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Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16257 - 16266
Gammaherpesviruses (gamma HVs) have a dynamic strategy for lifelong persistence, involving productive infection, latency, and intermittent reactivation. In... 
ACUTE-PHASE RESPONSE | DNA-BINDING | CREB-BINDING PROTEIN | READING FRAME 50 | LYTIC SWITCH PROTEIN | VIRAL REACTIVATION | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOMA-ASSOCIATED HERPESVIRUS | BARR-VIRUS EBV | NF-KAPPA-B | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Rhadinovirus - immunology | STAT3 Transcription Factor - chemistry | Trans-Activators - chemistry | Recombinant Fusion Proteins - metabolism | Immediate-Early Proteins - metabolism | Immediate-Early Proteins - chemistry | Trans-Activators - genetics | B-Lymphocytes - virology | Protein Interaction Domains and Motifs | Rhadinovirus - physiology | Dimerization | Interleukin-6 - metabolism | Peptide Fragments - genetics | Virus Activation | B-Lymphocytes - metabolism | Genes, Reporter | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Line | Peptide Fragments - metabolism | Signal Transduction | Gene Expression Regulation | Recombinant Fusion Proteins - chemistry | Peptide Fragments - chemistry | Tyrosine - metabolism | Animals | B-Lymphocytes - immunology | Immediate-Early Proteins - genetics | Trans-Activators - metabolism | Mice | Protein Processing, Post-Translational | Mutation | Receptors, Interleukin-6 - agonists | Amino Acid Substitution | Receptors, Interleukin-6 - metabolism | infection | gammaherpesvirus | virology | STAT3 | tyrosine | tyrosine phosphorylation | gene expression
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1428 - 1433
A monodonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of... 
T lymphocytes | Proteins | Antigens | Immunization | Dendritic cells | Antibodies | T lymphocyte epitopes | Epitopes | Cytoplasm | Adducts | TCR | vaccine development | DENDRITIC CELLS | vaccines | RECEPTOR DEC-205 | MULTIDISCIPLINARY SCIENCES | MOUSE | MODEL | TRANSNUCLEAR | antibody conjugates | protein engineering | IN-VIVO | MURINE GAMMAHERPESVIRUS 68 | MICE | T-CELLS | Vaccines, Subunit - genetics | Epitopes, T-Lymphocyte - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | Lectins, C-Type - metabolism | Protein Engineering | Tumor Virus Infections - immunology | Amino Acid Sequence | Immunoconjugates - metabolism | Mice, Transgenic | Receptors, Cell Surface - immunology | Mice, Knockout | Epitopes, T-Lymphocyte - chemistry | Antigens, Viral - immunology | Immunoconjugates - genetics | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | CD8-Positive T-Lymphocytes - immunology | Herpesviridae Infections - immunology | Receptors, Cell Surface - genetics | Antigens, CD - immunology | Minor Histocompatibility Antigens | Viral Vaccines - genetics | Lectins, C-Type - immunology | Molecular Sequence Data | Antigens, Viral - genetics | Rhadinovirus - immunology | Lectins, C-Type - genetics | Lectins, C-Type - chemistry | Herpesviridae Infections - prevention & control | Immunoconjugates - immunology | Cysteine Endopeptidases - metabolism | Antigen Presentation | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Epitopes, T-Lymphocyte - immunology | Rhadinovirus - genetics | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Antigens, Viral - chemistry | Vaccines, Subunit - immunology | Tumor Virus Infections - prevention & control | Animals | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Viral Vaccines - immunology | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2016, Volume 113, Issue 36, pp. 10085 - 10090
Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic,... 
Virus | Herpes | Circadian | Clock | Influenza | influenza | IMMUNITY | circadian | ESSENTIAL COMPONENT | herpes | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | clock | virus | Circadian rhythms | Influenza viruses | Herpesviruses | Health aspects | Chromatin | Transcription factors | Circadian rhythm | Herpes viruses | Cells | Biological Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2015, Volume 194, Issue 6, pp. 2746 - 2756
CD4(+) T cells are critical for the control of virus infections, T cell memory, and immune surveillance. We studied the differentiation and function of murine... 
