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1. Full Text RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance
by Moraes-Vieira, Pedro M and Yore, Mark M and Dwyer, Peter M and Syed, Ismail and Aryal, Pratik and Kahn, Barbara B
Cell Metabolism, ISSN 1550-4131, 03/2014, Volume 19, Issue 3, pp. 512 - 526
Insulin resistance is a major cause of diabetes and is highly associated with adipose tissue (AT) inflammation in obesity. RBP4, a retinol transporter, is... 
UNIQUE POPULATION | DENDRITIC CELLS | PLASMA RETINOL | OB/OB MICE | ENDOCRINOLOGY & METABOLISM | REGULATORY T-CELLS | RETINOL-BINDING-PROTEIN | RETINOL-BINDING-PROTEIN-4 | DIET-INDUCED OBESITY | EXPRESSION | MACROPHAGE ACTIVATION | CELL BIOLOGY | Mannose-Binding Lectins - metabolism | Cell Proliferation | Antigen-Presenting Cells - cytology | Humans | Transcriptome | Adipose Tissue - cytology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Recombinant Proteins - biosynthesis | Glucose Intolerance | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Adipose Tissue - metabolism | Lectins, C-Type - metabolism | Retinol-Binding Proteins, Plasma - metabolism | Antigen-Presenting Cells - metabolism | Signal Transduction | Bone Marrow Cells - cytology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Insulin Resistance | Receptors, Cell Surface - metabolism | Recombinant Proteins - genetics | Macrophages - cytology | Recombinant Proteins - pharmacology | Retinol-Binding Proteins, Plasma - pharmacology | Macrophages - metabolism | Animals | Macrophages - drug effects | Liver - cytology | Mice | Th1 Cells - cytology | Retinol-Binding Proteins, Plasma - genetics | Adipose tissues | Antigens | Glucose metabolism | Physiological aspects | Insulin resistance | Inflammation | Retinoids | Glucose | T cells | Dextrose | Index Medicus
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2. Full Text Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
by Mody, Nimesh and Kotani, Ko and Graham, Timothy E and Quadro, Loredana and Zabolotny, Janice M and Peroni, Odile D and Preitner, Frederic and Yang, Qin and Kahn, Barbara B
Nature, ISSN 0028-0836, 07/2005, Volume 436, Issue 7049, pp. 356 - 362
In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 ( also known as... 
GLUT4 GLUCOSE-TRANSPORTER | ADIPOCYTES | TRANSTHYRETIN | PROLIFERATOR-ACTIVATED RECEPTORS | MULTIDISCIPLINARY SCIENCES | PLASMA RETINOL | MUSCLE | RETINOL-BINDING-PROTEIN | KNOCKOUT MICE | VITAMIN-A | ADIPOSE-TISSUE | Liver - enzymology | Monosaccharide Transport Proteins - deficiency | Oligonucleotide Array Sequence Analysis | Phosphoenolpyruvate Carboxykinase (GTP) - metabolism | Muscle Proteins - deficiency | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Obesity - blood | Adipose Tissue - metabolism | Liver - drug effects | Retinol-Binding Proteins - metabolism | Insulin Resistance - physiology | Muscle Proteins - metabolism | Retinol-Binding Proteins - genetics | Muscles - metabolism | Thiazolidinediones - pharmacology | Monosaccharide Transport Proteins - metabolism | Hepatocytes - drug effects | Disease Models, Animal | Monosaccharide Transport Proteins - genetics | Insulin - pharmacology | Glucose Transporter Type 4 | Retinol-Binding Proteins, Plasma | Gene Expression Regulation | Mice, Knockout | Obesity - metabolism | Muscle Proteins - genetics | Diabetes Mellitus, Type 2 - blood | Animals | Signal Transduction - drug effects | Muscles - drug effects | Liver - cytology | Mice | Adipose Tissue - drug effects | Hepatocytes - enzymology | Obesity | Insulin | Diabetes | Index Medicus
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3. Full Text Transgenic mice over-expressing RBP4 have RBP4-dependent and light-independent retinal degeneration
by Du, Mei and Phelps, Eric and Balangue, Michael J and Dockins, Aaron and Moiseyev, Gennadiy and Shin, Younghwa and Kane, Shelley and Otalora, Laura and Ma, Jian-Xing and Farjo, Rafal and Farjo, Krysten M
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 08/2017, Volume 58, Issue 10, pp. 4095 - 4103
PURPOSE. Transgenic mice overexpressing serum retinol-binding protein (RBP4-Tg) develop progressive retinal degeneration, characterized by microglia... 
