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Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2007, Volume 445, Issue 7124, pp. 219 - 223
The liver has a central role in glucose homeostasis, as it has the distinctive ability to produce and consume glucose. On feeding, glucose influx triggers gene... 
HOMEOSTASIS | METABOLISM | LIPOGENESIS | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN-1C | LIVER | TRANSCRIPTION | ALPHA | X-RECEPTOR | MICE | DEFICIENCY | Transcription, Genetic - drug effects | Humans | DNA-Binding Proteins - metabolism | DNA-Binding Proteins - agonists | Liver - drug effects | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - chemistry | Response Elements - genetics | Orphan Nuclear Receptors | Fatty Acids - metabolism | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Fasting | Gene Expression Regulation - genetics | Liver - metabolism | Glucose-6-Phosphate - pharmacology | Retinoid X Receptors - chemistry | Glucose - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Gene Expression Regulation - drug effects | Animals | Lipid Metabolism - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Glucose - metabolism | Ligands | Mice | Transcription, Genetic - genetics | Benzylamines - pharmacology | Glucose-6-Phosphate - metabolism | Homeostasis - genetics | Fatty Acids - biosynthesis | Receptors, Cytoplasmic and Nuclear - metabolism | Medical research | Glucose | Gene expression | Insulin | Liver | Binding sites | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 06/2009, Volume 23, Issue 6, pp. 1643 - 1654
Late-onset Alzheimer's disease is often connected with nutritional misbalance, such as enhanced cholesterol intake, deficiency in polyunsaturated fatty acids,... 
Shedding | Vitamin A | Nuclear receptors | Alzheimer's disease | Amyloid precursor protein | vitamin A | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID-PRECURSOR-PROTEIN | shedding | X-RECEPTOR | BETA-PEPTIDE | NEUROBLASTOMA-CELLS | HIPPOCAMPAL-NEURONS | VITAMIN-A | CELL BIOLOGY | nuclear receptors | RESPONSE ELEMENT | amyloid precursor protein | BIOLOGY | LONG-TERM POTENTIATION | EXPRESSION | Amyloid Precursor Protein Secretases - genetics | Up-Regulation | Tretinoin - chemistry | Humans | Male | PPAR gamma - metabolism | Receptors, Calcitriol - genetics | Receptors, Retinoic Acid - genetics | DNA-Binding Proteins - metabolism | Keratolytic Agents - metabolism | Receptors, Thyroid Hormone - genetics | Tretinoin - metabolism | Liver X Receptors | Acitretin - metabolism | Amyloid beta-Protein Precursor - metabolism | Membrane Proteins - metabolism | Molecular Structure | Orphan Nuclear Receptors | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | PPAR gamma - genetics | Cell Line | Promoter Regions, Genetic | Membrane Proteins - genetics | Gene Expression Regulation | ADAM10 Protein | Mice, Transgenic | Receptors, Retinoic Acid - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Receptors, Calcitriol - metabolism | DNA-Binding Proteins - genetics | Acitretin - chemistry | Receptors, Thyroid Hormone - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Alzheimer Disease - metabolism | Mice | ADAM Proteins - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 12/2012, Volume 56, Issue 6, pp. 2288 - 2296
Nuclear receptors (NRs) play crucial roles in the regulation of hepatic cholesterol synthesis, metabolism, and conversion to bile acids, but their actions in... 
NPC1L1 | PATHWAY | CELLULAR CHOLESTEROL | MACROPHAGES | GENE-EXPRESSION | ALPHA | MICE | ABSORPTION | SECRETION | GASTROENTEROLOGY & HEPATOLOGY | MODULATION | RNA-Binding Proteins - genetics | Steroid Hydroxylases - metabolism | Receptors, Estrogen - metabolism | Receptors, Steroid - metabolism | Bile Ducts - metabolism | Gene Expression Profiling | Hepatocytes - metabolism | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Receptors, Calcitriol - genetics | Bile Ducts - cytology | Receptors, Thyroid Hormone - genetics | Liver X Receptors | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | ATP Binding Cassette Transporter 1 | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Steroid Hydroxylases - genetics | PPAR delta - genetics | PPAR gamma - genetics | Hepatocyte Nuclear Factor 4 - metabolism | Receptors, Estrogen - genetics | Cells, Cultured | Rats | Hepatocyte Nuclear Factor 4 - genetics | Receptors, Calcitriol - metabolism | Transcription Factors - genetics | Cholesterol - metabolism | Orphan Nuclear Receptors - genetics | Receptors, Thyroid Hormone - metabolism | Transcription Factors - metabolism | Animals | Receptors, Steroid - genetics | PPAR delta - metabolism | Homeostasis - genetics | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19888 - 19899
Farnesoid X receptor alpha (FXR alpha) as a bile acid sensor plays potent roles in multiple metabolic processes, and its antagonist has recently revealed... 