ANTIVIRAL PROTECTION | EFFECTOR FUNCTIONS | VIRUS-INFECTION | CD8(+) EFFECTOR | GAMMAHERPESVIRUS INFECTION | PERSISTENT GAMMAHERPESVIRUS | PERIPHERAL-TISSUES | IMMUNOLOGY | MEDIATED CONTROL | MEMORY CELLS | TRANSCRIPTION FACTOR | Tumor Necrosis Factor-alpha - metabolism | Tumor Virus Infections - genetics | T-Lymphocytes, Regulatory - metabolism | Spleen - immunology | Tumor Virus Infections - virology | Cell Survival - genetics | Apoptosis - genetics | Rhadinovirus - immunology | Interferon-gamma - metabolism | Th1 Cells - immunology | Host-Pathogen Interactions - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Flow Cytometry | Tumor Necrosis Factor-alpha - immunology | Tumor Virus Infections - immunology | CD8-Positive T-Lymphocytes - metabolism | Antigens, Ly - metabolism | Herpesviridae Infections - genetics | Rhadinovirus - physiology | Spleen - pathology | B-Lymphocytes - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Cell Survival - immunology | Herpesviridae Infections - virology | Mice, Knockout | Cell Differentiation - immunology | Animals | Apoptosis - immunology | B-Lymphocytes - immunology | Antigens, Ly - immunology | Spleen - metabolism | Interferon-gamma - immunology | CD8-Positive T-Lymphocytes - immunology | Herpesviridae Infections - immunology
Journal Article
Journal of Virology, ISSN 0022-538X, 2014, Volume 88, Issue 19, pp. 11600 - 11610
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2011, Volume 7, Issue 10, p. e1002300
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2012, Volume 8, Issue 5, p. e1002703
Journal Article
Virology, ISSN 0042-6822, 2013, Volume 448, pp. 196 - 209
Abstract KSHV establishes characteristic latent infections in vitro, while RRV, a related macaque rhadinovirus, establishes characteristic permissive... 
Infectious Disease | Promoter | KSHV | Sp1 | RRV | Replication | Macaque | Transactivator | Rhadinovirus | Rta | TRANSCRIPTIONAL ACTIVATION | MACAQUE RHADINOVIRUS | LYTIC SWITCH PROTEIN | NUCLEAR ANTIGEN | SARCOMA-ASSOCIATED HERPESVIRUS | RETROPERITONEAL FIBROMATOSIS | MONKEY RHADINOVIRUS | HUMAN SALIVARY-GLAND | VIROLOGY | KAPOSIS-SARCOMA | GENE-EXPRESSION | Primate Diseases - metabolism | Humans | Herpesviridae Infections - veterinary | Molecular Sequence Data | Sp1 Transcription Factor - metabolism | Macaca mulatta | Trans-Activators - chemistry | Viral Proteins - metabolism | Immediate-Early Proteins - metabolism | Herpesvirus 8, Human - metabolism | Immediate-Early Proteins - chemistry | Trans-Activators - genetics | Herpesviridae Infections - metabolism | Herpesvirus 8, Human - chemistry | Herpesviridae Infections - genetics | Primate Diseases - genetics | Rhadinovirus - physiology | Amino Acid Sequence | Cell Line | Promoter Regions, Genetic | Rhadinovirus - genetics | Response Elements | Viral Proteins - chemistry | Viral Proteins - genetics | Herpesvirus 8, Human - genetics | Herpesviridae Infections - virology | Primate Diseases - virology | Sequence Alignment | Animals | Immediate-Early Proteins - genetics | Sp1 Transcription Factor - genetics | Virus Replication | Gene Expression Regulation, Viral | Protein Binding | Trans-Activators - metabolism | Virus diseases | Health aspects | replication | macaque | transactivator | promoter | rhadinovirus | Spl
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2013, Volume 9, Issue 10, p. e1003640
Kaposi sarcoma-associated herpesvirus (KSHV) establishes a lifelong latent infection and causes several malignancies in humans. Murine herpesvirus 68 (MHV-68)... 
DNA-BINDING DOMAIN | TRANSCRIPTIONAL ACTIVATION | CRYSTAL-STRUCTURE | MICROBIOLOGY | LATENT NUCLEAR ANTIGEN | ORIGIN | REPLICATION | HUMAN-HERPESVIRUS-8 | VIROLOGY | GENE-EXPRESSION | TERMINAL REPEAT | BET PROTEINS | PARASITOLOGY | Spleen - virology | Chromatin - metabolism | Antigens, Viral - metabolism | Transcription Factors - chemistry | Humans | Protein Multimerization | Antigens, Viral - genetics | Crystallography, X-Ray | Structure-Activity Relationship | Viral Proteins - metabolism | Virus Latency - physiology | Rhadinovirus - chemistry | HEK293 Cells | Protein Structure, Quaternary | Herpesvirus 8, Human - chemistry | Nuclear Proteins - genetics | Rhadinovirus - physiology | Herpesvirus 8, Human - physiology | Protein-Serine-Threonine Kinases - metabolism | Viral Proteins - chemistry | Chromosomal Proteins, Non-Histone | Protein-Serine-Threonine Kinases - genetics | Viral Proteins - genetics | Antigens, Viral - chemistry | Nuclear Proteins - metabolism | Chromatin - virology | Transcription Factors - genetics | Nuclear Proteins - chemistry | Transcription Factors - metabolism | Animals | Spleen - metabolism | Mice | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Chromatin - genetics | Physiological aspects | Host-parasite relationships | Human herpesvirus 8 | Research | Viral proteins | Health aspects | Immunology | Deoxyribonucleic acid | DNA | Mutation | Binding sites | Kaposis sarcoma | Crystal structure
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