolism | MicroRNA | Psoriasis | Analysis | Bone morphogenetic proteins | T cells | Transforming growth factors | Tretinoin | RNA
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11. Full Text Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats
by Long, Yu and Li, Sixin and Li, Yanwu and Qin, Jingchun and Xie, Liwei and Gan, Liping and Jie, Fengming and Wu, Yanli and Du, Qun
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 09/2018, Volume 105, pp. 781 - 788
Regulatory T (Treg) cells and T helper 17 (Th17) cells play crucial roles in ulcerative colitis (UC). Kuijieling (KJL) is an effective Chinese medicine formula... 
Ilex rotunda Thunb | Whitmania pigra Whitman | Interleukin-2 | Interleukin-10 | Interleukin-21 | Interleukin-23 | Paeonia lactiflora pall | Forkhead box P3 | Atractylodes macrocephala | Interleukin-6 | Inflammatory bowel disease | Retinoic acid-related orphan receptor γt | Chinese medicine | T helper-17 cell | Kuijieling | Transforming growth factor-β1 (TGF-β1) | Signal transducer and activator of transcription 5 | radix Glycyrrhizae Preparata | Regulatory T cell | Signal transducer and activator of transcription 3 | Interleukin-17 | Ulcerative colitis | MEDICINE, RESEARCH & EXPERIMENTAL | ACUTE LUNG INJURY | T-CELL | PHARMACOLOGY & PHARMACY | MICE | Transforming growth factor-beta 1 (TGF-beta 1) | ULCERATIVE-COLITIS | MECHANISMS | AUTOIMMUNE | INFLAMMATORY-BOWEL-DISEASE | Retinoic acid-related orphan receptor gamma t | EXPRESSION | INSIGHTS | Immunohistochemistry | Interleukins | Microbiology | Bone morphogenetic proteins | T cells | Transforming growth factors | Cell differentiation | Tretinoin
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12. Full Text The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients
by Chu, Shuyuan and Zhong, Xiaoning and Zhang, Jianquan and Lao, Qifang and He, Zhiyi and Bai, Jing
International Immunopharmacology, ISSN 1567-5769, 11/2011, Volume 11, Issue 11, pp. 1780 - 1788
Foxp3- and ROR gamma t-expressing cells are involved in acquired immune responses. The change in Foxp3 and ROR gamma t expression in lung tissue and their role... 
Retinoic-acid related orphan receptor gamma t | Chronic obstructive pulmonary disease | Forkhead box P3 | Emphysema | STIMULATION | MECHANISMS | IMMUNOLOGY | T(H)17 CELLS | INTERLEUKIN-17 | INFLAMMATION | GENE-EXPRESSION | CELLS CONTROL | PHARMACOLOGY & PHARMACY | COPD | LYMPHOCYTES | Receptors, CCR6 - biosynthesis | Receptors, Interleukin - biosynthesis | Smoking - immunology | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | RNA, Messenger - biosynthesis | Female | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Real-Time Polymerase Chain Reaction | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Severity of Illness Index | Forkhead Transcription Factors - biosynthesis | Gene Expression | Lung - pathology | RNA, Messenger - genetics | Smoking - genetics | Interleukin-17 - biosynthesis | Forkhead Transcription Factors - genetics | Blotting, Western | Smoking - metabolism | Smoking - pathology | Nuclear Receptor Subfamily 1, Group F, Member 3 - biosynthesis | Pulmonary Disease, Chronic Obstructive - immunology | Lung - immunology | Lung diseases, Obstructive | Smokers
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13. Full Text Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice
by McGee, Halvor S and Stallworth, Arthur L and Agrawal, Tanupriya and Shao, Zhifei and Lorence, Lindsey and Agrawal, Devendra K
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2010, Volume 43, Issue 5, pp. 520 - 529
We previously reported that Fms-like tyrosine kinase 3 ligand (Flt3-L) reversed airway hyperresponsiveness (AHR) and airway inflammation, and increased the... 
T helper cell type 17 | Suppressors of cytokine signaling | House dust mite | Retinoic acid-related orphan receptor-γt | Airway hyperresponsiveness | suppressors of cytokine signaling | airway hyperresponsiveness | retinoic acid-related orphan receptor-gamma t | house dust mite | COLONY-STIMULATING FACTOR | ALLERGEN EXPOSURE | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLT3 LIGAND | NEUTROPHIL RECRUITMENT | CELL BIOLOGY | SOCS PROTEINS | RESPIRATORY SYSTEM | INSULIN-RESISTANCE | GROWTH-FACTOR | TH17 CELLS | Bronchial Hyperreactivity - immunology | Cell Count | Membrane Proteins - pharmacology | Th2 Cells - immunology | RNA, Messenger - metabolism | Th2 Cells - drug effects | Receptors, Interleukin - metabolism | T-Lymphocytes, Helper-Inducer - drug effects | T-Lymphocytes, Helper-Inducer - immunology | Methacholine Chloride - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Pyroglyphidae - drug effects | T-Lymphocytes, Helper-Inducer - cytology | Bronchoalveolar Lavage Fluid - cytology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Immunization | Lung - pathology | Cell Separation | Lung - parasitology | RNA, Messenger - genetics | Gene Expression Regulation - drug effects | Bronchial Hyperreactivity - pathology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Lung - drug effects | Mice | Mice, Inbred BALB C | Suppressor of Cytokine Signaling Proteins - metabolism | Cytokines - biosynthesis | Lung - immunology | CD4 Antigens - metabolism | Pyroglyphidae - immunology | retinoic acid–related orphan receptor–γt
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14. Full Text Evaluation of transcription factor that regulates T helper 17 and regulatory T cells function in periodontal health and disease
by Karthikeyan, B and Talwar, Talwar and Arun, K.V and Kalaivani, S
Journal of Pharmacy and Bioallied Sciences, ISSN 0976-4879, 08/2015, Volume 7, Issue 6, pp. S672 - S676
The differentiation of naοve T helper (Th) cells towards Th17 and regulatory T cells (Treg) is regulated by the transcription factors retinoic acid related... 