Serum retinol-binding protein | Retinal degeneration | RBP4 | SERUM RETINOL | VISUAL CYCLE | retinal degeneration | ACTIVATION | MECHANISM | serum retinol-binding protein | VITAMIN-A METABOLISM | OUTER SEGMENTS | INSULIN-RESISTANCE | INFLAMMATION | OPHTHALMOLOGY | RETINOL-BINDING-PROTEIN-4 | BINDING-PROTEIN 4 | Electroretinography | Retina - radiation effects | Retinoids - metabolism | Retinal Degeneration - genetics | Mice, Inbred C57BL | Gene Expression Regulation - physiology | Male | Mice, Transgenic | Radiation Injuries, Experimental - pathology | Retinal Degeneration - metabolism | Retinol-Binding Proteins, Plasma - antagonists & inhibitors | Dark Adaptation | Animals | Piperidines - pharmacology | Light | Female | Mice | Retinol-Binding Proteins, Plasma - metabolism | Retinal Degeneration - pathology | Retinol-Binding Proteins, Plasma - genetics | Radiation Injuries, Experimental - genetics | Radiation Injuries, Experimental - metabolism | Index Medicus | Retina
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4. Full Text Plasma Levels and Adipose Tissue Messenger Ribonucleic Acid Expression of Retinol-Binding Protein 4 Are Reduced during Calorie Restriction in Obese Subjects but Are Not Related to Diet-Induced Changes in Insulin Sensitivity
by Vitkova, Michaela and Klimcakova, Eva and Kovacikova, Michaela and Valle, Carine and Moro, Cédric and Polak, Jan and Hanacek, Jiri and Capel, Frédéric and Viguerie, Nathalie and Richterova, Blanka and Bajzova, Magda and Hejnova, Jindra and Stich, Vladimir and Langin, Dominique
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2330 - 2335
Context: Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance. Objective: We investigated whether RBP4 adipose tissue mRNA... 
DIABETES-MELLITUS | ADIPOCYTES | ENDOCRINOLOGY & METABOLISM | RESISTANCE | FAT | RETINOL-BINDING-PROTEIN | VITAMIN-A | Obesity - diet therapy | Adipose Tissue - physiology | Glucose Transporter Type 4 - genetics | Caloric Restriction | Retinol-Binding Proteins, Plasma | Humans | Middle Aged | Insulin Resistance | Obesity - physiopathology | Insulin - blood | RNA, Messenger - metabolism | Diet, Reducing | Retinol-Binding Proteins - metabolism | Gene Expression - physiology | Weight Loss - physiology | Retinol-Binding Proteins - genetics | Adult | Female | Glucose Clamp Technique | Index Medicus | Abridged Index Medicus | Obesity | Gene Expression | Glucose Transporter Type 4 | Biochemistry, Molecular Biology | Insulin | Life Sciences | Weight Loss | Adipose Tissue | Retinol-Binding Proteins | RNA, Messenger
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5. Full Text Development of a mouse IgA monoclonal antibody-based enzyme-linked immunosorbent sandwich assay for the analyses of RBP4
by Lee, Nam Seok and Kim, Han Soo and Park, Se Eun and Blüher, Matthias and Park, Cheol-Young and Youn, Byung-Soo
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2578 - 6
Elevated circulating Retinol-binding protein 4 (RBP4) has been associated with insulin resistance, dyslipidemia, and hypertension. However, many commonly used... 