OBESITY | HOMEOSTASIS | NATURAL PRODUCT | CHOLESTEROL | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILE-ACID RECEPTOR | LIGAND | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | AGONIST | Glucose-6-Phosphatase - genetics | Receptors, Leptin - genetics | Humans | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Crystallography, X-Ray | Male | Hepatocytes - metabolism | Hepatocytes - cytology | Protein Isoforms - metabolism | ATP-Binding Cassette Transporters - genetics | Protein Isoforms - agonists | Receptors, Cytoplasmic and Nuclear - chemistry | ATP-Binding Cassette Transporters - metabolism | Benzamides - pharmacology | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Hepatocytes - drug effects | Benzamides - chemistry | Recombinant Proteins - metabolism | Signal Transduction | Isoxazoles - antagonists & inhibitors | Gene Expression Regulation | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Mice, Knockout | Isoxazoles - pharmacology | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Receptors, Leptin - deficiency | Animals | ATP Binding Cassette Subfamily B Member 11 | Retinoid X Receptors - agonists | Glucose-6-Phosphatase - antagonists & inhibitors | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Mice | Molecular Docking Simulation | Mutation | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | ATP-Binding Cassette Transporters - antagonists & inhibitors | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Protein Structure and Folding | FXR | homodimerization | molecular pharmacology | crystal structure | nuclear receptor | transcription target gene | metabolic disease | antagonist
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 44, pp. 30538 - 30555
Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces soluble and insoluble amyloid-beta (A beta) in Alzheimer disease... 
BEXAROTENE THERAPY | ABCA1 | ALZHEIMERS-DISEASE | DEPOSITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | A-BETA | TRANSGENIC MOUSE MODEL | MILD COGNITIVE IMPAIRMENT | BRAIN | APOLIPOPROTEIN-E | Disks Large Homolog 4 Protein | Liver - pathology | Nicotinic Acids - pharmacokinetics | Humans | Male | Tetrahydronaphthalenes - adverse effects | ATP Binding Cassette Transporter 1 - metabolism | Liver - drug effects | Tetrahydronaphthalenes - administration & dosage | Amyloid beta-Peptides - metabolism | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Membrane Proteins - metabolism | Nicotinic Acids - administration & dosage | Drug Evaluation, Preclinical | Nicotinic Acids - adverse effects | Retinoid X Receptors - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Bexarotene | Peptide Fragments - metabolism | Administration, Oral | Mice, Inbred C57BL | Solubility | Alzheimer Disease - drug therapy | Tetrahydronaphthalenes - pharmacokinetics | Genotype | Mice, Transgenic | Organ Size - drug effects | Animals | Retinoid X Receptors - agonists | Apolipoproteins E - genetics | Guanylate Kinases - metabolism | Index Medicus | Molecular Bases of Disease | Oligomeric Aβ | Alzheimer Disease | Drug Delivery | Aβ Complex | Apolipoprotein E (ApoE) | Amyloid-β (AB) | RXR Agonists | Hepatomegaly | ABCG1 Lipid Transporters | Drug Action | ApoE
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 05/2011, Volume 18, Issue 5, pp. 556 - 563
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2006, Volume 116, Issue 7, pp. 1902 - 1912
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2015, Volume 35, Issue 42, pp. 14370 - 14385
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 01/2012, Volume 26, Issue 1, pp. 37 - 51
Journal Article