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2013, 1. Aufl., ISBN 9780470979655, xii, 393
Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral... 
RNA viruses | Viral vaccines | genetics | Viral proteins | RNA, Viral | Reverse genetics | Viral proteins - Genetics
Book
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 8, pp. 1074 - 1087
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics... 
JOUBERT-SYNDROME | RPGRIP1 | TRANSPORT | CENTRIOLE BIOGENESIS | PROTEIN | C-ELEGANS | MUTATIONS | PHOTORECEPTOR CELLS | MASTER REGULATOR | PRIMARY CILIA | CELL BIOLOGY | Humans | Pregnancy Proteins - genetics | Databases, Genetic | Suppressor Factors, Immunologic - genetics | Photoreceptor Cells - ultrastructure | Pregnancy Proteins - metabolism | Ellis-Van Creveld Syndrome - genetics | Cerebellum - abnormalities | Genetic Testing - methods | Suppressor Factors, Immunologic - metabolism | Membrane Proteins - deficiency | Transfection | RNA Interference | HEK293 Cells | Kidney Diseases, Cystic - genetics | Genomics - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Caenorhabditis elegans - metabolism | Cilia - pathology | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Abnormalities, Multiple | Genetic Markers | Eye Abnormalities - genetics | Cilia - metabolism | Zebrafish - genetics | Cilia - genetics | Mice, Knockout | Proteins - genetics | Caenorhabditis elegans - ultrastructure | Phenotype | Animals | Cerebellar Diseases - genetics | Ciliary Motility Disorders - pathology | Proteins - metabolism | Photoreceptor Cells - metabolism | Zebrafish - metabolism | Retina - abnormalities | High-Throughput Nucleotide Sequencing | Ciliary Motility Disorders - metabolism | Mutation | Ciliary Motility Disorders - genetics | RNA | Cilia and ciliary motion | Genetic research | Biosynthesis | Genetic aspects | Research | Gene expression | Properties | Index Medicus | reverse genetics | cilia | ciliopathies | Joubert syndrome | whole-genome siRNA screen | Jeune syndrome
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7649, pp. 235 - 239
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2008, Volume 40, Issue 6, pp. 730 - 740
Gastric cancer is classified into intestinal and diffuse types, the latter including a highly malignant form, linitis plastica. A two-stage genome-wide... 
GENOTYPE DATA | PROJECT | PROSTATE-CANCER | GENETICS & HEREDITY | RISK | POLYMORPHISM | STEM-CELL ANTIGEN | TUMOR-GROWTH | EXPRESSION | STOMACH | MILLENNIUM GENOME | Carcinoma, Papillary - genetics | Adenocarcinoma - pathology | Cell Proliferation | Cricetulus | Membrane Glycoproteins - metabolism | Adenocarcinoma, Mucinous - pathology | Humans | GPI-Linked Proteins | Stomach Neoplasms - pathology | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Carcinoma, Signet Ring Cell - genetics | Case-Control Studies | Immunoenzyme Techniques | Genetic Variation | Haplotypes - genetics | Transcription, Genetic | Adenocarcinoma - genetics | Neoplasm Proteins - genetics | Odds Ratio | CHO Cells | Korea | Stomach Neoplasms - genetics | Promoter Regions, Genetic | Cricetinae | Genetic Predisposition to Disease | Antigens, Neoplasm | Carcinoma, Signet Ring Cell - pathology | Gene Frequency | Japan | RNA, Messenger - genetics | Exons - genetics | Epithelium | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Papillary - pathology | Genome, Human - genetics | Linkage Disequilibrium | Membrane Glycoproteins - genetics | Animals | Polymorphism, Single Nucleotide - genetics | Mice | Adenocarcinoma, Mucinous - genetics | Intestinal Neoplasms | Prostate-specific antigen | Physiological aspects | Genetic aspects | Single nucleotide polymorphisms | Research | Diagnosis | Stomach cancer | Health aspects | Risk factors | Studies | Mortality | Genomics | Gastrointestinal diseases | Genetic diversity | Mutation | Diabetes | Alzheimers disease | Cells | Cancer | Transcription | Epithelial cells | Exons | Intestine | Stem cells | Single-nucleotide polymorphism | Gastric cancer | Gene polymorphism | Prostate | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 9, pp. 2343 - 2348
Rotaviruses (RVs) are highly important pathogens that cause severe diarrhea among infants and young children worldwide. The understanding of the molecular... 