OBESITY | HUMAN PLASMA | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | MASS | CARDIOVASCULAR-DISEASE | RETINOL-BINDING-PROTEIN | RETINOL-BINDING-PROTEIN-4 | SERUM | IMMUNOASSAY | ADIPOSE-TISSUE | Immunodominant Epitopes - immunology | Retinol-Binding Proteins, Plasma - analysis | Antibodies, Monoclonal, Murine-Derived - immunology | Enzyme-Linked Immunosorbent Assay | Humans | Retinol-Binding Proteins, Plasma - urine | Antibodies, Monoclonal, Murine-Derived - chemistry | Immunosorbents - chemistry | Immunoglobulin Subunits - immunology | Animals | Antibody Specificity - immunology | Immunoglobulin A - immunology | HEK293 Cells | Mice | Protein Stability | Retinol-Binding Proteins, Plasma - immunology | Urine | Enzymes | Immunoglobulin G | Dyslipidemia | Data processing | Quantitation | Serum proteins | Immunoglobulin A | Insulin | Western blotting | Vitamin A | Clonal deletion | Light chains | Monoclonal antibodies | Enzyme-linked immunosorbent assay | Retinol-binding protein
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6. Full Text Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein
by Gouras, Peter and Cosma, Maria P and Quadro, Loredana and Blaner, William S and Colantuoni, Vittorio and Freeman, Sarah and Salchow, Daniel J and Vogel, Silke and Gottesman, Max E and Piantedosi, Roseann
The EMBO Journal, ISSN 0261-4189, 09/1999, Volume 18, Issue 17, pp. 4633 - 4644
Retinol‐binding protein (RBP) is the sole specific transport protein for retinol (vitamin A) in the circulation, and its single known function is to deliver... 
electroretinogram | retinol‐binding protein | high performance liquid chromatography | knockout mice | vitamin A | Vitamin A | Knockout mice | Electroretinogram | High performance liquid chromatography | Retinol-binding protein | TRANSTHYRETIN | YOLK-SAC | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | retinol-binding protein | PREALBUMIN | ACID RECEPTORS | CELL BIOLOGY | METABOLISM | PLASMA RETINOL | DEFICIENT | CO-REPRESSOR | EXPRESSION | Electroretinography | Age Factors | Humans | Mice, Inbred C57BL | Biological Availability | Male | Chromatography, High Pressure Liquid | Retinol-Binding Proteins - physiology | Mice, Knockout | Vitamin A - metabolism | Retina - physiology | Vision, Ocular - physiology | Animals | Diet | Time Factors | Retinol-Binding Proteins - chemistry | Retinol-Binding Proteins - genetics | Female | Mice | Models, Genetic | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Chromatography, Gel | Transgenes | Vitamin A - blood | retinol | 11-cis-retinal | Index Medicus | Space life sciences
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7. Full Text Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue
by Wongsiriroj, Nuttaporn and Jiang, Hongfeng and Piantedosi, Roseann and Zhang Yang, Kryscilla Jian and Kluwe, Johannes and Schwabe, Robert F and Ginsberg, Henry and Goldberg, Ira J and Blaner, William S
Journal of Lipid Research, ISSN 0022-2275, 01/2014, Volume 55, Issue 1, pp. 104 - 114
Approximately 80-90% of all retinoids in the body are stored as retinyl esters (REs) in the liver. Adipose tissue also contributes significantly to RE storage.... 