regulatory T cells | retinoic acid-related orphan receptor gamma transcription and Forkhead box p3 transcription factors | T helper 17 | Periodontitis | Periodontal disease | Care and treatment | Transcription factors | Dosage and administration | Research | Cell differentiation | Gene expression | T cells | Tretinoin | Disease | Cytokines | Pathogenesis | Polymerization | Inflammation | Patients | Studies | Acids | Lymphocytes | Agreements | Molecular biology | Dental Science - Original
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15. Full Text Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt
by Kummer, David A and Cummings, Maxwell D and Abad, Marta and Barbay, Joseph and Castro, Glenda and Wolin, Ronald and Kreutter, Kevin D and Maharoof, Umar and Milligan, Cynthia and Nishimura, Rachel and Pierce, Joan and Schalk-Hihi, Celine and Spurlino, John and Urbanski, Maud and Venkatesan, Hariharan and Wang, Aihua and Woods, Craig and Xue, Xiaohua and Edwards, James P and Fourie, Anne M and Leonard, Kristi
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2017, Volume 27, Issue 9, pp. 2047 - 2057
A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift... 
Agonist | Retinoic acid-related orphan nuclear receptor gamma t | Neutral antagonist | Inverse agonist | IL-17 | Th17 | RORγt | CHEMISTRY, MEDICINAL | NUCLEAR RECEPTORS | ROR gamma t | CHEMISTRY, ORGANIC | SUPPRESSION | receptor gamma t | LIGANDS | DIGOXIN | Retinoic acid-related orphan nuclear | CELL-DIFFERENTIATION | Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors | Th17 Cells - drug effects | Drug Inverse Agonism | Humans | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Quinolines - chemistry | Drug Design | Molecular Docking Simulation | Structure-Activity Relationship | Quinolines - pharmacology
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16. Protective effects of astragaloside IV against ovalbumin-induced allergic rhinitis are mediated by T-box protein expressed in T cells/GATA-3 and forkhead box protein 3/retinoic acid-related orphan nuclear receptor γt
by Li, Keqiong and Chen, Yi and Jiang, Rong and Chen, Dilong and Wang, Hong and Xiong, Wei and Li, Danyang and Liu, Zehong and Li, Xiaopeng and Li, Jing and Yuan, Ke
Molecular Medicine Reports, ISSN 1791-2997, 08/2017, Volume 16, Issue 2, pp. 1207 - 1215
3O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol, or Astragaloside IV (AST), is one of the major active ingredients isolated from Astragalus... 
Astragaloside I V | Forkhead box protein 3 | Allergic rhinitis | Forkhead box protein 3/retinoic acid-related orphan nuclear receptor γt | GATA-3 | T-box protein expressed in T cells | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | MECHANISM | forkhead box protein 3/retinoic acid-related orphan nuclear receptor gamma t | TH1 LINEAGE COMMITMENT | T-BET/GATA-3 | forkhead box protein 3 | IN-VITRO | ONCOLOGY | INFLAMMATION | astragaloside IV | GENE-EXPRESSION | ASTHMA | allergic rhinitis | TRANSCRIPTION FACTOR | MODULATION | T-Lymphocyte Subsets - immunology | Spleen - immunology | Triterpenes - pharmacology | Male | Rhinitis, Allergic - metabolism | RNA, Messenger - metabolism | Rhinitis, Allergic - diagnosis | Immunoglobulin E - blood | Dexamethasone - pharmacology | Immunoglobulin E - immunology | Allergens - immunology | Protective Agents - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Ovalbumin - adverse effects | Female | Nasal Mucosa - metabolism | GATA3 Transcription Factor - metabolism | Disease Models, Animal | RNA, Messenger - genetics | Nuclear Proteins - metabolism | T-Box Domain Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Spleen - metabolism | Nasal Mucosa - immunology | T-Lymphocyte Subsets - metabolism | Rhinitis, Allergic - etiology | Biomarkers | Mice | Rhinitis, Allergic - drug therapy | Saponins - pharmacology
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17. Full Text 3-Substituted Quinolines as RORγt Inverse Agonists
by Tanis, Virginia M and Venkatesan, Hariharan and Cummings, Maxwell D and Albers, Michael and Kent Barbay, J and Herman, Krystal and Kummer, David A and Milligan, Cynthia and Nelen, Marina I and Nishimura, Rachel and Schlueter, Thomas and Scott, Brian and Spurlino, John and Wolin, Ronald and Woods, Craig and Xue, Xiaohua and Edwards, James P and Fourie, Anne M and Leonard, Kristi
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1463 - 1470
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma... 
Retinoic acid-related orphan nuclear receptor gamma t | Th17 | Inverse agonist | IL-17 | RORγt | gamma t | CHEMISTRY, MEDICINAL | LIGANDS | PATHWAY | ROR gamma t | CHEMISTRY, ORGANIC | Retinoic acid-related orphan nuclear receptor
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