Vaccine | Reporter virus | Rotavirus | Reverse genetics | reverse genetics | NSP1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | reporter virus | INNATE IMMUNE-RESPONSE | VACCINIA VIRUS | BLUETONGUE VIRUS | CLONED CDNA | vaccine | MESSENGER-RNA | rotavirus | RNA-CAPPING ENZYME | SYNTHETIC RNA | EXPRESSION | Luciferases - metabolism | Cricetulus | Humans | Methyltransferases - metabolism | Reverse Genetics - methods | DNA, Complementary - genetics | Methyltransferases - genetics | Multienzyme Complexes - metabolism | Green Fluorescent Proteins - genetics | Orthoreovirus - metabolism | Vaccinia virus - genetics | Viral Proteins - metabolism | Luciferases - genetics | Base Sequence | Nucleotidyltransferases - metabolism | Genes, Reporter | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Transduction, Genetic | Vaccinia virus - metabolism | Orthoreovirus - genetics | Orthoreovirus, Mammalian - genetics | Gene Expression Regulation | Viral Nonstructural Proteins - genetics | Viral Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Multienzyme Complexes - genetics | Plasmids - metabolism | Animals | Epithelial Cells - virology | Plasmids - chemistry | Cell Line, Tumor | Nucleotidyltransferases - genetics | Viral Nonstructural Proteins - metabolism | DNA-Directed RNA Polymerases - metabolism | Phosphoric Monoester Hydrolases - metabolism | DNA, Complementary - metabolism | Orthoreovirus, Mammalian - metabolism | Genetic aspects | Gene expression | Health aspects | Rotaviruses | Viruses | Genetics | Microbiology | Pathogenesis | Plasmids | Medical immunity | Index Medicus | Biological Sciences
Journal Article
by French, Juliet D and Ghoussaini, Maya and Edwards, Stacey L and Meyer, Kerstin B and Michailidou, Kyriaki and Ahmed, Shahana and Khan, Sofia and Maranian, Mel J and O’Reilly, Martin and Hillman, Kristine M and Betts, Joshua A and Carroll, Thomas and Bailey, Peter J and Dicks, Ed and Beesley, Jonathan and Tyrer, Jonathan and Maia, Ana-Teresa and Beck, Andrew and Knoblauch, Nicholas W and Chen, Shou-Tung and Chen, Constance and Kraft, Peter and Barnes, Daniel and González-Neira, Anna and Alonso, M. Rosario and Herrero, Daniel and Tessier, Daniel C and Vincent, Daniel and Bacot, Francois and Luccarini, Craig and Baynes, Caroline and Conroy, Don and Dennis, Joe and Bolla, Manjeet K and Wang, Xianshu and Wang, Qin and Hopper, John L and Southey, Melissa C and Schmidt, Marjanka K and Broeks, Annegien and Verhoef, Senno and Cornelissen, Sten and Muir, Kenneth and Lophatananon, Artitaya and Stewart-Brown, Sarah and Siriwanarangsan, Pornthep and Fasching, Peter A and Loehberg, Christian R and Ekici, Arif B and Beckmann, Matthias W and Peto, Julian and dos Santos Silva, Isabel and Johnson, Nichola and Aitken, Zoe and Sawyer, Elinor J and Tomlinson, Ian and Kerin, Michael J and Miller, Nicola and Marme, Frederik and Schneeweiss, Andreas and Sohn, Christof and Burwinkel, Barbara and Guénel, Pascal and Truong, Thérèse and Laurent-Puig, Pierre and Menegaux, Florence and Bojesen, Stig E and Nordestgaard, Børge G and Nielsen, Sune F and Flyger, Henrik and Milne, Roger L and Zamora, M. Pilar and Arias Perez, Jose Ignacio and Benitez, Javier and Anton-Culver, Hoda and Brenner, Hermann and Müller, Heiko and Arndt, Volker and Stegmaier, Christa and Meindl, Alfons and Lichtner, Peter and Schmutzler, Rita K and Engel, Christoph and Brauch, Hiltrud and Hamann, Ute and Justenhoven, Christina and Aaltonen, Kirsimari and Heikkilä, Päivi and Aittomäki, Kristiina and Blomqvist, Carl and Matsuo, Keitaro and Ito, Hidemi and Iwata, Hiroji and Sueta, Aiko and Bogdanova, Natalia V and Antonenkova, Natalia N and Dörk, Thilo and Lindblom, Annika and Margolin, Sara and Mannermaa, Arto and ... and KConFab Investigators and GENICA Network and kConFab Investigators
The American Journal of Human Genetics, ISSN 0002-9297, 04/2013, Volume 92, Issue 4, pp. 489 - 503
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2017, Volume 13, Issue 2, pp. e1006609 - e1006609
Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of... 
VARIANTS | DISEASE | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | FUNCTIONAL ANNOTATION | WIDE ASSOCIATION | IDENTIFICATION | NEPHROPATHY | EXPRESSION | GENOMEWIDE ASSOCIATION SCANS | TOOL | Humans | Asian Continental Ancestry Group - genetics | Glomerulonephritis, IGA - genetics | Galactosyltransferases - genetics | Gene Regulatory Networks | RNA Interference | Cell Line | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Gene Frequency | Gene Expression Regulation | Molecular Chaperones - genetics | Genotype | Glycosylation | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Phenotype | Glomerulonephritis, IGA - ethnology | Alleles | Galactose - deficiency | Immunoglobulin A - blood | Genetic Predisposition to Disease - ethnology | Models, Genetic | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Ubiquitin-Protein Ligases - genetics | Glomerulonephritis, IGA - blood | Cohort Studies | Genomics | Physiological aspects | Genetic aspects | Research | Kidney diseases | Immunoglobulin A | Health aspects | Galactose metabolism | Risk factors | Immunoglobulins | Nephrology | Genealogy | Disease | Physicians | Colleges & universities | Genomes | Medicine | Ethnicity | Hospitals | Rodents | Surgeons | Blood diseases | Asians | Index Medicus
Journal Article