Cellular retinol-binding protein type I | Diacylglycerol acyltransferase 1 | 9-cis-retinoic acid or 9-cis-RA | Retinolbinding protein or RBP4 | RAT-LIVER | LIPID-METABOLISM | VITAMIN-A-DEFICIENCY | TRIACYLGLYCEROL SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COA-DIACYLGLYCEROL ACYLTRANSFERASE | BINDING-PROTEIN | STELLATE CELLS | cellular retinol-binding protein type I | ACTIVATED RECEPTOR-BETA/DELTA | diacylglycerol acyltransferase 1 | ACYL-COENZYME-A | ACID-RECEPTOR | retinol-binding protein or RBP4 | Epididymis - metabolism | Retinol O-Fatty-Acyltransferase - genetics | Retinoids - metabolism | Gene Expression | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Adipose Tissue, White - metabolism | Esters | Male | Retinol O-Fatty-Acyltransferase - metabolism | Esterification | Mice, Knockout | Triglycerides - metabolism | Phosphatidylcholine-Sterol O-Acyltransferase - genetics | Retinol-Binding Proteins, Cellular - genetics | Animals | Female | Mice | PPAR delta - metabolism | Phosphatidylcholine-Sterol O-Acyltransferase - metabolism | Protein-Serine-Threonine Kinases - metabolism | Retinol-Binding Proteins, Cellular - metabolism | Index Medicus
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8. Full Text First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus
by Fruscalzo, Arrigo and Londero, Ambrogio P and Driul, Lorenza and Henze, Andrea and Tonutti, Laura and Ceraudo, Maria and Zanotti, Giuseppe and Berni, Rodolfo and Schweigert, Florian J and Raila, Jens
Clinical Chemistry and Laboratory Medicine (CCLM), ISSN 1434-6621, 09/2015, Volume 53, Issue 10, pp. 1643 - 1651
The objective of the study was to investigate the relationship between first trimester maternal serum levels of the TTR-RBP4-ROH complex components and the... 
gestational diabetes mellitus (GDM) | transthyretin (TTR) | large for gestational age fetus (LGA) | protein microheterogeneity | first trimester | insulin | retinol (ROH) | serum retinol binding protein (RBP4) | SERUM RETINOL | TRANSTHYRETIN | RETINOL-BINDING-PROTEIN | PREECLAMPSIA | VITAMIN-A | FETAL-GROWTH RESTRICTION | PREGNANT-WOMEN | RETINOL-BINDING-PROTEIN-4 | MEDICAL LABORATORY TECHNOLOGY | MICROHETEROGENEITY | ASSOCIATION | Diabetes, Gestational - diagnosis | Diabetes, Gestational - blood | Retinol-Binding Proteins, Plasma - analysis | Pregnancy Trimester, First - blood | Humans | Biomarkers - blood | Chromatography, High Pressure Liquid | Vitamin A - analysis | Maternal Serum Screening Tests | Gestational Age | Case-Control Studies | Pregnancy | Adult | Female | Prealbumin - analysis | Retrospective Studies | Insulin - therapeutic use | Vitamin A - blood | Physiological aspects | Diagnosis, Laboratory | Diabetes in pregnancy | Diagnosis | Biological markers | Methods | Index Medicus
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9. Full Text Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
by Graham, Timothy E and Yang, Qin and Blüher, Matthias and Hammarstedt, Ann and Ciaraldi, Theodore P and Henry, Robert R and Wason, Christopher J and Oberbach, Andreas and Jansson, Per-Anders and Smith, Ulf and Kahn, Barbara B and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
The New England Journal of Medicine, ISSN 0028-4793, 06/2006, Volume 354, Issue 24, pp. 2552 - 2563
In this study, serum levels of retinol-binding protein 4, a molecule secreted by adipocytes, correlated with the magnitude of insulin resistance in subjects... 
METABOLIC DEFECTS | MEDICINE, GENERAL & INTERNAL | PLASMA-CONCENTRATIONS | GLUCOSE | RETINOL-BINDING-PROTEIN | HYPERINSULINEMIA | ADIPOSITY | DYSLIPIDEMIA | CORONARY-HEART-DISEASE | FAT DISTRIBUTION | NIDDM | Cross-Sectional Studies | Glucose Transporter Type 4 - metabolism | Retinol-Binding Proteins, Plasma | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Obesity - blood | Thinness - metabolism | Obesity - metabolism | Metabolic Syndrome - blood | Diabetes Mellitus, Type 2 - blood | Retinol-Binding Proteins - metabolism | Insulin Resistance - physiology | Adipocytes - metabolism | Glucose Metabolism Disorders - metabolism | Thinness - blood | Glucose Metabolism Disorders - blood | Adult | Female | Exercise - physiology | Blood Glucose - metabolism | Insulin resistance | Diabetes | Glucose | Insulin | Rodents | Index Medicus | Abridged Index Medicus | Obesity/blood/metabolism | Blood Glucose/metabolism | Adipocytes/metabolism | Thinness/blood/metabolism | Exercise/physiology | MEDICIN OCH HÄLSOVETENSKAP | Diabetes Mellitus | Glucose Transporter Type 4/metabolism | Type 2/blood/genetics/metabolism | Glucose Metabolism Disorders/blood/metabolism | Insulin Resistance/physiology | Metabolic Syndrome X/blood | Retinol-Binding Proteins/metabolism | MEDICAL AND HEALTH SCIENCES
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10. Full Text Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: A community-based, randomized placebo-controlled trial
by Gannon, Bryan and Kaliwile, Chisela and Arscott, Sara A and Schmaelzle, Samantha and Chileshe, Justin and Kalungwana, Ngándwe and Mosonda, Mofu and Pixley, Kevin and Masi, Cassim and Tanumihardjo, Sherry A
American Journal of Clinical Nutrition, ISSN 0002-9165, 12/2014, Volume 100, Issue 6, pp. 1541 - 1550
Background: Biofortification is a strategy to relieve vitamin A (VA) deficiency. Biofortified maize contains enhanced provitamin A concentrations and has been... 
Zambia | 13C-retinol dilution | Biofortified maize | Plant carotenoids | Retinol | SERUM RETINOL | SUGAR FORTIFICATION | RETINOL-DILUTION TECHNIQUE | retinol | BETA-CAROTENE | NUTRITION & DIETETICS | BODY STORES | SCHOOLCHILDREN | METABOLISM | RATIO MASS-SPECTROMETRY | biofortified maize | NUTRITION | plant carotenoids | ACETATE | Food, Fortified - analysis | Zea mays - chemistry | Humans | Liver - metabolism | Male | Vitamin A Deficiency - diet therapy | beta Carotene - administration & dosage | Vitamin A - administration & dosage | Vitamin A Deficiency - epidemiology | C-Reactive Protein - metabolism | Diet | Liver - drug effects | Vitamin A Deficiency - blood | Female | Zambia - epidemiology | Child | Vitamin A - blood | Corn | Nutritional aspects | Vitamin A in human nutrition | Vitamin A | Properties | Liver | Dietary supplements | Clinical trials | Placebo effect | Children & youth | Index Medicus | Abridged Index Medicus
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11. Full Text Identification of 9-cis-retinoic acid as a pancreasspecific autacoid that attenuates glucose-stimulated insulin secretion
by Kane, Maureen A and Folias, Alexandra E and Pingitore, Attilio and Perri, Mariarita and Obrochta, Kristin M and Krois, Charles R and Cione, Erika and Ryu, Joo Yeon and Napoli, Joseph L
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 50, pp. 21884 - 21889
Vitamin A | Rexinoids | Retinol
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12. Full Text Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein
by Perduca, Massimiliano and Nicolis, Stefania and Mannucci, Barbara and Galliano, Monica and Monaco, Hugo L
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 04/2018, Volume 1863, Issue 4, pp. 458 - 466
RBP4 (plasma retinol-binding protein) is the 21 kDa transporter of all-trans retinol that circulates in plasma as a moderately tight 1:1 molar complex of the... 
RBP4, Plasma retinol-binding protein | Lipocalin, TTR, Transthyretin, formerly called prealbumin | X-ray structure | Fatty acid | COMPLEX | TRANSTHYRETIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMNIOTIC-FLUID | VITAMIN-A | PREALBUMIN | CELL BIOLOGY | REFINEMENT | TRANSPORT | BIOPHYSICS | INSULIN-RESISTANCE | URINE | Humans | Retinol-Binding Proteins, Plasma - urine | Fluorescence | Models, Molecular | Crystallography, X-Ray | Static Electricity | Vitamin A - metabolism | Retinol-Binding Proteins, Plasma - chemistry | Amniotic Fluid - metabolism | Mass Spectrometry | Fatty Acid-Binding Proteins - blood | Ligands | Retinol-Binding Proteins, Plasma - metabolism | Retinol-Binding Proteins, Plasma - isolation & purification | Proteins | Retinoids | Mass spectrometry | Saturated fatty acids | Protein binding | Index Medicus
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